Effects of insulin on vascular responses to spinal cord stimulation and vasoactive agents in pithed rats

British Journal of Pharmacology

Volumn 140, Issue 6, 2003, Pages 1137-1145

  Takatori, Shingo ^a   Mizote, Masako ^a   Zamami, Yoshito ^a   Kurosaki, Yuji ^a   Kawasaki, Hiromu ^a  

^a OKAYAMA UNIVERSITY   (Japan)

Author keywords

Adrenergic pressor; Calcitonin gene related peptide; CGRPergic depressor; Insulin; Pithed rats; Spinal cord stimulation

Indexed keywords

ACETYLCHOLINE; ANGIOTENSIN; CALCITONIN GENE RELATED PEPTIDE; CALCITONIN GENE RELATED PEPTIDE[8-37]; INSULIN; NORADRENALIN; VASOACTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE; BLOOD VESSEL REACTIVITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG POTENTIATION; HYPERTENSION; INFUSION; MALE; NONHUMAN; PRESSOR RESPONSE; PRIORITY JOURNAL; RAT; SPINAL ANIMAL; SPINAL CORD; SPINAL CORD STIMULATION; STATISTICAL SIGNIFICANCE;

ACETYLCHOLINE; ANGIOTENSIN II; ANIMALS; BLOOD PRESSURE; CALCITONIN GENE-RELATED PEPTIDE; CARDIOVASCULAR AGENTS; DECEREBRATE STATE; DOSE-RESPONSE RELATIONSHIP, DRUG; HEART RATE; INSULIN; MALE; NITROPRUSSIDE; NOREPINEPHRINE; RATS; RATS, WISTAR; SPINAL CORD; VASOCONSTRICTOR AGENTS; VASODILATOR AGENTS;

EID: 0344826039     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705539     Document Type: Article

References (30)

1. ANDERSON, E.A. & MARK, A.L. (1993). The vasodilator action of insulin. Implication for the insulin hypothesis of hypertension. Hypertension, 21, 136-141.
2. BRAIN, S.D., WILLIAMS, T.J., TIPPINS, J.R., MORRIS, H.R. & MACINTYRE, I. (1985). Calcitonin gene-related peptide is a potent vasodilator. Nature, 313, 54-56.
3. CREAGER, M.A., LIANG, C.S. & COFFMAN, J.D. (1985). Beta adrenergic-mediated vasodilator response to insulin in the human forearm. J. Pharmacol. Exp. Ther., 235, 709-714.
4. DEFRONZO, R.A. (1981). The effect of insulin on renal sodium metabolism. A review with clinical implications. Diabetologia, 21, 165-171.
5. FERRANNINI, E., BUZZIGOLI, G., BONADONNA, R., GIORICO, M.A., OLEGGINI, M., GRAZIADEI, L., PEDRINELLI, R., BRANDI, L. & BEVILACQUA, S. (1987). Insulin resistance in essential hypertension. N. Engl. J. Med., 317, 350-357.
6. FURCHGOTT, R.F. & ZAWADZKI, J.V. (1980). The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature, 288, 373-376.
7. GANS, R.O., BILO, H.J., VON MAARSCHALKERWEERD, W.W., HEINE, R.J., NAUTA, J.J. & DONKER, A.J. (1991). Exogenous insulin augments in healthy volunteers the cardiovascular reactivity to noradrenaline but not to angiotensin II. J. Clin. Invest., 88, 512-518.
8. HENRION, D. & LAHER, I. (1994). Insulin potentiates norepinephrine-induced vascular tone by activation of protein kinase C and tyrosine kinase. Can. J. Physiol. Pharmacol., 72, 849-854.
9. HSUEH, W.A. & LAW, R.E. (1999). Insulin signaling in the arterial wall. Am. J. Cardiol., 84, 21J-24J.
10. KATAKAM, P.V., UJHELYI, M.R. & MILLER, A.W. (1999). EDHF-mediated relaxation is impaired in fructose-fed rats. J. Cardiovasc. Pharmacol., 34, 461-467.
11. KAWASAKI, H., TAKASAKI, K., SAITO, A. & GOTO, K. (1988). Calcitonin gene-related peptide acts as a novel vasodilator neurotransmitter in mesenteric resistance vessels of the rat. Nature, 335, 164-167.
12. KIMURA, M., JEFFERIS, A.M., WATANABE, H. & CHIN-DUSTING, J. (2002). Insulin inhibits acetylcholine responses in rat isolated mesenteric arteries via a non-nitric oxide nonprostanoid pathway. Hypertension, 39, 35-40.
13. LEMBO, G., IACCARINO, G., RENDINA, V., VOLPE, M. & TRIMARCO, B. (1994). Insulin blunts sympathetic vasoconstriction through the alpha 2-adrenergic pathway in humans. Hypertension, 24, 429-438.
14. LEMBO, G., NAPOLI, R., CAPALDO, B., RENDINA, V., IACCARINO, G., VOLPE, M., TRIMARCO, B. & SACCA, L. (1992). Abnormal sympathetic overactivity evoked by insulin in skeletal muscle of patients with essential hypertension. J. Clin. Invest., 90, 24-29.
15. MARIGLIANO, A., TEDDE, R., SECHI, L.A., PALA, A., PISANU, G. & PACIFICO, A. (1990). Insulinemia and blood pressure. Relationships in patients with primary and secondary hypertension, and with or without glucose metabolism impairment. Am. J. Hypertens., 3, 521-526.
16. MIMAKI, Y., KAWASAKI, H., OKAZAKI, M., NAKATSUMA, A., ARAKI, H. & GOMITA, Y. (1998). Involvement of calcitonin gene-related peptide (CGRP) receptors in insulin-induced vasodilatation in mesenteric resistance blood vessels of rats. Br. J. Pharmacol., 123, 1684-1690.
17. MORGAN, D.A., BALON, T.W., GINSBERG, B.H. & MARK, A.L. (1993). Nonuniform regional sympathetic nerve responses to hyperinsulinemia in rats. Am. J. Physiol., 264, R423-R427.
18. PIEPER, G.M., MEIER, D.A. & HAGER, S.R. (1995). Endothelium dysfunction in a model of hyperglycemia and hyperinsulinemia. Am. J. Physiol., 269, H845-H850.
19. POLLARE, T., LITHELL, H. & BERNE, C. (1990). Insulin resistance is a characteristic feature of primary hypertension independent of obesity. Metabolism, 39, 167-174.
20. RANDIN, D., VOLLENWEIDER, P., TAPPY, L., JEQUIER, E., NICOD, P. & SCHERRER, U. (1994). Effect of adrenergic and cholinergic blockade on insulin-induced stimulation of calf blood flow in humans. Am. J. Physiol., 266, R809-R816.
21. REAVEN, G.M. (1988). Role of insulin resistance in human disease. Diabetes, 37, 1595-1607.
22. SAUTER, A., GOLDSTEIN, M., ENGEL, J. & UETA, K. (1983). Effect of insulin on central catecholamines. Brain Res., 260, 330-333.
23. SCHERRER, U. & SARTORI, C. (1997). Insulin as a vascular and sympathoexcitatory hormone. Implication for blood pressure regulation, insulin sensitivity, and cardiovascular morbidity. Circulation, 96, 4104-4113.
24. SHIMOSAWA, T., ANDO, K., ONO, A., TAKAHASHI, K., ISSHIKI, M., KANDA, M., OGATA, E. & FUJITA, T. (1992). Insulin inhibits norepinephrine overflow from peripheral sympathetic nerve ending. Biochem. Biophys. Res. Commun., 188, 330-335.
25. STEINBERG, H.O., BRECHTEL, G., JOHNSON, A., FINEBERG, N. & BARON, A.D. (1994). Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release. J. Clin. Invest., 94, 1172-1179.
26. TAGUCHI, T., KAWASAKI, H., IMAMURA, T. & TAKASAKI, K. (1992). Endogenous calcitonin gene-related peptide mediates non-adrenergic noncholinergic depressor response to spinal cord stimulation in the pithed rat. Circ. Res., 71, 357-364.
27. TOWNSEND, R.R., YAMAMOTO, R., NICKOLS, M., DIPETTE, D.J. & NICKOLS, G.A. (1992). Insulin enhances pressor responses to norepinephrine in rat mesenteric vasculature. Hypertension, 19 (Suppl. II), II105-II110.
28. WAMBACH, G.K. & LIU, D. (1992). Insulin attenuates vasoconstriction by noradrenaline, serotonin and potassium chloride in rat mesenteric arterioles. Clin. Exp. Hypertens. A, 14, 733-740.
29. WIMALAWANSA, S.J. (1996). Calcitonin gene-related peptide and its receptors: molecular genetics, physiology, pathophysiology, and therapeutic potentials. Endocr. Rev., 17, 533-585.
30. WIMALAWANSA, S.J. (1997). Amylin, calcitonin gene-related peptide, calcitonin, and adrenomedullin: a peptide superfamily. Crit. Rev. Neurobiol., 11, 167-239.