The influence of rare genetic variation in SLC30A8 on diabetes incidence and β-Cell function

Journal of Clinical Endocrinology and Metabolism

Volumn 99, Issue 5, 2014, Pages

  Billings, Liana K ^a,b,d,e   Jablonski, Kathleen A ^f   Ackerman, Rachel J ^a   Taylor, Andrew ^a,g   Fanelli, Rebecca R ^a   McAteer, Jarred B ^a,g   Guiducci, Candace ^g   Delahanty, Linda M ^a,b   Dabelea, Dana ^h   Kahn, Steven E ⁱ   Franks, Paul W ^c,j   Hanson, Robert L ^k   Maruthur, Nisa M ^l   Shuldiner, Alan R ^m   Mayer Davis, Elizabeth J ⁿ   Knowler, William C ^k   Florez, Jose C ^a,b,g  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^d NORTHSHORE UNIVERSITY HEALTHSYSTEM   (United States)

^e UNIVERSITY OF CHICAGO   (United States)

^f GEORGE WASHINGTON UNIVERSITY   (United States)

^g BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^h Food Science and Human Nutrition   (United States)

ⁱ UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^j LUND UNIVERSITY   (Sweden)

^k NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^l JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^m UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

ⁿ University of North Carolina   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ZINC;

ALLELE; ARTICLE; CONTROLLED STUDY; DIABETES CONTROL; DISEASE ASSOCIATION; FOLLOW UP; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HUMAN; INSULIN RELEASE; MAJOR CLINICAL STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET CELL FUNCTION; PRIORITY JOURNAL; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; SLC30A8 GENE;

ADULT; ALLELES; CATION TRANSPORT PROTEINS; DIABETES MELLITUS, TYPE 2; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INCIDENCE; INSULIN; INSULIN-SECRETING CELLS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84899963164     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2013-2378     Document Type: Article

References (20)

1. Billings LK, Florez JC. The genetics of type 2 diabetes: what have we learned from GWAS Ann N Y Acad Sci. 2010;1212:59-77.
2. Ingelsson E, Langenberg C, Hivert MF, et al. Detailed physiologic characterization reveals diverse mechanisms for novel genetic loci regulating glucose and insulin metabolism in humans. Diabetes. 2010;59:1266-1275.
3. Kirchhoff K, Machicao F, Haupt A, et al. Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion. Diabetologia. 2008;51:597-601.
4. Kanoni S, Nettleton JA, Hivert MF, et al. Total zinc intake may modify the glucose-raising effect of a zinc transporter (SLC30A8) variant: a 14-cohort meta-analysis. Diabetes. 2011;60:2407-2416.
5. Chimienti F, Devergnas S, Favier A, Seve M. Identification and cloning of a-cell-spec ific zinc transporter, ZnT-8, localized into insulin secretory granules. Diabetes. 2004;53:2330-2337.
6. Nicolson TJ, Bellomo EA, Wijesekara N, et al. Insulin storage and glucose homeostasis in m ice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants. Diabetes. 2009;58:2070-2083.
7. Chimienti F, Devergnas S, Pattou F, et al. In vivo expressio n and functional characterization of the zinc transporter ZnT8 in glucoseinduced insulin secretion. J Cell Sci. 2006;119:4199-4206.
8. Pound LD, Sarkar SA, Benninger RK, et al. Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion. Biochem J. 2009;421:371-376.
9. Wijesekara N, Dai FF, Hardy AB, et al.-Cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion. Diabetologia. 2010;53:1656-1668.
10. Moore AF, Jablonski KA, McAteer JB, et al. Extension of type 2 diabetes genome-wide association scan results in the diabetes prevention program. Diabetes. 2008;57:2503-2510.
11. The Diabetes Pr evention Program. Design and methods for a clinical trial in the prevention of type 2 diabetes. Diabetes Care. 1999;22:623-634.
12. Knowler WC Barrett-Connor E Fowler SE et al. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin N Engl J Med. 2002 346 393-403.
13. Seltzer HS, Allen EW, Herron AL Jr., Brennan MT. Insulin secretion in response to glycemic s timulus: relation of delayed initial release to carbohydrate intolerance in mild diabetes mellitus. J Clin Invest. 1967;46:323-335.
14. UtzschneiderKM,Prigeon RL, FaulenbachMV,et al. Oral disposition index p redicts the development of future diabetes above and beyond fasting and 2-h glucose levels. Diabetes Care. 2009;32:335-341.
15. Majithia AR, Jablonski KA, McAteer JB, et al. Association of the SLC30A8 missense polymorphism R325W with proinsulin levels at baseline and after lifestyle, metformin or troglitazone intervention in the Diabetes Prevention Program. Diabetologia. 2011;54:2570-2574.
16. Dupuis J, Langenberg C, Prokopenko I, et al. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet. 2010;42:105-116.
17. Mayer-Davis EJ, Sparks KC, Hirst K, et al. Dietary intake in the diabetes prevention program cohort: baseline and 1-year post randomization. Ann Epidemiol. 2004;14:763-772.
18. Li B, Leal SM. Methods for detecting associations with rare variants for common diseases: application to analysis of sequence data.AmJ Hum Genet. 2008;83:311-321.
19. Wu MC, Lee S, Cai T, Li Y, Boehnke M, Lin X. Rare-variant association testing for sequencing data with the sequence kernel association test. Am J Hum Genet. 2011;89:82-93.
20. Lönnerdal B. Dietary factors influencing zinc absorption. J Nutr. 2000;130:1378S-1383S.