Radiation-induced mitotic catastrophe in FANCD2 primary fibroblasts

International Journal of Radiation Biology

Volumn 90, Issue 5, 2014, Pages 373-381

  Leskovac, Andreja ^a   Petrovic, Sandra ^a   Guc Scekic, Marija ^b,c   Vujic, Dragana ^b,c   Joksic, Gordana ^a  

^a UNIVERSITY OF BELGRADE   (Serbia)

^b UNIVERSITY OF BELGRADE   (Serbia)

^c Mother and Child Health Care Institute of Serbia Dr Vukan Cupic   (Serbia)

Author keywords

Fanconi anemia; Ionizing irradiation; Micronuclei; Mitotic catastrophe; H2AX

Indexed keywords

FANCONI ANEMIA GROUP D2 PROTEIN; HISTONE H2AX;

ARTICLE; CASE REPORT; CELL CYCLE; CELL NUCLEUS; CELL PROLIFERATION; CHILD; CHROMOSOME DAMAGE; CONTROLLED STUDY; CYTOKINESIS; FANCONI ANEMIA; FIBROBLAST; G2 PHASE CELL CYCLE CHECKPOINT; HISTONE PHOSPHORYLATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IONIZING RADIATION; MICRONUCLEUS TEST; MITOSIS; PRIORITY JOURNAL; RADIOSENSITIVITY; SCHOOL CHILD;

CELL NUCLEUS; CELLS, CULTURED; CHILD; CYTOKINESIS; FANCONI ANEMIA; FANCONI ANEMIA COMPLEMENTATION GROUP D2 PROTEIN; FIBROBLASTS; HISTONES; HUMANS; MITOSIS; PHOSPHORYLATION; RADIATION TOLERANCE; SIGNAL TRANSDUCTION;

EID: 84899878264     PISSN: 09553002     EISSN: 13623095     Source Type: Journal    
DOI: 10.3109/09553002.2014.892224     Document Type: Article

References (44)

1. Alter BP. 2002. Radiosensitivity in Fanconi' s anemia patients. Radiother Oncol 62: 345-347.
2. Banath JP, Klokov D, MacPhail SH, Banuelos CA, Olive PL. 2010. Residual gammaH2AX foci as an indication of lethal DNA lesions. BMC Cancer 10 : 4.
3. Bigelow SB, Rary JM, Bender MA. 1979. G2 chromosomal radiosensitivityin Fanconi' s anemia. Mutat Res 63: 189-199.
4. Bremer M, Schindler D, Gross M, Dork T, Morlot S, Karstens JH. 2003. Fanconi ' s anemia and clinical radiosensitivity report on two adultpatients with locally advanced solid tumors treated by radiotherapy. Strahlenther Onkol 179: 748-753.
5. Chan KL, Palmai-Pallag T, Ying S, Hickson ID. 2009. Replication stressinduces sister-chromatid bridging at fragile site loci in mitosis. Nature Cell Biol 11 : 753-760.
6. Cloos CR, Daniels DH, Kalen A, Matthews K, Du J, Goswami PC, Cullen JJ. 2009. Mitochondrial DNA depletion induces radioresistanceby suppressing G2 checkpoint activation in human pancreaticcancer cells. Radiat Res 171: 581-587.
7. D ' Andrea AD. 2010. Susceptibility pathways in Fanconi' s anemia andbreast cancer. New Eng J Med 362: 1909-1919.
8. Dickey JS, Redon CE, Nakamura AJ, Baird BJ, Sedelnikova OA, Bonner WM. 2009. H2AX: Functional roles and potential applications. Chromosoma 118 : 683-692.
9. Djuzenova C, Flentje M, Plowman PN. 2004. Radiation response invitro of fi broblasts from a fanconi anemia patient with markedclinical radiosensitivity. Strahlenther Onkol 180: 789-797.
10. Duckworth-Rysiecki G, Taylor AM. 1985. Eff ects of ionizing radiationon cells from Fanconi' s anemia patients. Cancer Res 45: 416-420.
11. Fenech M. 1993. The cytokinesis-block micronucleus technique:A detailed description of the method and its application to genotoxicitystudies in human populations. Mutat Res 285: 35-44.
12. Firat E, Gaedicke S, Tsurumi C, Esser N, Weyerbrock A, Niedermann G. 2011. Delayed cell death associated with mitoticcatastrophe in gamma-irradiated stem-like glioma cells. RadiatOncol 6 : 71.
13. Gallmeier E, Calhoun ES, Rago C, Brody JR, Cunningham SC, Hucl T, Gorospe M, Kohli M, Lengauer C, Kern SE. 2006. Targeteddisruption of FANCC and FANCG in human cancer provides apreclinical model for specifi c therapeutic options. Gastroenterology130 : 2145-2154.
14. Gluckman E. 1990. Radiosensitivity in Fanconi anemia: Applicationto the conditioning for bone marrow transplantation. RadiotherOncol 18(Suppl. 1): 88-93.
15. Hamasaki K, Imai K, Nakachi K, Takahashi N, Kodama Y, Kusunoki Y.2007. Short-term culture and gammaH2AX fl ow cytometry determinediff erences in individual radiosensitivity in human peripheralT lymphocytes. Environ Molec Mutagen 48: 38-47.
16. Higurashi M, Conen PE. 1973. In vitro chromosomal radiosensitivity in" chromosomal breakage syndromes ". Cancer 32 : 380-383.
17. Hows JM, Chapple M, Marsh JC, Durrant S, Yin JL, Swirsky D, Gordon-Smithe C. 1989. Bone marrow transplantation forFanconi' s anaemia: The HammersmiThexperience 1977-89. BoneMarrow Transplant 4 : 629-634.
18. Huang X, Tran T, Zhang L, Hatcher R, Zhang P. 2005. DNA damageinducedmitotic catastrophe is mediated by the Chk1-dependentmitotic exit DNA damage checkpoint. Proc Natl Acad Sci USA102 : 1065-1070.
19. Hucl T, Rago C, Gallmeier E, Brody JR, Gorospe M, Kern SE. 2008. A syngeneic variance library for functional annotation of humanvariation: application to BRCA2. Cancer Res 68: 5023-5030.
20. Imreh G, Norberg HV, Imreh S, Zhivotovsky B. 2011. Chromosomalbreaks during mitotic catastrophe trigger gammaH2AX-ATMp53-mediated apoptosis. J Cell Sci 124 : 2951-2963.
21. Joksic I, Vujic D, Guc-Scekic M, Leskovac A, Petrovic S, Ojani M, Trujillo JP, Surralles J, Zivkovic M, Stankovic A, Slijepcevic P, JoksicG. 2012. Dysfunctional telomeres in primary cells from Fanconi anemiaFANCD2 patients. Genome Integrity 3 : 6.
22. Kalb R, Duerr M, Wagner M, Herterich S, Gross M, Digweed M, Joenje H, Hoehn H, Schindler D. 2004. Lack of sensitivity ofprimary Fanconi' s anemia fi broblasts to UV and ionizing radiation. Radiat Res 161: 318-325.
23. Kalb R, Neveling K, Hoehn H, Schneider H, Linka Y, BatishSD, Hunt C, Berwick M, Callen E, Surralles J, et al 2007 Hypomorphic mutations in the gene encoding a key Fanconianemia protein, FANCD2, sustain a significant group ofFA-D2 patients with severe phenotype. Am J Human Genet 80 :895-910.
24. Klokov D, MacPhail SM, Banath JP, Byrne JP, Olive PL. 2006. Phosphorylated histone H2AX in relation to cell survival in tumorcells and xenografts exposed to single and fractionated doses ofX-rays. Radiother Oncol 80: 223-229.
25. Kubbies M, Schindler D, Hoehn H, Schinzel A, Rabinovitch PS. 1985. Endogenous blockage and delay of the chromosome cycle despitenormal recruitment and growth phase explain poor proliferationand frequent edomitosis in Fanconi anemia cells. Am J HumanGenet 37 : 1022-1030.
26. Kumari U, Ya Jun W, Huat Bay B, Lyakhovich A. 2013. Evidence of mitochondrialdysfunction and impaired ROS detoxifying machinery inFanconi Anemia cells. Oncogene 33 : 165-172.
27. Leskovac A, Vujic D, Guc-Scekic M, Petrovic S, Joksic I, Slijepcevic P, Joksic G. 2010. Fanconi anemia is characterized by delayed repairkinetics of DNA double-strand breaks. Tohoku J Experim Med221 : 69-76.
28. Lyakhovich A. 2013. Damaged mitochondria and overproduction ofROS in Fanconi anemia cells. Rare Diseases 1 : e24048.
29. MacPhail SH, Banath JP, Yu Y, Chu E, Olive PL. 2003. Cell cycledependentexpression of phosphorylated histone H2AX: Reducedexpression in unirradiated but not X-irradiated G1-phase cells. Radiat Res 159: 759-767.
30. Marcou Y, D ' Andrea A, Jeggo PA, Plowman PN. 2001. Normal cellularradiosensitivity in an adult Fanconi anaemia patient with markedclinical radiosensitivity. Radiother Oncol 60: 75-79.
31. Mozdarani H. 2012. Biological complexities in radiation carcinogenesisand cancer radiotherapy: Impact of new biological paradigms. Genes 3 : 90-114.
32. Naim V, Rosselli F. 2009. The FANC pathway and BLM collaborateduring mitosis to prevent micro-nucleation and chromosomeabnormalities. Nature Cell Biol 11: 761-768.
33. Okada H, Mak TW. 2004. Pathways of apoptotic and non-apoptoticdeath in tumour cells. Nature Rev Cancer 4: 592-603.
34. Pagano G, Aiello Talamanca A, Castello G, Pallardo FV, Zatterale A, Degan P. 2012. Oxidative stress in Fanconi anaemia: From cells andmolecules toward prospects in clinical management. Biolog Chem393 : 11-21.
35. Petrovic S, Leskovac A, Kotur-Stevuljevic J, Joksic J, Guc-Scekic M, VujicD, Joksic G. 2011. Gender-related diff erences in the oxidant state ofcells in Fanconi anemia heterozygotes. Biolog Chem 392 : 625-632.
36. Rani R, Li J, Pang Q. 2008. Diff erential p53 engagement in responseto oxidative and oncogenic stresses in Fanconi anemia mice. Cancer Res 68: 9693-9702.
37. Sala-Trepat M, Rouillard D, Escarceller M, Laquerbe A, Moustacchi E, Papadopoulo D. 2000. Arrest of S-phase progression is impaired inFanconi anemia cells. Experim Cell Res 260 : 208-215.
38. Sasaki MS, Tonomura A. 1973. A high susceptibility of Fanconi' sanemia to chromosome breakage by DNA cross-linking agents. Cancer Res 33: 1829-1836.
39. Sobeck A, Stone S, Costanzo V, de Graaf B, Reuter T, de Winter J, Wallisch M, Akkari Y, Olson S, Wang W, Joenje H, Christian JL, Lupardus PJ, Cimprich KA, Gautier J, Hoatlin ME. 2006. Fanconi anemia proteins are required to prevent accumulation ofreplication-associated DNA double-strand breaks. Molec CellularBiol 26 : 425-437.
40. Surralles J, Xamena N, Creus A, Marcos R. 1995. The suitability ofthe micronucleus assay in human lymphocytes as a newbiomarker of excision repair. Mutat Res 342: 43-59.
41. Suzuki M, Suzuki K, Kodama S, Watanabe M. 2006. Phosphorylatedhistone H2AX foci persist on rejoined mitotic chromosomes innormal human diploid cells exposed to ionizing radiation. RadiatRes 165: 269-276.
42. Taniguchi T, Garcia-Higuera I, Xu B, Andreassen PR, Gregory RC, Kim ST, Lane WS, Kastan MB, D ' Andrea AD. 2002. Convergence ofthe Fanconi anemia and ataxia telangiectasia signaling pathways. Cell 109 : 459-472.
43. Vinciguerra P, Godinho SA, Parmar K, Pellman D, D ' Andrea AD. 2010. Cytokinesis failure occurs in Fanconi anemia pathway-defi cientmurine and human bone marrow hematopoietic cells. J Clin Investig120: 3834-3842.
44. Yoshioka Y, Yamazaki H, Yoshida K, Ozeki S, Inoue T, Yoneda M.2004. Impact of mitochondrial DNA on radiation sensitivity oftransformed human fi broblast cells: Clonogenic survival, micronucleus formation and cellular ATP level. Radiat Res 162 :143-147.