Quality by design development of brivanib alaninate tablets: Degradant and moisture control strategy

International Journal of Pharmaceutics

Volumn 469, Issue 1, 2014, Pages 111-120

  Badawy, Sherif I F ^a   Lin, Judy ^a   Gokhale, Madhushree ^a   Desai, Sachin ^a   Nesarikar, Vishwas V ^a   Lamarche, Keirnan R ^a   Subramanian, Ganeshkumar A ^a   Narang, Ajit S ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

BMS 540215; Brivanib alaninate; Control strategy; Hydrolysis; Quality by design; Sorption desorption moisture transfer; Stability

Indexed keywords

BRIVANIB ALANINATE; ALANINE; ANGIOGENESIS INHIBITOR; BRIVANIB; PRODRUG; TABLET; TRIAZINE DERIVATIVE; WATER;

ARTICLE; CONTROL STRATEGY; CONTROLLED STUDY; DRUG DEGRADATION; DRUG DESIGN; DRUG HYDROLYSIS; DRUG PACKAGING; DRUG QUALITY; HUMIDITY; HYDROLYSIS KINETICS; PRIORITY JOURNAL; SHELF LIFE; TABLET MANUFACTURE; WATER CONTENT; ANALOGS AND DERIVATIVES; CHEMICAL MODEL; CHEMISTRY; COMPUTER SIMULATION; DRUG STABILITY; HYDROLYSIS; KINETICS; MEDICINAL CHEMISTRY; PHARMACEUTICS; PROCEDURES; QUALITY CONTROL; SOLUBILITY; STANDARDS; TABLET; TEMPERATURE;

ALANINE; ANGIOGENESIS INHIBITORS; CHEMISTRY, PHARMACEUTICAL; COMPUTER SIMULATION; DRUG STABILITY; HUMIDITY; HYDROLYSIS; KINETICS; MODELS, CHEMICAL; PRODRUGS; QUALITY CONTROL; SOLUBILITY; TABLETS; TECHNOLOGY, PHARMACEUTICAL; TEMPERATURE; TRIAZINES; WATER;

EID: 84899817632     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.04.059     Document Type: Article

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