Impact of genetics on low bone mass in adults

Journal of Bone and Mineral Research

Volumn 23, Issue 10, 2008, Pages 1584-1590

  Sigurdsson, Gunnar ^a   Halldorsson, Bjarni V ^b,c   Styrkarsdottir, Unnur ^b   Kristjansson, Kristleifur ^b   Stefansson, Kari ^b  

^a LANDSPITALI UNIVERSITY HOSPITAL   (Iceland)

^b DECODE GENETICS   (Iceland)

^c REYKJAVIK UNIVERSITY   (Iceland)

Author keywords

Bone densitometry; Bone mass; Family screening; Family studies; Genetics

Indexed keywords

ADULT; ANALYSIS OF VARIANCE; ARTICLE; BONE DENSITY; BONE MASS; CONTROLLED STUDY; COST EFFECTIVENESS ANALYSIS; ENVIRONMENTAL FACTOR; FEMALE; GENETICS; HEREDITY; HERITABILITY; HIP; HUMAN; ICELAND; LUMBAR SPINE; MAJOR CLINICAL STUDY; MALE; MENOPAUSE; NUCLEAR FAMILY; OSTEOPENIA; PREVALENCE; RISK FACTOR; SCREENING;

ADULT; AGED; AGED, 80 AND OVER; BONE DENSITY; COHORT STUDIES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; ICELAND; LIKELIHOOD FUNCTIONS; MALE; MIDDLE AGED;

EID: 52949092366     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.080507     Document Type: Article

References (33)

1. Kanis JA, Melton LJ III, Christiansen C, Johnston CC, Khaltaev N 1994 The diagnosis of osteoporosis. J Bone Miner Res 9:1137-1141.
2. Cummings SR, Black DM, Nevitt MC, Browner W, Cauley J, Ensrud K, Genant HK, Palermo L, Scott J, Vogt TM 1993 Bone density at various sites for prediction of hip fractures. The Study of Osteoporotic Fractures Research Group. Lancet 341:72-75.
3. Kanis JA 1994 Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Synopsis of a WHO report. WHO Study Group. Osteoporos Int 4:368-381.
4. Ng MY, Sham PC, Paterson AD, Chan V, Kung AW 2006 Effect of environmental factors and gender on the heritability of bone mineral density and bone size. Ann Hum Genet 70:428-438.
5. Tabensky A, Duan Y, Edmonds J, Seeman E 2001 The contribution of reduced peak accrual of bone and age-related bone loss to osteoporosis at the spine and hip: Insights from the daughters of women with vertebral or hip fractures. J Bone Miner Res 16:1101-1107.
6. Deng HW, Chen WM, Conway T, Zhou Y, Davies KM, Stegman MR, Deng H, Recker RR 2000 Determination of bone mineral density of the hip and spine in human pedigrees by genetic and life-style factors. Genet Epidemiol 19:160-177.
7. Recker RR, Deng HW 2002 Role of genetics in osteoporosis. Endocrine 17:55-66.
8. Stewart TL, Ralston SH 2000 Role of genetic factors in the pathogenesis of osteoporosis. J Endocrinol 166:235-245.
9. Ferrari S, Rizzoli R, Slosman D, Bonjour JP 1998 Familial resemblance for bone mineral mass is expressed before puberty. J Clin Endocrinol Metab 83:358-361.
10. Jones G, Nguyen TV 2000 Associations between maternal peak bone mass and bone mass in prepubertal male and female children. J Bone Miner Res 15:1998-2004.
11. Brown LB, Streeten EA, Shapiro JR, McBride D, Shuldiner AR, Peyser PA, Mitchell BD 2005 Genetic and environmental influences on bone mineral density in pre- and post-menopausal women. Osteoporos Int 16:1849-1856.
12. Guéguen R, Jouanny P, Guillemin F, Kuntz C, Pourel J, Siest G 1995 Segregation analysis and variance components analysis of bone mineral density in healthy families. J Bone Miner Res 10:2017-2022.
13. Cardon LR, Garner C, Bennett ST, Mackay IJ, Edwards RM, Cornish J, Hegde M, Murray MA, Reid IR, Cundy T 2000 Evidence for a major gene for bone mineral density in idiopathic osteoporotic families. J Bone Miner Res 15:1132-1137.
14. Livshits G, Deng HW, Nguyen TV, Yakovenko K, Recker RR, Eisman JA 2004 Genetics of bone mineral density: Evidence for a major pleiotropic effect from an intercontinental study. J Bone Miner Res 19:914-923.
15. Deng HW, Livshits G, Yakovenko K, Xu FH, Conway T, Davies KM, Deng H, Recker RR 2002 Evidence for a major gene for bone mineral density/content in human pedigrees identified via probands with extreme bone mineral density. Ann Hum Genet 66:61-74.
16. Baudoin C, Cohen-Solal ME, Beaudreuil J, De Vernejoul MC 2002 Genetic and environmental factors affect bone density variances of families of men and women with osteoporosis. J Clin Endocrinol Metab 87:2053-2059.
17. Styrkarsdottir U, Cazier J-B, Kong A, Rolfsson O, Larsen H, Bjarnadottir E, Johannsdottir VD, Sigurdardottir MS, Bagger Y, Christiansen C, Reynisdottir I, Grant SFA, Jonasson K, Frigge ML, Gulcher JR, Sigurdsson G, Stefansson K 2003 Linkage of osteoporosis to chromosome 20p12 and association to BMP2. PLoS Biol 1:351-360.
18. Guo SW 1998 Inflation of sibling recurrence-risk ratio, due to ascertainment bias and/or overreporting. Am J Hum Genet 63:252-258.
19. Amundadottir LT, Thorvaldsson S, Gudbjartsson DF, Sulem P, Kristjansson K, Arnason S, Gulcher JR, Bjornsson J, Kong A, Thorsteinsdottir U, Stefansson K 2004 Cancer as a complex phenotype: Pattern of cancer distribution within and beyond the nuclear family. PLoS Med 1:e65.
20. Steingrimsdottir L, Gunnarsson O, Indridason OS, Franzson L, Sigurdsson G 2005 Relationship between serum parathyroid hormone levels, vitamin D sufficiency, and calcium intake. JAMA 294:2336-2341.
21. Gudmundsdottir SL, Indridason OS, Franzson L, Sigurdsson G 2005 Age-related decline in bone mass measured by dual-energy X-ray absorptiometry and quantitative ultrasound in a population-based sample of both sexes: Identification of useful ultrasound thresholds for osteoporosis screening. J Clin Densitom 8:80-86.
22. Liu PY, Qin YJ, Zhou Q, Recker RR, Deng HW 2004 Complex segregation analyses of bone mineral density in Chinese. Ann Hum Genet 68:154-164.
23. Deng FY, Lei SF, Li MX, Jiang C, Dvornyk V, Deng HW 2006 Genetic determination and correlation of body mass index and bone mineral density at the spine and hip in Chinese Han ethnicity. Osteoporos Int 17:119-124.
24. Nguyen TV, Livshits G, Center JR, Yakovenko K, Eisman JA 2003 Genetic determination of bone mineral density: Evidence for a major gene. J Clin Endocrinol Metab 88:3614-3620.
25. Duncan EL, Cardon LR, Sinsheimer JS, Wass JA, Brown MA 2003 Site and gender specificity of inheritance of bone mineral density. J Bone Miner Res 18:1531-1538.
26. Hodgson SF, Watts NB, Bilezikian JP, Clarke BL, Gray TK, Harris DW, Johnston CC Jr, Kleerekoper M, Lindsay R, Luckey MM, McClung MR, Nankin HR, Petak SM, Recker RR, Anderson RJ, Bergman DA, Bloomgarden ZT, Dickey RA, Palumbo PJ, Peters AL, Rettinger HI, Rodbard HW, Rubenstein HA 2003 American Association of Clinical Endocrinologists medical guidelines for clinical practice for the prevention and treatment of postmenopausal osteoporosis: 2001 edition, with selected updates for 2003. Endocr Pract 9:544-564.
27. Yang F, Shen H, Jiang H, Deng HW 2006 On genetic studies of bone loss. J Bone Miner Res 21:1676-1677.
28. Makovey J, Nguyen TV, Naganathan V, Wark JD, Sambrook PN 2007 Genetic effects on bone loss in peri- and postmenopausal women: A longitudinal twin study. J Bone Miner Res 22:1773-1780.
29. Havill LM, Mahaney MC, Binkley T, Specker BL 2007 Effects of genes, sex, age, and activity on BMC, bone size, and areal and volumetric BMD. J Bone Miner Res 22:737-746.
30. Ioannidis JP, Ng MY, Sham PC, Zintzaras E, Lewis CM, Deng HW, Econs MJ, Karasik D, Devoto M, Kammerer CM, Spector T, Andrew T, Cupples LA, Duncan EL, Foroud T, Kiel DP, Koller D, Langdahl B, Mitchell BD, Peacock M, Recker R, Shen H, Sol-Church K, Spotila LD, Uitterlinden AG, Wilson SG, Kung AW, Ralston SH 2007 Meta-analysis of genomewide scans provides evidence for sex- and site-specific regulation of bone mass. J Bone Miner Res 22:173-183.
31. Deng HW, Stegman MR, Davies KM, Conway T, Recker RR 1999 Genetic determination of variation and covariation of peak bone mass at the hip and spine. J Clin Densitom 2:251-263.
32. Brown LB, Streeten EA, Shuldiner AR, Almasy LA, Peyser PA, Mitchell BD 2004 Assessment of sex-specific genetic and environmental effects on bone mineral density. Genet Epidemiol 27:153-161.
33. Yang TL, Zhao LJ, Liu YJ, Liu JF, Recker RR, Deng HW 2006 Genetic and environmental correlations of bone mineral density at different skeletal sites in females and males. Calcif Tissue Int 78:212-217.