Breakdown in REM sleep circuitry underlies REM sleep behavior disorder

Trends in Neurosciences

Volumn 37, Issue 5, 2014, Pages 279-288

  Peever, John ^a   Luppi, Pierre Hervé ^b   Montplaisir, Jacques ^c  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITÉ DE LYON   (France)

^c HÔPITAL DU SACRÉ COEUR DE MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CLONAZEPAM; DOPAMINE RECEPTOR STIMULATING AGENT; MELATONIN;

CLINICAL FEATURE; DISEASE COURSE; DREAM; HUMAN; IDIOPATHIC DISEASE; MUSCLE ATONIA; NERVE DEGENERATION; NEUROSCIENCE; PARASOMNIA; PARKINSON DISEASE; PRIORITY JOURNAL; REM SLEEP; REVIEW; SKELETAL MUSCLE; BRAIN; NERVE CELL NETWORK; NERVE TRACT; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY;

BRAIN; HUMANS; NERVE NET; NEURAL PATHWAYS; REM SLEEP BEHAVIOR DISORDER; SLEEP, REM;

EID: 84899925184     PISSN: 01662236     EISSN: 1878108X     Source Type: Journal    
DOI: 10.1016/j.tins.2014.02.009     Document Type: Review

References (123)

1. Iranzo A., et al. Neurodegenerative disease status and post-mortem pathology in idiopathic rapid-eye-movement sleep behaviour disorder: an observational cohort study. Lancet Neurol. 2013, 12:443-453.
2. Dauvilliers Y., et al. Family history of idiopathic REM behavior disorder: a multicenter case-control study. Neurology 2013, 80:2233-2235.
3. Schenck C.H., Mahowald M.W. REM sleep behavior disorder: clinical, developmental, and neuroscience perspectives 16 years after its formal identification in SLEEP. Sleep 2002, 25:120-138.
4. De Cock V.C., et al. Restoration of normal motor control in Parkinson's disease during REM sleep. Brain 2007, 130:450-456.
5. Schenck C.H., Mahowald M.W. REM sleep parasomnias. Neurol. Clin. 1996, 14:697-720.
6. Boeve B.F. Idiopathic REM sleep behaviour disorder in the development of Parkinson's disease. Lancet Neurol. 2013, 12:469-482.
7. Iranzo A., et al. Rapid-eye-movement sleep behaviour disorder as an early marker for a neurodegenerative disorder: a descriptive study. Lancet Neurol. 2006, 5:572-577.
8. Boissard R., et al. Localization of the GABAergic and non-GABAergic neurons projecting to the sublaterodorsal nucleus and potentially gating paradoxical sleep onset. Eur. J. Neurosci. 2003, 18:1627-1639.
9. Boissard R., et al. The rat ponto-medullary network responsible for paradoxical sleep onset and maintenance: a combined microinjection and functional neuroanatomical study. Eur. J. Neurosci. 2002, 16:1959-1973.
10. Luppi P.H., et al. The neuronal network responsible for paradoxical sleep and its dysfunctions causing narcolepsy and rapid eye movement (REM) behavior disorder. Sleep Med. Rev. 2011, 15:153-163.
11. Brooks P.L., Peever J.H. Impaired GABA and glycine transmission triggers cardinal features of rapid eye movement sleep behavior disorder in mice. J. Neurosci. 2011, 31:7111-7121.
12. Scherfler C., et al. White and gray matter abnormalities in idiopathic rapid eye movement sleep behavior disorder: a diffusion-tensor imaging and voxel-based morphometry study. Ann. Neurol. 2011, 69:400-407.
13. Garcia-Lorenzo D., et al. The coeruleus/subcoeruleus complex in rapid eye movement sleep behaviour disorders in Parkinson's disease. Brain 2013, 136:2120-2129.
14. Brooks P.L., Peever J.H. Glycinergic and GABA(A)-mediated inhibition of somatic motoneurons does not mediate rapid eye movement sleep motor atonia. J. Neurosci. 2008, 28:3535-3545.
15. Brooks P.L., Peever J.H. Identification of the transmitter and receptor mechanisms responsible for REM sleep paralysis. J. Neurosci. 2012, 32:9785-9795.
16. Schenck C.H., et al. Potentially lethal behaviors associated with rapid eye movement sleep behavior disorder: review of the literature and forensic implications. J. Forensic Sci. 2009, 54:1475-1484.
17. Oudiette D., et al. Nonviolent elaborate behaviors may also occur in REM sleep behavior disorder. Neurology 2009, 72:551-557.
18. Fantini M.L., et al. Aggressive dream content without daytime aggressiveness in REM sleep behavior disorder. Neurology 2005, 65:1010-1015.
19. American Academy of Sleep Medicine International Classification Of Sleep Disorders 2 2005, American Academy of Sleep Medicine.
20. Frauscher B., et al. Normative EMG values during REM sleep for the diagnosis of REM sleep behavior disorder. Sleep 2012, 35:835-847.
21. Fantini M.L., et al. Periodic leg movements in REM sleep behavior disorder and related autonomic and EEG activation. Neurology 2002, 59:1889-1894.
22. Ohayon M.M., et al. Violent behavior during sleep. J. Clin. Psychiatry 1997, 58:369-376. quiz 377.
23. Kang S.H., et al. REM sleep behavior disorder in the Korean elderly population: prevalence and clinical characteristics. Sleep 2013, 36:1147-1152.
24. Boot B.P., et al. Probable rapid eye movement sleep behavior disorder increases risk for mild cognitive impairment and Parkinson disease: a population-based study. Ann. Neurol. 2012, 71:49-56.
25. Bjornara K.A., et al. REM sleep behavior disorder in Parkinson's disease: is there a gender difference?. Parkinsonism Relat. Disord. 2013, 19:120-122.
26. Schenck C.H., et al. HLA class II genes associated with REM sleep behavior disorder. Ann. Neurol. 1996, 39:261-263.
27. Postuma R.B., et al. Environmental risk factors for REM sleep behavior disorder: a multicenter case-control study. Neurology 2012, 79:428-434.
28. Gagnon J.F., et al. Rapid-eye-movement sleep behaviour disorder and neurodegenerative diseases. Lancet Neurol. 2006, 5:424-432.
29. Manni R., et al. Secondary "incidental" REM sleep behavior disorder: do we ever think of it?. Sleep Med. 2011, 12(Suppl. 2):S50-S53.
30. Gagnon J.F., et al. REM sleep behavior disorder and REM sleep without atonia in Parkinson's disease. Neurology 2002, 59:585-589.
31. Sixel-Doring F., et al. Associated factors for REM sleep behavior disorder in Parkinson disease. Neurology 2011, 77:1048-1054.
32. Ferman T.J., et al. Inclusion of RBD improves the diagnostic classification of dementia with Lewy bodies. Neurology 2011, 77:875-882.
33. Boeve B.F., et al. REM sleep behavior disorder and degenerative dementia: an association likely reflecting Lewy body disease. Neurology 1998, 51:363-370.
34. Iranzo A., et al. Characteristics of idiopathic REM sleep behavior disorder and that associated with MSA and PD. Neurology 2005, 65:247-252.
35. Gagnon J.F., et al. Update on the pharmacology of REM sleep behavior disorder. Neurology 2006, 67:742-747.
36. Winkelman J.W., James L. Serotonergic antidepressants are associated with REM sleep without atonia. Sleep 2004, 27:317-321.
37. Olson E.J., et al. Rapid eye movement sleep behaviour disorder: demographic, clinical and laboratory findings in 93 cases. Brain 2000, 123:331-339.
38. Bonakis A., et al. REM sleep behaviour disorder (RBD) and its associations in young patients. Sleep Med. 2009, 10:641-645.
39. Dauvilliers Y., et al. REM sleep characteristics in narcolepsy and REM sleep behavior disorder. Sleep 2007, 30:844-849.
40. Buskova J., et al. Olfactory dysfunction in narcolepsy with and without cataplexy. Sleep Med. 2010, 11:558-561.
41. Bayard S., et al. Olfactory dysfunction in narcolepsy with cataplexy. Sleep Med. 2010, 11:876-881.
42. Oudiette D., et al. A motor signature of REM sleep behavior disorder. Mov. Disord. 2012, 27:428-431.
43. Schenck C.H., et al. Delayed emergence of a parkinsonian disorder in 38% of 29 older men initially diagnosed with idiopathic rapid eye movement sleep behaviour disorder. Neurology 1996, 46:388-393.
44. Postuma R.B., et al. Quantifying the risk of neurodegenerative disease in idiopathic REM sleep behavior disorder. Neurology 2009, 72:1296-1300.
45. Wing Y.K., et al. Prospective outcome of rapid eye movement sleep behaviour disorder: psychiatric disorders as a potential early marker of Parkinson's disease. J. Neurol. Neurosurg. Psychiatry 2012, 83:470-472.
46. Schenck C.H., et al. Delayed emergence of a parkinsonian disorder or dementia in 81% of older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder: a 16-year update on a previously reported series. Sleep Med. 2013, 14:744-748.
47. Claassen D.O., et al. REM sleep behavior disorder preceding other aspects of synucleinopathies by up to half a century. Neurology 2010, 75:494-499.
48. Postuma R.B., et al. Potential early markers of Parkinson disease in idiopathic REM sleep behavior disorder. Neurology 2006, 66:845-851.
49. Postuma R.B., et al. How does parkinsonism start? Prodromal parkinsonism motor changes in idiopathic REM sleep behaviour disorder. Brain 2012, 135:1860-1870.
50. Massicotte-Marquez J., et al. Executive dysfunction and memory impairment in idiopathic REM sleep behavior disorder. Neurology 2008, 70:1250-1257.
51. Fantini M.L., et al. Idiopathic REM sleep behavior disorder: toward a better nosologic definition. Neurology 2005, 64:780-786.
52. Ferini-Strambi L., et al. Cardiac autonomic activity during wakefulness and sleep in REM sleep behavior disorder. Sleep 1996, 19:367-369.
53. Lanfranchi P.A., et al. Cardiac autonomic regulation during sleep in idiopathic REM sleep behavior disorder. Sleep 2007, 30:1019-1025.
54. Postuma R.B., et al. Prodromal autonomic symptoms and signs in Parkinson's disease and dementia with Lewy bodies. Mov. Disord. 2013, 28:597-604.
55. Fantini M.L., et al. Slowing of electroencephalogram in rapid eye movement sleep behavior disorder. Ann. Neurol. 2003, 53:774-780.
56. Iranzo A., et al. Electroencephalographic slowing heralds mild cognitive impairment in idiopathic REM sleep behavior disorder. Sleep Med. 2010, 11:534-539.
57. Vendette M., et al. Brain perfusion and markers of neurodegeneration in rapid eye movement sleep behavior disorder. Mov. Disord. 2011, 26:1717-1724.
58. Chaudhuri K.R. Autonomic dysfunction in movement disorders. Curr. Opin. Neurol. 2001, 14:505-511.
59. Diederich N.J., et al. Progressive worsening of spatial and chromatic processing deficits in Parkinson disease. Arch. Neurol. 2002, 59:1249-1252.
60. Katzenschlager R., Lees A.J. Olfaction and Parkinson's syndromes: its role in differential diagnosis. Curr. Opin. Neurol. 2004, 17:417-423.
61. Mosimann U.P., et al. Visual perception in Parkinson disease dementia and dementia with Lewy bodies. Neurology 2004, 63:2091-2096.
62. Ponsen M.M., et al. Idiopathic hyposmia as a preclinical sign of Parkinson's disease. Ann. Neurol. 2004, 56:173-181.
63. Dang-Vu T.T., et al. Hippocampal perfusion predicts impending neurodegeneration in REM sleep behavior disorder. Neurology 2012, 79:2302-2306.
64. Iranzo A., et al. Serial dopamine transporter imaging of nigrostriatal function in patients with idiopathic rapid-eye-movement sleep behaviour disorder: a prospective study. Lancet Neurol. 2011, 10:797-805.
65. Fantini M.L., et al. The effects of pramipexole in REM sleep behavior disorder. Neurology 2003, 61:1418-1420.
66. Schmidt M.H., et al. Use of pramipexole in REM sleep behavior disorder: results from a case series. Sleep Med. 2006, 7:418-423.
67. Kumru H., et al. Lack of effects of pramipexole on REM sleep behavior disorder in Parkinson disease. Sleep 2008, 31:1418-1421.
68. Sasai T., et al. Effectiveness of pramipexole, a dopamine agonist, on rapid eye movement sleep behavior disorder. Tohoku J. Exp. Med. 2012, 226:177-181.
69. Aurora R.N., et al. Best practice guide for the treatment of REM sleep behavior disorder (RBD). J. Clin. Sleep Med. 2010, 6:85-95.
70. Mahowald M.W., Schenck C.H. REM sleep parasomnias. Principles and Practices of Sleep Medicine 2005, 897-916. Saunders. M.H. Kryger (Ed.).
71. Ferri R., et al. Effects of long-term use of clonazepam on nonrapid eye movement sleep patterns in rapid eye movement sleep behavior disorder. Sleep Med. 2013, 14:399-406.
72. Kunz D., Mahlberg R. A two-part, double-blind, placebo-controlled trial of exogenous melatonin in REM sleep behaviour disorder. J. Sleep Res. 2010, 19:591-596.
73. Boeve B.F., et al. Melatonin for treatment of REM sleep behavior disorder in neurologic disorders: results in 14 patients. Sleep Med. 2003, 4:281-284.
74. McCarter S.J., et al. Treatment outcomes in REM sleep behavior disorder. Sleep Med. 2013, 14:237-242.
75. Nakamura Y., et al. Intracellular analysis of trigeminal motoneuron activity during sleep in the cat. Science 1978, 199:204-207.
76. Soja P.J., et al. The postsynaptic inhibitory control of lumbar motoneurons during the atonia of active sleep: effect of strychnine on motoneuron properties. J. Neurosci. 1991, 11:2804-2811.
77. Kodama T., et al. Changes in inhibitory amino acid release linked to pontine-induced atonia: an in vivo microdialysis study. J. Neurosci. 2003, 23:1548-1554.
78. McGinty D.J., Harper R.M. Dorsal raphe neurons: depression of firing during sleep in cats. Brain Res. 1976, 101:569-575.
79. Lai Y.Y., et al. Changes in monoamine release in the ventral horn and hypoglossal nucleus linked to pontine inhibition of muscle tone: an in vivo microdialysis study. J. Neurosci. 2001, 21:7384-7391.
80. Burgess C., et al. An endogenous glutamatergic drive onto somatic motoneurons contributes to the stereotypical pattern of muscle tone across the sleep-wake cycle. J. Neurosci. 2008, 28:4649-4660.
81. Chan E., et al. Endogenous excitatory drive modulating respiratory muscle activity across sleep-wake states. Am. J. Respir. Crit. Care Med. 2006, 174:1264-1273.
82. Fenik V.B., et al. REM sleep-like atonia of hypoglossal (XII) motoneurons is caused by loss of noradrenergic and serotonergic inputs. Am. J. Respir. Crit. Care Med. 2005, 172:1322-1330.
83. Trulson M.E., et al. Raphe unit activity during REM sleep in normal cats and in pontine lesioned cats displaying REM sleep without atonia. Brain Res. 1981, 226:75-91.
84. Soja P.J., et al. Effects of excitatory amino acid antagonists on the phasic depolarizing events that occur in lumbar motoneurons during REM periods of active sleep. J. Neurosci. 1995, 15:4068-4076.
85. Siegel J.M., et al. Behavioral states in the chronic medullary and midpontine cat. Electroencephalogr. Clin. Neurophysiol. 1986, 63:274-288.
86. Luppi P.H., et al. Paradoxical (REM) sleep genesis by the brainstem is under hypothalamic control. Curr. Opin. Neurobiol. 2013, 23:786-792.
87. Lu J., et al. A putative flip-flop switch for control of REM sleep. Nature 2006, 441:589-594.
88. Baghdoyan H.A., et al. Site-specific enhancement and suppression of desynchronized sleep signs following cholinergic stimulation of three brainstem regions. Brain Res. 1984, 306:39-52.
89. Siegel J.M., et al. Neuronal activity in narcolepsy: identification of cataplexy-related cells in the medial medulla. Science 1991, 252:1315-1318.
90. Maloney K.J., et al. Differential c-Fos expression in cholinergic, monoaminergic, and GABAergic cell groups of the pontomesencephalic tegmentum after paradoxical sleep deprivation and recovery. J. Neurosci. 1999, 19:3057-3072.
91. Clement O., et al. Evidence that neurons of the sublaterodorsal tegmental nucleus triggering paradoxical (REM) sleep are glutamatergic. Sleep 2011, 34:419-423.
92. Lai Y.Y., Siegel J.M. Medullary regions mediating atonia. J. Neurosci. 1988, 8:4790-4796.
93. Schenkel E., Siegel J.M. REM-sleep without atonia after lesions of the medial medulla. Neurosci. Lett. 1989, 98:159-165.
94. Holmes C.J., et al. Distribution of cholinergic, GABAergic and serotonergic neurons in the medial medullary reticular formation and their projections studied by cytotoxic lesions in the cat. Neuroscience 1994, 62:1155-1178.
95. Vetrivelan R., et al. Medullary circuitry regulating rapid eye movement sleep and motor atonia. J. Neurosci. 2009, 29:9361-9369.
96. Lim A.S., et al. Characterization of REM-sleep associated ponto-geniculo-occipital waves in the human pons. Sleep 2007, 30:823-827.
97. Karlsson K.A., et al. The neural substrates of infant sleep in rats. PLoS Biol. 2005, 3:e143.
98. Gassel M.M., et al. Rubrospinal influences during desynchronized sleep. Nature 1966, 209:1218-1220.
99. Grace K.P., et al. 5-HT1A receptor-responsive pedunculopontine tegmental neurons suppress REM sleep and respiratory motor activity. J. Neurosci. 2012, 32:1622-1633.
100. Evarts E.V. Temporal patterns of discharge of pyramidal tract neurons during sleep and waking in the monkey. J. Neurophysiol. 1964, 27:152-171.
101. Brown R.E., et al. Control of sleep and wakefulness. Physiol. Rev. 2012, 92:1087-1187.
102. Boeve B.F., et al. Pathophysiology of REM sleep behaviour disorder and relevance to neurodegenerative disease. Brain 2007, 130:2770-2788.
103. Mathis J., et al. Isolated mediotegmental lesion causing narcolepsy and rapid eye movement sleep behaviour disorder: a case evidencing a common pathway in narcolepsy and rapid eye movement sleep behaviour disorder. J. Neurol. Neurosurg. Psychiatry 2007, 78:427-429.
104. Karlsson K.A., Blumberg M.S. Active medullary control of atonia in week-old rats. Neuroscience 2005, 130:275-283.
105. Jouvet M. Recherches sur les structures nerveuses et les mecanismes responsables des differentes phases du sommeil physiologique. Arch. Ital. Biol. 1962, 100:125-206.
106. Verhave P.S., et al. REM sleep behavior disorder in the marmoset MPTP model of early Parkinson disease. Sleep 2011, 34:1119-1125.
107. Provini F., et al. Status dissociatus after surgery for tegmental ponto-mesencephalic cavernoma: a state-dependent disorder of motor control during sleep. Mov. Disord. 2004, 19:719-723.
108. Tippmann-Peikert M., et al. REM sleep behavior disorder initiated by acute brainstem multiple sclerosis. Neurology 2006, 66:1277-1279.
109. Plazzi G., Montagna P. Remitting REM sleep behavior disorder as the initial sign of multiple sclerosis. Sleep Med. 2002, 3:437-439.
110. Schenck C.H., et al. A case of REM sleep behavior disorder with autopsy-confirmed Alzheimer's disease: postmortem brain stem histochemical analyses. Biol. Psychiatry 1996, 40:422-425.
111. Uchiyama M., et al. Incidental Lewy body disease in a patient with REM sleep behavior disorder. Neurology 1995, 45:709-712.
112. Benarroch E.E. New findings on the neuropathology of multiple system atrophy. Auton. Neurosci. 2002, 96:59-62.
113. Turner R.S., et al. The pathology of REM sleep behavior disorder with comorbid Lewy body dementia. Neurology 2000, 55:1730-1732.
114. Schenck C.H., et al. Lewy body variant of Alzheimer's disease (AD) identified by postmortem ubiquitin staining in a previously reported case of AD associated with REM sleep behavior disorder. Biol. Psychiatry 1997, 42:527-528.
115. Boeve B., et al. Synucleinopathy pathology and REM sleep behavior disorder plus dementia or parkinsonism. Neurology 2003, 61:40-45.
116. Albin R.L., et al. Decreased striatal dopaminergic innervation in REM sleep behavior disorder. Neurology 2000, 55:1410-1412.
117. Eisensehr I., et al. Reduced striatal dopamine transporters in idiopathic rapid eye movement sleep behaviour disorder - Comparison with Parkinson's disease and controls. Brain 2000, 123:1155-1160.
118. Kotagal V., et al. Symptoms of rapid eye movement sleep behavior disorder are associated with cholinergic denervation in Parkinson disease. Ann. Neurol. 2012, 71:560-568.
119. Grace K.P., et al. Identification of the mechanism mediating genioglossus muscle suppression in REM sleep. Am. J. Respir. Crit. Care Med. 2012, 187:311-319.
120. Torontali Z., et al. Cholinergic involvement in control of REM sleep paralysis. J. Physiol. 2014, (in press).
121. Miyamoto M., et al. Preclinical substantia nigra dysfunction in rapid eye movement sleep behaviour disorder. Sleep Med. 2012, 13:102-106.
122. Gilman S., et al. REM sleep behavior disorder is related to striatal monoaminergic deficit in MSA. Neurology 2003, 61:29-34.
123. Iranzo A., et al. Excessive muscle activity increases over time in idiopathic REM sleep behavior disorder. Sleep 2009, 32:1149-1153.