A polycaprolactone-tricalcium phosphate composite scaffold as an autograft-free spinal fusion cage in a sheep model

Biomaterials

Volumn 35, Issue 22, 2014, Pages 5647-5659

  Li, Yi ^a,b,c,d   Wu, Zhi gang ^a   Li, Xiao kang ^a   Guo, Zheng ^a   Wu, Su hua ^a   Zhang, Yong quan ^a   Shi, Lei ^a   Teoh, Swee hin ^e   Liu, Yu chun ^e   Zhang, Zhi yong ^b,c  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c National Tissue Engineering Center of China   (China)

^d No 89 Hospital of PLA   (China)

^e Nanyang Technological University   (Singapore)

Author keywords

Biodegradable; Fusion cage; Polycaprolactone; Ti6Al4V; Tricalcium phosphate

Indexed keywords

BIODEGRADATION; BONE; COMPUTERIZED TOMOGRAPHY; POLYMETHYL METHACRYLATES; SCAFFOLDS (BIOLOGY); TISSUE;

BIODEGRADABLE; BIOMECHANICAL ANALYSIS; CLINICAL APPLICATION; FUSION CAGES; HISTOLOGICAL EVALUATION; QUANTITATIVE APPROACH; TI-6AL-4V; TRI-CALCIUM PHOSPHATES;

POLYCAPROLACTONE;

CALCIUM PHOSPHATE CERAMIC; POLYCAPROLACTONE; BONE PROSTHESIS; POLYESTER; TITANIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOGRAFT; BIOMECHANICS; BONE GROWTH; BONE TISSUE; COMPOSITE GRAFT; CONTROLLED STUDY; MICRO-COMPUTED TOMOGRAPHY; MUSCLE RIGIDITY; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RADIODIAGNOSIS; RANGE OF MOTION; RIGIDITY; SHEEP; SPINE FUSION IMPLANT; TISSUE SECTION; TITANIUM CAGE; ANIMAL; BIODEGRADABLE IMPLANT; BONE DEVELOPMENT; BONE PROSTHESIS; CHEMISTRY; COMPARATIVE STUDY; FEMALE; PROCEDURES; SPINE FUSION; TISSUE SCAFFOLD;

OVIS ARIES;

ABSORBABLE IMPLANTS; ANIMALS; AUTOGRAFTS; BONE DEVELOPMENT; BONE SUBSTITUTES; FEMALE; POLYESTERS; SHEEP; SPINAL FUSION; TISSUE SCAFFOLDS; TITANIUM;

EID: 84899934890     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2014.03.075     Document Type: Article

References (48)

1. Garfin S.R., Mirkovic S., Herkowitz H.N. Spinal stenosis: indications for laminectomy. Instr Course Lect 1994, 43:411-414.
2. Shedid D., Benzel E.C. Decision making process: problem based decision making. Neurosurgery 2007, 60:S166-S169.
3. Peek Richard D., Wiltse Leon L. History of spinal fusion. Spinal fusion 1990, p.3-p.8. Springer, New York. M. Jerome, B. Howard (Eds.).
4. Dennis S., Watkins R., Landaker S., Dillin W., Springer D. Comparison of disc space heights after anterior lumbar interbody fusion. Spine 1989, 14:876-878.
5. Stonecipher T., Wright S. Posterior lumbar interbody fusion with facet-screw fixation. Spine 1989, 14:468-471.
6. Togawa D., Bauer T.W., Lieberman I.H., Sakai H. Lumbar intervertebral body fusion cages: histological evaluation of clinically failed cages retrieved from humans. JBone Jt Surg Am 2004, 86:70-79.
7. McAfee P.C., Farey I.D., Sutterlin C.E., Gurr K.R., Warden K.E., Cunningham B.W. 1989 Volvo Award in basic science. Device-related osteoporosis with spinal instrumentation. Spine 1989, 14:919-926.
8. Van Dijk M., Smit T.H., Sugihara S., Burger E.H., Wuisman P.I. The effect of cage stiffness on the rate of lumbar interbody fusion: an invivo model using poly(l-lactic Acid) and titanium cages. Spine 2002, 27:682-688.
9. Ohlin A., Karlsson M., Duppe H., Hasserius R., Redlund-Johnell I. Complications after transpedicular stabilization of the spine. A survivorship analysis of 163 cases. Spine 1994, 19:2774-2779.
10. Wilke H.J., Kettler A., Goetz C., Claes L. Subsidence resulting from simulated postoperative neck movements: an invitro investigation with a new cervical fusion cage. Spine 2000, 25:2762-2770.
11. Hutmacher D.W. Scaffolds in tissue engineering bone and cartilage. Biomaterials 2000, 21:2529-2543.
12. Hutmacher D.W., Schantz T., Zein I., Ng K.W., Teoh S.H., Tan K.C. Mechanical properties and cell cultural response of polycaprolactone scaffolds designed and fabricated via fused deposition modeling. JBiomed Mater Res 2001, 55:203-216.
13. Zein I., Hutmacher D.W., Tan K.C., Teoh S.H. Fused deposition modeling of novel scaffold architectures for tissue engineering applications. Biomaterials 2002, 23:1169-1185.
14. Endres M., Hutmacher D.W., Salgado A.J., Kaps C., Ringe J., Reis R.L., et al. Osteogenic induction of human bone marrow-derived mesenchymal progenitor cells in novel synthetic polymer-hydrogel matrices. Tissue Eng 2003, 9:689-702.
15. Lu L., Zhang Q., Wootton D., Chiou R., Li D., Lu B., et al. Biocompatibility and biodegradation studies of PCL/β-TCP bone tissue scaffold fabricated by structural porogen method. JMater Sci Mater Med 2012, 23:2217-2226.
16. Zhang Z.Y., Teoh S.H., Hui J.H., Fisk N.M., Choolani M., Chan J.K. The potential of human fetal mesenchymal stem cells for off-the-shelf bone tissue engineering application. Biomaterials 2012, 33:2656-2672.
17. Zhang Z.Y., Teoh S.H., Chong M.S., Lee E.S., Tan L.G., Mattar C.N., et al. Neo-vascularization and bone formation mediated by fetal mesenchymal stem cell tissue-engineered bone grafts in critical-size femoral defects. Biomaterials 2010, 31:608-620.
18. Yu H.D., Zhang Z.Y., Win K.Y., Chan J., Teoh S.H., Han M.Y. Bioinspired fabrication of 3D hierarchical porous nanomicrostructures of calcium carbonate for bone regeneration. Chem Commun 2010, 46:6578-6580.
19. Zhang Z.Y., Teoh S.H., Teo E.Y., Khoon Chong M.S., Shin C.W., Tien F.T., et al. Acomparison of bioreactors for culture of fetal mesenchymal stem cells for bone tissue engineering. Biomaterials 2010, 31:8684-8695.
20. Yeo A., Cheok C., Teoh S.H., Zhang Z.Y., Buser D., Bosshardt D.D. Lateral ridge augmentation using a PCL-TCP scaffold in a clinically relevant but challenging micropig model. Clin Oral Implants Res 2012, 23:1322-1332.
21. Toth J.M., Wang M., Scifert J.L., Cornwall G.B., Estes B.T., Seim H.B., et al. Evaluation of 70/30 D,L-PLa for use as a resorbable interbody fusion cage. Orthopedics 2002, 25:s1131-s1140.
22. Wilke H.J., Wenger K., Claes L. Testing criteria for spinal implants: recommendations for the standardization of invitro stability testing of spinal implants. Eur Spine J 1998, 7:148-154.
23. Chen X., Matsui Y., Ohno K., Michi K. Histomorphometric evaluation of the effect of hyperbaric oxygen treatment on healing around hydroxyapatite implants in irradiated rat bone. Int J Oral Maxillofac Implants 1999, 14:61-68.
24. Toth J.M., Estes B.T., Wang M., Seim H.B., Scifert J.L., Turner A.S., et al. Evaluation of 70/30 poly (L-lactide-co-D,L-lactide) for use as a resorbable interbody fusion cage. JNeurosurg 2002, 97:423-432.
25. Dorai Z., Morgan H., Coimbra C. Titanium cage reconstruction after cervical corpectomy. JNeurosurg 2003, 99:3-7.
26. Sugawara T., Itoh Y., Hirano Y., Higashiyama N., Mizoi K. Long term outcome and adjacent disc degeneration after anterior cervical discectomy and fusion with titanium cylindrical cages. Acta Neurochir 2009, 151:303-309.
27. Keaveny T.M., Hayes W.C. Mechanical properties of cortical and trabecular bone. Bone growth 1993, 285-344. CRC Press, Boca Raton, FL. B.K. Hall (Ed.).
28. Kanayama M., Cunningham B.W., Haggerty C.J., Abumi K., Kaneda K., McAfee P.C. Invitro biomechanical investigation of the stability and stress-shielding effect of lumbar interbody fusion devices. JNeurosurg 2000, 93:259-265.
29. Epari D.R., Kandziora F., Duda G.N. Stress shielding in box and Cylinder cervical interbody fusion cage designs. Spine 2005, 30:908-914.
30. Liu Y., Lim J., Teoh S.H. Review: development of clinically relevant scaffolds for vascularised bone tissue engineering. Biotechnol Adv 2013, 31:688-705.
31. Johnsson R., Axelsson P., Stromqvist B. Posterolateral lumbar fusion using facet joint fixation with biodegradable rods: a pilot study. Eur Spine J 1997, 6:144-148.
32. Hojo Y., Kotani Y., Ito M., Abumi K., Kadosawa T., Shikinami Y., et al. Abiomechanical and histological evaluation of a bioresorbable lumbar interbody fusion cage. Biomaterials 2005, 26:2643-2651.
33. Smith A.J., Arginteanu M., Moore F., Steinberger A., Camins M. Increased incidence of cage migration and nonunion in instrumented transforaminal lumbar interbody fusion with bioabsorbable cages. JNeurosurg Spine 2010, 13:388-393.
34. Slivka M.A., Spenciner D.B., Seim H.B., Welch W.C., Serhan H.A., Turner A.S. High rate of fusion in sheep cervical spines following anterior interbody surgery with absorbable and nonabsorbable implant devices. Spine 2006, 31:2772-2777.
35. Wuisman P.I., Smit T.H. Bioresorbable polymers: heading for a new generation of spinal cages. Eur Spine J 2006, 15:133-148.
36. Hutmacher D.W., Goh J.C., Teoh S.H. An introduction to biodegradable materials for tissue engineering applications. Ann Acad Med Singap 2001, 30:183-191.
37. Kokubo T., Kim H.M., Kawashita M. Novel bioactive materials with different mechanical properties. Biomaterials 2003, 24:2161-2175.
38. Buser D., Dula K., Hirt H.P., Schenk R.K. Lateral ridge augmentation using autografts and barrier membranes: a clinical study with 40 partially edentulous patients. JOral Maxillofac Surg 1996, 54:420-432.
39. Buser D., Dula K., Hess D., Hirt H.P., Belser U.C. Localized ridge augmentation with autografts and barrier membranes. Periodontol 2000, 1999(19):151-163.
40. Von Arx T., Buser D. Horizontal ridge augmentation using autogenous block grafts and the guided bone regeneration technique with collagen membranes: a clinical study with 42 patients. Clin Oral Implants Res 2006, 17:359-366.
41. Pitt C.G., Chasalow F.I., Hibionada Y.M., Klimas D.M., Schindler A. Aliphatic polyesters. I. The degradation of poly (e-caprolactone) invivo. JAppl Polym Sci 1981, 26:3779-3787.
42. Lei Y., Rai B., Ho K.H., Teoh S.H. Invitro degradation of novel bioactive polycaprolactone 20% tricalcium phosphate composite scaffolds for bone engineering. Mater Sci Eng C 2007, 27:293-298.
43. Rai B., Teoh S.H., Ho K.H., Hutmacher D.W., Cao T., Chen F., et al. The effect of rhBMP-2 on canine osteoblasts seeded onto 3D bioactive polycaprolactone scaffolds. Biomaterials 2004, 25:5499-5506.
44. Sun H., Mei L., Song C., Cui X., Wang P. The invivo degradation, absorption and excretion of PCL-based implant. Biomaterials 2006 Mar, 27:1735-1740.
45. Abbah S.A., Lam C.X., Ramruttun A.K., Goh J.C., Wong H.K. Fusion performance of Low Dose rhBMP-2 and BMSCs in biodegradable scaffolds: a Comparative study in a large animal model of anterior lumbar interbody fusion. Spine 2011, 36:1752-1759.
46. Kandziora F., Pflugmacher R., Scholz M., Schnake K., Lucke M., Schröder R., et al. Comparison between sheep and human cervical spines: an anatomic, radiographic, bone mineral density, and biomechanical study. Spine 2001, 26:1028-1037.
47. Wilke H.J., Kettler A., Claes L.E. Are sheep spines a valid biomechanical model for human spines?. Spine 1997, 22:2365-2374.
48. Sheng S.R., Wang X.Y., Xu H.Z., Zhu G.Q., Zhou Y.F. Anatomy of large animal spines and its comparison to the human spine: a systematic review. Eur Spine J 2010, 19:46-56.