Elucidating the mechanisms of protein antigen adsorption to the CAF/NAF liposomal vaccine adjuvant systems: Effect of charge, fluidity and antigen-to-lipid ratio

Biochimica et Biophysica Acta - Biomembranes

Volumn 1838, Issue 8, 2014, Pages 2001-2010

  Hamborg, Mette ^a   Rose, Fabrice ^a   Jorgensen, Lene ^a   Bjorklund, Katrine ^a   Pedersen, Helene B ^a   Christensen, Dennis ^b   Foged, Camilla ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b STATENS SERUM INSTITUT   (Denmark)

Author keywords

Adjuvant; Antigen adsorption; Drug delivery; Liposome; Subunit vaccine

Indexed keywords

ADJUVANT; ALPHA LACTALBUMIN; AMPHOLYTE; ANTIGEN; CATION; CATIONIC LIPOSOMAL ADJUVANT CAF01; DIMETHYLDIOCTADECYLAMMONIUM BROMIDE; DISTEAROYLPHOSPHATIDYLCHOLINE; LIPID; LIPOSOME; LYSOZYME; TREHALOSE 6,6' DIBEHENATE; UNCLASSIFIED DRUG; VACCINE;

ADSORPTION; ARTICLE; COLLOID; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; FLUORESCENCE ANALYSIS; HYDROPHOBICITY; ISOELECTRIC POINT; LIGHT SCATTERING; LIPID MEMBRANE; MOLECULAR INTERACTION; MOLECULAR STABILITY; PHASE TRANSITION; PRIORITY JOURNAL; PROTEIN ANTIGEN ADSORPTION; PROTEIN STRUCTURE; SURFACE CHARGE; TEMPERATURE; TRANSMISSION ELECTRON MICROSCOPY;

ADJUVANT; ANTIGEN ADSORPTION; DRUG DELIVERY; LIPOSOME; SUBUNIT VACCINE;

ADJUVANTS, IMMUNOLOGIC; CALORIMETRY, DIFFERENTIAL SCANNING; CRYOELECTRON MICROSCOPY; HUMANS; LACTALBUMIN; LIPIDS; LIPOSOMES; MEMBRANE FLUIDITY; MURAMIDASE; QUATERNARY AMMONIUM COMPOUNDS; VACCINES;

EID: 84899772433     PISSN: 00052736     EISSN: 18792642     Source Type: Journal    
DOI: 10.1016/j.bbamem.2014.04.013     Document Type: Article

References (48)

1. R. Rappuoli Reverse vaccinology Curr. Opin. Microbiol. 3 2000 445 450
2. R. Rappuoli, C.W. Mandl, S. Black, and E. De Gregorio Vaccines for the twenty-first century society Nat. Rev. Immunol. 11 2011 865 872
3. J.H. Wilson-Welder, M.P. Torres, M.J. Kipper, S.K. Mallapragada, M.J. Wannemuehler, and B. Narasimhan Vaccine adjuvants: current challenges and future approaches J. Pharm. Sci. 98 2009 1278 1316
4. R. Rappuoli Bridging the knowledge gaps in vaccine design Nat. Biotechnol. 25 2007 1361 1366
5. J.W. Yoo, D.J. Irvine, D.E. Discher, and S. Mitragotri Bio-inspired, bioengineered and biomimetic drug delivery carriers Nat. Rev. Drug Discov. 10 2011 521 535
6. J. Davidsen, I. Rosenkrands, D. Christensen, A. Vangala, D. Kirby, Y. Perrie, E.M. Agger, and P. Andersen Characterization of cationic liposomes based on dimethyldioctadecylammonium and synthetic cord factor from M. tuberculosis (trehalose 6,6′-dibehenate) - a novel adjuvant inducing both strong CMI and antibody responses Biochim. Biophys. Acta 1718 2005 22 31
7. M. Henriksen-Lacey, V.W. Bramwell, D. Christensen, E.M. Agger, P. Andersen, and Y. Perrie Liposomes based on dimethyldioctadecylammonium promote a depot effect and enhance immunogenicity of soluble antigen J. Control. Release 142 2009 180 186
8. A.T. Kamath, B. Mastelic, D. Christensen, A.F. Rochat, E.M. Agger, D.D. Pinschewer, P. Andersen, P.H. Lambert, and C.A. Siegrist Synchronization of dendritic cell activation and antigen exposure is required for the induction of Th1/Th17 responses J. Immunol. 188 2012 4828 4837
9. I.F. Matsunaga, and D.B. Moody Mincle is a long sought receptor for mycobacterial cord factor J. Exp. Med. 206 2009 2865 2868
10. D. Christensen, M. Henriksen-Lacey, A.T. Kamath, T. Lindenstrom, K.S. Korsholm, J.P. Christensen, A.F. Rochat, P.H. Lambert, P. Andersen, C.A. Siegrist, Y. Perrie, and E.M. Agger A cationic vaccine adjuvant based on a saturated quaternary ammonium lipid have different in vivo distribution kinetics and display a distinct CD4 T cell-inducing capacity compared to its unsaturated analog J. Control. Release 160 2012 468 476
11. M. Henriksen-Lacey, D. Christensen, V.W. Bramwell, T. Lindenstrom, E.M. Agger, P. Andersen, and Y. Perrie Liposomal cationic charge and antigen adsorption are important properties for the efficient deposition of antigen at the injection site and ability of the vaccine to induce a CMI response J. Control. Release 145 2010 102 108
12. M. Henriksen-Lacey, A. Devitt, and Y. Perrie The vesicle size of DDA:TDB liposomal adjuvants plays a role in the cell-mediated immune response but has no significant effect on antibody production J. Control. Release 154 2011 131 137
13. A. Joseph, N. Itskovitz-Cooper, S. Samira, O. Flasterstein, H. Eliyahu, D. Simberg, I. Goldwaser, Y. Barenholz, and E. Kedar A new intranasal influenza vaccine based on a novel polycationic lipid - ceramide carbamoyl-spermine (CCS) - I. Immunogenicity and efficacy studies in mice Vaccine 24 2006 3990 4006
14. Y. Perrie, P.M. Frederik, and G. Gregoriadis Liposome-mediated DNA vaccination: the effect of vesicle composition Vaccine 19 2001 3301 3310
15. M. Henriksen-Lacey, K.S. Korsholm, P. Andersen, Y. Perrie, and D. Christensen Liposomal vaccine delivery systems Expert Opin. Drug Deliv. 8 2011 505 519
16. L.R. Tsuruta, W. Quintilio, M.H. Costa, and A.M. Carmona-Ribeiro Interactions between cationic liposomes and an antigenic protein: the physical chemistry of the immunoadjuvant action J. Lipid Res. 38 1997 2003 2011
17. M. Hamborg, L. Jorgensen, A.R. Bojsen, D. Christensen, and C. Foged Protein antigen adsorption to the DDA/TDB liposomal adjuvant: effect on protein structure, stability, and liposome physicochemical characteristics Pharm. Res. 30 2012 140 155
18. C.C. Bigelow On the average hydrophobicity of proteins and relation between it and protein structure J. Theor. Biol. 16 1967 187 211
19. E. Keshavarz, and S. Nakai Relationship between hydrophobicity and interfacial-tension of proteins Biochim. Biophys. Acta 576 1979 269 279
20. K.R. Acharya, D.I. Stuart, N.P.C. Walker, M. Lewis, and D.C. Phillips Refined structure of baboon alpha-lactalbumin at 1.7-A resolution - comparison with C-type lysozyme J. Mol. Biol. 208 1989 99 127
21. C.C.F. Blake, D.F. Koenig, G.A. Mair, A.C.T. North, D.C. Phillips, and V.R. Sarma Structure of hen egg-white lysozyme - a 3-dimensional fourier synthesis at 2 A resolution Nature 206 1965 757 761
22. D. Christensen, D. Kirby, C. Foged, E.M. Agger, P. Andersen, Y. Perrie, and H.M. Nielsen Alpha,alpha′-trehalose 6,6′-dibehenate in non-phospholipid-based liposomes enables direct interaction with trehalose, offering stability during freeze-drying Biochim. Biophys. Acta 1778 2008 1365 1373
23. K. Brew, T.C. Vanaman, and R.L. Hill Comparison of amino acid sequence of bovine alpha-lactalbumin and hens egg white lysozyme J. Biol. Chem. 242 1967 3747 3748
24. W.J. Browne, A.C.T. North, and D.C. Phillips A possible 3-dimensional structure of bovine alpha-lactalbumin based on that of hens egg-white lysozyme J. Mol. Biol. 42 1969 65 86
25. D.I. Stuart, K.R. Acharya, N.P.C. Walker, S.G. Smith, M. Lewis, and D.C. Phillips Alpha-lactalbumin possesses a novel calcium-binding loop Nature 324 1986 84 87
26. E.D. Chrysina, K. Brew, and K.R. Acharya Crystal structures of apo- and holo-bovine alpha-lactalbumin at 2.2-A resolution reveal an effect of calcium on inter-lobe interactions J. Biol. Chem. 275 2000 37021 37029
27. K. Kuwajima The molten globule state of alpha-lactalbumin FASEB J. 10 1996 102 109
28. D. Chaudhuri, M. Narayan, and L.J. Berliner Conformation-dependent interaction of alpha-lactalbumin with model and biological membranes: a spin-label ESR study Protein J. 23 2004 95 101
29. M.J. Kronman, and L.G. Holmes Inter- and intramolecular interactions of alpha-lactalbumin. 4. Location of tryptophan groups Biochemistry 4 1965 526 532
30. W.R. Glomm, S. Volden, O. Halskau, and M.H.G. Ese Same system-different results: the importance of protein. Introduction protocols in Langmuir-monolayer studies of lipid-protein interactions Anal. Chem. 81 2009 3042 3050
31. P. Toimil, G. Prieto, J. Minones, J.M. Trillo, and F. Sarmiento Interaction of human serum albumin with monofluorinated phospholipid monolayers J. Colloid Interface Sci. 388 2012 162 169
32. D. Marsh Lateral pressure in membranes Biochim. Biophys. Acta Rev. Biomembr. 1286 1996 183 223
33. D.R. Shnek, D.W. Pack, D.Y. Sasaki, and F.H. Arnold Specific protein attachment to artificial membranes via coordination to lipid-bound copper(II) Langmuir 10 1994 2382 2388
34. I. Langmuir, and V.J. Schaefer Properties and structure of protein monolayers Chem. Rev. 24 1939 181 202
35. S. May, and A. Ben-Shaul Molecular theory of lipid-protein interaction and the L-alpha-H-II transition Biophys. J. 76 1999 751 767
36. S. May, Y. Kozlovsky, A. Ben-Shaul, and M.M. Kozlov Tilt modulus of a lipid monolayer Eur. Phys. J. E 14 2004 299 308
37. D. Vollhardt, and V.B. Fainerman Progress in characterization of Langmuir monolayers by consideration of compressibility Adv. Colloid Interf. Sci. 127 2006 83 97
38. J.T. Davies, and E.K. Rideal Properties of Monolayers, Interfacial Phenomena 1961 Academic Press Inc. New York 217 279
39. M. Kepczynski, J. Lewandowska, K. Witkowska, S. Kedracka-Krok, V. Mistrikova, J. Bednar, P. Wydro, and M. Nowakowska Bilayer structures in dioctadecyldimethylammonium bromide/oleic acid dispersions Chem. Phys. Lipids 164 2011 359 367
40. D. Papahadjopoulos, M. Moscarello, E.H. Eylar, and T. Isac Effects of proteins on thermotropic phase transitions of phospholipid membranes Biochim. Biophys. Acta 401 1975 317 335
41. O. Halskau, N.A. Froystein, A. Muga, and A. Martinez The membrane-bound conformation of alpha-lactalbumin studied by NMR-monitored H-1 exchange J. Mol. Biol. 321 2002 99 110
42. A.V. Agasoster, O. Halskau, E. Fuglebakk, N.A. Froystein, A. Muga, H. Holmsen, and A. Martinez The interaction of peripheral proteins and membranes studied with alpha-lactalbumin and phospholipid bilayers of various compositions J. Biol. Chem. 278 2003 21790 21797
43. D. Harries, S. May, and A. Ben-Shaul Adsorption of charged macromolecules on mixed fluid membranes Colloids Surf. A Physicochem. Eng. Asp. 208 2002 41 50
44. S. May, and A. Ben-Shaul A molecular model for lipid-mediated interaction between proteins in membranes Phys. Chem. Chem. Phys. 2 2000 4494 4502
45. I. Rodland, O. Halskau, A. Martinez, and H. Holmsen Alpha-lactalbumin binding and membrane integrity - effect of charge and degree of unsaturation of glycerophospholipids Biochim. Biophys. Acta Biomembr. 1717 2005 11 20
46. L.A.M. Rupert, D. Hoekstra, and J.B.F.N. Engberts Fusogenic behavior of didodecyldimethylammonium bromide bilayer vesicles J. Am. Chem. Soc. 107 1985 2628 2631
47. A.M. Carmona-Ribeiro, and H. Chaimovich Salt-induced aggregation and fusion of dioctadecyldimethylammonium chloride and sodium dihexadecylphosphate vesicles Biophys. J. 50 1986 621 628
48. P. Saveyn, J. Cocquyt, P. Bomans, P. Frederik, M. De Cuyper, and P. Van der Meeren Osmotically induced morphological changes of extruded dioctadecyldimethylammonium chloride (DODAC) dispersions Langmuir 23 2007 4775 4781