A liver-X-receptor ligand, T0901317, attenuates IgE production and airway remodeling in chronic asthma model of mice

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Shi, Ying ^a   Xu, Xiantao ^a   Tan, Yan ^a   Mao, Shan ^a   Fang, Surong ^a   Gu, Wei ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; DEXAMETHASONE; GELATINASE B; IMMUNOGLOBULIN E; INTERLEUKIN 13; INTERLEUKIN 4; N (2,2,2 TRIFLUOROETHYL) N [4 (2,2,2 TRIFLUORO 1 HYDROXY 1 TRIFLUOROMETHYLETHYL)PHENYL]BENZENESULFONAMIDE; OVALBUMIN; TRANSFORMING GROWTH FACTOR BETA1; ALLERGEN; FLUORINATED HYDROCARBON; LIGAND; LIVER X RECEPTOR; ORPHAN NUCLEAR RECEPTOR; SULFONAMIDE; TO-901317;

AIRWAY REMODELING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; BREATHING MUSCLE; CONTROLLED STUDY; DRUG MECHANISM; FEMALE; IMMUNOGLOBULIN PRODUCTION; INFLAMMATORY CELL; LUNG LAVAGE; MOUSE; MUSCLE THICKNESS; NONHUMAN; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY TRACT ALLERGY; RESPIRATORY TRACT INFLAMMATION; SMOOTH MUSCLE; ANIMAL; BAGG ALBINO MOUSE; DRUG EFFECTS; INFLAMMATION; LUNG; METABOLISM;

AIRWAY REMODELING; ALLERGENS; ANIMALS; ASTHMA; BRONCHOALVEOLAR LAVAGE FLUID; COLLAGEN; FEMALE; HYDROCARBONS, FLUORINATED; IMMUNOGLOBULIN E; INFLAMMATION; LIGANDS; LUNG; MATRIX METALLOPROTEINASE 9; MICE; MICE, INBRED BALB C; MUSCLE, SMOOTH; ORPHAN NUCLEAR RECEPTORS; OVALBUMIN; SULFONAMIDES; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84899794892     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0092668     Document Type: Article

References (30)

1. Janowski BA, Willy PJ, Devi TR, Falck JR, Mangelsdorf DJ (1996) An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha. Nature 383: 728-731. (Pubitemid 26360651)
2. Costet P, Luo Y, Wang N, Tall AR (2000) Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor. J Biol Chem 275: 28240-28245.
3. Venkateswaran A, Laffitte BA, Joseph SB, Mak PA, Wilpitz DC et al (2000) Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha. Proc Natl Acad Sci U S A 97: 12097-12102.
4. Joseph SB, Castrillo A, Laffitte BA, Mangelsdorf DJ, Tontonoz P (2003) Reciprocal regulation of inflammation and lipid metabolism by liver X receptors: Nat Med 9: 213-219. (Pubitemid 36227724)
5. Castrillo A, Joseph SB, Marathe C, Mangelsdorf DJ, Tontonoz P (2003) Liver X receptor-dependent repression of matrix metalloproteinase-9 expression in macrophages. J Biol Chem 278: 10443-10449. (Pubitemid 36800310)
6. Benayoun L, Pretolani M (2003) Airway remodeling in asthma: mechanisms and therapeutic perspectives. Med Sci 19: 319-326. (Pubitemid 36323353)
7. Solan PD, Piraino G, Hake PW, Denenberg A, O'Connor M et al (2011) Liver X receptor a activation with the synthetic ligand T0901317 reduces lung injury and inflammation after hemorrhage and resuscitation via inhibition of the nuclear factor kB pathway 35: 367-374.
8. Crisafulli C, Mazzon E, Paterniti I, Galuppo M, Bramanti P et al (2010) Effects of Liver x receptor agonist treatment on signal transduction pathways in acute lung inflammation. Respir Res 22: 11-19.
9. Smoak K, Madenspacher J, Jeyaseelan S, Williams B, Dixon D et al (2008) Effects of liver X receptor agonist treatment on pulmonary inflammation and host defense:J Immunol. 180: 3305-3312.
10. Wang D, Liu M, Wang Y, Luo M, Wang J et al (2011) Synthetic LXR agonist T0901317 attenuates lipopolysaccharide-induced acute lung injury in rats. Int Immunopharmacol 11: 2098-2103.
11. Delvecchio CJ, Bilan P, Radford K, Stephen J, Trigatti BL et al (2007) Liver X receptor stimulates cholesterol efflux and inhibits expression of proinflammatory mediators in human airway smooth muscle cells. Mol Endocrinol 21: 1324-1334. (Pubitemid 46984740)
12. Blaschke F, Leppanen O, Takata Y, Caglayan E, Liu J et al (2004) Liver X receptor agonists suppress vascular smooth muscle cell proliferation and inhibit neointima formation in balloon-injured rat carotid arteries. Circ Res 95: 110-123.
13. Fowler AJ, Sheu MY, Schmuth M, Kao J, Fluhr JW et al (2003) Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: liver-X-receptor-specific inhibition of inflammation and primary cytokine production. J Invest Dermatol 120: 246-255. (Pubitemid 36513075)
14. Tagaya E, Tamaoki J (2007) Mechanisms of airway remodeling in asthma. Allergol Int 56: 331-340. (Pubitemid 350306387)
15. Warner SM, Knight DA (2008) Airway modeling and remodeling in the pathogenesis of asthma. Curr Opin Allergy Clin Immunol 8: 44-48.
16. Park MC, Kwon YJ, Chung SJ, Park YB, Lee SK (2010) Liver X receptor agonist prevents the evolution of collagen-induced arthritis in mice. Rheumatology 49: 882-890.
17. Hamelmann E, Tadeda K, Oshiba A, Gelfand EW (1999) Role of IgE in the development of allergic airway inflammation and airway hyperresponsiveness-a murine model. Allergy 54: 297-305. (Pubitemid 29232384)
18. Heine G, Dahten A, Hilt K, Ernst D, Milovanovic M et al (2009) Liver X receptors control IgE expression in B cells. J Immunol 182: 5276-5282.
19. Nunomura S, Endo K, Makishima M, Ra C (2010) Oxysterol represses high-affinity IgE receptor-stimulated mast cell activation in Liver X receptordependent and -independent manners. FEBS Lett 584: 1143-1148.
20. Brusselle GG, Kips JC, Tavernier JH, van der Heyden JG, Cuvelier CA et al (1994) Attenuation of allergic airway inflammation in IL-4 deficient mice. Clin Exp Allergy 24: 73-80 (Pubitemid 24210819)
21. Walter DM, McIntire JJ, Berry G, McKenzie ANJ, Donaldson DD et al (2001) Critical Role for IL-13 in the Development of Allergen-Induced Airway Hyperreactivity. J Immunol 167: 4668-4675. (Pubitemid 32954348)
22. Makinde T, Murphy RF, Agrawal DK (2007) The regulatory role of TGF-beta in airway remodeling in asthma. Immunol Cell Biol 85: 348-356. (Pubitemid 47035605)
23. Brown SD, Baxter KM, Stephenson ST, Esper AM, Brown LA et al (2012) Airway TGF-β1 and oxidant stress in children with severe asthma: association with airflow limitation. J Allergy Clin Immunol 129: 388-396
24. Vignola AM, Chanez P, Chiappara G, Merendino A, Pace E et al (1997) Transforming growth factor-beta expression in mucosal biopsies in asthma and chronic bronchitis. Am J Respir Crit Care Med 156: 591-599. (Pubitemid 27352000)
25. Brinckerhoff CE, Matrisian LM (2002) Matrix metalloproteinases: a tail of a frog that became a prince. Nat Rev Mol Cell Biol 3: 207-214.
26. Lee YC, Song CH, Lee HB, Oh JL, Rhee YK et al (2001) A murine model of toluene diisocyanate-induced asthma can be treated with matrix metalloproteinase inhibitor. J Allergy Clin Immunol 108: 1021-1026. (Pubitemid 33151557)
27. Birrell MA, De Alba J, Catley MC, Hardaker E, Wong S et al (2008) Liver X receptor agonists increase airway reactivity in a model of asthma via increasing airway smooth muscle growth. J Immunol 181: 4265-4271.
28. Houck KA, Borchert KM, Hepler CD, Thomas JS, Bramlett KS et al (2004) T0901317 is a dual LXR/FXR agonist. Mol Genet Metab 83: 184-187. (Pubitemid 39311292)
29. Li YT, Swales KE, Thomas GJ, Warner TD, Bishop-Bailey D (2007) Farnesoid x receptor ligands inhibit vascular smooth muscle cell inflammation and migration. Arterioscler Thromb Vasc Biol 27: 2606-2611. (Pubitemid 350158912)
30. Louis R, Schleich F, Barnes PJ (2012) Corticosteroids: still at the frontline in asthma treatment? Clin Chest Med 33: 531-541.