Chemerin suppresses murine allergic asthma by inhibiting CCL2 production and subsequent airway recruitment of inflammatory dendritic cells

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 69, Issue 6, 2014, Pages 763-774

  Zhao, L ^a   Yang, W ^a   Yang, X ^a   Lin, Y ^a   Lv, J ^a   Dou, X ^b   Luo, Q ^b   Dong, J ^b   Chen, Z ^c   Chu, Y ^a,d   He, R ^a,d  

^a FUDAN UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

^c ZHONGSHAN HOSPITAL OF FUDAN UNIVERSITY   (China)

^d FUDAN UNIVERSITY   (China)

Author keywords

allergic asthma; CCL2; chemerin; inflammatory dendritic cells; lung epithelial cells

Indexed keywords

CD11B ANTIGEN; CHEMERIN; GLYCOPROTEIN P 15095; LIPOPOLYSACCHARIDE; MACROPHAGE DERIVED CHEMOKINE; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; OVALBUMIN; THYMUS AND ACTIVATION REGULATED CHEMOKINE; CHEMERIN PROTEIN, MOUSE; CHEMOTACTIC FACTOR; SIGNAL PEPTIDE;

ADOPTIVE TRANSFER; AIRWAY CONSTRICTION; ALLERGIC AIRWAY INFLAMMATION; ALLERGIC ASTHMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BONE MARROW CELL; CD4+ T LYMPHOCYTE; CELL AGGREGATION; CELL STIMULATION; CHEMOPROPHYLAXIS; CHEMOTAXIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DISEASE MODEL; DRUG EFFECT; FEMALE; IN VITRO STUDY; INFANT; INFLAMMATORY CELL; LUNG ALVEOLUS EPITHELIUM; LUNG LAVAGE; MOUSE; MURINE MODEL; NONHUMAN; OVALBUMIN-INDUCED AIRWAY INFLAMMATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; TH2 CELL; ANIMAL; ASTHMA; BIOSYNTHESIS; CYTOLOGY; DRUG EFFECTS; IMMUNOLOGY; IMMUNOPHENOTYPING; LUNG ALVEOLUS CELL; METABOLISM; PATHOLOGY; RESPIRATORY HYPERSENSITIVITY;

ADOPTIVE TRANSFER; ANIMALS; ANTIGENS, CD11B; ANTIGENS, CD11C; ASTHMA; BRONCHOALVEOLAR LAVAGE FLUID; CD4-POSITIVE T-LYMPHOCYTES; CHEMOKINE CCL2; CHEMOTACTIC FACTORS; DENDRITIC CELLS; DISEASE MODELS, ANIMAL; FEMALE; IMMUNOPHENOTYPING; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; OVALBUMIN; PNEUMOCYTES; RESPIRATORY HYPERSENSITIVITY;

EID: 84899915444     PISSN: 01054538     EISSN: 13989995     Source Type: Journal    
DOI: 10.1111/all.12408     Document Type: Article

References (33)

1. Kim HY, DeKruyff RH, Umetsu DT,. The many paths to asthma: phenotype shaped by innate and adaptive immunity. Nat Immunol 2010; 11: 577-584.
2. Barrett NA, Austen KF,. Innate cells and T helper 2 cell immunity in airway inflammation. Immunity 2009; 31: 425-437.
3. Lambrecht BN, Hammad H,. Lung dendritic cells in respiratory viral infection and asthma: from protection to immunopathology. Annu Rev Immunol 2012; 30: 243-270.
4. Lambrecht BN, De Veerman M, Coyle AJ, Gutierrez-Ramos JC, Thielemans K, Pauwels RA,. Myeloid dendritic cells induce Th2 responses to inhaled antigen, leading to eosinophilic airway inflammation. J Clin Invest 2000; 106: 551-559.
5. de Heer HJ, Hammad H, Soullie T, Hijdra D, Vos N, Willart MA, et al. Essential role of lung plasmacytoid dendritic cells in preventing asthmatic reactions to harmless inhaled antigen. J Exp Med 2004; 200: 89-98.
6. van Rijt LS, Jung S, Kleinjan A, Vos N, Willart M, Duez C, et al. In vivo depletion of lung CD11c+ dendritic cells during allergen challenge abrogates the characteristic features of asthma. J Exp Med 2005; 201: 981-991.
7. Kool M, van Nimwegen M, Willart MA, Muskens F, Boon L, Smit JJ, et al. An anti-inflammatory role for plasmacytoid dendritic cells in allergic airway inflammation. J Immunol 2009; 183: 1074-1082.
8. Bondue B, Wittamer V, Parmentier M,. Chemerin and its receptors in leukocyte trafficking, inflammation and metabolism. Cytokine Growth Factor Rev 2011; 22: 331-338.
9. Albanesi C, Scarponi C, Bosisio D, Sozzani S, Girolomoni G,. Immune functions and recruitment of plasmacytoid dendritic cells in psoriasis. Autoimmunity 2010; 43: 215-219.
10. Albanesi C, Scarponi C, Pallotta S, Daniele R, Bosisio D, Madonna S, et al. Chemerin expression marks early psoriatic skin lesions and correlates with plasmacytoid dendritic cell recruitment. J Exp Med 2009; 206: 249-258.
11. De Palma G, Castellano G, Del Prete A, Sozzani S, Fiore N, Loverre A, et al. The possible role of ChemR23/Chemerin axis in the recruitment of dendritic cells in lupus nephritis. Kidney Int 2011; 79: 1228-1235.
12. Cash JL, Hart R, Russ A, Dixon JP, Colledge WH, Doran J, et al. Synthetic chemerin-derived peptides suppress inflammation through ChemR23. J Exp Med 2008; 205: 767-775.
13. Luangsay S, Wittamer V, Bondue B, De Henau O, Rouger L, Brait M, et al. Mouse ChemR23 is expressed in dendritic cell subsets and macrophages, and mediates an anti-inflammatory activity of chemerin in a lung disease model. J Immunol 2009; 183: 6489-6499.
14. Bondue B, Vosters O, de Nadai P, Glineur S, De Henau O, Luangsay S, et al. ChemR23 dampens lung inflammation and enhances anti-viral immunity in a mouse model of acute viral pneumonia. PLoS Pathog 2011; 7: e1002358.
15. Demoor T, Bracke KR, Dupont LL, Plantinga M, Bondue B, Roy MO, et al. The role of ChemR23 in the induction and resolution of cigarette smoke-induced inflammation. J Immunol 2011; 186: 5457-5467.
16. Otero K, Vecchi A, Hirsch E, Kearley J, Vermi W, Del Prete A, et al. Nonredundant role of CCRL2 in lung dendritic cell trafficking. Blood 2010; 116: 2942-2949.
17. Kim HY, Chang YJ, Chuang YT, Lee HH, Kasahara DI, Martin T, et al. T-cell immunoglobulin and mucin domain 1 deficiency eliminates airway hyperreactivity triggered by the recognition of airway cell death. J Allergy Clin Immunol 2013; 132: 414-425.
18. Wang L, Zhao L, Lv J, Yin Q, Liang X, Chu Y, et al. BLT1-dependent alveolar recruitment of CD4(+)CD25(+) Foxp3(+) regulatory T cells is important for resolution of acute lung injury. Am J Respir Crit Care Med 2012; 186: 989-998.
19. Inaba K, Inaba M, Romani N, Aya H, Deguchi M, Ikehara S, et al. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J Exp Med 1992; 176: 1693-1702.
20. Sim SH, Liu Y, Wang D, Novem V, Sivalingam SP, Thong TW, et al. Innate immune responses of pulmonary epithelial cells to Burkholderia pseudomallei infection. PLoS ONE 2009; 4: e7308.
21. Zabel BA, Silverio AM, Butcher EC,. Chemokine-like receptor 1 expression and chemerin-directed chemotaxis distinguish plasmacytoid from myeloid dendritic cells in human blood. J Immunol 2005; 174: 244-251.
22. Medoff BD, Seung E, Hong S, Thomas SY, Sandall BP, Duffield JS, et al. CD11b+ myeloid cells are the key mediators of Th2 cell homing into the airway in allergic inflammation. J Immunol 2009; 182: 623-635.
23. van Rijt LS, Kuipers H, Vos N, Hijdra D, Hoogsteden HC, Lambrecht BN,. A rapid flow cytometric method for determining the cellular composition of bronchoalveolar lavage fluid cells in mouse models of asthma. J Immunol Methods 2004; 288: 111-121.
24. O'Boyle G, Brain JG, Kirby JA, Ali S,. Chemokine-mediated inflammation: identification of a possible regulatory role for CCR2. Mol Immunol 2007; 44: 1944-1953.
25. Robays LJ, Maes T, Lebecque S, Lira SA, Kuziel WA, Brusselle GG, et al. Chemokine receptor CCR2 but not CCR5 or CCR6 mediates the increase in pulmonary dendritic cells during allergic airway inflammation. J Immunol 2007; 178: 5305-5311.
26. Dieu MC, Vanbervliet B, Vicari A, Bridon JM, Oldham E, Ait-Yahia S, et al. Selective recruitment of immature and mature dendritic cells by distinct chemokines expressed in different anatomic sites. J Exp Med 1998; 188: 373-386.
27. Deshmane SL, Kremlev S, Amini S, Sawaya BE,. Monocyte chemoattractant protein-1 (MCP-1): an overview. J Interferon Cytokine Res 2009; 29: 313-326.
28. Hammad H, Chieppa M, Perros F, Willart MA, Germain RN, Lambrecht BN,. House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells. Nat Med 2009; 15: 410-416.
29. Oostendorp J, Hylkema MN, Luinge M, Geerlings M, Meurs H, Timens W, et al. Localization and enhanced mRNA expression of the orphan chemokine receptor L-CCR in the lung in a murine model of ovalbumin-induced airway inflammation. J Histochem Cytochem 2004; 52: 401-410.
30. Tsuchiya K, Siddiqui S, Risse PA, Hirota N, Martin JG,. The presence of LPS in OVA inhalations affects airway inflammation and AHR but not remodeling in a rodent model of asthma. Am J Physiol Lung Cell Mol Physiol 2012; 303: L54-L63.
31. Mikhak Z, Fukui M, Farsidjani A, Medoff BD, Tager AM, Luster AD,. Contribution of CCR4 and CCR8 to antigen-specific T(H)2 cell trafficking in allergic pulmonary inflammation. J Allergy Clin Immunol 2009; 123: 67-73.
32. Schneider D, Hong JY, Bowman ER, Chung Y, Nagarkar DR, McHenry CL, et al. Macrophage/epithelial cell CCL2 contributes to rhinovirus-induced hyperresponsiveness and inflammation in a mouse model of allergic airways disease. Am J Physiol Lung Cell Mol Physiol 2013; 304: L162-L169.
33. Swamy M, Jamora C, Havran W, Hayday A,. Epithelial decision makers: in search of the 'epimmunome'. Nat Immunol 2010; 11: 656-665.