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Volumn 9, Issue 4, 2014, Pages

Identification of a novel function of CX-4945 as a splicing regulator

Author keywords

[No Author keywords available]

Indexed keywords

CASEIN KINASE II; CX 4945; CYCLIN DEPENDENT KINASE 1; ENZYME INHIBITOR; SERINE ARGININE RICH PROTEIN; TG 003; TRANSCRIPTOME; UNCLASSIFIED DRUG; 5-(3-CHLOROPHENYLAMINO)BENZO(C)(2,6)NAPHTHYRIDINE-8-CARBOXYLIC ACID; CDK1 PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE; NAPHTHYRIDINE DERIVATIVE; PROTEIN KINASE INHIBITOR;

EID: 84899720390     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0094978     Document Type: Article
Times cited : (76)

References (53)
  • 1
    • 0013394889 scopus 로고    scopus 로고
    • Mechanisms of alternative pre-messenger RNA splicing
    • DOI 10.1146/annurev.biochem.72.121801.161720
    • Black DL (2003) Mechanisms of alternative pre-messenger RNA splicing. Annu Rev Biochem 72: 291-336. (Pubitemid 36930448)
    • (2003) Annual Review of Biochemistry , vol.72 , pp. 291-336
    • Black, D.L.1
  • 2
    • 0030279439 scopus 로고    scopus 로고
    • Directing alternative splicing: Cast and scenarios
    • DOI 10.1016/0168-9525(96)10037-8, PII S0168952596100378
    • Chabot B (1996) Directing alternative splicing: cast and scenarios. Trends Genet 12: 472-478. (Pubitemid 126335953)
    • (1996) Trends in Genetics , vol.12 , Issue.11 , pp. 472-478
    • Chabot, B.1
  • 3
    • 33745899048 scopus 로고    scopus 로고
    • Alternative splicing: New insights from global analyses
    • DOI 10.1016/j.cell.2006.06.023, PII S0092867406008178
    • Blencowe BJ (2006) Alternative splicing: new insights from global analyses. Cell 126: 37-47. (Pubitemid 44040990)
    • (2006) Cell , vol.126 , Issue.1 , pp. 37-47
    • Blencowe, B.J.1
  • 4
    • 56749098074 scopus 로고    scopus 로고
    • Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing
    • Pan Q, Shai O, Lee LJ, Frey BJ, Blencowe BJ (2008) Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing. Nat Genet 40: 1413-1415.
    • (2008) Nat Genet , vol.40 , pp. 1413-1415
    • Pan, Q.1    Shai, O.2    Lee, L.J.3    Frey, B.J.4    Blencowe, B.J.5
  • 8
    • 0037443035 scopus 로고    scopus 로고
    • Pre-mRNA splicing and human disease
    • DOI 10.1101/gad.1048803
    • Faustino NA, Cooper TA (2003) Pre-mRNA splicing and human disease. Genes Dev 17: 419-437. (Pubitemid 36258756)
    • (2003) Genes and Development , vol.17 , Issue.4 , pp. 419-437
    • Faustino, N.A.1    Cooper, T.A.2
  • 10
  • 11
    • 1842693352 scopus 로고    scopus 로고
    • Multiple roles of the SR protein family in splicing regulation
    • Sanford JR, Longman D, Caceres JF (2003) Multiple roles of the SR protein family in splicing regulation. Prog Mol Subcell Biol 31: 33-58.
    • (2003) Prog Mol Subcell Biol , vol.31 , pp. 33-58
    • Sanford, J.R.1    Longman, D.2    Caceres, J.F.3
  • 12
    • 0030218143 scopus 로고    scopus 로고
    • The SR protein family: Pleiotropic functions in pre-mRNA splicing
    • DOI 10.1016/0968-0004(96)10039-6
    • Valcarcel J, Green MR (1996) The SR protein family: pleiotropic functions in pre-mRNA splicing. Trends Biochem Sci 21: 296-301. (Pubitemid 26281032)
    • (1996) Trends in Biochemical Sciences , vol.21 , Issue.8 , pp. 296-301
    • Valcarcel, J.1    Green, M.R.2
  • 13
    • 0029372979 scopus 로고
    • The superfamily of arginine/serine-rich splicing factors
    • Fu XD (1995) The superfamily of arginine/serine-rich splicing factors. RNA 1: 663-680.
    • (1995) RNA , vol.1 , pp. 663-680
    • Fu, X.D.1
  • 14
    • 14744290800 scopus 로고    scopus 로고
    • RS domains contact the pre-mRNA throughout spliceosome assembly
    • DOI 10.1016/j.tibs.2005.01.002
    • Hertel KJ, Graveley BR (2005) RS domains contact the pre-mRNA throughout spliceosome assembly. Trends Biochem Sci 30: 115-118. (Pubitemid 40332526)
    • (2005) Trends in Biochemical Sciences , vol.30 , Issue.3 , pp. 115-118
    • Hertel, K.J.1    Graveley, B.R.2
  • 15
    • 0031042396 scopus 로고    scopus 로고
    • Phosphorylation of the ASF/SF2 RS domain affects both protein-protein and protein-RNA interactions and is necessary for splicing
    • Xiao SH, Manley JL (1997) Phosphorylation of the ASF/SF2 RS domain affects both protein-protein and protein-RNA interactions and is necessary for splicing. Genes Dev 11: 334-344. (Pubitemid 27079911)
    • (1997) Genes and Development , vol.11 , Issue.3 , pp. 334-344
    • Xiao, S.-H.1    Manley, J.L.2
  • 16
    • 0031929940 scopus 로고    scopus 로고
    • A specific subset of SR proteins shuttles continuously between the nucleus and the cytoplasm
    • Caceres JF, Screaton GR, Krainer AR (1998) A specific subset of SR proteins shuttles continuously between the nucleus and the cytoplasm. Genes Dev 12: 55-66. (Pubitemid 28083658)
    • (1998) Genes and Development , vol.12 , Issue.1 , pp. 55-66
    • Caceres, J.F.1    Screaton, G.R.2    Krainer, A.R.3
  • 17
    • 0032547829 scopus 로고    scopus 로고
    • Serine phosphorylation of SR proteins is required for their recruitment to sites of transcription in vivo
    • DOI 10.1083/jcb.143.2.297
    • Misteli T, Caceres JF, Clement JQ, Krainer AR, Wilkinson MF, et al. (1998) Serine phosphorylation of SR proteins is required for their recruitment to sites of transcription in vivo. J Cell Biol 143: 297-307. (Pubitemid 28487851)
    • (1998) Journal of Cell Biology , vol.143 , Issue.2 , pp. 297-307
    • Misteli, T.1    Caceres, J.F.2    Clement, J.Q.3    Krainer, A.R.4    Wilkinson, M.F.5    Spector, D.L.6
  • 18
    • 0030028882 scopus 로고    scopus 로고
    • The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution
    • Colwill K, Pawson T, Andrews B, Prasad J, Manley JL, et al. (1996) The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution. EMBO J 15: 265-275. (Pubitemid 26029629)
    • (1996) EMBO Journal , vol.15 , Issue.2 , pp. 265-275
    • Colwill, K.1    Pawson, T.2    Andrews, B.3    Prasad, J.4    Manley, J.L.5    Bell, J.C.6    Duncan, P.I.7
  • 19
    • 0030778935 scopus 로고    scopus 로고
    • Characterization and comparison of four serine- and arginine-rich (SR) protein kinases
    • Nayler O, Stamm S, Ullrich A (1997) Characterization and comparison of four serine-and arginine-rich (SR) protein kinases. Biochem J 326 (Pt 3): 693-700. (Pubitemid 27438041)
    • (1997) Biochemical Journal , vol.326 , Issue.3 , pp. 693-700
    • Nayler, O.1    Stamm, S.2    Ullrich, A.3
  • 20
    • 77949408107 scopus 로고    scopus 로고
    • Rapid-response splicing reporter screens identify differential regulators of constitutive and alternative splicing
    • Younis I, Berg M, Kaida D, Dittmar K, Wang C, et al. (2010) Rapid-response splicing reporter screens identify differential regulators of constitutive and alternative splicing. Mol Cell Biol 30: 1718-1728.
    • (2010) Mol Cell Biol , vol.30 , pp. 1718-1728
    • Younis, I.1    Berg, M.2    Kaida, D.3    Dittmar, K.4    Wang, C.5
  • 21
    • 0027962510 scopus 로고
    • Purification and characterization of a kinase specific for the serine-and arginine-rich pre-mRNA splicing factors
    • Gui JF, Tronchere H, Chandler SD, Fu XD (1994) Purification and characterization of a kinase specific for the serine-and arginine-rich pre-mRNA splicing factors. Proc Natl Acad Sci USA 91: 10824-10828.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 10824-10828
    • Gui, J.F.1    Tronchere, H.2    Chandler, S.D.3    Fu, X.D.4
  • 25
    • 33646205043 scopus 로고    scopus 로고
    • Use of transcriptional synergy to augment sensitivity of a splicing reporter assay
    • Levinson N, Hinman R, Patil A, Stephenson CR, Werner S, et al. (2006) Use of transcriptional synergy to augment sensitivity of a splicing reporter assay. RNA 12: 925-930.
    • (2006) RNA , vol.12 , pp. 925-930
    • Levinson, N.1    Hinman, R.2    Patil, A.3    Stephenson, C.R.4    Werner, S.5
  • 27
    • 0035884180 scopus 로고    scopus 로고
    • Specific inhibition of serine- and arginine-rich splicing factors phosphorylation, spliceosome assembly, and splicing by the antitumor drug NB-506
    • Pilch B, Allemand E, Facompre M, Bailly C, Riou JF, et al. (2001) Specific inhibition of serine-and arginine-rich splicing factors phosphorylation, spliceosome assembly, and splicing by the antitumor drug NB-506. Cancer Res 61: 6876-6884. (Pubitemid 32896513)
    • (2001) Cancer Research , vol.61 , Issue.18 , pp. 6876-6884
    • Pilch, B.1    Allemand, E.2    Facompre, M.3    Bailly, C.4    Riou, J.-F.5    Soret, J.6    Tazi, J.7
  • 29
    • 49649108878 scopus 로고    scopus 로고
    • A high-throughput screening strategy identifies cardiotonic steroids as alternative splicing modulators
    • Stoilov P, Lin CH, Damoiseaux R, Nikolic J, Black DL (2008) A high-throughput screening strategy identifies cardiotonic steroids as alternative splicing modulators. Proc Natl Acad Sci USA 105: 11218-11223.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 11218-11223
    • Stoilov, P.1    Lin, C.H.2    Damoiseaux, R.3    Nikolic, J.4    Black, D.L.5
  • 30
    • 45249091505 scopus 로고    scopus 로고
    • Substances that can change alternative splice-site selection
    • DOI 10.1042/BST0360483
    • Sumanasekera C, Watt DS, Stamm S (2008) Substances that can change alternative splice-site selection. Biochem Soc Trans 36: 483-490. (Pubitemid 351839360)
    • (2008) Biochemical Society Transactions , vol.36 , Issue.3 , pp. 483-490
    • Sumanasekera, C.1    Watt, D.S.2    Stamm, S.3
  • 31
    • 78650321320 scopus 로고    scopus 로고
    • CX-4945, an orally bioavailable selective inhibitor of protein kinase CK2, inhibits prosurvival and angiogenic signaling and exhibits antitumor efficacy
    • Siddiqui-Jain A, Drygin D, Streiner N, Chua P, Pierre F, et al. (2010) CX-4945, an orally bioavailable selective inhibitor of protein kinase CK2, inhibits prosurvival and angiogenic signaling and exhibits antitumor efficacy. Cancer Res 70: 10288-10298.
    • (2010) Cancer Res , vol.70 , pp. 10288-10298
    • Siddiqui-Jain, A.1    Drygin, D.2    Streiner, N.3    Chua, P.4    Pierre, F.5
  • 32
    • 0037212102 scopus 로고    scopus 로고
    • LigandFit: A novel method for the shape-directed rapid docking of ligands to protein active sites
    • DOI 10.1016/S1093-3263(02)00164-X, PII S109332630200164X
    • Venkatachalam CM, Jiang X, Oldfield T, Waldman M (2003) LigandFit: a novel method for the shape-directed rapid docking of ligands to protein active sites. J Mol Graph Model 21: 289-307. (Pubitemid 35441326)
    • (2003) Journal of Molecular Graphics and Modelling , vol.21 , Issue.4 , pp. 289-307
    • Venkatachalam, C.M.1    Jiang, X.2    Oldfield, T.3    Waldman, M.4
  • 33
    • 0037269847 scopus 로고    scopus 로고
    • Protein kinase CK2: Structure, regulation and role in cellular decisions of life and death
    • DOI 10.1042/BJ20021469
    • Litchfield DW (2003) Protein kinase CK2: structure, regulation and role in cellular decisions of life and death. Biochem J 369: 1-15. (Pubitemid 36174119)
    • (2003) Biochemical Journal , vol.369 , Issue.1 , pp. 1-15
    • Litchfield, D.W.1
  • 34
    • 53249090648 scopus 로고    scopus 로고
    • Protein kinase CK2 in human diseases
    • Guerra B, Issinger OG (2008) Protein kinase CK2 in human diseases. Curr Med Chem 15: 1870-1886.
    • (2008) Curr Med Chem , vol.15 , pp. 1870-1886
    • Guerra, B.1    Issinger, O.G.2
  • 37
    • 70349320107 scopus 로고    scopus 로고
    • Protein kinase CK2 in health and disease: CK2: A key player in cancer biology
    • Trembley JH, Wang G, Unger G, Slaton J, Ahmed K (2009) Protein kinase CK2 in health and disease: CK2: a key player in cancer biology. Cell Mol Life Sci 66: 1858-1867.
    • (2009) Cell Mol Life Sci , vol.66 , pp. 1858-1867
    • Trembley, J.H.1    Wang, G.2    Unger, G.3    Slaton, J.4    Ahmed, K.5
  • 39
    • 0034950640 scopus 로고    scopus 로고
    • Expression and role of Bcl-xL in human hepatocellular carcinomas
    • DOI 10.1053/jhep.2001.25387
    • Takehara T, Liu X, Fujimoto J, Friedman SL, Takahashi H (2001) Expression and role of Bcl-xL in human hepatocellular carcinomas. Hepatology 34: 55-61. (Pubitemid 32591483)
    • (2001) Hepatology , vol.34 , Issue.1 , pp. 55-61
    • Takehara, T.1    Liu, X.2    Fujimoto, J.3    Friedman, S.L.4    Takahashi, H.5
  • 40
  • 41
    • 0030863326 scopus 로고    scopus 로고
    • In vivo regulation of alternative pre-mRNA splicing by the Clk1 protein kinase
    • Duncan PI, Stojdl DF, Marius RM, Bell JC (1997) In vivo regulation of alternative pre-mRNA splicing by the Clk1 protein kinase. Mol Cell Biol 17: 5996-6001. (Pubitemid 27411107)
    • (1997) Molecular and Cellular Biology , vol.17 , Issue.10 , pp. 5996-6001
    • Duncan, P.I.1    Stojdl, D.F.2    Marius, R.M.3    Bell, J.C.4
  • 42
    • 0035805108 scopus 로고    scopus 로고
    • Selectivity of 4,5,6,7-tetrabromobenzotriazole, an ATP site-directed inhibitor of protein kinase CK2 ('casein kinase-2')
    • DOI 10.1016/S0014-5793(01)02404-8, PII S0014579301024048
    • Sarno S, Reddy H, Meggio F, Ruzzene M, Davies SP, et al. (2001) Selectivity of 4, 5, 6, 7-tetrabromobenzotriazole, an ATP site-directed inhibitor of protein kinase CK2 ('casein kinase-29). FEBS Lett 496: 44-48. (Pubitemid 32436419)
    • (2001) FEBS Letters , vol.496 , Issue.1 , pp. 44-48
    • Sarno, S.1    Reddy, H.2    Meggio, F.3    Ruzzene, M.4    Davies, S.P.5    Donella-Deana, A.6    Shugar, D.7    Pinna, L.A.8
  • 45
    • 0026716104 scopus 로고
    • SR proteins: A conserved family of pre-mRNA splicing factors
    • Zahler AM, Lane WS, Stolk JA, Roth MB (1992) SR proteins: a conserved family of pre-mRNA splicing factors. Genes Dev 6: 837-847.
    • (1992) Genes Dev , vol.6 , pp. 837-847
    • Zahler, A.M.1    Lane, W.S.2    Stolk, J.A.3    Roth, M.B.4
  • 46
    • 78650917050 scopus 로고    scopus 로고
    • Structural basis of CX-4945 binding to human protein kinase CK2
    • Ferguson AD, Sheth PR, Basso AD, Paliwal S, Gray K, et al. (2011) Structural basis of CX-4945 binding to human protein kinase CK2. FEBS Lett 585: 104-110.
    • (2011) FEBS Lett , vol.585 , pp. 104-110
    • Ferguson, A.D.1    Sheth, P.R.2    Basso, A.D.3    Paliwal, S.4    Gray, K.5
  • 47
    • 0035230130 scopus 로고    scopus 로고
    • The splice of life: Alternative splicing and neurological disease
    • DOI 10.1038/35049061
    • Dredge BK, Polydorides AD, Darnell RB (2001) The splice of life: alternative splicing and neurological disease. Nat Rev Neurosci 2: 43-50. (Pubitemid 33673348)
    • (2001) Nature Reviews Neuroscience , vol.2 , Issue.1 , pp. 43-50
    • Dredge, B.K.1    Polydorides, A.D.2    Darnell, R.B.3
  • 48
    • 33749054403 scopus 로고    scopus 로고
    • Splicing regulation in neurologic disease
    • DOI 10.1016/j.neuron.2006.09.017, PII S0896627306007240
    • Licatalosi DD, Darnell RB (2006) Splicing regulation in neurologic disease. Neuron 52: 93-101. (Pubitemid 44466357)
    • (2006) Neuron , vol.52 , Issue.1 , pp. 93-101
    • Licatalosi, D.D.1    Darnell, R.B.2
  • 49
    • 42549100051 scopus 로고    scopus 로고
    • Alternative splicing and disease
    • Kim E, Goren A, Ast G (2008) Alternative splicing and disease. RNA Biol 5: 17-19.
    • (2008) RNA Biol , vol.5 , pp. 17-19
    • Kim, E.1    Goren, A.2    Ast, G.3
  • 50
    • 0019876755 scopus 로고
    • Purification and properties of calf thymus casein kinases i and II
    • Dahmus ME (1981) Purification and properties of calf thymus casein kinases I and II. J Biol Chem 256: 3319-3325.
    • (1981) J Biol Chem , vol.256 , pp. 3319-3325
    • Dahmus, M.E.1
  • 51
    • 16644402765 scopus 로고    scopus 로고
    • Effects of phosphorylation by protein kinase CK2 on the human basal components of the RNA polymerase II transcription machinery
    • Cabrejos ME, Allende CC, Maldonado E (2004) Effects of phosphorylation by protein kinase CK2 on the human basal components of the RNA polymerase II transcription machinery. J Cell Biochem 93: 2-10.
    • (2004) J Cell Biochem , vol.93 , pp. 2-10
    • Cabrejos, M.E.1    Allende, C.C.2    Maldonado, E.3
  • 52
    • 84878111705 scopus 로고    scopus 로고
    • Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: Development of chemical probe ML315
    • Coombs TC, Tanega C, Shen M, Wang JL, Auld DS, et al. (2013) Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: development of chemical probe ML315. Bioorg Med Chem Lett 23: 3654-3661.
    • (2013) Bioorg Med Chem Lett , vol.23 , pp. 3654-3661
    • Coombs, T.C.1    Tanega, C.2    Shen, M.3    Wang, J.L.4    Auld, D.S.5
  • 53
    • 72649098153 scopus 로고    scopus 로고
    • Cdc2-like kinase 2 is an insulin-regulated suppressor of hepatic gluconeogenesis
    • Rodgers JT, Haas W, Gygi SP, Puigserver P (2010) Cdc2-like kinase 2 is an insulin-regulated suppressor of hepatic gluconeogenesis. Cell Metab 11: 23-34.
    • (2010) Cell Metab , vol.11 , pp. 23-34
    • Rodgers, J.T.1    Haas, W.2    Gygi, S.P.3    Puigserver, P.4


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