AKAP12 mediates barrier functions of fibrotic scars during CNS repair

PLoS ONE

Volumn 9, Issue 4, 2014, Pages

  Cha, Jong Ho ^a   Wee, Hee Jun ^a   Seo, Ji Hae ^a,g   Ahn, Bum Ju ^a   Park, Ji Hyeon ^a   Yang, Jun Mo ^a   Lee, Sae Won ^c   Kim, Eun Hee ^d   Lee, Ok Hee ^d   Heo, Ji Hoe ^d   Lee, Hyo Jong ^e   Gelman, Irwin H ^f   Arai, Ken ^g   Lo, Eng H ^g   Kim, Kyu Won ^a,b  

^a Seoul National University   (South Korea)

^b Seoul National University   (South Korea)

^c Seoul National University Hospital   (South Korea)

^d Yonsei University College of Medicine   (South Korea)

^e Inje University   (South Korea)

^f ROSWELL PARK CANCER INSTITUTE   (United States)

^g MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE ANCHORING PROTEIN; CYCLIC AMP DEPENDENT PROTEIN KINASE ANCHORING PROTEIN 12; UNCLASSIFIED DRUG; AKAP12 PROTEIN, MOUSE; CELL CYCLE PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN INJURY; CELL MIGRATION; CONTROLLED STUDY; DISEASE ASSOCIATION; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; MALE; MEMBRANE PERMEABILITY; MOUSE; NONHUMAN; PATHOLOGICAL ANATOMY; PROTEIN EXPRESSION; REGULATORY MECHANISM; SCAR FORMATION; TISSUE REGENERATION; VALIDATION STUDY; ANIMAL; C57BL MOUSE; CENTRAL NERVOUS SYSTEM; FIBROSIS; GENETICS; KNOCKOUT MOUSE; METABOLISM; PHYSIOLOGY; WESTERN BLOTTING; WISTAR RAT; WOUND HEALING;

A KINASE ANCHOR PROTEINS; ANIMALS; BLOTTING, WESTERN; CELL CYCLE PROTEINS; CENTRAL NERVOUS SYSTEM; FIBROSIS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RATS, WISTAR; WOUND HEALING;

EID: 84899713413     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0094695     Document Type: Article

References (32)

1. Gurtner GC, Werner S, Barrandon Y, Longaker MT (2008) Wound repair and regeneration. Nature 453: 314-321. (Pubitemid 351693137)
2. Chew DJ, Fawcett JW, Andrews MR (2012) The challenges of long-distance axon regeneration in the injured CNS. Prog Brain Res 201: 253-294.
3. London A, Cohen M, Schwartz M (2013) Microglia and monocyte-derived macrophages: functionally distinct populations that act in concert in CNS plasticity and repair. Front Cell Neurosci 7: 34.
4. Sirisinha S (2011) Insight into the mechanisms regulating immune homeostasis in health and disease. Asian Pac J Allergy Immunol 29: 1-14.
5. Shearer MC, Fawcett JW (2001) The astrocyte/meningeal cell interface-a barrier to successful nerve regeneration? Cell Tissue Res 305: 267-273. (Pubitemid 32681903)
6. Silver J, Miller JH (2004) Regeneration beyond the glial scar. Nat Rev Neurosci 5: 146-156. (Pubitemid 38160289)
7. Bradbury EJ, McMahon SB (2006) Spinal cord repair strategies: why do they work? Nat Rev Neurosci 7: 644-653. (Pubitemid 44106746)
8. Kawano H, Kimura-Kuroda J, Komuta Y, Yoshioka N, Li HP, et al. (2012) Role of the lesion scar in the response to damage and repair of the central nervous system. Cell Tissue Res.
9. Hellal F, Hurtado A, Ruschel J, Flynn KC, Laskowski CJ, et al. (2011) Microtubule stabilization reduces scarring and causes axon regeneration after spinal cord injury. Science 331: 928-931.
10. Goritz C, Dias DO, Tomilin N, Barbacid M, Shupliakov O, et al. (2011) A pericyte origin of spinal cord scar tissue. Science 333: 238-242.
11. Xia W, Unger P, Miller L, Nelson J, Gelman IH (2001) The Src-suppressed C kinase substrate, SSeCKS, is a potential metastasis inhibitor in prostate cancer. Cancer Res 61: 5644-5651. (Pubitemid 32694952)
12. Akakura S, Huang C, Nelson PJ, Foster B, Gelman IH (2008) Loss of the SSeCKS/Gravin/AKAP12 gene results in prostatic hyperplasia. Cancer Res 68: 5096-5103.
13. Su B, Bu Y, Engelberg D, Gelman IH (2010) SSeCKS/Gravin/AKAP12 inhibits cancer cell invasiveness and chemotaxis by suppressing a protein kinase C- Raf/MEK/ERK pathway. J Biol Chem 285: 4578-4586.
14. Weiser DC, Pyati UJ, Kimelman D (2007) Gravin regulates mesodermal cell behavior changes required for axis elongation during zebrafish gastrulation. Genes Dev 21: 1559-1571. (Pubitemid 46955727)
15. Watson BD, Dietrich WD, Busto R, Wachtel MS, Ginsberg MD (1985) Induction of reproducible brain infarction by photochemically initiated thrombosis. Ann Neurol 17: 497-504. (Pubitemid 15019990)
16. Wang LC, Futrell N, Wang DZ, Chen FJ, Zhai QH, et al. (1995) A reproducible model of middle cerebral infarcts, compatible with long-term survival, in aged rats. Stroke 26: 2087-2090.
17. Choi SA, Kim EH, Lee JY, Nam HS, Kim SH, et al. (2007) Preconditioning with chronic cerebral hypoperfusion reduces a focal cerebral ischemic injury and increases apurinic/apyrimidinic endonuclease/redox factor-1 and matrix metalloproteinase-2 expression. Curr Neurovasc Res 4: 89-97.
18. Jeong CH, Lee HJ, Cha JH, Kim JH, Kim KR, et al. (2007) Hypoxia-inducible factor-1 alpha inhibits self-renewal of mouse embryonic stem cells in Vitro via negative regulation of the leukemia inhibitory factor-STAT3 pathway. J Biol Chem 282: 13672-13679. (Pubitemid 47100567)
19. Bundesen LQ, Scheel TA, Bregman BS, Kromer LF (2003) Ephrin-B2 and EphB2 regulation of astrocyte-meningeal fibroblast interactions in response to spinal cord lesions in adult rats. J Neurosci 23: 7789-7800. (Pubitemid 37052347)
20. Herrmann JE, Imura T, Song B, Qi J, Ao Y, et al. (2008) STAT3 is a Critical Regulator of Astrogliosis and Scar Formation after Spinal Cord Injury. Journal of Neuroscience 28: 7231-7243.
21. Kuroiwa T, Xi G, Hua Y, Nagaraja TN, Fenstermacher JD, et al. (2009) Development of a rat model of photothrombotic ischemia and infarction within the caudoputamen. Stroke 40: 248-253.
22. Ikeshima-Kataoka H, Shen JS, Eto Y, Saito S, Yuasa S (2008) Alteration of inflammatory cytokine production in the injured central nervous system of tenascin-deficient mice. In Vivo 22: 409-413.
23. Baskaya MK, Rao AM, Dogan A, Donaldson D, Dempsey RJ (1997) The biphasic opening of the blood-brain barrier in the cortex and hippocampus after traumatic brain injury in rats. Neurosci Lett 226: 33-36. (Pubitemid 27190398)
24. O'Neill CA, Garrod D (2011) Tight junction proteins and the epidermis. Exp Dermatol 20: 88-91.
25. Kniesel U, Wolburg H (2000) Tight junctions of the blood-brain barrier. Cell Mol Neurobiol 20: 57-76. (Pubitemid 30090916)
26. Bazzoni G, Dejana E (2004) Endothelial cell-to-cell junctions: molecular organization and role in vascular homeostasis. Physiol Rev 84: 869-901. (Pubitemid 38823769)
27. Herrmann JE, Imura T, Song B, Qi J, Ao Y, et al. (2008) STAT3 is a critical regulator of astrogliosis and scar formation after spinal cord injury. J Neurosci 28: 7231-7243.
28. Okada S, Nakamura M, Katoh H, Miyao T, Shimazaki T, et al. (2006) Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury. Nature Medicine 12: 829-834. (Pubitemid 44050074)
29. Dragunow M (2013) Meningeal and choroid plexus cells-novel drug targets for CNS disorders. Brain Res 1501: 32-55.
30. Lo EH (2010) Degeneration and repair in central nervous system disease. Nat Med 16: 1205-1209.
31. Choi YK, Kim JH, Kim WJ, Lee HY, Park JA, et al. (2007) AKAP12 regulates human blood-retinal barrier formation by downregulation of hypoxia-inducible factor-1alpha. J Neurosci 27: 4472-4481.
32. Lee SW, Kim WJ, Choi YK, Song HS, Son MJ, et al. (2003) SSeCKS regulates angiogenesis and tight junction formation in blood-brain barrier. Nat Med 9: 900-906. (Pubitemid 36889933)