Candida albicans suppresses nitric oxide generation from macrophages via a secreted molecule

PLoS ONE

Volumn 9, Issue 4, 2014, Pages

  Collette, John R ^a,b   Zhou, Huaijin ^a,c   Lorenz, Michael C ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c Glycos Biotechnologies Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; NITRIC OXIDE; CULTURE MEDIUM; NOS2 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; CANDIDA ALBICANS; COCULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; FUNGAL CELL; FUNGUS GROWTH; MACROPHAGE; MOUSE; NONHUMAN; SACCHAROMYCES CEREVISIAE; ANIMAL; CELL LINE; CULTURE MEDIUM; ENZYME REPRESSION; ENZYMOLOGY; GENE EXPRESSION; GENETICS; HOST PATHOGEN INTERACTION; IMMUNOLOGY; INNATE IMMUNITY; METABOLISM; PHYSIOLOGY;

ANIMALS; CANDIDA ALBICANS; CELL LINE; COCULTURE TECHNIQUES; CULTURE MEDIA, CONDITIONED; ENZYME REPRESSION; GENE EXPRESSION; HOST-PATHOGEN INTERACTIONS; IMMUNITY, INNATE; INTERFERON-GAMMA; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; SACCHAROMYCES CEREVISIAE;

EID: 84899891795     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0096203     Document Type: Article

References (32)

1. Netea MG, Brown GD, Kullberg BJ, Gow NA (2008) An integrated model of the recognition of Candida albicans by the innate immune system. Nat Rev Microbiol 6: 67-78. (Pubitemid 350286221)
2. Vazquez-Torres A, Jones-Carson J, Warner T, Balish E (1995) Nitric oxide enhances resistance of SCID mice to mucosal candidiasis. J Infect Dis 172: 192-198.
3. Newman SL, Holly A (2001) Candida albicans is phagocytosed, killed, and processed for antigen presentation by human dendritic cells. Infect Immun 69: 6813-6822. (Pubitemid 32995440)
4. Shiloh MU, MacMicking JD, Nicholson S, Brause JE, Potter S, et al. (1999) Phenotype of mice and macrophages deficient in both phagocyte oxidase and inducible nitric oxide synthase. Immunity 10: 29-38. (Pubitemid 29077381)
5. Vazquez-Torres A, Jones-Carson J, Balish E (1995) Nitric oxide production does not directly increase macrophage candidacidal activity. Infect Immun 63: 1142-1144.
6. Hromatka BS, Noble SM, Johnson AD (2005) Transcriptional response of Candida albicans to nitric oxide and the role of the YHB1 gene in nitrosative stress and virulence. Mol Biol Cell 16: 4814-4826. (Pubitemid 41416462)
7. Ullmann BD, Myers H, Chiranand W, Lazzell AL, Zhao Q, et al. (2004) Inducible defense mechanism against nitric oxide in Candida albicans. Eukaryot Cell 3: 715-723. (Pubitemid 38763858)
8. Fernandez-Arenas E, Bleck CK, Nombela C, Gil C, Griffiths G, et al. (2009) Candida albicans actively modulates intracellular membrane trafficking in mouse macrophage phagosomes. Cell Microbiol 11: 560-589.
9. Vylkova S, Lorenz MC (2014) Modulation of phagosomal pH by Candida albicans promotes hyphal morphogenesis and requires Stp2p, a regulator of amino acid transport. PLoS Pathog in press.
10. Vylkova S, Carman AJ, Danhof HA, Collette JR, Zhou H, et al. (2011) The Fungal Pathogen Candida albicans Autoinduces Hyphal Morphogenesis by Raising Extracellular pH. MBio 2.
11. Frohner IE, Bourgeois C, Yatsyk K, Majer O, Kuchler K (2009) Candida albicans cell surface superoxide dismutases degrade host-derived reactive oxygen species to escape innate immune surveillance. Mol Microbiol 71: 240-252.
12. Chinen T, Qureshi MH, Koguchi Y, Kawakami K (1999) Candida albicans suppresses nitric oxide (NO) production by interferon-gamma (IFN-gamma) and lipopolysaccharide (LPS)-stimulated murine peritoneal macrophages. Clin Exp Immunol 115: 491-497. (Pubitemid 29130365)
13. Schroppel K, Kryk M, Herrmann M, Leberer E, Rollinghoff M, et al. (2001) Suppression of type 2 NO-synthase activity in macrophages by Candida albicans. Int J Med Microbiol 290: 659-668. (Pubitemid 32232445)
14. Fonzi WA, Irwin MY (1993) Isogenic strain construction and gene mapping in Candida albicans. Genetics 134: 717-728. (Pubitemid 23193572)
15. Gillum AM, Tsay EY, Kirsch DR (1984) Isolation of the Candida albicans gene for orotidine-59-phosphate decarboxylase by complementation of S. cerevisiae ura3 and E. coli pyrF mutations. Mol Gen Genet 198: 179-182. (Pubitemid 15180998)
16. Lo HJ, Kohler JR, DiDomenico B, Loebenberg D, Cacciapuoti A, et al. (1997) Nonfilamentous C. albicans mutants are avirulent. Cell 90: 939-949. (Pubitemid 27381632)
17. Negredo A, Monteoliva L, Gil C, Pla J, Nombela C (1997) Cloning, analysis and one-step disruption of the ARG5,6 gene of Candida albicans. Microbiology 143 (Pt 2): 297-302. (Pubitemid 27092164)
18. Noble SM, Johnson AD (2005) Strains and strategies for large-scale gene deletion studies of the diploid human fungal pathogen Candida albicans. Eukaryot Cell 4: 298-309. (Pubitemid 40257130)
19. Brachmann CB, Davies A, Cost GJ, Caputo E, Li J, et al. (1998) Designer deletion strains derived from Saccharomyces cerevisiae S288C: a useful set of strains and plasmids for PCR-mediated gene disruption and other applications. Yeast 14: 115-132. (Pubitemid 28062863)
20. Lorenz MC, Fink GR (2001) The glyoxylate cycle is required for fungal virulence. Nature 412: 83-86. (Pubitemid 32851514)
21. Mortimer RK, Johnston JR (1986) Genealogy of principal strains of the yeast genetic stock center. Genetics 113: 35-43. (Pubitemid 16042668)
22. Sherman F (1991) Getting started with yeast. In: Guthrie C, Fink GR, editors. Methods in Enzymology. San Diego: Academic Press. 3-21.
23. Jimenez-Lopez C, Collette JR, Brothers KM, Shepardson KM, Cramer RA, et al. (2013) Candida albicans induces arginine biosynthetic genes in response to host-derived reactive oxygen species. Eukaryot Cell 12: 91-100.
24. Lyons CR, Orloff GJ, Cunningham JM (1992) Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line. J Biol Chem 267: 6370-6374.
25. Stahl P, Gordon S (1982) Expression of a mannosyl-fucosyl receptor for endocytosis on cultured primary macrophages and their hybrids. J Cell Biol 93: 49-56. (Pubitemid 12117039)
26. Baydoun AR, Morgan DM (1998) Inhibition of ornithine decarboxylase potentiates nitric oxide
27. Fickling SA, Holden DP, Cartwright JE, Nussey SS, Vallance P, et al. (1999) Regulation of macrophage nitric oxide synthesis by endothelial cells: a role for NG, NG-dimethylarginine. Acta Physiol Scand 167: 145-150.
28. McCall TB, Feelisch M, Palmer RM, Moncada S (1991) Identification of Niminoethyl-L-ornithine as an irreversible inhibitor of nitric oxide synthase in phagocytic cells. Br J Pharmacol 102: 234-238.
29. Lorenz MC, Bender JA, Fink GR (2004) Transcriptional response of Candida albicans upon internalization by macrophages. Eukaryot Cell 3: 1076-1087. (Pubitemid 39385215)
30. Gonzalez A, Hung CY, Cole GT (2011) Coccidioides releases a soluble factor that suppresses nitric oxide production by murine primary macrophages. Microb Pathog 50: 100-108.
31. Kawakami K, Zhang T, Qureshi MH, Saito A (1997) Cryptococcus neoformans inhibits nitric oxide production by murine peritoneal macrophages stimulated with interferon-gamma and lipopolysaccharide. Cell Immunol 180: 47-54. (Pubitemid 27433617)
32. Rocco NM, Carmen JC, Klein BS (2011) Blastomyces dermatitidis yeast cells inhibit nitric oxide production by alveolar macrophage inducible nitric oxide synthase. Infect Immun 79: 2385-2395.