Structure and biological properties of lentztrehalose: A novel trehalose analog

Journal of Antibiotics

Volumn 67, Issue 4, 2014, Pages 319-322

  Wada, Shun Ichi ^a   Ohba, Shun Ichi ^a   Someno, Tetsuya ^a   Hatano, Masaki ^a   Nomoto, Akio ^a  

^a INSTITUTE OF MICROBIAL CHEMISTRY   (Japan)

Author keywords

antitumor; Lentzea; lentztrehalose; trehalase; trehalose

Indexed keywords

ANTINEOPLASTIC AGENT; HYDROLASE; LENTZTREHALOSE; TREHALASE; TREHALOSE; UNCLASSIFIED DRUG;

ACTINOBACTERIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BACTERIUM ISOLATION; BIOLOGICAL ACTIVITY; CARCINOMA CELL; DRUG STRUCTURE; DRUG SYNTHESIS; EHRLICH ASCITES TUMOR; FEMALE; LENTZEA; MAMMAL CELL; MICROORGANISM; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SARCOMA 180; WEIGHT GAIN;

ACTINOBACTERIA; ANIMALS; ANTINEOPLASTIC AGENTS; BONE DENSITY CONSERVATION AGENTS; CARCINOMA, EHRLICH TUMOR; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; FEMALE; HUMANS; MICE; MICE, INBRED ICR; MOLECULAR STRUCTURE; NON-NUTRITIVE SWEETENERS; OSTEOPOROSIS, POSTMENOPAUSAL; SARCOMA 180; SUBSTRATE SPECIFICITY; SURVIVAL ANALYSIS; TREHALASE; TREHALOSE; TUMOR BURDEN; WEIGHT GAIN;

EID: 84899711128     PISSN: 00218820     EISSN: 18811469     Source Type: Journal    
DOI: 10.1038/ja.2013.143     Document Type: Article

References (12)

1. Elbein, A. D., Pan, Y. T., Pastuszak, I & Carroll, D. New insights on trehalose: a multifunctional molecule. Glycobiology 13, 17R-27R (2003).
2. Ohtake, S. & Wang, Y. J. Trehalose: current use and future applications. J. Pharm. Sci. 100, 2020-2053 (2011).
3. Nishizaki, Y. et al. Disaccharide-trehalose inhibits bone resorption in ovariectomized mice. Nutr. Res. 20, 653-664 (2000).
4. Ukawa, Y., Gu, Y., Ohtsuki, M., Suzuki, I. & Hisamatsu, M. Antitumor effect of trehalose on sarcoma 180 in ICR mice. J. Appl. Glycosci. 52, 367-368 (2005).
5. Arai, C. et al. Trehalose prevents adipocyte hypertrophy and mitigates insulin resistance. Nutr. Res. 30, 840-848 (2010).
6. Okuda, J., Miwa, I., Maeda, K. & Tokui, K. Rapid and sensitive, colorimetric determination of the anomers of D-glucose with D-glucose oxidase, peroxidase, and mutarotase. Carbohydr. Res. 58, 267-270 (1977).
7. Arai, C. et al. Trehalose suppresses lipopolysaccharide-induced osteoclastogenesis bone marrow in mice. Nutr. Res. 21, 993-999 (2001).
8. Kawaguchi, T. et al. Unusual amino acid derivatives from the mushroom Pleurocybella porrigens. Tetrahedron 66, 504-507 (2010).
9. Nakashima, T. et al. Trehangelins A, B and C, novel photo-oxidative hemolysis inhibitors produced by an endophytic actinomycete, Polymorphospora rubra K07-0510. J. Antibiot. 66, 311-317 (2013).
10. Shirling, E. B. & Gottlieb, D. Methods for characterization of Streptomyces species. Int. J. Syst. Bacteriol. 16, 313-340 (1966).
11. Staneck, J. L. & Roberts, G. D. Simplified approach to identification of aerobic actinomycetes by thin-layer chromatography. Appl. Microbiol. 28, 226-231 (1974).
12. Igarashi, M. et al. Waldiomycin, a novel WalK-histidine kinase inhibitor from Streptomyces sp. MK844-mF10. J. Antibiot. 66, 459-464 (2013).