GPI-anchored protein complex, LY6K/TEX101, is required for sperm migration into the oviduct and male fertility in mice1

Biology of Reproduction

Volumn 90, Issue 3, 2014, Pages

  Fujihara, Yoshitaka ^a   Okabe, Masaru ^a   Ikawa, Masahito ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

ACE; ADAM3; GPI anchored protein; Knockout; Testis

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE; GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORED PROTEIN; LYMPHOCYTE ANTIGEN; TESTIS EXPRESSED GENE 101; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; FERTILIZATION IN VITRO; GENE INACTIVATION; GENE LOCUS; GERM CELL; IN VITRO STUDY; MALE; MALE FERTILITY; MALE INFERTILITY; MOUSE; NONHUMAN; OVIDUCT; PHENOTYPE; PRIORITY JOURNAL; SPERM; SPERMATOZOON; SPERMATOZOON MIGRATION; TESTIS;

ACE; ADAM3; GPI-ANCHORED PROTEIN; KNOCKOUT; TESTIS;

ADAM PROTEINS; ANIMALS; ANTIGENS, LY; BLOTTING, WESTERN; CALCIUM-BINDING PROTEINS; FALLOPIAN TUBES; FEMALE; FERTILITY; FERTILIZATION IN VITRO; GENETIC VECTORS; GLYCOSYLPHOSPHATIDYLINOSITOLS; HYDROLYSIS; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, KNOCKOUT; MOLECULAR CHAPERONES; PREGNANCY; PROTEINS; REAL-TIME POLYMERASE CHAIN REACTION; SPERM MOTILITY; SPERM-OVUM INTERACTIONS; TRANSFECTION; TRYPSIN;

EID: 84899958161     PISSN: 00063363     EISSN: 15297268     Source Type: Journal    
DOI: 10.1095/biolreprod.113.112888     Document Type: Article

References (28)

1. Yamaguchi R, Muro Y, Isotani A, Tokuhiro K, Takumi K, Adham I, Ikawa M, Okabe M. Disruption of ADAM3 impairs the migration of sperm into oviduct in mouse. Biol Reprod 2009; 81:142-146.
2. Shamsadin R, Adham IM, Nayernia K, Heinlein UA, Oberwinkler H, Engel W. Male mice deficient for germ-cell cyritestin are infertile. Biol Reprod 1999; 61:1445-1451.
3. Tokuhiro K, Ikawa M, Benham AM, Okabe M. Protein disulfide isomerase homolog PDILT is required for quality control of sperm membrane protein ADAM3 and male infertility. Proc Natl Acad Sci U S A 2012; 109:3850-3855.
4. Ikawa M, Tokuhiro K, Yamaguchi R, Benham AM, Tamura T, Wada I, Satouh Y, Inoue N, Okabe M. Calsperin is a testis-specific chaperone required for sperm fertility. J Biol Chem 2011; 286:5639-5646.
5. Ikawa M, Nakanishi T, Yamada S, Wada I, Kominami K, Tanaka H, Nozaki M, Nishimune Y, Okabe M. Calmegin is required for fertilin alpha/beta heterodimerization and sperm fertility. Dev Biol 2001; 240: 254-261.
6. Kondoh G, Tojo H, Nakatani Y, Komazawa N, Murata C, Yamagata K, Maeda Y, Kinoshita T, Okabe M, Taguchi R, Takeda J. Angiotensinconverting enzyme is a GPI-anchored protein releasing factor crucial for fertilization. Nat Med 2005; 11:160-166.
7. Yamaguchi R, Yamagata K, Ikawa M, Moss SB, Okabe M. Aberrant distribution of ADAM3 in sperm from both angiotensin-converting enzyme (Ace)- and calmegin (Clgn)-deficient mice. Biol Reprod 2006; 75:760-766.
8. Fujihara Y, Tokuhiro K, Muro Y, Kondoh G, Araki Y, Ikawa M, Okabe M. Expression of TEX101, regulated by ACE, is essential for the production of fertile mouse spermatozoa. Proc Natl Acad Sci U S A 2013; 110:8111-8116.
9. Tsukamoto H, Yoshitake H, Mori M, Yanagida M, Takamori K, Ogawa H, Takizawa T, Araki Y. Testicular proteins associated with the germ cellmarker, TEX101: involvement of cellubrevin in TEX101-trafficking to the cell surface during spermatogenesis. Biochem Biophys Res Commun 2006; 345:229-238.
10. Yoshitake H, Tsukamoto H, Maruyama-Fukushima M, Takamori K, Ogawa H, Araki Y. TEX101, a germ cell-marker glycoprotein, is associated with lymphocyte antigen 6 complex locus k within the mouse testis. Biochem Biophys Res Commun 2008; 372:277-282.
11. Maruyama M, Yoshitake H, Tsukamoto H, Takamori K, Araki Y. Molecular expression of Ly6k, a putative glycosylphosphatidyl-inositolanchored membrane protein on the mouse testicular germ cells. Biochem Biophys Res Commun 2010; 402:75-81.
12. Okabe M. The cell biology of mammalian fertilization. Development 2013; 140:4471-4479.
13. Ikawa M, Inoue N, Benham AM, Okabe M. Fertilization: a sperm's journey to and interaction with the oocyte. J Clin Invest 2010; 120: 984-994.
14. Yamaguchi R, Fujihara Y, Ikawa M, Okabe M. Mice expressing aberrant sperm-specific protein PMIS2 produce normal-looking but fertilizationincompetent spermatozoa. Mol Biol Cell 2012; 23:2671-2679.
15. Ikawa M, Wada I, Kominami K, Watanabe D, Toshimori K, Nishimune Y, Okabe M. The putative chaperone calmegin is required for sperm fertility. Nature 1997; 387:607-611.
16. Kim T, Oh J, Woo JM, Choi E, Im SH, Yoo YJ, Kim DH, Nishimura H, Cho C. Expression and relationship of male reproductive ADAMs in mouse. Biol Reprod 2006; 74:744-750.
17. Kurita A, Takizawa T, Takayama T, Totsukawa K, Matsubara S, Shibahara H, Orgebin-Crist MC, Sendo F, Shinkai Y, Araki Y. Identification, cloning, and initial characterization of a novel mouse testicular germ cell-specific antigen. Biol Reprod 2001; 64:935-945.
18. Niwa H, Yamamura K, Miyazaki J. Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene 1991; 108:193-199.
19. Fujihara Y, Kaseda K, Inoue N, Ikawa M, Okabe M. Production of mouse pups from germline transmission-failed knockout chimeras. Transgenic Res 2013; 22:195-200.
20. Hasuwa H, Muro Y, Ikawa M, Kato N, Tsujimoto Y, Okabe M. Transgenic mouse sperm that have green acrosome and red mitochondria allow visualization of sperm and their acrosome reaction in vivo. Exp Anim 2010; 59:105-107.
21. Nakagata N. Production of normal young following insemination of frozen-thawed mouse spermatozoa into fallopian tubes of pseudopregnant females. Jikken Dobutsu 1992; 41:519-522.
22. Toyoda Y, Yokoyama M, Hoshi T. Studies on the fertilization of mouse eggs in vitro. Jpn J Anim Reprod 1971; 16:147-151.
23. Nishimura H, Kim E, Nakanishi T, Baba T. Possible function of the ADAM1a/ADAM2 Fertilin complex in the appearance of ADAM3 on the sperm surface. J Biol Chem 2004; 279:34957-34962.
24. Cho C, Bunch DO, Faure JE, Goulding EH, Eddy EM, Primakoff P, Myles DG. Fertilization defects in sperm from mice lacking fertilin beta. Science 1998; 281:1857-1859.
25. Shen C, Kuang Y, Liu J, Feng J, Chen X, Wu W, Chi J, Tang L, Wang Y, Fei J, Wang Z. Prss37 is required for male fertility in the mouse. Biol Reprod 2013; 88:123.
26. Krutskikh A, Poliandri A, Cabrera-Sharp V, Dacheux JL, Poutanen M, Huhtaniemi I. Epididymal protein Rnase10 is required for post-testicular sperm maturation and male fertility.FASEB J2012; 26:4198-4209.
27. Marcello MR, Jia W, Leary JA, Moore KL, Evans JP. Lack of tyrosylprotein sulfotransferase-2 activity results in altered sperm-egg interactions and loss of ADAM3 and ADAM6 in epididymal sperm. J Biol Chem 2011; 286:13060-13070.
28. Grzmil P, Kim Y, Shamsadin R, Neesen J, Adham IM, Heinlein UA, Schwarzer UJ, Engel W. Human cyritestin genes (CYRN1 and CYRN2) are non-functional. Biochem J 2001; 357:551-556.