High prevalence of PfCRT K76T mutation in Plasmodium falciparum isolates in Ghana

Acta Tropica

Volumn 136, Issue 1, 2014, Pages 32-36

  Afoakwah, Richmond ^a   Boampong, Johnson N ^a   Egyir Yawson, Alexander ^b   Nwaefuna, Ekene K ^b   Verner, Orish N ^c   Asare, Kwame K ^a  

^a UNIVERSITY OF CAPE COAST   (Ghana)

^b Ghana Atomic Energy Commission   (Ghana)

^c Effia Nkwanta Regional Hospital   (Ghana)

Author keywords

Chloroquine; Malaria; Mutation; Plasmodium falciparum

Indexed keywords

CHLOROQUINE; HEMOGLOBIN; ANTIMALARIAL AGENT; CARRIER PROTEIN; PFCRT PROTEIN, PLASMODIUM FALCIPARUM; PROTOZOAL PROTEIN;

DISEASE CONTROL; DISEASE INCIDENCE; DISEASE PREVALENCE; DISEASE TREATMENT; MALARIA; MUTATION; POLYMORPHISM;

ADULT; AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; DRUG MARKETING; DRUG USE; GENE; GENE FREQUENCY; GENE MUTATION; GENETIC VARIABILITY; GEOGRAPHIC DISTRIBUTION; GHANA; HUMAN; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; NONHUMAN; PARASITE ISOLATION; PARASITE PREVALENCE; PFCRT GENE; PLASMODIUM FALCIPARUM; SEASONAL VARIATION; WILD TYPE; ANIMAL; EPIDEMIOLOGY; GENETICS; MALARIA, FALCIPARUM; METABOLISM; MUTATION; PARASITOLOGY; SINGLE NUCLEOTIDE POLYMORPHISM;

GHANA;

ADULT; ANIMALS; ANTIMALARIALS; CHLOROQUINE; GHANA; HUMANS; MALARIA, FALCIPARUM; MEMBRANE TRANSPORT PROTEINS; MUTATION; PLASMODIUM FALCIPARUM; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTOZOAN PROTEINS;

EID: 84899882644     PISSN: 0001706X     EISSN: 18736254     Source Type: Journal    
DOI: 10.1016/j.actatropica.2014.03.030     Document Type: Article

References (32)

1. Afari E.A., Akanmori B.D., Nakano T., Ofori-Adjei T. Plasmodium falciparum sensitivity to chloroquine in vivo in three ecological zones in Ghana. Trans. R. Soc. Trop. Med. Hyg. 1992, 86:231-232.
2. Beck H., Ley S.C. Monitoring of malaria drug resistance associated SNPs in Plasmodium falciparum on microarray. Methods in Malaria Research 2008, 248-257. MR4/ATCC, Manassas, VA. K. Mell, I. Ljungstrom, H. Perlmann, A. Scherf, M. Wahlgren (Eds.).
3. Beausoliel E.G. Studies on alleged chloroquine resistance of malaria parasites in Axim, Ghana 1967, World Health Organization, WHO/Mal/67.601.
4. Bereczky S., Mårtensson A., Gil J.P., Färnert A. Short report: rapid DNA extraction from archive blood spots on filter paper for genotyping of Plasmodium falciparum. Am. J. Trop. Med. Hyg. 2005, 72:249-251.
5. Djimdé A., Doumbo O.K., Cortese J.F., Kayentao K., Doumbo S., Diourté Y., Coulibaly D., Dicko A., Su X., Nomura T., Fidock D.A., Wellems T.E., Plowe C.V. A molecular marker for chloroquine-resistant falciparum malaria. N. Engl. J. Med. 2001, 344:257-263.
6. Dokomajilar C., Lankoade M.Z., Dorsey G., Zongo I., Ouedraogo J.B., Rosenthal P.J. Roles of specific Plasmodium falciparum mutations in resistance to amodiaquine and sulfadoxine-pyrimethamine in Burkina Faso. Am. J. Trop. Med. Hyg. 2006, 75:162-165.
7. Dondorp A.M., Nosten F., Yi P., Das D., Phyo A.P., Tarning J., Lwin K.M., Ariey F., Hanpithakpong W., Lee S.J., Ringwald P., Silamut K., Imwong M., Chotivanich K., Lim P., Herdman T., An S.S., Yeung S., Singhasivanon P., Day N.P.J., Lindegardh N., Socheat D., White N.J. Artemisinin resistance in Plasmodium falciparum malaria. N. Engl. J. Med. 2009, 361:455-467.
8. Duah N.O., Matrevi S.A., de Souza D.K., Binnah D.D., Tamakloe M.M., Opoku V.S., Onwona C.O., Narh C.A., Quashie N.B., Abuaku B., Duplessis C., Kronmann K.C., Koram K.A. Increased pfmdr1 gene copy number and the decline in pfcrt and pfmdr1 resistance alleles in Ghanaian Plasmodium falciparum isolates after the change of anti-malarial drug treatment policy. Malar. J. 2013, 12:377.
9. Duah N.O., Wilson M.D., Ghansah A., Abuaku B., Edoh D., Quashie N.B., Koram K.A. Mutations in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance genes, and treatment outcomes in Ghanaian children with uncomplicated malaria. J. Trop. Pediatr. 2007, 53:27-31.
10. Durand R., Jafari S., Vauzelle J., Delabre J., Jesic Z., Le Bras J. Analysis of pfcrt point mutations and chloroquine susceptibility in isolates of Plasmodium falciparum. Mol. Biochem. Parasitol. 2001, 114:95-102.
11. Fidock D.A., Nomura T., Talley A.K., Cooper R.A., Dzekunov S.M., Ferdig M.T., Ursos L.M.B., Sidhu A.B.S., Naudé B., Deitsch K.W., Su X., Wootton J.C., Roepe P.D., Wellems T.E. Mutations in the Plasmodium falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance. Mol. Cell 2000, 6:861-871.
12. Giha H.A., Elbashir M.I., Elbasit I.E., Elgadir T.M., ElGhazali G.E., Mackinnon M.J., Babiker H.A. Drug resistance-virulence relationship in Plasmodium falciparum causing severe malaria in an area of seasonal and unstable transmission. Acta Trop. 2006, 97:181-187.
13. Holmgren G., Gil J.P., Ferreira P.M., Veiga M.I., Obonyo C.O., Bjorkman A. Amodiaquine resistant Plasmodium falciparum malaria in vivo is associated with selection of PfCRT 76T and PfMDR1 86Y. Infect. Genet. Evol. 2006, 6:309-314.
14. Kublin J.G., Cortese J.F., Njunju E.M., Mukadam R.A., Wirima J.J., Kazembe P.N., Djimde A.A., Kouriba B., Taylor T.E., Plowe C.V. Reemergence of chloroquine-sensitive Plasmodium falciparum malaria after cessation of chloroquine use in Malawi. J. Infect. Dis. 2003, 187:1870-1875.
15. Lakshmanan V., Bray P.G., Verdier-Pinard D., Johnson D.J., Horrocks P., Muhle R.A., Alakpa G.E., Hughes R.H., Ward S.A., Krogstad D.J., Sidhu A.B., Fidock D.A. A critical role for PfCRT K76T in Plasmodium falciparum verapamil-reversible chloroquine resistance. EMBO J. 2005, 24:2294-2305.
16. Laufer M.K., Thesing P.C., Eddington N.D., Masonga R., Dzinjalamala F.K., Takala S.L., Taylor T.E., Plowe C.V. Return of chloroquine antimalarial efficacy in Malawi. N. Engl. J. Med. 2006, 355:1959-1966.
17. Mayengue P.I., Kalmbach Y., Issifou S., Kremsner P.G., Ntoumi F. No variation in the prevalence of point mutations in the PfCRT and PfMDR1 genes in isolates from Gabonese patients with uncomplicated or severe Plasmodium falciparum malaria. Parasitol. Res. 2007, 100:487-493.
18. Meerman L., Ord R., Bousema J.T., van Niekerk M., Osman E., Hallett R., Pinder M., Walraven G., Sutherland C.J. Carriage of chloroquine-resistant parasites and delay of effective treatment increase the risk of severe malaria in Gambian children. J. Infect. Dis. 2005, 192:1651-1657.
19. Mohammed A., Ndaro A., Kalinga A., Manjuranao A., Mosha J.F., Mosha D.F., van Zwetselaar M., Koenderink J.B., Mosha F.W., Alifrangis M., Reyburn H., Roper C., Kavishe R.A. Trends in chloroquine resistance marker, Pfcrt-K76T mutation ten years after chloroquine withdrawal in Tanzania. Malar. J. 2013, 12:415.
20. Mwai L., Ochong E., Abdirahman A., Kiara S.M., Ward S., Kokwaro G., Sasi P., Marsh K., Borrmann S., Mackinnon M., Nzila A. Chloroquine resistance before and after its withdrawal in Kenya. Malar. J. 2009, 8:106.
21. Neequaye, Ofori-Adjei J., Odame D., Coker I., Annan-Mensah L. Falciparum malaria not sensitive to chloroquine emerges in Accra in 1987. Ghana Med. J. 1987, 22:6-10.
22. Ochong E.O., van den Broek I.V.F., Keus K., Nzila A. Association between chloroquine and amodiaquine resistance and allelic variation in the plasmodium falciparum multiple drug resistance 1 gene and the chloroquine resistance transporter gene in isolates from the upper Nile in southern Sudan. Am. J. Trop. Med. Hyg. 2003, 69:184-187. Short report:.
23. Ofori-Adjei D., Adjepon-Yamoah K.K., Commey J.O.O., Ofori-Adjei E. In-vivo sensitivity of P. falciparum to chloroquine in Accra, Ghana. Ghana Med. J. 1988, 22:11-14.
24. Ranjit M.R., Das A., Chhotray G.P., Das B.P., Das B.N., Acharya A.S. The PfCRT (K76T) point mutation favours clone multiplicity and disease severity in Plasmodium falciparum infection. Trop. Med. Int. Health 2004, 9:857-861.
25. Sidhu A.B., Verdier-Pinard D., Fidock D.A. Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations. Science 2002, 298:210-213.
26. Thomsen T.T., Madsen L.B., Hansson H.H., Tomas E.V., Charlwood D., Bygbjerg I.C., Alifrangis M. Rapid selection of Plasmodium falciparum chloroquine resistance transporter gene and multidrug resistance gene-1 haplotypes associated with past chloroquine and present artemether-lumefantrine use in Inhambane District, southern Mozambique. Am. J. Trop. Med. Hyg. 2013, 88:536-541.
27. Veiga M.I., Ferreira P.E., Bjorkman A., Gil J.P. Multiplex PCR-RFLP methods for PfCRT, PfMDR1 and PfDHFR mutations in Plasmodium falciparum. Mol. Cell. Probes 2006, 20:100-104.
28. Wele M., Djimde A.A., Guindo A., Beavogui A.H., Traore I.Z., Sadou A., Blaise D., Diallo D.A., Wellems T.E., Doumbo O.K. High frequency of Pfcrt 76T in two Malian villages and its prevalence in severe relative to non-severe malaria. Acta Trop. 2011, 119:11-13.
29. White N.J. Malaria. Manson's Tropical Disease 2009, 1201-1300. Saunder Elsevier Ltd., Philadelphia. G.C. Cook, A.I. Zumla (Eds.).
30. WHO Guidelines for Malaria Treatment 2006, World Health Organization, Geneva.
31. WHO World Malaria Report 2008 2008, World Health Organization, Geneva.
32. Wootton J.C., Feng X., Ferdig M.T., Cooper R.A., Mu J., Baruch D.I., Magill A.J., Su X. Genetic diversity and chloroquine selective sweeps in Plasmodium falciparum. Nature 2002, 418:320-323.