Association of GALNT3 gene polymorphisms with bone mineral density in Chinese postmenopausal women: The peking vertebral fracture study

Menopause

Volumn 21, Issue 5, 2014, Pages 515-521

  Li, Nan ^a,b   Wang, Xiran ^c   Jiang, Yan ^b   Wang, Wenbo ^d   Huang, Wei ^e   Zheng, Xin ^f   Wang, Qiuping ^g   Ning, Zhiwei ^h   Pei, Yu ^a   Li, Chunlin ^a   Nie, Min ^b   Li, Mei ^b   Wang, Ou ^b   Xing, Xiaoping ^b   He, Shuli ^b   Yu, Wei ⁱ   Lin, Qiang ⁱ   Xu, Ling ^b   Xia, Weibo ^b  

^a CHINESE PLA GENERAL HOSPITAL   (China)

^b PEKING UNION MEDICAL COLLEGE HOSPITAL   (China)

^c General Hospital of the Second Artillery Force   (China)

^d PEKING UNIVERSITY SHOUGANG HOSPITAL   (China)

^e Beijing Haidian Hospital   (China)

^f CHINA REHABILITATION RESEARCH CENTER   (China)

^g Beijing Liangxiang Hospital   (China)

^h CAPITAL MEDICAL UNIVERSITY   (China)

ⁱ PEKING UNION MEDICAL COLLEGE   (China)

Author keywords

Bone mineral density; Fracture; GALNT3; Single nucleotide polymorphisms

Indexed keywords

CALCIUM; N ACETYLGALACTOSAMINYLTRANSFERASE; N ACETYLGALACTOSAMINYLTRANSFERASE 3; PHOSPHORUS; UNCLASSIFIED DRUG; POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE;

AGED; ALLELE; ANALYSIS OF COVARIANCE; ARTICLE; BODY MASS; BONE DENSITY; CALCIUM BLOOD LEVEL; CHINA; CHINESE; CLINICAL STUDY; CONTROLLED STUDY; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; FEMUR NECK; FRAGILITY FRACTURE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENOTYPE; HAPLOTYPE; HIP; HUMAN; INTRON; LUMBAR SPINE; MAJOR CLINICAL STUDY; MULTIPLE LINEAR REGRESSION ANALYSIS; NUCLEOTIDE SEQUENCE; OSTEOPOROSIS; PHENOTYPE; PHOSPHATE BLOOD LEVEL; POSTMENOPAUSE; QUESTIONNAIRE; SINGLE NUCLEOTIDE POLYMORPHISM; SPINE FRACTURE; ASIAN CONTINENTAL ANCESTRY GROUP; EPIDEMIOLOGY; GENE SILENCING; GENETIC PREDISPOSITION; GENETICS; LUMBAR VERTEBRA; MIDDLE AGED; POSTMENOPAUSE OSTEOPOROSIS; STATISTICAL MODEL;

AGED; ASIAN CONTINENTAL ANCESTRY GROUP; CHINA; FEMALE; GENE SILENCING; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HUMANS; LOGISTIC MODELS; LUMBAR VERTEBRAE; MIDDLE AGED; N-ACETYLGALACTOSAMINYLTRANSFERASES; OSTEOPOROSIS, POSTMENOPAUSAL; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; SPINAL FRACTURES;

EID: 84899931634     PISSN: 10723714     EISSN: 15300374     Source Type: Journal    
DOI: 10.1097/GME.0b013e3182a34981     Document Type: Article

References (29)

1. Consensus development conference: diagnosis, prophylaxis, and treatmentof osteoporosis. Am J Med 1993;94:646-650.
2. Dennison E, Mohamed MA, Cooper C. Epidemiology of osteoporosis.Rheum Dis Clin North Am 2006;32:617-629.
3. Cummings SR, Melton LJ. Epidemiology and outcomes of osteoporoticfractures. Lancet 2002;359:1761-1767.
4. Kanis JA, Borgstrom F, De Laet C, et al. Assessment of fracture risk.Osteoporos Int 2005;16:581-589.
5. Arden NK, Baker J, Hogg C, Baan K, Spector TD. The heritability ofbone mineral density, ultrasound of the calcaneus and hip axis length: astudy of postmenopausal twins. J Bone Miner Res 1996;11:530-534.
6. Arden NK, Spector TD. Genetic influences on muscle strength, lean bodymass, and bone mineral density: a twin study. J Bone Miner Res1997;12:2076-2081.
7. Dequeker J, Nijs J, Verstraeten A, Geusens P, Gevers G. Genetic determinantsof bone mineral content at the spine and radius: a twin study.Bone 1987;8:207-209.
8. Harris M, Nguyen TV, Howard GM, Kelly PJ, Eisman JA. Genetic andenvironmental correlations between bone formation and bone mineraldensity: a twin study. Bone 1998;22:141-145.
9. Nguyen TV, Howard GM, Kelly PJ, Eisman JA. Bone mass, lean mass,and fat mass: same genes or same environments? Am J Epidemiol1998;147:3-16.
10. Duncan EL, Cardon LR, Sinsheimer JS, Wass JA, Brown MA. Site andgender specificity of inheritance of bone mineral density. J Bone MinerRes 2003;18:1531-1538.
11. Sigurdsson G, Halldorsson BV, Styrkarsdottir U, Krisiansson K, Stefansson K.Impact of genetics on low bone mass in adults. J Bone Miner Res 2008;23:1584-1590.
12. Flicker L, Hopper J, Rodgers L, et al. Bone density determinants in elderlywomen: a twin study. J Bone Miner Res 1995;10:1607-1613.
13. Schuit SC, van der Klift M, Weel AE, et al. Fracture incidence and associationwith bone mineral density in elderly men and women: theRotterdam Study. Bone 2004;34:195-202.
14. Watts NB, Cooper C, Lindsay R, et al. Relationship between changes inbone mineral density and vertebral fracture risk associated with risedronate:greater increases in bone mineral density do not relate to greater decreases infracture risk. J Clin Densitom 2004;7:255-261.
15. Estrada K, Styrkarsdottir U, Evangelou E, et al. Genome-wide metaanalysisidentifies 56 bone mineral density loci and reveals 14 loci associatedwith risk of fracture. Nat Genet 2012;44:491-501.
16. Duncan EL, Danoy P, Kemp JP, et al. Genome-wide association studyusing extreme truncate selection identifies novel genes affecting bonemineral density and fracture risk. PLoS Genet 2011;7:e1001372.
17. Topaz O, Shurman DL, Bergman R, et al. Mutations in GALNT3,encoding a protein involved in O-linked glycosylation, cause familialtumoral calcinosis. Nat Genet 2004;36:579-581.
18. Ralston SH, Uitterlinden AG. Genetics of osteoporosis. Endocr Rev2010;31:629-662.
19. Zhao J, Xia W, Nie M, et al. A haplotype of MATN3 is associated withvertebral fracture in Chinese postmenopausal women: Peking VertebralFracture (PK-VF) study. Bone 2012;50:917-924.
20. Zhao J, Xia W, Nie M, et al. The levels of bone turnover markers inChinese postmenopausal women: Peking Vertebral Fracture study. Menopause2011;18:1237-1243.
21. Zhang ZH, Shen JX, Liu ZH. Retrospective study on standardization ofBMD machines in China. Chin J Osteoporos 2005;11:133-145.
22. Genant HK, Wu CY, van Kuijk C, Nevitt MC. Vertebral fracture assessmentusing a semiquantitative technique. J Bone Miner Res 1993;8:1137-1148.
23. Ichikawa S, Sorenson AH, Austin AM, et al. Ablation of the Galnt3 geneleads to low-circulating intact fibroblast growth factor 23 (Fgf23) concentrationsand hyperphosphatemia despite increased Fgf23 expression. Endocrinology 2009;150:2543-2550.
24. Urakawa I, Yamazaki Y, Shimada T, et al. Klotho converts canonicalFGF receptor into a specific receptor for FGF23. Nature 2006;444:770-774.
25. Kawano K, Ogata N, Chiano M, et al. Klotho gene polymorphisms associatedwith bone density of aged postmenopausal women. J BoneMiner Res 2002;17:1744-1751.
26. Ogata N, Matsumura Y, Shiraki M, et al. Association of Klotho genepolymorphism with bone density and spondylosis of the lumbar spine inpostmenopausal women. Bone 2002;31:37-42.
27. Yamada Y, Ando F, Niino N, Shimokata H. Association of polymorphismsof the androgen receptor and Klotho genes with bone mineraldensity in Japanese women. J Mol Med 2005;83:50-57.
28. Riancho JA, Valero C, Hernández JL, et al. Association of the F352Vvariant of the Klotho gene with bone mineral density. Biogerontology2007;8: 121-127.
29. Pagani F, Baralle FE. Genomic variants in exons and introns: identifyingthe splicing spoilers. Nat Rev Genet 2004;5:389-396.