Multi-kinase inhibitor c1 triggers mitotic catastrophe of glioma stem cells mainly through melk kinase inhibition

PLoS ONE

Volumn 9, Issue 4, 2014, Pages

  Minata, Mutsuko ^a   Gu, Chunyu ^a,f   Joshi, Kaushal ^a   Nakano Okuno, Mariko ^a   Hong, Christopher ^a   Nguyen, Chi Hung ^c   Kornblum, Harley I ^d   Molla, Annie ^e   Nakano, Ichiro ^a,b  

^a THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c CNRS   (France)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e INSTITUT ALBERT BONNIOT   (France)

^f CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CELL ENZYME; MATERNAL EMBYONIC LEUCINE ZIPPER KINASE; MULTIKINASE INHIBITOR; UNCLASSIFIED DRUG; COMPLEMENT COMPONENT C1S INHIBITOR; MELK PROTEIN, HUMAN; PEPTIDE; PROTEIN KINASE INHIBITOR; PROTEIN SERINE THREONINE KINASE; SIOMYCIN A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER STEM CELL; CELL SURVIVAL; CONTROLLED STUDY; DISEASE ACTIVITY; DNA DAMAGE; DNA REPAIR; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; DRUG TARGETING; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; GLIOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MITOSIS INHIBITION; MOLECULAR DYNAMICS; MOLECULAR PATHOLOGY; MOUSE; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN INTERACTION; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS; SURVIVAL RATE; ANIMAL; CHEMICAL STRUCTURE; DRUG EFFECTS; IMMUNOCOMPROMIZED PATIENT; IMMUNOHISTOCHEMISTRY; METABOLISM; TUMOR CELL CULTURE; XENOGRAFT;

ANIMALS; CELL SURVIVAL; COMPLEMENT C1 INHIBITOR PROTEIN; DNA DAMAGE; DNA REPAIR; DOWN-REGULATION; GLIOMA; HETEROGRAFTS; HUMANS; IMMUNOCOMPROMISED HOST; IMMUNOHISTOCHEMISTRY; MICE; MODELS, MOLECULAR; NEOPLASTIC STEM CELLS; PEPTIDES; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; TUMOR CELLS, CULTURED;

EID: 84899688448     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0092546.g002     Document Type: Article

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