Hedgehog pathway inhibition in chondrosarcoma using the smoothened inhibitor IPI-926 directly inhibits sarcoma cell growth

Molecular Cancer Therapeutics

Volumn 13, Issue 5, 2014, Pages 1259-1269

  Campbell, Veronica T ^a   Nadesan, Puviindran ^c   Ali, S Amanda ^c   Wang, Chang Ye Yale ^c   Whetstone, Heather ^c   Poon, Raymond ^c   Wei, Qingxia ^c   Keilty, John ^a   Proctor, Jennifer ^a   Wang, Lauren W ^b   Apte, Suneel S ^b   McGovern, Karen ^a   Alman, Benjamin A ^c,e,f   Wunder, Jay S ^d,e  

^a Infinity Pharmaceuticals Inc   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

^c Hospital for Sick Children   (United States)

^d MOUNT SINAI HOSPITAL   (Canada)

^e UNIVERSITY OF TORONTO   (Canada)

^f DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; DOXORUBICIN; SARIDEGIB; SONIC HEDGEHOG PROTEIN; ADAMTSL1 PROTEIN, HUMAN; ANTINEOPLASTIC AGENT; G PROTEIN COUPLED RECEPTOR; IPI-926; SCLEROPROTEIN; SMO PROTEIN, HUMAN; VERATRUM ALKALOID;

ANIMAL TISSUE; ARTICLE; CANCER CHEMOTHERAPY; CANCER INHIBITION; CATARACT; CELL PROLIFERATION; CHONDROSARCOMA; CONTROLLED STUDY; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; GENE TARGETING; HISTOPATHOLOGY; IN VIVO STUDY; MOUSE; NONHUMAN; PHENOTYPE; PRIMARY TUMOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; SARCOMA CELL; TREATMENT DURATION; TUMOR CALCINOSIS; TUMOR GROWTH; TUMOR XENOGRAFT; ANIMAL; ANTAGONISTS AND INHIBITORS; CALCINOSIS; DISEASE MODEL; DRUG EFFECTS; DRUG SCREENING; GENETICS; HUMAN; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE; TUMOR VOLUME;

ANIMALS; ANTINEOPLASTIC AGENTS; CALCINOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; CHONDROSARCOMA; DISEASE MODELS, ANIMAL; EXTRACELLULAR MATRIX PROTEINS; HEDGEHOG PROTEINS; HUMANS; MICE; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; TUMOR BURDEN; VERATRUM ALKALOIDS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84899830182     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-13-0731     Document Type: Article

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