Different molecular profiles are associated with breast cancer cell homing compared with colonisation of bone: Evidence using a novel bone-seeking cell line

Endocrine-Related Cancer

Volumn 21, Issue 2, 2014, Pages 327-341

  Nutter, Faith ^a   Holen, Ingunn ^a   Brown, Hannah K ^a   Cross, Simon S ^b   Alyson Evans, C ^a   Walker, Matthew ^a   Coleman, Robert E ^a   Westbrook, Jules A ^c   Selby, Peter J ^c   Brown, Janet E ^a,c   Ottewell, Penelope D ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

^c UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

Bone; Breast; Metastasis

Indexed keywords

3,4 METHYLENEDIOXYAMPHETAMINE; CALVASCULIN; CARCINOEMBRYONIC ANTIGEN RELATED CELL ADHESION MOLECULE 1; CD146 ANTIGEN; CELL ADHESION MOLECULE; EPHRIN RECEPTOR B2; FIBROBLAST GROWTH FACTOR RECEPTOR 4; FIBRONECTIN; GELATINASE A; GELATINASE B; GROWTH ASSOCIATED PROTEIN; GROWTH ASSOCIATED PROTEIN FN1; H RAS PROTEIN; INTERLEUKIN 1BETA; INTERSTITIAL COLLAGENASE; MATRIX METALLOPROTEINASE 17; MESSENGER RNA; NUCLEOSIDE DIPHOSPHATE KINASE A; PROTEIN P107; PROTEIN P130; RAS PROTEIN; SERBP1 PROTEIN; SMAD2 PROTEIN; STROMELYSIN; STROMELYSIN 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE COLONIZATION; BONE MASS; BONE METASTASIS; BONE SEEKING CELL LINE; BREAST CANCER; BREAST CANCER CELL LINE; CANCER GROWTH; CANCER PATIENT; CANCER RECURRENCE; CANCER STAGING; CELL ADHESION; CELL CLONE; CELL COUNTING; CELL GROWTH; CELL HOMING; CELL MIGRATION; CELL PROLIFERATION; COCULTURE; CONTROLLED STUDY; CORTICAL BONE; DISEASE FREE INTERVAL; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR MATRIX; FEMALE; FOLLOW UP; GENE EXPRESSION; GENE EXPRESSION ASSAY; GENE EXPRESSION PROFILING; GENETIC ASSOCIATION; GROWTH PLATE; GROWTH RATE; HOUSEKEEPING GENE; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOTHESIS; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LONG BONE; MICRO-COMPUTED TOMOGRAPHY; MOUSE; NONHUMAN; ONCOGENE H RAS; OSTEOLYSIS; PHENOTYPE; PRIMARY TUMOR; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRABECULAR BONE; TUMOR CELL INOCULATION; TUMOR MICROENVIRONMENT; UPREGULATION; WOUND CLOSURE;

BONE; BREAST; METASTASIS;

ANIMALS; BONE NEOPLASMS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL MOVEMENT; FEMALE; GENE EXPRESSION PROFILING; HUMANS; INTERLEUKIN-1BETA; MICE; MICE, NUDE;

EID: 84899861265     PISSN: 13510088     EISSN: 14796821     Source Type: Journal    
DOI: 10.1530/ERC-13-0158     Document Type: Article

References (38)

1. Adams CL & Nelson WJ 1998 Cytomechanics of cadherin-mediated cell-cell adhesion. Current Opinion in Cell Biology 10 572-577. (doi:10.1016/S0955-0674(98)80031-8)
2. Andersen K, Mori H, Fata J, Bascom J, Oyjord T, Mælandsmo GM & Bissell M 2011 The metastasis-promoting protein S100A4 regulates mammary branching morphogenesis. Developmental Biology 352 181-190. (doi:10.1016/j. ydbio.2010.12.033)
3. Bae YK, Kim A, Kim MK, Choi JE, Kang SH & Lee SJ 2013 Fibronectin expression in carcinoma cells correlates with tumor aggressiveness and poor clinical outcome in patients with invasive breast cancer. Human Pathology 44 2028-2037. (doi:10.1016/j.humpath.2013.03.006)
4. Bellahcène A, Bachelier R, Detry C, Lidereau R, Clézardin P & Castronovo V 2007 Transcriptome analysis reveals an osteoblast-like phenotype for human osteotropic breast cancer cells. Breast Cancer Research and Treatment 101 135-148. (doi:10.1007/s10549-006-9279-8)
5. Bussard KM, Gay CV & Mastro AM 2008 The bone microenvironment in metastasis; what is special about bone? Cancer Metastasis Reviews 27 41-55. (doi:10.1007/s10555-007-9109-4)
6. Chambers AF, Groom AC & MacDonald IC 2002 Dissemination and growth of cancer cells in metastatic sites. Nature Reviews. Cancer 2, 563-572. (doi:10.1038/nrc865)
7. Chu YW, Yang PC, Yang SC, Shyu YC, Hendrix MJ, Wu R & Wu CW 1997 Selection of invasive and metastatic subpopulations from a human lung adenocarcinoma cell line. American Journal of Respiratory Cell and Molecular Biology 17 353-360. (doi:10.1165/ajrcmb.17.3.2837)
8. Coleman RE, Marshall H, Cameron D, Dodwell D, Burkinshaw R, Keane M, Gil M, Houston SJ, Grieve MB, Barrett-Lee PJ et al. 2011 Breast-cancer adjuvant therapy with zoledronic acid. New England Journal of Medicine 365 1396-1405. (doi:10.1056/NEJMoa1105195)
9. Ding Ellis MJ, Li S, Larson DE, Chen K, Wallis JW, Harris CC, McLellan MD, Fulton RS, Fulton LL, Abbott RM et al. 2010 Genome remodelling in a basal like breast cancer metastasis and xenograft. Nature 464 999-1005. (doi:10.1038/nature08989)
10. Dumont B, Castronovo V, Peulen O, Blétard N, Clézardin P, Delvenne P, DePauw EA, Turtoi A & BellahcèneA2012 Differentialproteomicanalysis of a human breast tumor and its matched bone metastasis identifies cell membrane and extracellular proteins associated with bone metastasis. Journal of Proteome Research 11 2247-2260. (doi:10.1021/ pr201022n)
11. Fernandez-Garcia B, Eiró N, Maŕin L, González-Reyes S, Gonzalez LO, Lamelas ML & Vizoso FJ 2014 Expression and prognostic significance of fibronectin and matrix metalloproteases in breast cancer metastasis. Histopathology 64 512-522. (doi:10.1111/his.12300)
12. Friedrich RE, Eisenmann J, Röser K, Scheuer HA & Löning T 2010 Expression of proteases in giant cell lesions of the jaws, tendon sheath and salivary glands. Anticancer Research 30 1645-1652.
13. Henriquez NV, van Overveld PG, Que I, Buijs JT, Bachelier R, Kaijzel EL, Löwik CW, Clezardin P & van der Pluijm G 2007 Advances in optical imaging and novel model systems for cancer metastasis research. Clinical & Experimental Metastasis 24 699-705. (doi:10.1007/s10585-007-9115-5)
14. Kang Y, Siegel PM, Shu W, Drobnjak M, Kakonen SM, Cordón-Cardo C, Guise TA & Massagué J 2003 A multigenic program mediating breast cancer metastasis to bone. Cancer Cell 3 537-549. (doi:10.1016/S1535-6108(03) 00132-6)
15. Kaplan RN, Riba RD, Zacharoulis S, Bramley AH, Vincent L, Costa C, MacDonald DD, Jin DK, Shido K, Kerns SA et al. 2005 VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature 438 820-827. (doi:10.1038/nature04186)
16. Karakosta A, Golias Ch, Charalabopoulos A, Peschos D, Batistatou A & Charalabopoulos K 2005 Genetic models of human cancer as a multistep process. Paradigm models of colorectal cancer, breast cancer, chronic myelogenosus and lymphoblastic leukaemia. Journal of Experimental & Clinical Cancer Research 24 505-514.
17. Kiefel H, Bondong S, Pfeifer M, Schirmer U, Erbe-Hoffmann N, Schäfer H, Sebens S & Altevogt P 2012 EMT-associated up-regulation of L1CAM provides insights into L1CAM-mediated integrin signalling and NF-kB activation. Carcinogenesis 33 1919-1929. (doi:10.1093/carcin/bgs220)
18. Kim MS, Lee EJ, Kim HR & Moon A 2003 p38 kinase is a key signaling molecule for H-Ras-induced cell motility and invasive phenotype in human breast epithelial cells. Cancer Research 63 5454-5461.
19. Klein CA 2004 Gene expression signatures, cancer cell evolution and metastatic progression. Cell Cycle 3 28-30. (doi:10.4161/cc.3.1.634)
20. Lawson Blatch GL & Edkins AL 2009 Cancer stem cells in breast cancer and metastasis. Breast Cancer Research and Treatment 118 241-254. (doi:10.1007/s10549-009-0524-9)
21. Lee WY, Su WC, Lin PW, Guo HR, Chang TW & Chen HH 2004 Expression of S100A4 and Met: potential predictors for metastasis and survival in early-stage breast cancer. Oncology 66 429-438. (doi:10.1159/000079496)
22. Leopold PL, Vincent J & Wang H 2012 A comparison of epithelial-to-mesenchymal transition and re-epithelialization. Seminars in Cancer Biology 22 471-483. (doi:10.1016/j.semcancer.2012.07.003)
23. Lipton A 2010 Implications of bone metastases and the benefits of bone-targeted therapy. Seminars in Oncology 37 (Suppl 2) S15-S29. (doi:10.1053/j.seminoncol.2010.10.002)
24. Maeda T, Alexander CM & Friedl A 2004 Induction of syndecan-1 expression in stromal fibroblasts promotes proliferation of human breast cancer cells. Cancer Research 64 612-621. (doi:10.1158/0008-5472.CAN-03-2439)
25. Major Cook RJ, Lipton A, Smith MR, Terpos E & Coleman RE 2009 Natural history of malignant bone disease in breast cancer and the use of cumulative mean functions to measure skeletal morbidity. BMC Cancer 9 272. (doi:10.1186/1471-2407-9-272)
26. 1-integrin enhances production of osteoclast-stimulating activity. Blood 96 1953-1960.
27. Mishra A, Shiozawa Y, Pienta KJ & Taichman RS 2011 Homing of cancer cells to the bone. Cancer Microenvironment 4 221-235. (doi:10.1007/s12307-011- 0083-6)
28. Ottewell PD, Mönkkönen H, Jones M, Lefley DV, Coleman RE & Holen I 2008 Antitumor effects of doxorubicin followed by zoledronic acid in a mouse model of breast cancer. Journal of the National Cancer Institute 100 1167-1178. (doi:10.1093/jnci/djn240)
29. Parker B & Sukumar S 2003 Distant metastasis in breast cancer: molecular mechanisms and therapeutic targets. Cancer Biology & Therapy 2 14-21. (doi:10.4161/cbt.2.3.364)
30. Phadke PA, Mercer RR, Harms JF, Jia Y, Frost AR, Jewell JL, Bussard KM, Nelson S, Moore C, Kappes JC et al. 2006 Kinetics of metastatic breast cancer cell trafficking in bone. Clinical Cancer Research 12 1431-1440. (doi:10.1158/1078-0432.CCR-05-1806)
31. van der Pluijm G, Vloedgraven H, Papapoulos S, Löwick C, Grzesik W, Kerr J & Robey PG 1997 Attachment characteristics and involvement of integrins in adhesion of breast cancer cell lines to extracellular bone matrix components. Laboratory Investigation 77 665-675.
32. Saad S, Gottlieb DJ, Bradstock KF, Overall CM & Bendall LJ 2002 Cancer cell-associated fibronectin induces release of matrix metallo-proteinase-2 from normal fibroblasts. Cancer Research 62 283-289.
33. Shiozawa Y, Pienta KJ & Taichman RS 2011 Hematopoietic stem cell niche is a potential therapeutic target for bone metastatic tumors. Clinical Cancer Research 17 5553-5558. (doi:10.1158/1078-0432.CCR-10-2505)
34. Ueda Y, Hirai Si, Osada Si, Suzuki A, Mizuno K & Ohno S 1996 Protein kinase C dactivates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf. Journal of Biological Chemistry 271 23512-23519. (doi:10.1074/jbc.271.38.2351)
35. Watson DM, Elton RA, Jack WJ, Dixon JM, Chetty U & Miller WR 1991 The H-ras oncogene product p21 and prognosis in human breast cancer. Breast Cancer Research and Treatment 17 161-169. (doi:10.1007/BF01806365)
36. Wells A, Yates C & Shepard CR 2008 E-cadherin as an indicator of mesenchymal to epithelial reverting transitions during the metastatic seeding of disseminated carcinomas. Clinical & Experimental Metastasis 25 621-628. (doi:10.1007/s10585-008-9167-1)
37. Yang J & Weinberg RA 2008 Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Developmental Cell 14 818-829. (doi:10.1016/j.devcel.2008.05.009)
38. 2. Theranostics 2 577-588. (doi:10.7150/thno.4443)