Conservation of the α4β7 lymphocyte homing receptor in HIV-infected patients with distinct transmission routes and disease progression profiles

AIDS Research and Human Retroviruses

Volumn 30, Issue 5, 2014, Pages 493-497

  Hait, Sabrina H ^a,b   Darc, Mirela ^a,b   Machado, Elizabeth S ^a   Soares, Esmeralda A ^b   Sprinz, Eduardo ^c   Soares, Marcelo A ^a,b  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b INSTITUTO NACIONAL DE CÂNCER   (Brazil)

^c HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA4BETA7 INTEGRIN; GLYCOPROTEIN GP 120; HOMING RECEPTOR; MUCOSAL ADDRESSIN CELL ADHESION MOLECULE 1; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; INTEGRIN; INTEGRIN ALPHA4BETA7;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; BLOOD SAMPLING; CARBOXY TERMINAL SEQUENCE; CD4 LYMPHOCYTE COUNT; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; DISEASE COURSE; DNA POLYMORPHISM; EXON; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; INFECTION SENSITIVITY; INTESTINE LYMPHATIC TISSUE; MAJOR CLINICAL STUDY; NONHUMAN; NUCLEOTIDE SEQUENCE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; VIRUS ATTACHMENT; VIRUS CELL INTERACTION; VIRUS LOAD; VIRUS TRANSMISSION; ADULT; ANIMAL; CHILD; CONSERVED SEQUENCE; DISEASE TRANSMISSION; DNA SEQUENCE; FEMALE; GENETIC VARIATION; GENETICS; GENOTYPE; IMMUNOLOGY; INFANT; MALE; MOLECULAR GENETICS; POLYMERASE CHAIN REACTION; PRESCHOOL CHILD; TRANSMISSION;

ADULT; ANIMALS; CHILD; CHILD, PRESCHOOL; CONSERVED SEQUENCE; DISEASE PROGRESSION; DISEASE TRANSMISSION, INFECTIOUS; FEMALE; GENETIC VARIATION; GENOTYPE; HIV INFECTIONS; HIV-1; HUMANS; INFANT; INTEGRINS; MALE; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, DNA;

EID: 84899813859     PISSN: 08892229     EISSN: 19318405     Source Type: Journal    
DOI: 10.1089/aid.2013.0248     Document Type: Article

References (16)

1. Hemler ME: VLA proteins in the integrin family: Structures, functions, and their role on leukocytes. Annu Rev Immunol 1990;8:365-400
2. Kinashi T: Intracellular signalling controlling integrin activation in lymphocytes. Nat Rev Immunol 2005;5(7):546-559
3. Mehandru S, Poles MA, Tenner-Racz K, et al.: Mechanisms of gastrointestinal CD4 + T-cell depletion during acute and early human immunodeficiency virus type 1 infection. J Virol 2007;81(2):599-612
4. Arthos J, Cicala C, Martinelli E, et al.: HIV-1 envelope protein binds to and signals through integrin a4b7, the gut mucosal homing receptor for peripheral T cells. Nat Immunol 2008;9(3):225-227
5. Loftus JC, Smith JW, and Ginsberg MH: Integrin-mediated cell adhesion: The extracellular face. J Biol Chem 1994; 269(41):25235-25238
6. Schiffer SG, Hemler ME, Lobb RR, Tizard R, and Osborn L: Molecular mapping of functional antibody binding sites of alpha 4 integrin. J Biol Chem 1995;270(24):14270-14273
7. Vinogradova O, Velyvis A, Velyviene A, et al.: A structural mechanism of integrin aIIbb3 'inside-out' activation as regulated by its cytoplasmic face. Cell 2002;110(5):587-597
8. Freguja R, Gianesin K, Zanchetta M, and De Rossi A: Cross-talk between virus and host innate immunity in pediatric HIV-1 infection and disease progression. New Microbiol 2012;35(3):249-257
9. Salem AH, Farid E, Fadel R, et al.: Distribution of four HIV type 1-resistance polymorphisms (CCR5-delta32, CCR5-m303, CCR2-64I, and SDF1-3'A) in the Bahraini population. AIDS Res Hum Retroviruses 2009;25(10):973-977
10. Darc M, Hait SH, Soares EA, et al.: Polymorphisms in the a4 integrin of neotropical primates: Insights for binding of natural ligands and HIV-1 gp120 to the human a4b7. PLoS One 2011;6(9):e24461
11. Casado C, Colombo S, Rauch A, et al.: Host and viral genetic correlates of clinical definitions of HIV-1 disease progression. PLoS One 2010;5(6):e11079
12. Abrams EJ, Weedon J, Steketee RW, et al.: Association of human immunodeficiency virus (HIV) load early in life with disease progression among HIV-infected infants. New York City Perinatal HIV Transmission Collaborative Study Group. J Infect Dis 1998;178(1):101-108
13. Huhtala M, Heino J, Casciari D, de Luise A, and Johnson MS: Integrin evolution: Insights from ascidian and teleost fish genomes. Matrix Biol 2005;24(2):83-95
14. Ansari AA, Reimann KA, Mayne AE, et al.: Blocking of a4b7 gut-homing integrin during acute infection leads to decreased plasma and gastrointestinal tissue viral loads in simian immunodeficiency virus-infected rhesus macaques. J Immunol 2011;186(2):1044-1059
15. Crowe DT, Chiu H, Fong S, and Weissman IL: Regulation of the avidity of integrin alpha 4 beta 7 by the beta 7 cytoplasmic domain. J Biol Chem 1994;269(20):14411-14418
16. He X, Mokili JL, Hong K, et al.: Conservancy of the a4b7 integrin mimotope in the V2 domain of HIV type 1 CRF07-BC compared to subtype B' strains in China. AIDS Res Hum Retroviruses 2011;27(10):1127-1133.