A feasibility study testing four hypotheses with phase II outcomes in advanced colorectal cancer (MRC FOCUS3): A model for randomised controlled trials in the era of personalised medicine?

British Journal of Cancer

Volumn 110, Issue 9, 2014, Pages 2178-2186

  Maughan, T S ^a   Meade, A M ^b   Adams, R A ^c   Richman, S D ^d   Butler, R ^e   Fisher, D ^b   Wilson, R H ^f   Jasani, B ^g   Taylor, G R ^d   Williams, G T ^g   Sampson, J R ^g   Seymour, M T ^h   Nichols, L L ^b   Kenny, S L ^b   Nelson, A ^g   Sampson, C M ^g   Hodgkinson, E ⁱ   Bridgewater, J A ^j   Furniss, D L ⁱ   Roy, R ^k   Pope, M J ^b,c   Pope, J K ^b,c   Parmar, M ^b   Quirke, P ^d   Kaplan, R ^b   more..

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b MRC CLINICAL TRIALS UNIT   (United Kingdom)

^c VELINDRE CANCER CENTRE   (United Kingdom)

^d UNIVERSITY OF LEEDS   (United Kingdom)

^e UNIVERSITY HOSPITAL OF WALES   (United Kingdom)

^f QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^g CARDIFF UNIVERSITY   (United Kingdom)

^h UNIVERSITY OF LEEDS   (United Kingdom)

ⁱ SHEFFIELD TEACHING HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^j UNIVERSITY COLLEGE LONDON   (United Kingdom)

^k CASTLE HILL HOSPITAL   (United Kingdom)

more..

Author keywords

biomarkers; colorectal cancer; multi arm trials; personalised medicine

Indexed keywords

B RAF KINASE; BEVACIZUMAB; BIOLOGICAL MARKER; CETUXIMAB; DNA; DNA TOPOISOMERASE; FLUOROURACIL; FOLINIC ACID; IRINOTECAN; K RAS PROTEIN; OXALIPLATIN;

ADULT; ADVANCED CANCER; ADVANCED COLORECTAL CANCER; AGED; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER SURVIVAL; COLORECTAL CANCER; CONTROLLED STUDY; DNA DETERMINATION; DRUG DOSE INCREASE; DRUG RESPONSE; EXPERIMENTAL THERAPY; FEASIBILITY STUDY; FEMALE; GENE MUTATION; HUMAN; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MUTATIONAL ANALYSIS; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; RANDOMIZED CONTROLLED TRIAL;

AGED; AGED, 80 AND OVER; COLORECTAL NEOPLASMS; DISEASE-FREE SURVIVAL; DNA MUTATIONAL ANALYSIS; FEASIBILITY STUDIES; FEMALE; HUMANS; INDIVIDUALIZED MEDICINE; MALE; MIDDLE AGED; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS B-RAF; RAS PROTEINS; TREATMENT OUTCOME; TUMOR MARKERS, BIOLOGICAL;

EID: 84899973910     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.2014.182     Document Type: Article

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