Effects of age on insulin resistance and secretion in subjects without diabetes

Internal Medicine

Volumn 53, Issue 9, 2014, Pages 941-947

  Oya, Junko ^a   Nakagami, Tomoko ^a   Yamamoto, Yayoi ^a   Fukushima, Sayaka ^a   Takeda, Masanobu ^b   Endo, Yasuhiro ^c   Uchigata, Yasuko ^a  

^a TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^b Yamanouchi Hospital   (Japan)

^c Saitama ken Saiseikai Kurihashi Hospital   (Japan)

Author keywords

Age; Insulin resistance; Insulin secretion

Indexed keywords

INSULIN;

ADULT; AGED; AGING; ALCOHOLISM; ARTICLE; BETA CELL FUNCTION; BODY MASS; CELL FUNCTION; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; HOMEOSTASIS AND REGULATION; HUMAN; IMMUNOASSAY; IMMUNOLUMINESCENCE ASSAY; INSULIN RELEASE; INSULIN RESISTANCE; LIFESTYLE; MALE; PHYSICAL ACTIVITY; POSTMENOPAUSE; QUESTIONNAIRE; SMOKING; AGE; BLOOD; DIABETES MELLITUS; INCIDENCE; JAPAN; MIDDLE AGED; PHYSIOLOGY; RETROSPECTIVE STUDY; RISK FACTOR;

ADULT; AGE FACTORS; AGED; AGING; BODY MASS INDEX; DIABETES MELLITUS; FEMALE; HUMANS; INCIDENCE; INSULIN; INSULIN RESISTANCE; JAPAN; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; RISK FACTORS;

EID: 84899745818     PISSN: 09182918     EISSN: 13497235     Source Type: Journal    
DOI: 10.2169/internalmedicine.53.1580     Document Type: Article

References (38)

1. International Diabetes Federation. IDF Diabetes Atlas. 5th ed. 2011: 26-29.
2. Kaneko R, Ishikawa A, Ishii H, et al. Jinko Mondai Kenkyu (Estimated Japanese population in future). J Population Problems 68: 90-127, 2012 (in Japanese).
3. Weyer C, Bogardus C, Mott DM, Pratley RE. The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. J Clin Invest 104: 787-794, 1999.
4. Haffner SM, Howard G, Mayer E, et al. Insulin sensitivity and acute insulin response in African-Americans, non-Hispanic whites, and Hispanics with NIDDM: The Insulin Resistance Atherosclerosis Study. Diabetes 46: 63-69, 1997.
5. Taniguchi A, Nakai Y, Fukushima M, et al. Pathogenic factors responsible for glucose intolerance in patients with NIDDM. Diabetes 41: 1540-1546, 1992.
6. Defronzo RA. Glucose intolerance and aging: evidence for tissue insensitivity to insulin. Diabetes 28: 1095-1101, 1979.
7. Chen M, Bergman RN, Pacini G, Porte D Jr. Pathogenesis of agerelated glucose intolerance in man: insulin resistance and decreased beta-cell function. J Clin Endocrinol Metab 60: 13-20, 1985.
8. Chiu KC, Lee NP, Cohan P, Chuang LM. Beta cell function declines with age in glucose tolerant Caucasians. Clin Endcrinol 53: 569-575, 2000.
9. Gumbiner B, Polonsky KS, Beltz WF, Wallace P, Brechtel G, Fink RI. Effects of aging on insulin secretion. Diabetes 38: 1549-1556, 1989.
10. Toyoda K, Fukushima M, Mitsui R, et al. Factors responsible for age-related elevation in fasting plasma glucose: a cross-sectional study in Japanese men. Metabolism 57: 299-303, 2008.
11. Takai T, Sakura H, Uchigata Y, Iwamoto Y. Insulin sensitivity and secretion indices in Japanese subjects with normal and impaired glucose tolerance. Diabetol Int 3: 80-85, 2012.
12. Bressler P, Bailey S, Matsuda M, DeFronzo RA. Insulin resistance and coronary artery disease. Diabetologia 39: 1345-1350, 1996.
13. World Health Organization. Definition and diagnosis of diabetes mellitus and intermediate hyperglycemia: report of a WHO/IDF consultation. WHO, Geneva, 2006.
14. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28: 412-419, 1985.
15. Basu R, Breda E, Oberg AL, et al. Mechanisms of the ageassociated deterioration in glucose tolerance. Contribution of alterations in insulin secretion, action, and clearance. Diabetes 52: 1738-1748, 2003.
16. Coon PJ, Rogus EM, Drinkwater D, Muller DC, Goldberg AP. Role of body fat distribution in the decline in insulin sensitivity and glucose tolerance with age. J Clin Endocrinol Metab 75: 1125-1132, 1992.
17. Wang J, Thornton JC, Russell M, Burastero S, Heymsfield S, Pierson RN Jr. Asians have lower body mass index (BMI) but higher percent body fat than do whites: comparisons of anthropometric mesurements. Am J Clin Nutr 60: 23-28, 1994.
18. Qiao Q, Nakagami T, Tuomilehto J, et al; International Diabetes Epidemiology Group, DECODA Study Group. Comparison of the fasting and 2-h glucose criteria for diabetes in different Asian cohorts. Diabetologia 43: 1470-1475, 2000.
19. Chan JC, Malik V, Jia W, et al. Diabetes in Asia: epidemiology, risk factors, and pathophysiology. JAMA 301: 2129-2140, 2009.
20. Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC. β-cell deficit and increased β-cell apoptosis in humans with type 2 diabetes. Diabetes 52: 102-110, 2003.
21. Funakoshi S, Fujimoto S, Hamasaki A, et al. Analysis of factors influencing pancreatic β-cell function in Japanese patients with type 2 diabetes: Association with body mass index and duration of diabetic exposure. Diabetes Res Clin Pract 82: 353-358, 2008.
22. Avogaro A, Watanabe RM, Gottardo L, et al. Glucose tolerance during moderate alcohol intake: Insights on insulin action from glucose/lactate dynamics. J Clin Endocrinol Metab 87: 1233-1238, 2002.
23. Crandall JP, Polsky S, Howard AA, et al. Alcohol consumption and diabetes risk in the Diabetes Prevention Program. Am J Clin Nutr 90: 595-601, 2009.
24. Flanagan DEH, Pratt E, Murphy J, et al. Alcohol consumption alters insulin secretion and cardiac autonomic activity. Eur J Clin Invest 32: 187-192, 2002.
25. Garaulet M, Perex-Llamas F, Fuente T, Zamora S, Tebar FJ. Anthropometric, computed tomography and fat cell data in an obese population: Relationship with insulin, leptin, tumor necrosis factor-alpha, sex hormone-binding globulin and sex hormones. Eur J Endocrinol 143: 657-666, 2000.
26. Bjorntorp P. The regulation of adipose tissue distribution in humans. Int J Obes Relat Metab Disord 20: 291-302, 1996.
27. D'Eon TM, Souza SC, Aronovitz M, Obin MS, Fried SK, Greenberg AS. Estrogen regulation of adiposity and fuel partitioning. Evidence of genomic and non-genomic regulation of lipogenic and oxidative pathways. J Biol Chem 280: 35983-35991, 2005.
28. Corbould A. Effects of androgens on insulin action in women: is androgen excess a component of female metabolic syndrome? Diabetes Metab Res Rev 24: 520-532, 2008.
29. Karakelides H, Irving BA, Short KR, O'Brien P, Nair KS. Age, obesity, and sex effects on insulin sensitivity and skeletal muscle mitochondrial function. Diabetes 59: 89-97, 2010.
30. Staron RS, Hagerman FC, Hukida RS, et al. Fiber type composition of the vastus lateralis muscle of young men and women. J Histochem Cytochem 48: 623-629, 2000.
31. Chen M, Halter JB, Porte D Jr. Pathogenesis of age-related glucose intolerance of the elderly. J Am Geriatr Soc 35: 417-424, 1987.
32. Meneilly GS, Ryan AS, Veldhuis JD, Elahi D. Increased disorderliness of basal insulin release, attenuated insulin secretory burst mass, and reduced ultradian rhythmicity of insulin secretion in older individuals. J Clin Endocrinol Metab 82: 4088-4093, 1997.
33. Elahi D, Andersen DK, Muller DC, Tobin JD, Brown JC, Andres R. The enteric enhancement of glucose-stimulated insulin release. The role of GIP in aging, obesity, and non-insulin-dependent diabetes mellitus. Diabetes 33: 950-957, 1984.
34. Corpas E, Harman SM, Blackman MR. Human growth hormone and human aging. Endocr Rev 14: 20-39, 1993.
35. Lamberts SW, van den Beld AW, van der Lely AJ. The endocrinology of aging. Science 278: 419-424, 1997.
36. Iozzo P, Beck-Nielsen H, Laakso M, Smith U, Yki-Jarvinen H, Ferrannini E. Independent influence of age on basal insulin secretion in nondiabetic humans. J Clin Endocrinol Metab 84: 863-868, 1999.
37. Bonora E, Targher G, Alberiche M, et al. Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity. Diabetes Care 23: 57-63, 2000.
38. The Japanese Ministry of Health, Labor and Welfare. Kokumin Kenko Eiyo No Genjo-Heisei 19 nen Kosei Rodosho Kokumin Kenko Eiyo Chosa Hokoku Yori-(The state of national health and nutrition-report from examination of national health and nutrition). Dai-ichi Shuppan Co., Ltd., Tokyo, 2010: 44-48 (in Japanese).