Amplification of aminoglycoside resistance gene aphA1 in Acinetobacter baumannii results in tobramycin therapy failure

mBio

Volumn 5, Issue 2, 2014, Pages

  McGann, Patrick ^a   Courvalin, Patrice ^b   Snesrud, Erik ^a   Clifford, Robert J ^a   Yoon, Eun Jeong ^b   Onmus Leone, Fatma ^a   Ong, Ana C ^a   Kwak, Yoon I ^a   Grillot Courvalin, Catherine ^b   Lesho, Emil ^a   Waterman, Paige E ^a  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^b INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE; COLISTIN; DNA FRAGMENT; MEROPENEM; TOBRAMYCIN; VANCOMYCIN;

ACINETOBACTER BAUMANNII; ACINETOBACTER INFECTION; ADULT; ANTIBIOTIC RESISTANCE; APHA1 GENE; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIUM ISOLATION; CONCENTRATION (PARAMETERS); COPY NUMBER VARIATION; DRUG MECHANISM; DRUG SUBSTITUTION; DRUG TREATMENT FAILURE; DRUG WITHDRAWAL; GENE AMPLIFICATION; GENE SEQUENCE; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MALE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSPOSON;

ACID PHOSPHATASE; ACINETOBACTER BAUMANNII; ACINETOBACTER INFECTIONS; ANTI-BACTERIAL AGENTS; DNA TRANSPOSABLE ELEMENTS; DNA, BACTERIAL; DRUG RESISTANCE, BACTERIAL; GENE AMPLIFICATION; GENE DOSAGE; GENOME, BACTERIAL; HUMANS; MALE; MICROBIAL SENSITIVITY TESTS; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, DNA; TOBRAMYCIN; TREATMENT FAILURE; YOUNG ADULT;

EID: 84899880829     PISSN: 21612129     EISSN: 21507511     Source Type: Journal    
DOI: 10.1128/mBio.00915-14     Document Type: Article

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