Immunomodulatory Effect of Red Onion (Allium cepa Linn) Scale Extract on Experimentally Induced Atypical Prostatic Hyperplasia in Wistar Rats

Mediators of Inflammation

Volumn 2014, Issue , 2014, Pages

  Elberry, Ahmed A ^a,b   Mufti, Shagufta ^c   Al Maghrabi, Jaudah ^c   Abdel Sattar, Essam ^d   Ghareib, Salah A ^a   Mosli, Hisham A ^c   Gabr, Salah A ^e  

^a KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

^b BENI SUEF UNIVERSITY   (Egypt)

^c King Abdulaziz University   (Saudi Arabia)

^d CAIRO UNIVERSITY   (Egypt)

^e NUCLEAR RESEARCH CENTER   (Egypt)

Author keywords

[No Author keywords available]

Indexed keywords

CLUSTERIN; INTERLEUKIN 6; INTERLEUKIN 8; ONION EXTRACT; QUERCETIN; QUERCETIN 4' BETA O DEXTRO GLUCOSIDE; QUERCETIN DERIVATIVE; SABAL EXTRACT; SOMATOMEDIN C; TESTOSTERONE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; IMMUNOLOGIC FACTOR; PLANT EXTRACT; TRANSFORMING GROWTH FACTOR BETA1;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CASTRATION; CELL PROLIFERATION; COLUMNAR EPITHELIUM; CONTROLLED STUDY; GENE EXPRESSION; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; IMMUNOMODULATION; INFLAMMATION; MALE; NEUTROPHIL; NONHUMAN; ONION; PROSTATE HYPERTROPHY; PROSTATE VENTRAL LOBE; RAT; SABAL; STROMA CELL; SUSPENSION; ANIMAL; CHEMISTRY; METABOLISM; PROSTATIC HYPERPLASIA; WISTAR RAT;

ANIMALS; IMMUNOLOGIC FACTORS; INTERLEUKIN-6; INTERLEUKIN-8; MALE; ONIONS; PLANT EXTRACTS; PROSTATIC HYPERPLASIA; RATS; RATS, WISTAR; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84899946157     PISSN: 09629351     EISSN: 14661861     Source Type: Journal    
DOI: 10.1155/2014/640746     Document Type: Article

References (61)

1. Sciarra A., Mariotti G., Salciccia S., Gomez A. A., Monti S., Toscano V., di Silverio F., Prostate growth and inflammation. Journal of Steroid Biochemistry and Molecular Biology 2008 108 3-5 254 260 2-s2.0-38749135796 10.1016/j.jsbmb.2007.09.013 (Pubitemid 351179630)
2. Stamatiou K., Alevizos A., Natzar M., Mihas C., Mariolis A., Michalodimitrakis E., Sofras F., Associations among benign prostate hypertrophy, atypical adenomatous hyperplasia and latent carcinoma of the prostate. Asian Journal of Andrology 2007 9 2 229 233 2-s2.0-33947254588 10.1111/j.1745-7262. 2007.00187.x (Pubitemid 46416584)
3. Bostwick D. G., Srigley J., Grignon D., Maksem J., Humphrey P., Van der Kwast T. H., Bose D., Harrison J., Young R. H., Atypical adenomatous hyperplasia of the prostate: morphologic criteria for its distinction from well-differentiated carcinoma. Human Pathology 1993 24 8 818 832 2-s2.0-0027220464 10.1016/0046-8177(93)90131-Y (Pubitemid 23238960)
4. Novara G., Galfano A., Berto R. B., Ficarra V., Navarrete R. V., Artibani W., Inflammation, apoptosis, and BPH: what is the evidence? European Urology 2006 5 4 401 409 2-s2.0-33644787123 10.1016/j.eursup.2006.02.003 (Pubitemid 43340414)
5. Sandhu J. S., Prostate cancer and chronic prostatitis. Current Urology Reports 2008 9 4 328 332 2-s2.0-48749110020 10.1007/s11934-008-0056-6
6. Rigas B., Sun Y., Induction of oxidative stress as a mechanism of action of chemopreventive agents against cancer. British Journal of Cancer 2008 98 7 1157 1160 2-s2.0-41649096518 10.1038/sj.bjc.6604225 (Pubitemid 351481667)
7. Rahman K., Lowe G. M., Garlic and cardiovascular disease: a critical review. Journal of Nutrition 2006 136 3 736S 740S 2-s2.0-33644843461 (Pubitemid 43363766)
8. Galeone C., Pelucchi C., Levi F., Negri E., Franceschi S., Talamini R., Giacosa A., La Vecchia C., Onion and garlic use and human cancer. American Journal of Clinical Nutrition 2006 84 5 1027 1032 2-s2.0-33750916726 (Pubitemid 44730372)
9. de Martino A., Filomeni G., Aquilano K., Ciriolo M. R., Rotilio G., Effects of water garlic extracts on cell cycle and viability of HepG2 hepatoma cells. Journal of Nutritional Biochemistry 2006 17 11 742 749 2-s2.0-33749679855 10.1016/j.jnutbio.2005.12.005 (Pubitemid 44557047)
10. Bravi F., Bosetti C., dal Maso L., Talamini R., Montella M., Negri E., Ramazzotti V., Franceschi S., la Vecchia C., Food groups and risk of benign prostatic hyperplasia. Urology 2006 67 1 73 79 2-s2.0-30344450110 10.1016/j.urology.2005.07.030 (Pubitemid 43069259)
11. Griffiths G., Trueman L., Crowther T., Thomas B., Smith B., Onions-a global benefit to health. Phytotherapy Research 2002 16 7 603 615 2-s2.0-0036846711 10.1002/ptr.1222 (Pubitemid 35334179)
12. Tram N. L., Hazama C., Shimoyamada M., Ando H., Kato K., Yamauchi R., Antioxidative compounds from the outer scales of onion. Journal of Agricultural and Food Chemistry 2005 53 21 8183 8189 2-s2.0-27644501495 10.1021/jf051264d (Pubitemid 41568558)
13. Gülşen A., Makris D. P., Kefalas P., Biomimetic oxidation of quercetin: isolation of a naturally occurring quercetin heterodimer and evaluation of its in vitro antioxidant properties. Food Research International 2007 40 1 7 14 2-s2.0-33750950073 10.1016/j.foodres.2006.07.009 (Pubitemid 44738533)
14. Singh B. N., Singh B. R., Singh R. L., Prakash D., Singh D. P., Sarma B. K., Upadhyay G., Singh H. B., Polyphenolics from various extracts/fractions of red onion (Allium cepa) peel with potent antioxidant and antimutagenic activities. Food and Chemical Toxicology 2009 47 6 1161 1167 2-s2.0-67349266561 10.1016/j.fct.2009.02.004
15. Shoskes D. A., Zeitlin S. I., Shahed A., Rajfer J., Quercetin in men with category III chronic prostatitis: a preliminary prospective, double-blind, placebo-controlled trial. Urology 1999 54 6 960 963 2-s2.0-0033252747
16. Trease G. E., Evans W. C., Pharmacognosy 1983 London, UK Bailliere Tindall Press
17. Wagner H., Bladt S., Plant Drug Analysis: A Thin Layer Chromatography Atlas 1996 London, UK Springer
18. Singleton V. L., Rossi J. A., Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. American Journal of Enology and Viticulture 1965 16 144 158
19. Hertog M. G. L., Content of potentially anticarcinogenic flavonoids of 28 vegetables and 9 fruits commonly consumed in the Netherlands. Journal of Agricultural and Food Chemistry 1992 40 12 2379 2383 2-s2.0-33751391867
20. Abdel-Sattar E. A., Mouneir S. M., Asaad G. F., Abdallah H. M., Protective effect of Calligonum comosum on haloperidol-induced oxidative stress in rat. Toxicology and Industrial Health 2014 30 2 147 153 10.1177/ 0748233712452601
21. Braca A., Nunziatina D., Lorenzo D. B., Cosimo P., Mateo P., Ivano M., Antioxidant principles from Bauhinia terapotensis. Journal of Natural Products 2001 64 892 895
22. Abou Zid S. F., Elsherbeiny G. M., Increase in flavonoids content in red onion peel bymechanical shredding. Journal of Medicinal Plants Research 2008 2 9 258 260
23. Golomb E., Kruglikova A., Dvir D., Abramovici A., Induction of atypical prostatic hyperplasia in rats by sympathomimetic stimulation. The Prostate 1998 34 214 221 (Pubitemid 28156612)
24. Sandford L., Searle J. W., Kerr J. F., Successive waves of apoptosis in the rat prostate after repeated withdrawal of testosterone stimulation. Pathology 1984 16 4 406 410 2-s2.0-0021718260 (Pubitemid 15193322)
25. Engelstein D., Shmueli J., Bruhis S., Servadio C., Abramovici A., Citral and testosterone interactions in inducing benign and atypical prostatic hyperplasia in rats. Comparative Biochemistry and Physiology 1996 115 2 169 177 2-s2.0-0030267155 10.1016/S0742-8413(96)00057-6 (Pubitemid 26425803)
26. Scolnik M. D., Servadio C., Abramovici A., Comparative study of experimentally induced benign and atypical hyperplasia in the ventral prostate of different rat strains. Journal of Andrology 1994 15 4 287 297 2-s2.0-0028040924 (Pubitemid 24256641)
27. Lillie R. D., Histopathologic Techniques and Practical Histochemistry 1965 New York, NY, USA McGraw-Hill
28. de Nunzio C., Kramer G., Marberger M., Montironi R., Nelson W., Schröder F., Sciarra A., Tubaro A., The controversial relationship between benign prostatic hyperplasia and prostate cancer: the role of inflammation. European Urology 2011 60 1 106 117 2-s2.0-79957957222 10.1016/j.eururo.2011.03. 055
29. Hobisch A., Rogatsch H., Hittmair A., Immunohistochemical localization of interleukin-6 and its receptor in benign, premalignant and malignant prostate tissue. The Journal of Pathology 2000 191 239 244 (Pubitemid 30441246)
30. Gounder S. K., Chang V. T., Hoover D., Gonzalez M. L., Ahmed S., Finch-Cruz C., Duque L., Zhong F., Toomey K., Kasimis B. S., Prostate cancer immunohistochemical (IHC) stains and survival in stage D3 patients. J Clin Oncol 2008 26 15 22187
31. Bostwick D. G., Cooner W. H., Denis L., Jones G. W., Scardino P. T., Murphy G. P., The association of benign prostatic hyperplasia and cancer of the prostate. Cancer 1992 70 1 291 301 2-s2.0-0026681736
32. Abramovici A., Servadio C., Shmuely J., Sandbank U., Experimental induction of atypical hyperplasia in rat ventral prostate. Progress in clinical and biological research 1987 243 559 568 2-s2.0-0023066543
33. Geldof A. A., Engel C., Rao B. R., Estrogenic action of commonly used fragrant agent citral induces prostatic hyperplasia. Urological Research 1992 20 2 139 144 2-s2.0-0026561977
34. Brolin J., Skoog L., Ekman P., Immunohistochemistry and biochemistry in detection of androgen, progesterone, and estrogen receptors in benign and malignant human prostatic tissue. Prostate 1992 20 4 281 295 2-s2.0-0026755277 10.1002/pros.2990200404
35. Ho S. M., Leav I., Merk F. B., Yu M., Kwan P. W. L., Ziar J., Induction of atypical hyperplasia, apoptosis, and type II estrogen- binding sites in the ventral prostates of noble rats treated with testosterone and pharmacologic doses of estradiol-17 β Laboratory Investigation 1995 73 3 356 365 2-s2.0-0029116814
36. Soulitzis N., Karyotis I., Delakas D., Spandidos D. A., Expression analysis of peptide growth factors VEGF, FGF2, TGFB1, EGF and IGF1 in prostate cancer and benign prostatic hyperplasia. International Journal of Oncology 2006 29 2 305 314 2-s2.0-33845685422
37. Marinese D., Patel R., Walden P. D., Mechanistic investigation of the adrenergic induction of ventral prostate hyperplasia in mice. Prostate 2003 54 3 230 237 2-s2.0-0037441363 10.1002/pros.10170 (Pubitemid 36120321)
38. Shin I. S., Lee M. Y., Ha H. K., Seo C. S., Shin H. K., Inhibitory effect of Yukmijihwang-tang, a traditional herbal formula against testosterone-induced benign prostatic hyperplasia in rats. BMC Complementary and Alternative Medicine 2012 20 12 48
39. Peng C. C., Liu J. H., Chang C. H., Chung J. Y., Chen K. C., Chou K. Y., Peng R. Y., Action mechanism of Ginkgo biloba leaf extract intervened by exercise therapy in treatment of benign prostate hyperplasia. Evidence-Based Complementary and Alternative Medicine 2013 2013 12 10.1155/2013/408734 408734
40. Ma C. H., Lin W. L., Lui S. L., Cai X. Y., Wong V. T., Ziea E., Zhang Z. J., Efficacy and safety of Chinese herbal medicine for benign prostatic hyperplasia: systematic review of randomized controlled trials. Asian Journal of Andrology 2013 15 471 482
41. Ma Z., Nguyen T. H., Huynh T. H., Do P. T., Huynh H., Reduction of rat prostate weight by combined quercetin-finasteride treatment is associated with cell cycle deregulation. Journal of Endocrinology 2004 181 3 493 507 2-s2.0-3042803764 10.1677/joe.0.1810493 (Pubitemid 38868199)
42. Jung J. Y., Lim Y., Moon M. S., Kim J. Y., Kwon O., Onion peel extracts ameliorate hyperglycemia and insulin resistance in high fat diet/streptozotocin- induced diabetic rats. Nutrition and Metabolism 2011 8, article 18 2-s2.0-79953114290 10.1186/1743-7075-8-18
43. Djavan B., Eckersberger E., Espinosa G., Kramer G., Handisurya A., Lee C., Marberger M., Lepor H., Steiner G. E., Complex Mechanisms in Prostatic Inflammatory Response. European Urology 2009 8 13 872 878 2-s2.0-72049091771 10.1016/j.eursup.2009.11.003
44. Giri D., Ozen M., Ittmann M., Interleukin-6 is an autocrine growth factor in human prostate cancer. The American Journal of Pathology 2001 159 6 2159 2165 2-s2.0-0035180451 (Pubitemid 33104270)
45. Radeke H. H., Meier B., Topley N., Floge J., Habermehl G. G., Resch K., Interleukin 1- and tumor necrosis factor- induce oxygen radical production in mesangial cells. Kidney International 1990 37 2 767 775 2-s2.0-0025069960 (Pubitemid 20056850)
46. Descazeaud A., Weinbreck N., Robert G., Vacherot F., Abbou C. C., Labrousse F., Allory Y., Rubin M. A., De La Taille A., Transforming growth factor β -receptor II protein expression in benign prostatic hyperplasia is associated with prostate volume and inflammation. BJU International 2011 108 2 E23 E28 2-s2.0-79957935538 10.1111/j.1464-410X.2010.09699.x
47. Coskun O., Kanter M., Korkmaz A., Oter S., Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and β -cell damage in rat pancreas. Pharmacological Research 2005 51 2 117 123 2-s2.0-11144328863 10.1016/j.phrs.2004.06.002 (Pubitemid 40040541)
48. Bland J. S., Clinical Nutrition: A Functional Approach 1999 Gig Harbor, Wash, USA The Institute for Functional Medicine
49. Xing N., Chen Y., Mitchell S. H., Young C. Y. F., Quercetin inhibits the expression and function of the androgen receptor in LNCaP prostate cancer cells. Carcinogenesis 2001 22 3 409 414 2-s2.0-0035095666 (Pubitemid 32203819)
50. Vijayababu M. R., Arunkumar A., Kanagaraj P., Venkataraman P., Krishnamoorthy G., Arunakaran J., Quercetin downregulates matrix metalloproteinases 2 and 9 proteins expression in prostate cancer cells (PC-3). Molecular and Cellular Biochemistry 2006 287 1-2 109 116 2-s2.0-33745945847 10.1007/s11010-005-9085-3 (Pubitemid 44057398)
51. Bhatia N., Agarwal C., Agarwal R., Differential responses of skin cancer-chemopreventive agents silibinin, quercetin, and epigallocatechin 3-gallate on mitogenic signaling and cell cycle regulators in human epidermoid carcinoma A431 cells. Nutrition and Cancer 2001 39 2 292 299 2-s2.0-0035226608 (Pubitemid 33694049)
52. Choi J. A., Kim J. Y., Lee J. Y., Kang C. M., Kwon H. J., Yoo Y. D., Kim T. W., Lee Y. S., Lee S. J., Induction of cell cycle arrest and apoptosis in human breast cancer cells by quercetin. International journal of oncology 2001 19 4 837 844 2-s2.0-0035489192
53. Shoskes D. A., Nickel J. C., Kattan M. W., Phenotypically directed multimodal therapy for chronic prostatitis/chronic pelvic pain syndromepp. A prospective study using UPOINT. Urology 2010 75 6 1249 1253 2-s2.0-77952879701 10.1016/j.urology.2010.01.021
54. Wu S., Sun H., Qi X., Tu Z., Effect of epristeride on the expression of IGF-1 and TGF- β receptors in androgen-induced castrated rat prostate. Experimental Biology and Medicine 2001 226 10 954 960 2-s2.0-0035525671
55. Furlanetto R. W., DiCarlo J. N., Wisehart C., The type II insulin-like growth factor receptor does not mediate deoxyribonucleic acid synthesis in human fibroblasts. Journal of Clinical Endocrinology and Metabolism 1987 64 6 1142 1149 2-s2.0-0023240155 (Pubitemid 17074770)
56. Culig Z., Hobisch A., Cronauer M. V., Radmayr C., Hittmair A., Zhang J., Thurnher M., Bartsch G., Klocke H., Regulation of prostatic growth and function by peptide growth factors. Prostate 1996 28 392 405 (Pubitemid 26187724)
57. Senthilkumar K., Elumalai P., Arunkumar R., Banudevi S., Gunadharini N. D., Sharmila G., Selvakumar K., Arunakaran J., Quercetin regulates insulin like growth factor signaling and induces intrinsic and extrinsic pathway mediated apoptosis in androgen independent prostate cancer cells (PC-3). Molecular and Cellular Biochemistry 2010 344 1-2 173 184 2-s2.0-78449279609 10.1007/s11010-010-0540-4
58. Ranelletti F. O., Ricci R., Larocca L. M., Maggiano N., Capelli A., Scambia G., Benedetti-Panici P., Mancuso S., Rumi C., Piantelli M., Growth-inhibitory effect of quercetin and presence of type-II estrogen-binding sites in human colon-cancer cell lines and primary colorectal tumors. International Journal of Cancer 1992 50 3 486 492 2-s2.0-0026543798
59. Wei Y. Q., Zhao X., Kariya Y., Fukata H., Teshigawara K., Uchida A., Induction of apoptosis by quercetin: involvement of heat shock protein. Cancer Research 1994 54 18 4952 4957 2-s2.0-0028108990 (Pubitemid 24289427)
60. Lines T. C., Ono M., FRS 1000, an extract of red onion peel, strongly inhibits phosphodiesterase 5A (PDE 5A). Phytomedicine 2006 13 4 236 239 2-s2.0-32844473004 10.1016/j.phymed.2004.12.001 (Pubitemid 43255322)
61. Deng C. H., Chen H. R., Qiu S. P., Liu J. Z., Zheng K. L., Mei H., Effect of nitric oxide donor and alpha1-receptor antagonist on proliferation/apoptosis of hyperplastic prostatic stromal cells in vitro. Zhonghua Wai Ke Za Zhi 2004 42 4 201 204 2-s2.0-3543141795