Decreased perivascular CGRP-containing nerves in Otsuka Long-Evans Tokushima Fatty rats with insulin resistance and hypertension

Hypertension Research

Volumn 37, Issue 5, 2014, Pages 398-404

  Takatori, Shingo ^a,b   Fujiwara, Hiroki ^b   Zamami, Yoshito ^a   Hashikawa Hobara, Narumi ^c   Kawasaki, Hiromu ^a,b  

^a MATSUYAMA UNIVERSITY   (Japan)

^b OKAYAMA UNIVERSITY   (Japan)

^c OKAYAMA UNIVERSITY OF SCIENCE   (Japan)

Author keywords

calcitonin gene related peptide containing nerve; insulin resistance; OLETF rat; rat mesenteric artery; vascular responsiveness

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; CHOLESTEROL; INSULIN; TRIACYLGLYCEROL; GLUCOSE BLOOD LEVEL;

ADRENERGIC NERVE CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL INNERVATION; BLOOD VESSEL TONE; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CHRONIC DISEASE; COMPARATIVE STUDY; CONTROLLED STUDY; FLUID INTAKE; FOOD INTAKE; GLUCOSE BLOOD LEVEL; HEART RATE; HYPERINSULINEMIA; HYPERTENSION; IMMUNOHISTOCHEMISTRY; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; MESENTERIC ARTERY; MESENTERY BLOOD FLOW; NERVE FIBER; NERVE STIMULATION; NONHUMAN; PERFUSION PRESSURE; RAT; REGULATORY MECHANISM; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL; VASOCONSTRICTION; ANIMAL; BLOOD; BLOOD PRESSURE; METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; OTSUKA LONG EVANS TOKUSHIMA FATTY RAT; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALS; BLOOD GLUCOSE; BLOOD PRESSURE; CALCITONIN GENE-RELATED PEPTIDE; CHOLESTEROL; DIABETES MELLITUS, TYPE 2; HEART RATE; HYPERTENSION; INSULIN; INSULIN RESISTANCE; MESENTERIC ARTERIES; NERVE FIBERS; RATS; RATS, INBRED OLETF; TRIGLYCERIDES;

EID: 84899813651     PISSN: 09169636     EISSN: 13484214     Source Type: Journal    
DOI: 10.1038/hr.2013.151     Document Type: Article

References (39)

1. Adler AI, Stratton IM, Neil HA, Yudkin JS, Matthews DR, Cull CA, Wrigh AD, Tumer RC, Holman RR. Association of systolic blood pressure with macrovascular and microvascular complications of type 2 diabetes (UKPDS 36): Prospective observational study. BMJ 2000; 321: 412-419
2. Norhammar A, Tenerz A, Nilsson G, Hamsten A, Efendíc S, Ryde'n L, Malmberg K. Glucose metabolism in patients with acute myocardial infarction and no previous diagnosis of diabetes mellitus: A prospective study. Lancet 2002; 359: 2140-2144
3. Skarfors ET, Selinus KI, Lithell HO. Risk factors for developing non-insulin dependent diabetes: A 10 year follow up of men in Uppsala. BMJ 1991; 303: 755-760
4. Haffner SM, Valdez RA, Hazuda HP, Mitchell BD, Morales PA, Stern MP. Prospective analysis of the insulin-resistance syndrome (syndrome X). Diabetes 1992; 41: 715-722
5. Lissner L, Bengtsson C, Lapidus L, Kristjansson K, Wedel H. Fasting insulin in relation to subsequent blood pressure changes and hypertension in women. Hypertension 1992; 20: 797-801
6. Meehan WP, Buchanan TA, Hsueh W. Chronic insulin administration elevates blood pressure in rats. Hypertension 1994; 23: 1012-1017
7. Takatori S, Mizote M, Zamami Y, Kurosaki Y, Kawasaki H. Effects of insulin on vascular responses to spinal cord stimulation and vasoactive agents in pithed rats. Br J Pharmacol 2003; 140: 1137-1145
8. DeFronzo RA. Is insulin resistance atherogenic. Possible mechanisms. Atherosclerosis 2006; 7: 11-15
9. Kashyap SR, DeFronzo RA. The insulin resistance syndrome: Physiological considerration. Diab Vasc Dis Res 2007; 4: 13-19
10. Grundy SM, Becker D, Clark LT, Cooper RS, Denke MA, Howard WJ, Hunninghake DB, Illingworth DR, Luepker RV, McBride P, McKenney JM, Pasternak RC, Stone NJ, Horn LV. Third report of the National Cholesterol Education Program (NCEP). Expert panel on detection, evaluation and treatment of high blood cholesterol in adults (Adult Treatment Panel III) final report. Circulation 2002; 106: 3143-3421
11. Miranda PJ, Defronzo RA, Califf RM, Guyton JR. Metabolic syndrome: Evaluation of pathologic and therapeutic outcome. Am Heart J 2005; 149: 20-32
12. Takatori S, Zamami Y, Mio M, Kurosaki Y, Kawasaki H. Chronic hyperinsulinemia enhances adrenergic vasoconstriction and decreases calcitonin gene-related peptide-containing nerve-mediated vasodilation in pithed rats. Hypertens Res 2006; 29: 361-368
13. Takatori S, Zamami Y, Yabumae N, Hanafusa N, Mio M, Egawa T, Kawasaki H. Pioglitazone opposes neurogenic vascular dysfunction associated with chronic hyperinsulinaemia. Br J Pharmacol 2008; 153: 1388-1398
14. Jin X, Amitani K, Zamami Y, Takatori S, Hobara N, Kawamura N, Hirata T, Wada A, Kitamura Y, Kawasaki H. Ameliorative effect of Eucommia ulmoides Oliv. leaves extract (ELE) on insulin resistance and abnormal perivascular innervation in fructose-drinking rats. J Ethnopharmacol 2010; 128: 672-678
15. Osborn JW, Fink GD, Sved AF, Toney GM, Raizada MK. Circulating angiotensin II and dietary salt: Converging signals for neurogenic hypertension. Curr Hypertens Rep 2007; 9: 228-235
16. Sundlö f G, Wallin BG. Human muscle nerve sympathetic activity at rest. Relationship to blood pressure and age. J Physiol 1978; 274: 621-637
17. Narkiewicz K, Phillips BG, Kato M, Hering D, Bieniaszewski L, Somers VK. Genderselective interaction between aging, blood pressure, and sympathetic nerve activity. Hypertension 2005; 45: 522-525
18. Kawasaki H, Saito A, Takasaki K. Age-related decrease of calcitonin gene-related peptide-containing vasodilator innervation in the mesenteric resistance vessel of the spontaneously hypertensive rat. Circ Res 1990; 67: 733-743
19. Kawasaki H. Effects of chronic administration of antihypertensive drugs on vasodilation mediated by calcitonin gene-related peptide-containing vasodilator nerves in spontaneously hypertensive rats. Clin Exp Pharmacol Physiol 1992; 19: 569-573
20. Kawasaki H, Nuki Y, Yamaga N, Kurosaki Y, Taguchi T. Decreased depressor response mediated by calcitonin gene-related peptide (CGRP)-containing vasodilator nerves to spinal cord stimulation and levels of CGRP mRNA of the dorsal root ganglia in spontaneously hypertensive rats. Hypertens Res 2000; 23: 693-699
21. Hobara N, Gessei-Tsutsumi N, Goda M, Takayama F, Akiyama S, Kurosaki Y, Kawasaki H. Long-Term inhibition of angiotensin prevents reduction of periarterial innervation of calcitonin gene-related peptide (CGRP)-containing nerves in spontaneously hypertensive rats. Hypertens Res 2005; 28: 465-474
22. Kawano K, Hirashima T, Mori S, Saitoh Y, Kurosumi M, Natori T. Spontaneous longterm hyperglycemic rat with diabetic complications. Otsuka Long-Evans Tokushima Fatty (OLETF) strain. Diabetes 1992; 41: 1422-1428
23. Kawasaki H, Takasaki K, Saito A, Goto K. Calcitonin gene-related peptide acts as a novel vasodilator neurotransmitter in mesenteric resistance vessels of the rat. Nature 1988; 335: 164-167
24. Hobara N, Goda M, Takayama F, Kawasaki H. Innervation and functional changes in mesenteric perivascular calcitonin gene-related peptide (CGRP)- And neuropeptide Y (NPY)-containing nerves followi topical phenol treatment. Neuroscience 2006; 141: 1087-1099
25. Hobara N, Goda M, Yoshida N, Takatori S, Kitamura Y, Mio M, Kawasaki H. Angiotensin II type 2 receptors facilitate reinnervation of phenol-lesioned vascular calcitonin generelated peptide-containing nerves in rat mesenteric arteries. Neuroscience 2007; 150: 730-741
26. Han SP, Naes L, Westfall TC. Inhibition of periarterial nerve stimulation-induced vasodilation of the mesenteric arterial bed by CGRP (8-37) and CGRP receptor desensitization. Biochem Biophys Res Commun 1990; 168: 786-791
27. Kawasaki H, Nuki C, Saito A, Takasaki K. NPY modulates neurotransmission of CGRPcontaining vasodilator nerves in rat mesenteric arteries. Am J Physiol 1991; 261: H683-H690
28. Nuki C, Kawasaki H, Takasaki K, Wada A. Pharmacological characterization of presynaptic calcitonin gene-related peptide (CGRP) receptors on CGRP-containing vasodilator nerves in rat mesenteric resistance vessels. J Pharmacol Exp Ther 1994; 268: 59-64
29. Kawasaki H, Nuki C, Saito A, Takasaki K. Role of calcitonin gene-related peptidecontaining nerves in the vascular adrenergic neurotransmission. J Pharmacol Exp Ther 1990; 252: 403-409
30. Zamami Y, Takatori S, Hobara N, Yabumae N, Tangsucharit P, Jin X, Hashikawa H, Kitamura Y, Sasaki K, Kawasaki H. Hyperinsulinemia induces hypertension associated with neurogenic vascular dysfunction resulting from abnormal perivascular innervations in rat mesenteric resistance arteries. Hypertens Res 2011; 34: 1190-1196
31. Li D, Peng J, Xin HY, Luo D, Zhang YS, Zhou Z, Jiang DJ, Deng HW, Li YJ. Calcitonin gene-related peptide-mediated antihypertensive and anti-platelet effects by rutaecarpine in spontaneously hypertensive rats. Peptide 2008; 29: 1781-1788
32. Wang L, Wang DH. TRPV1 gene knockout impairs postischemic recovery in isolated perfused heart in mice. Circulation 2005; 112: 3617-3623
33. Vaishnava P, Wang DH. Capsaicin sensitive-sensory nerves and blood pressure regulation. Curr Med Chem Cardiovasc Hematol Agents 2003; 1: 177-188
34. Mimaki Y, Kawasaki H, Okazaki M, Nakatsuma A, Araki H, Gomita Y. Involvement of calcitonin gene-related peptide (CGRP) receptors in insulin-induced vasodilatation in mesenteric resistance blood vessels of rats. Br J Pharmacol 1998; 123: 1684-1690
35. Nuki C, Kawasaki H, Takasaki K, Wada A. Pharmacological characterization of presynaptic calcitonin gene-related peptide (CGRP) receptors on CGRP-containing vasodilator nerves in rat mesenteric resistance vessels. J Pharmacol Exp Ther 1994; 268: 59-64
36. Meeking DR, Cummings MH, Thorne S, Donald A, Clarkson P, Crook JR, Watts GF, Shaw KM. Endothelial dysfunction in type 2 diabetic subjects with and without microalbuminuria. Diabet Med 1999; 16: 841-847
37. Yu HI, Sheu WH, Lai CJ, Lee WJ, Chen YT. Endothelial dysfunction in type 2 diabetes mellitus subjects with peripheral artery disease. Int J Cardiol 2001; 78: 19-25
38. Green DJ, Maiorana AJ, Tschakovsky ME, Pyke KE, Weisbrod CJ, O'Driscoll G. Relationship between changes in brachial artery flow-mediated dilation and basal release of nitric oxide in subjects with type 2 diabetes. Am J Physiol Heart Circ Physiol 2006; 291: H1193-H1199
39. Jin X, Satoh-Otonashi Y, Zamami Y, Koyama T, Sun P, Kitamura Y, Kawasaki H. Characterization of the inhibitory effect of vascular endothelium on agonist-induced vasoconstriction in rat mesenteric resistance arteries. J Pharmacol Sci 2008; 108: 95-103