Control of angiogenesis by galectins involves the release of platelet-derived proangiogenic factors

PLoS ONE

Volumn 9, Issue 4, 2014, Pages

  Etulain, Julia ^a   Negrotto, Soledad ^a   Tribulatti, María Virginia ^b   Croci, Diego Omar ^c   Carabelli, Julieta ^b   Campetella, Oscar ^b   Rabinovich, Gabriel Adrián ^c,d   Schattner, Mirta ^a  

^a ACADEMIA NACIONAL DE MEDICINA   (Argentina)

^b UNIVERSIDAD NACIONAL DE SAN MARTÍN   (Argentina)

^c Universidad Nacional de Río Cuarto Consejo Nacional de Investigaciones Científicas y Técnicas   (Argentina)

^d UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; CYCLOOXYGENASE 1; ENDOSTATIN; GALECTIN; GALECTIN 1; GALECTIN 3; GALECTIN 8; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; VASCULOTROPIN;

ANGIOGENESIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; REGULATORY MECHANISM; THROMBOCYTE FUNCTION;

BLOOD PLATELETS; CELL LINE; ENDOSTATINS; GALECTIN 1; GALECTIN 3; GALECTINS; HUMANS; NEOVASCULARIZATION, PHYSIOLOGIC; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84899736814     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0096402     Document Type: Article

References (36)

1. Carmeliet P (2005) Angiogenesis in life, disease and medicine. Nature 438: 932-936.
2. Rafii DC, Psaila B, Butler J, Jin DK, Lyden D (2008) Regulation of vasculogenesis by platelet-mediated recruitment of bone marrow-derived cells. Arterioscler Thromb Vasc Biol 28: 217-222. (Pubitemid 351161192)
3. Patzelt J, Langer HF (2012) Platelets in angiogenesis. Curr Vasc Pharmacol 10: 570-577.
4. van Nispen tot Pannerden H, de Haas F, Geerts W, Posthuma G, van Dijk S, et al. (2010) The platelet interior revisited: electron tomography reveals tubular alpha-granule subtypes. Blood 116: 1147-1156.
5. Chatterjee M, Huang Z, Zhang W, Jiang L, Hultenby K, et al. (2011) Distinct platelet packaging, release, and surface expression of proangiogenic and antiangiogenic factors on different platelet stimuli. Blood 117: 3907-3911.
6. Sehgal S, Storrie B (2007) Evidence that differential packaging of the major platelet granule proteins von Willebrand factor and fibrinogen can support their differential release. J Thromb Haemost 5: 2009-2016. (Pubitemid 47450016)
7. Ma L, Perini R, McKnight W, Dicay M, Klein A, et al. (2005) Proteinase-activated receptors 1 and 4 counter-regulate endostatin and VEGF release from human platelets. Proc Natl Acad Sci USA 102: 216-220. (Pubitemid 40094455)
8. Italiano JE Jr., Richardson JL, Patel-Hett S, Battinelli E, Zaslavsky A, et al. (2008) Angiogenesis is regulated by a novel mechanism: pro- and antiangiogenic proteins are organized into separate platelet alpha granules and differentially released. Blood 111: 1227-1233. (Pubitemid 351213404)
9. Battinelli EM, Markens BA, Italiano JE Jr. (2011) Release of angiogenesis regulatory proteins from platelet alpha granules: modulation of physiologic and pathologic angiogenesis. Blood 118: 1359-1369.
10. Bambace NM, Levis JE, Holmes CE (2010) The effect of P2Y-mediated platelet activation on the release of VEGF and endostatin from platelets. Platelets 21: 85-93.
11. Rabinovich GA, Baum LG, Tinari N, Paganelli R, Natoli C, et al. (2002) Galectins and their ligands: amplifiers, silencers or tuners of the inflammatory response? Trends Immunol 23: 313-320. (Pubitemid 34628775)
12. Yang RY, Rabinovich GA, Liu FT (2008) Galectins: structure, function and therapeutic potential. Expert Rev Mol Med 10: e17.
13. Al-Ansari S, Zeebregts CJ, Slart RH, Peppelenbosch M, Tio RA (2009) Galectins in atherosclerotic disease. Trends Cardiovasc Med 19: 164-169.
14. Liu FT, Rabinovich GA (2010) Galectins: regulators of acute and chronic inflammation. Ann N Y Acad Sci 1183: 158-182.
15. Norling LV, Perretti M, Cooper D (2009) Endogenous galectins and the control of the host inflammatory response. J Endocrinol 201: 169-184.
16. Rubinstein N, Alvarez M, Zwirner NW, Toscano MA, Ilarregui JM, et al. (2004) Targeted inhibition of galectin-1 gene expression in tumor cells results in heightened T cell-mediated rejection; A potential mechanism of tumor-immune privilege. Cancer Cell 5: 241-251. (Pubitemid 38402116)
17. Bidon-Wagner N, Le Pennec JP (2004) Human galectin-8 isoforms and cancer. Glycoconj J 19: 557-563. (Pubitemid 38316530)
18. Liu FT, Rabinovich GA (2005) Galectins as modulators of tumour progression. Nat Rev Cancer 5: 29-41.
19. Romaniuk MA, Negrotto S, Campetella O, Rabinovich GA, Schattner M (2011) Identification of galectins as novel regulators of platelet signaling and function. IUBMB Life 63: 521-527.
20. Romaniuk MA, Tribulatti MV, Cattaneo V, Lapponi MJ, Molinas FC, et al. (2010) Human platelets express and are activated by Galectin-8. Biochem J 432: 535-547.
21. Pacienza N, Pozner RG, Bianco GA, D'Atri LP, Croci DO, et al. (2008) The immunoregulatory glycan-binding protein galectin-1 triggers human platelet activation. Faseb J 22: 1113-1123. (Pubitemid 351519966)
22. Romaniuk MA, Croci DO, Lapponi MJ, Tribulatti MV, Negrotto S, et al. (2012) Binding of galectin-1 to alphaIIbbeta(3) integrin triggers "outside-in" signals, stimulates platelet activation, and controls primary hemostasis. Faseb J 26: 2788-2798.
23. Nangia-Makker P, Honjo Y, Sarvis R, Akahani S, Hogan V, et al. (2000) Galectin-3 induces endothelial cell morphogenesis and angiogenesis. Am J Pathol 156: 899-909. (Pubitemid 30626949)
24. Thijssen VL, Postel R, Brandwijk RJ, Dings RP, Nesmelova I, et al. (2006) Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy. Proc Natl Acad Sci U S A 103: 15975-15980. (Pubitemid 44657577)
25. Delgado VM, Nugnes LG, Colombo LL, Troncoso MF, Fernandez MM, et al. (2011) Modulation of endothelial cell migration and angiogenesis: a novel function for the "tandem-repeat" lectin galectin-8. Faseb J 25: 242-254.
26. Croci DO, Salatino M, Rubinstein N, Cerliani JP, Cavallin LE, et al. (2012) Disrupting galectin-1 interactions with N-glycans suppresses hypoxia-driven angiogenesis and tumorigenesis in Kaposi's sarcoma. J Exp Med 209: 1985-2000.
27. Croci DO, Cerliani JP, Dalotto-Moreno T, Mendez-Huergo SP, Mascanfroni ID, et al. (2014) Glycosylation-Dependent Lectin-Receptor Interactions Preserve Angiogenesis in Anti-VEGF Refractory Tumors. Cell 156: 744-758.
28. Hirabayashi J, Hashidate T, Arata Y, Nishi N, Nakamura T, et al. (2002) Oligosaccharide specificity of galectins: a search by frontal affinity chromatography. Biochim Biophys Acta 1572: 232-254. (Pubitemid 35246347)
29. Tribulatti MV, Figini MG, Carabelli J, Cattaneo V, Campetella O (2012) Redundant and antagonistic functions of galectin-1, -3, and -8 in the elicitation of T cell responses. J Immunol 188: 2991-2999.
30. Etulain J, Fondevila C, Negrotto S, Schattner M (2013) Platelet-mediated angiogenesis is independent of VEGF and fully inhibited by aspirin. Br J Pharmacol 170: 255-265.
31. Thijssen VL, Hulsmans S, Griffioen AW (2008) The galectin profile of the endothelium: altered expression and localization in activated and tumor endothelial cells. Am J Pathol 172: 545-553. (Pubitemid 351282039)
32. Heusschen R, Schulkens IA, van Beijnum J, Griffioen AW, Thijssen VL (2014) Endothelial LGALS9 splice variant expression in endothelial cell biology and angiogenesis. Biochim Biophys Acta 1842: 284-292.
33. Thijssen VL, Barkan B, Shoji H, Aries IM, Mathieu V, et al. (2010) Tumor cells secrete galectin-1 to enhance endothelial cell activity. Cancer Res 70: 6216-6224.
34. Cervi D, Yip TT, Bhattacharya N, Podust VN, Peterson J, et al. (2008) Platelet-associated PF-4 as a biomarker of early tumor growth. Blood 111: 1201-1207. (Pubitemid 351213401)
35. Zaslavsky A, Baek KH, Lynch RC, Short S, Grillo J, et al. (2010) Platelet-derived thrombospondin-1 is a critical negative regulator and potential biomarker of angiogenesis. Blood 115: 4605-4613.
36. Satelli A, Rao PS, Gupta PK, Lockman PR, Srivenugopal KS, et al. (2008) Varied expression and localization of multiple galectins in different cancer cell lines. Oncol Rep 19: 587-594. (Pubitemid 351330422)