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71149115670
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Large deletions and point mutations involving the dedicator of cytokinesis 8 (DOCK8) in the autosomal-recessive form of hyper-IgE syndrome
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Combined immunodeficiency associated with DOCK8 mutations
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DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation
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Jabara H.H., McDonald D.R., Janssen E., Massaad M.J., Ramesh N., Borzutzky A., Rauter I., Benson H., Schneider L., Baxi S., Recher M., Notarangelo L.D., Wakim R., Dbaibo G., Dasouki M., Al-Herz W., Barlan I., Baris S., Kutukculer N., Ochs H.D., Plebani A., Kanariou M., Lefranc G., Reisli I., Fitzgerald K.A., Golenbock D., Manis J., Keles S., Ceja R., Chatila T.A., Geha R.S. DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation. Nat. Immunol. 2012, 13:612-620.
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Plasmacytoid dendritic cell depletion in DOCK8 deficiency: rescue of severe herpetic infections with interferon alpha-2b therapy
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Keles S., Jabara H.H., Reisli R., McDonald D.R., Barlan I., Hanna-Wakim R., Dbaibo R., Lefranc R., Al-Herz W., Geha R.S., Chatila T.A. Plasmacytoid dendritic cell depletion in DOCK8 deficiency: rescue of severe herpetic infections with interferon alpha-2b therapy. J. Allergy Clin. Immunol. 2014, (in press).
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Gotoh K., Tanaka Y., Nishikimi A., Inayoshi A., Enjoji M., Takayanagi R., Sasazuki T., Fukui Y. Differential requirement for DOCK2 in migration of plasmacytoid dendritic cells versus myeloid dendritic cells. Blood 2008, 111:2973-2976.
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Gotoh K., Tanaka Y., Nishikimi A., Nakamura R., Yamada H., Maeda N., Ishikawa T., Hoshino K., Uruno T., Cao Q., Higashi S., Kawaguchi Y., Enjoji M., Takayanagi R., Kaisho T., Yoshikai Y., Fukui Y. Selective control of type I IFN induction by the Rac activator DOCK2 during TLR-mediated plasmacytoid dendritic cell activation. J. Exp. Med. 2010, 207:721-730.
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Harada Y., Tanaka Y., Terasawa M., Pieczyk M., Habiro K., Katakai T., Hanawa-Suetsugu K., Kukimoto-Niino M., Nishizaki T., Shirouzu M., Duan X., Uruno T., Nishikimi A., Sanematsu F., Yokoyama S., Stein J.V., Kinashi T., Fukui Y. DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses. Blood 2012, 119:4451-4461.
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Crawford G., Enders A., Gileadi U., Stankovic S., Zhang Q., Lambe T., Crockford T.L., Lockstone H.E., Freeman A., Arkwright P.D., Smart J.M., Ma C.S., Tangye S.G., Goodnow C.C., Cerundolo V., Godfrey D.I., Su H.C., Randall K.L., Cornall R.J. DOCK8 is critical for the survival and function of NKT cells. Blood 2013, 122:2052-2061.
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Randall K.L., Chan S.S., Ma C.S., Fung I., Mei Y., Yabas M., Tan A., Arkwright P.D., Al Suwairi W., Lugo Reyes S.O., Yamazaki-Nakashimada M.A., Garcia-Cruz Mde L., Smart J.M., Picard C., Okada S., Jouanguy E., Casanova J.L., Lambe T., Cornall R.J., Russell S., Oliaro J., Tangye S.G., Bertram E.M., Goodnow C.C. DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice. J. Exp. Med. 2011, 208:2305-2320.
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