The relationship between the antitumor effect of the IL-12 gene therapy and the expression of th1 cytokines in an HPV16-positive murine tumor model

Mediators of Inflammation

Volumn 2014, Issue , 2014, Pages

  García Paz, Flor ^a   Madrid Marina, Vicente ^a   Morales Ortega, Ausencio ^a   Santander González, Abimelec ^a   Peralta Zaragoza, Oscar ^a   Burguete García, Ana ^a   Torres Poveda, Kirvis ^a   Moreno, José ^a   Alcocer González, Juan ^b   Hernandez Marquez, Eva ^a   Bermúdez Morales, Victor ^a  

^a INSTITUTO NACIONAL DE SALUD PÚBLICA   (Mexico)

^b UNIVERSIDAD AUTÓNOMA DE NUEVO LEÓN   (Mexico)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 2; INTERLEUKIN 4; TH1 CYTOKINE; TH2 CYTOKINE; TH3 CYTOKINE; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER GENE THERAPY; CANCER INHIBITION; CANCER SURVIVAL; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; DNA IMMUNIZATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION; GENE TRANSFER; HUMAN PAPILLOMAVIRUS TYPE 16; MOUSE; NATURAL KILLER T CELL; NONHUMAN; PAPILLOMAVIRUS INFECTION; PERIPHERAL BLOOD MONONUCLEAR CELL; PLASMID; PROTEIN BLOOD LEVEL; REAL TIME POLYMERASE CHAIN REACTION; SURVIVAL RATE; SUSTAINED DRUG RELEASE; TUMOR MICROENVIRONMENT; UTERINE CERVIX CANCER; ANIMAL; BAGG ALBINO MOUSE; DISEASE MODEL; GENE THERAPY; GENETICS; METABOLISM; PATHOGENICITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TH1 CELL; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; CYTOKINES; DISEASE MODELS, ANIMAL; FEMALE; GENETIC THERAPY; HUMAN PAPILLOMAVIRUS 16; INTERFERON-GAMMA; INTERLEUKIN-10; INTERLEUKIN-12; INTERLEUKIN-4; MICE; MICE, INBRED BALB C; PLASMIDS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TH1 CELLS;

EID: 84899953507     PISSN: 09629351     EISSN: 14661861     Source Type: Journal    
DOI: 10.1155/2014/510846     Document Type: Article

References (33)

1. Mougin C., Dalstein V., Prétet J. L., Gay C., Schaal J. P., Riethmuller D., Epidemiology of HPV cervical infections: recent knowledge. Presse Medicale 2001 30 20 1017 1023 2-s2.0-0035832531 (Pubitemid 32547593)
2. Mougin C., Mo L., Dalstein V., Natural history of papillomavirus infections. Revue du Praticien 2006 56 17 1883 1889 2-s2.0-33845318545 (Pubitemid 44875355)
3. Díaz-Benitez C., Navarro-Flores C., Flores A., CD3zeta expression and T cell proliferation are inhibited by TGF-beta1 and IL-10 in cervical cancer patients. Journal of Clinical Immunology 2009 29 532 544
4. Ryu K. S., Soo Y. L., Kim B. K., Park Y. G., Kim Y. W., Hur S. Y., Kim T. E., Kim I.-K., Kim J. W., Alterations of HLA class I and II antigen expression in preinvasive, invasive and metastatic cervical cancers. Experimental and Molecular Medicine 2001 33 3 136 144 2-s2.0-0035975569 (Pubitemid 32954690)
5. Alcocer-González J. M., Berumen J., Taméz-Guerra R., Bermúdez-Morales V., Peralta-Zaragoza O., Hernández-Pando R., Moreno J., Gariglio P., Madrid-Marina V., In vivo expression of immunosuppressive cytokines in human papillomavirus-transfonned cervical cancer cells. Viral Immunology 2006 19 3 481 491 2-s2.0-33750962552 10.1089/vim.2006.19.481 (Pubitemid 44735060)
6. Bermudez-Morales V. H., Gutiérrez L. X., Alcocer-González J. M., Burguete A., Madrid-Marina V., Correlation between IL-10 gene expression and HPV infection in cervical cancer: a mechanism for immune response escape. Cancer Investigation 2008 26 10 1037 1043 2-s2.0-57749199105 10.1080/07357900802112693
7. Bais A. G., Beckmann I., Lindemans J., Ewing P. C., Meijer C. J. L. M., Snijders P. J. F., Helmerhorst T. J. M., A shift to a peripheral Th2-type cytokine pattern during the carcinogenesis of cervical cancer becomes manifest in CIN III lesions. Journal of Clinical Pathology 2005 58 10 1096 1100 2-s2.0-26244467124 10.1136/jcp.2004.025072 (Pubitemid 41416062)
8. Clerici M., Merola M., Ferrario E., Trabattoni D., Villa M. L., Stefanon B., Venzon D. J., Shearer G. M., De Palo G., Clerici E., Cytokine production patterns in cervical intraepithelial neoplasia: association with human papillomavirus infection. Journal of the National Cancer Institute 1997 89 3 245 250 2-s2.0-0031019375 (Pubitemid 27073762)
9. Lieberman J. A., Moscicki A.-B., Sumerel J. L., Ma Y., Scott M. E., Determination of cytokine protein levels in cervical mucus samples from young women by a multiplex immunoassay method and assessment of correlates. Clinical and Vaccine Immunology 2008 15 1 49 54 2-s2.0-43149093787 10.1128/CVI.00216-07 (Pubitemid 351966533)
10. Alves A., Vibert E., Trajcevski S., Solly S., Fabre M., Soubrane O., Qian C., Prieto J., Klatzmann D., Panis Y., Adjuvant interleukin-12 gene therapy for the management of colorectal liver metastases. Cancer Gene Therapy 2004 11 12 782 789 2-s2.0-10444241232 10.1038/sj.cgt.7700760 (Pubitemid 39636345)
11. Del Vecchio M., Bajetta E., Canova S., Lotze M. T., Wesa A., Parmiani G., Anichini A., Interleukin-12: biological properties and clinical application. Clinical Cancer Research 2007 13 16 4677 4685 2-s2.0-34548067624 10.1158/1078-0432.CCR-07-0776 (Pubitemid 47294773)
12. Fewell J. G., Matar M., Rice J. S., Brunhoeber E., Slobodkin G., Pence C., Worker M., Lewis D. H., Anwer K., Treatment of disseminated ovarian cancer using nonviral interleukin-12 gene therapy delivered intraperitoneally. Journal of Gene Medicine 2009 11 8 718 728 2-s2.0-70349511935 10.1002/jgm.1356
13. Wang Y., Fan K., Li J., Waller E., The regulation and activity of interleukin-12. Frontiers in Bioscience 2002 4 888 899
14. Yao L., Sgadari C., Furuke K., Bloom E. T., Teruya-Feldstein J., Tosato G., Contribution of natural killer cells to inhibition of angiogenesis by interleukin-12. Blood 1999 93 5 1612 1621 2-s2.0-0033104852 (Pubitemid 29102489)
15. Yin X., Yan X., Yang Q., Cao H., Liang H., AntiTumor mechanism of recombinant murine interleukin-12 vaccine. Cancer Biotherapy and Radiopharmaceuticals 2010 25 3 263 268 2-s2.0-77954950430 10.1089/cbr.2010.0771
16. Coughlin C. M., Salhany K. E., Wysocka M., Aruga E., Kurzawa H., Chang A. E., Hunter C. A., Fox J. C., Trinchieri G., Lee W. M. F., Interleukin-12, and interleukin-18 synergistically induce murine tumor regression which involves inhibition of angiogenesis. Journal of Clinical Investigation 1998 101 6 1441 1452 2-s2.0-0032521153 (Pubitemid 28145262)
17. Shi F., Rakhmilevich A. L., Heise C. P., Oshikawa K., Sondel P. M., Yang N.-S., Mahvi D. M., Intratumoral injection of interleukin-12 plasmid DNA, either naked or in complex with cationic lipid, results in similar tumor regression in a murine model. Molecular cancer therapeutics 2002 1 11 949 957 2-s2.0-0036726133
18. Yoshimoto T., Xu M., Mizoguchi I., Morishima N., Chiba Y., Mizuguchi J., Regulation of antitumor immune responses by the IL-12 family cytokines, IL-12, IL-23, and IL-27. Clinical and Developmental Immunology 2010 2010 9 2-s2.0-77957866376 10.1155/2010/832454 832454
19. Hallez S., Detremmerie O., Giannouli C., Thielemans K., Gajewski T. F., Burny A., Oberdan L., Interleukin-12-secreting human papillomavirus type 16-transformed cells provide a potent cancer vaccine that generates E7-directed immunity. International Journal of Cancer 1999 81 3 428 437 2-s2.0-0032916209 (Pubitemid 29165202)
20. Oshikawa K., Shi F., Rakhmilevich A. L., Sondel P. M., Mahvi D. M., Yang N.-S., Synergistic inhibition of tumor growth in a murine mammary adenocarcinoma model by combinational gene therapy using IL-12, pro-IL-18, and IL-1 β converting enzyme cDNA. Proceedings of the National Academy of Sciences of the United States of America 1999 96 23 13351 13356 2-s2.0-0033539579 10.1073/pnas.96.23.13351
21. + T cells. Immune Network 2013 13 63 69
22. Weber S. M., Shi F., Heise C., Warner T., Mahvi D. M., Interleukin-12 gene transfer results in CD8-dependent regression of murine CT26 liver tumors. Annals of Surgical Oncology 1999 6 2 186 194 2-s2.0-0032943223 (Pubitemid 29114283)
23. Colombo M. P., Trinchieri G., Interleukin-12 in anti-tumor immunity and immunotherapy. Cytokine and Growth Factor Reviews 2002 13 2 155 168 2-s2.0-0036005890 10.1016/S1359-6101(01)00032-6 (Pubitemid 34229390)
24. Gonzalez-Aparicio M., Alzuguren P., Mauleon I., Medina-Echeverz J., Hervas-Stubbs S., Mancheno U., Berraondo P., Crettaz J., Gonzalez-Aseguinolaza G., Prieto J., Hernandez-Alcoceba R., Oxaliplatin in combination with liver-specific expression of interleukin 12 reduces the immunosuppressive microenvironment of tumours and eradicates metastatic colorectal cancer in mice. Gut 2011 60 3 341 349 2-s2.0-79851516572 10.1136/gut.2010.211722
25. Guo Q.-Y., Yuan M., Peng J., Cui X.-M., Song G., Sui X., Lu S.-B., Antitumor activity of mixed heat shock protein/peptide vaccine and cyclophosphamide plus interleukin-12 in mice sarcoma. Journal of Experimental and Clinical Cancer Research 2011 30 1, article 24 2-s2.0-79951944535 10.1186/1756-9966-30-24
26. 1 promoter throughout Sp1 recognition sequence. Viral Immunology 2006 19 3 468 480 2-s2.0-33750954562 10.1089/vim.2006.19.468 (Pubitemid 44735059)
27. Tjiong M. Y., Van Der Vange N., Ter Schegget J. S., Burger M. P. M., Ten Kate F. W. J., Out T. A., Cytokines in cervicovaginal washing fluid from patients with cervical neoplasia. Cytokine 2001 14 6 357 360 2-s2.0-0035927495 10.1006/cyto.2001.0909 (Pubitemid 32730478)
28. Iancu I., Botezatu A., Goia-Ruşanu C., Stǎnescu A., Huicǎ I., Nistor E., Anton G., Pleşa A., TGF-beta signalling pathway factors in HPV-induced cervical lesions. Roumanian Archives of Microbiology and Immunology 2010 69 113 118
29. Sharma A., Rajappa M., Saxena A., Sharma M., Cytokine profile in Indian women with cervical intraepithelial neoplasia and cancer cervix. International Journal of Gynecological Cancer 2007 17 4 879 885 2-s2.0-34447333699 10.1111/j.1525-1438.2007.00883.x (Pubitemid 47063332)
30. Sur S., Lam J., Bouchard P., Sigounas A., Holbert D., Metzger W. J., Immunomodulatory effects of IL-12 on allergic lung inflammation depend on timing of doses. Journal of Immunology 1996 157 9 4173 4180 2-s2.0-0030293642 (Pubitemid 126449332)
31. Liang W., Wang X.-F., In vitro induction of specific anti-tumoral immunity against laryngeal carcinoma by using human interleukin-12 gene-transfected dendritic cells. Chinese Medical Journal 2011 124 9 1357 1361 2-s2.0-79955980246
32. Sin J.-I., Suppression of antitumour protective cytotoxic T lymphocyte responses to a human papillomavirus 16 E7 DNA vaccine by coinjection of interleukin-12 complementary DNA: involvement of nitric oxide in immune suppression. Immunology 2009 128 1 e707 e717 2-s2.0-68249142911 10.1111/j.1365-2567.2009.03068.x
33. Bermúdez-Humarán L. G., Cortes-Perez N. G., Lefèvre F., Guimarães V., Rabot S., Alcocer-Gonzalez J. M., Gratàdoux J.-J., Rodriguez-Padilla C., Tamez-Guerra R. S., Corthier G., Gruss A., Langella P., A novel mucosal vaccine based on live lactococci expressing E7 antigen and IL-12 induces systemic and mucosal immune responses and protects mice against human papillomavirus type 16-induced tumors. Journal of Immunology 2005 175 11 7297 7302 2-s2.0-28244455880 (Pubitemid 41713425)