More than skin-deep: The many dimensions of the psoriatic disease

Swiss Medical Weekly

Volumn 144, Issue , 2014, Pages

  Boehncke, Wolf Henning ^a   Boehncke, Sandra ^a  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

Comorbidities; Insulin resistance; Management; Mortality; Psoriasis; Screening

Indexed keywords

ANTIPSORIASIS AGENT; CYCLOSPORIN A; CYTOKINE; ETRETIN; INSULIN RECEPTOR; NITRIC OXIDE;

BIOLOGICAL THERAPY; BODY SURFACE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CLINICAL PRACTICE; COMORBIDITY; DERMATOLOGIST; DISEASE CONTROL; ENDOTHELIAL DYSFUNCTION; GUTTATE PSORIASIS; HUMAN; INFLAMMATORY DISEASE; INSULIN RESISTANCE; MAINTENANCE THERAPY; OBESITY; OPPORTUNISTIC INFECTION; PHOTOTHERAPY; PSORIASIS; PSORIATIC ARTHRITIS; PUSTULAR PSORIASIS; QUALITY OF LIFE; REVIEW; SYSTEMIC THERAPY; TOPICAL TREATMENT; INFLAMMATION; METABOLIC SYNDROME X;

CARDIOVASCULAR DISEASES; HUMANS; INFLAMMATION; METABOLIC SYNDROME X; PSORIASIS;

EID: 84899767202     PISSN: 14247860     EISSN: 14243997     Source Type: Journal    
DOI: 10.4414/smw.2014.13968     Document Type: Review

References (45)

1. Rapp SR, Feldman SR, Exum ML, Fleischer jr. AB, Reboussin DM. Psoriasis causes as much disability as other major medical diseases. J Am Acad Dermatol. 1999;41:401-7. (Pubitemid 29418506)
2. Dubertret L, Mrowietz U, Ranki A, van de Kerkhof PC, Chimenti S, Lotti T, et al. European patient perspectives on the impact of psoriasis: the EUROPSO patient memerbship survey. Br J Dermatol. 2006;155:729-36. 2008. (Pubitemid 44352553)
3. Parisi R, Symmons DPM, Griffiths CEM, Ashcroft DM. Global epidemiology of psoriasis: a systematic review of incidence and prevalence. J Invest Dermatol. 2013;133:377-85.
4. Augustin M, Glaeske G, Radtke MA, Schaefer I, Radtke M. Epidemiology and comorbidity of psoriasis in children. Br J Dermatol. 2010;162:633-6.
5. Nast A, Boehncke WH, Mrowietz U, Ockenfels HM, Philipp S, Reich K, et al. S3-guidelines on the treatment of psoriasis vulgaris. Update. J Dtsch Dermatol Ges. 2012;Suppl. 2:S1-95.
6. Mrowietz U, Kragballe K, Reich K, Spuls P, Griffiths CE, Nast A, et al. Definiiton of treatment goals for moderate to severe psoriasis: a European consensus. Arch Dermatol Res. 2011;303:1-10.
7. Augustin M, Reich K, Glaeske G, Schäfer I, Radtke M. Co-morbidity and age-related prevalence of psoriasis: analysis of health insurance data in Germany. Acta Derm Venerol. 2010;90:147-51.
8. Yeung H, Takeshita J, Mehta NN, Kimmel SE, Ogdie A, Margolis DJ, et al. Psoriasis severity and the prevalence of major medical comorbidity: a population-based study. JAMA Dermatol. 2013;149:1173-9.
9. Henseler T, Christophers E. Disease concomitance in psoriasis. J Am Acad Dermatol. 1995;32:982-6.
10. Griffiths CE, Barker JN. Pathogenesis and clinical features of psoriasis. Lancet. 2007;370:263-71. (Pubitemid 47069537)
11. Gerdes S, Zahl VA, Knopf H, Weichenthal M, Mrowietz U. Comedication related to comorbidities: a study in 1203 hospitalized patients with severe psoriasis. Br J Dermatol. 2008;159:1116-23.
12. Dowlatshahi EA, Wakkee M, Herings RM, Hollestein LM, Nijsten T. Increased antidepressant drug exposure in psoriasis patients: a longitudinal population-based cohort study. Acta Derm Venerol. 2013;93:544-50.
13. Abuabara K, Azfar RS, Shin DB, Neimann AL, Troxel AB, Gelfand JM. Cause-specific mortality in patients with severe psoriasis: a population-based cohort study. In the U.K. Br J Dermatol. 2010;163:586-92.
14. Elder JT, Bruce AT, Gudjonsson JE, Johnston A, Stuart PE, Tejasvi T, et al. Molecular dissection of psoriasis: integrating genetics and biology. J Invest Dermatol. 2010;130:1213-26.
15. Capon F, Burden AD, Trembath RC, Barker JN. Psoriasis and other complex trait dermatoses: from loci to functional pathways. J Invest Dermatol. 2012;132:915-22.
16. Tsoi LC, Spain SL, Knight J, Ellinghaus E, Stuart PE, Capon F, et al. Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. Nature Genet. 2012;44:1341-8.
17. Cargill M, Schrodi SJ, Chang M, Garcia VE, Brandon R, Callis KP, et al. A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes. Am J Hum Genet. 2007;80:273-90. (Pubitemid 46175676)
18. Capon F, Di Meglio P, Szaub J, Prescott NJ, Dunster C, Baumber L, et al. Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis. Hum Genet. 2007;122:201-6. (Pubitemid 47241785)
19. Rahman P, Imman RD, Maksymovwych WP, Reeve JP, Peddle L, Gladman DD. Association of interleukin 23 receptor variants with psoriatic arthritis. J Rheumatol. 2009;36:137-40.
20. Villanova F, Di Meglio P, Nestle FO. Biomarkers in psoriasis and psoriatic arthritis. Ann Rheum Dis. 2013;72(Suppl. 2): ii104-10.
21. Wolf N, Quaranta M, Prescott NJ, Allen M, Smith R, Burden AD, et al. Psoriasis is associated with pleiotropic susceptibility loci identified in type II diabetes und Crohn's Disease. J Med Genet. 2008;45:114-6. (Pubitemid 351252875)
22. Gupta Y, Möller S, Zillikens D, Boehncke WH, Ibrahim SM, Ludwig RJ. Genetic control of psoriasis is relatively distinct from that of metabolic syndrome and coronary artery disease. Exp Dermatol. 2013;22:552-3.
23. Gelfand JM, Shin DB, Neimann AL, Wang X, Margolis DJ, Troxel AB. The risk of lymphoma in patients with psoriasis. J Invest Dermatol. 2006;126:2194-201. (Pubitemid 44413165)
24. Gisondi P, Tessari G, Conti A, Piaserico S, Schianchi S, Peserico A, et al. Prevalence of metabolic syndrome in patients with psoriasis: a hospital-based case-control study. Br J Dermatol. 2007;157:68-73. (Pubitemid 46934281)
25. Malbris L, Akre O, Granath F, Yin L, Lindelöf B, et al. Increased risk for cardiovascular mortality in psoriasis inpatients but not in outpatients. Eur J Epidemiol. 2004;19:225-30. (Pubitemid 38461682)
26. Ludwig RJ, Herzog C, Rostock A, Ochsendorf FR, Zollner TM, Thaci D, et al. Psoriasis: a possible risk factor for development of coronary artery calcification. Br J Dermatol. 2007;156:271-6. (Pubitemid 46095954)
27. Boehncke WH, Boehncke S, Schön MP. Managing comorbid disease in patients with psoriasis. Br Med J. 2010;340:b5666.
28. Boehncke WH, Boehncke S, Tobin AM, Kirby B. The "psoriatic march": a concept of how severe psoriasis may drive cardiovascular comorbidity. Exp Dermatol. 2011;20:303-7.
29. Hogan AE, Tobin AM, Ahern T, Corrigan MA, Gaoatswe G, Jackson R, et al. Glucagon-like peptide-1 (GLP-1) and the regulation of human invariant natural killer T cells: lessons from obesity, diabetes and psoriasis. Diabetologia. 2011;54:2745-54.
30. Ahern T, Tobin AM, Corrigan M, Hogan A, Sweeney C, Kirby B, O'Shea D. Glucagon-like peptide-1 analogue therapy for psoriasis patients with obesity and type 2 diabetes: a prospective cohort study. J Eur Acad Dermatol Venereol. 2012 (e-pub ahead of print)
31. Buerger C, Richter B, Woth K, Salgo R, Malisiewicz B, Diehl S, et al. Interleukin-1β interferes with epidermal homeostasis through induction of insulin resistance: implications for psoriasis pathogenesis. J Invest Dermatol. 2012;132:2206-14.
32. Buerger C, Malisiewicz B, Eiser A, Hardt K, Boehncke WH. Mammalian target of rapamycin and its downstream signalling components are activated in psoriatic skin. Br J Dermatol. 2013;169:156-9.
33. Kimball AB, Gladman D, Gelfand JM, Gordon K, Horn EJ, Korman NJ, et al. National Psoriasis Foundation clinical consensus on psoriasis comorbidities and recommendations for screening. J Am Acad Dermatol. 2008;58:1031-42.
34. Boehncke WH, Boehncke S. Cardiovascular mortality in psoriasis and psoriatic arthritis: epidemiology, pathomechanisms, therapeutic implications, and perspectives. Curr Rheumatol Rep. 2012;14:343-8
35. Daudén E, Castañeda S, Suárez C, García- Campayo J, Blasco AJ, Aguilar MD, et al. Clinical practice guideline for an integrated approach to comorbidity in patients with psoriasis. J Eur Acad Dermatol Venerol. 2013;27:1387-404.
36. Wohlrab J, Fiedler G, Gerdes S, Nast A, Philipp S, Radtke MA, et al. Recommendations for detection of individual risk for comorbidities in patients with psoriasis. Arch Dermatol Res. 2013;305:91-8.
37. Gladman DD, Shuckett R, Russell ML, Thorne JC, Schachter RK. Psoriatic arthritis (PSA): an analysis of 220 patients. Q J Med 1987;62:127-41. (Pubitemid 17042878)
38. Veale DJ, Fitzgerald O. Psoriatic arthritis: pathogenesis and epidemiology. Clin Exp Rheumatol. 2002;20:S27-33.
39. Dominguez P, Gladman DD, Helliwell P, Mease PJ, Husni ME, Qureshi AA. Development of screening tools to identify psoriatic arthritis. Curr Rheum Rep. 2010;12:295-9.
40. Hansson GK. Inflamamtion, atherosclerosis, and coronary artery disease. N Engl J Med. 2005;352:1685-95.
41. Kim J Montagnani M, Koh KK, Quon MJ. Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms. Circulation. 2006;113:1888-904. (Pubitemid 43739401)
42. Boehncke S, Salgo R, Garbaraviciene J, Beschmann H, Hardt K, Diehl S, et al. Effective continuous systemic therapy of severe plaque-type psoriasis is accompanied by amelioration of biomarkers of cardiovascular risk: results of a prospective longitudinal observational study. J Eur Acad Dermatol Venereol. 2011;25:1187-93.
43. Boehncke S, Fichtlscherer S, Salgo R, Garbaraviciene J, Beschmann H, Diehl S, et al. Systemic therapy of plaque-type psoriasis ameliorates endothelial cell function: results of a prospective longitudinal pilot trial. Arch Dermatol Res. 2011;303:381-8.
44. Ahlehoff O, Skov L, Gislason G, Lindhardsen J, Kristensen SL, Iversen L, et al. Cardiovascular disease event rates in patients with severe psoriasis treated with systemic anti-inflammatory drugs: a Danish real-world cohort study. J Intern Med. 2013;273:197-204.
45. Armstrong AW, Brezinski EA, Follansbee MR, Armstrong EJ. Effects of Biologic Agents and Other Disease-Modifying Antirheumatic Drugs on Cardiovascular Outcomes in Psoriasis and Psoriatic Arthritis: A Systematic Review. Curr Pharm Des. 2013; e-pub ahead of print.