A New Operational Definition of Frailty: The Frailty Trait Scale

Journal of the American Medical Directors Association

Volumn 15, Issue 5, 2014, Pages 371.e7-371.e13

  García García, Francisco José ^a   Carcaillon, Laure ^b   Fernandez Tresguerres, Jesus ^c   Alfaro, Ana ^a   Larrion, Jose L ^d   Castillo, Carmen ^a   Rodriguez Mañas, Leocadio ^e  

^a HOSPITAL VIRGEN DE LA SALUD   (Spain)

^b INSERM   (France)

^c UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^d Universidad Pública de Navarra   (Spain)

^e HOSPITAL UNIVERSITARIO DE GETAFE   (Spain)

Author keywords

Aging; Comorbidity; Frailty; Lifestyle; Mortality; Sarcopenia; Weakness

Indexed keywords

BIOLOGICAL MARKER;

AGED; ARTICLE; CARDIOVASCULAR SYSTEM; COHORT ANALYSIS; COMORBIDITY; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; ENDURANCE; ENERGY BALANCE; FEMALE; FOLLOW UP; FRAILTY; FRAILTY TRAIT SCALE; GAIT; HOSPITALIZATION; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; NERVOUS SYSTEM; NUTRITION; PHYSICAL ACTIVITY; PREDICTIVE VALUE; PROSPECTIVE STUDY; RATING SCALE; RECEIVER OPERATING CHARACTERISTIC; SENSITIVITY AND SPECIFICITY; STRENGTH; SYNDROME; WEAKNESS; CONFIDENCE INTERVAL; DISABILITY; FRAIL ELDERLY; OUTCOME ASSESSMENT; STATISTICS AND NUMERICAL DATA; VERY ELDERLY;

AGED; AGED, 80 AND OVER; CONFIDENCE INTERVALS; DISABILITY EVALUATION; FEMALE; FRAIL ELDERLY; HOSPITALIZATION; HUMANS; MALE; MORTALITY; OUTCOME ASSESSMENT (HEALTH CARE); PROSPECTIVE STUDIES; ROC CURVE;

EID: 84899654467     PISSN: 15258610     EISSN: 15389375     Source Type: Journal    
DOI: 10.1016/j.jamda.2014.01.004     Document Type: Article

References (37)

1. Woo J., Leung J., Morley J.E. Comparison of frailty indicators based on clinical phenotype and the multiple deficit approach in predicting mortality and physical limitation. J Am Geriatr Soc 2012, 60:1478-1486.
2. Gobbens R.J., van Assen M.A., Luijkx K.G., et al. The Tilburg Frailty Indicator: Psychometric properties. J Am Med Dir Assoc 2010, 11:344-355.
3. Peters L.L., Boter H., Buskens E., Slaets J.P. Measurement properties of the Groningen Frailty Indicator in home-dwelling and institutionalized elderly people. J Am Med Dir Assoc 2012, 13:546-551.
4. Fried L.P., Tangen C.M., Walston J., et al. Frailty in older adults: Evidence for a phenotype. J Gerontol A Biol Sci Med Sci 2001, 56:M146-M156.
5. Rockwood K., Mitnitski A. Frailty in relation to the accumulation of deficits. J Gerontol A Biol Sci Med Sci 2007, 62:722-727.
6. Bergman H., Ferrucci L., Guralnik J., et al. Frailty: An emerging research and clinical paradigm-issues and controversies. J Gerontol A Biol Sci Med Sci 2007, 62:731-737.
7. Garcia-Garcia F.J., Larrion Zugasti J.L., Rodriguez Manas L. [Frailty: A phenotype under review]. Gac Sanit 2011, 25:51-58. Spanish.
8. Clegg A., Young J., Iliffe S., et al. Frailty in elderly people. Lancet 2013, 381:752-762.
9. Rodriguez-Manas L., Feart C., Mann G., et al. Searching for an operational definition of frailty: A Delphi method based consensus statement: The frailty operative definition-consensus conference project. J Gerontol A Biol Sci Med Sci 2013, 68:62-67.
10. Newman A.B., Gottdiener J.S., McBurnie M.A., et al. Associations of subclinical cardiovascular disease with frailty. J Gerontol A Biol Sci Med Sci 2001, 56:M158-M166.
11. Afilalo J., Karunananthan S., Eisenberg M.J., et al. Role of frailty in patients with cardiovascular disease. Am J Cardiol 2009, 103:1616-1621.
12. Alonso-Bouzon C., Carcaillon L., Garcia-Garcia F.J., et al. Association between endothelial dysfunction and frailty: The Toledo Study for Healthy Aging. Age (Dordr) 2013, Epub ahead of print.
13. Garcia-Garcia F.J., Gutierrez Avila G., Alfaro-Acha A., et al. The prevalence of frailty syndrome in an older population from Spain. The Toledo Study for Healthy Aging. J Nutr Health Aging 2011, 15:852-856.
14. Katz S., Ford A.B., Moskowitz R.W., et al. Studies of illness in the aged. The Index of ADL: A standardized measure of biological and psychosocial function. JAMA 1963, 185:914-919.
15. Lawton M.P., Brody E.M. Assessment of older people: Self-maintaining and instrumental activities of daily living. Gerontologist 1969, 9:179-186.
16. Sheikh J., Yesavage J. Geriatric Depression Scale (GDS): Recent evidence and development of a shorter version. Clin Gerontol 1986, 5:165-172.
17. Escribano-Aparicio M.V., Perez-Dively M., Garcia-Garcia F.J., et al. Validación del MMSE de Folstein en una población española de bajo nivel educativo. Rev Esp Geriatr Gerontol 1999, 34:319-326.
18. Folstein M.F., Folstein S.E., McHugh P.R. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975, 12:189-198.
19. Del Ser Quijano T., Sánchez Sánchez F., García de Yébenez M.J., et al. [Spanish version of the 7-minute screening neurocognitive battery. Normative data of an elderly population sample over 70.]. Neurologia 2004, 19:344-358. Spanish.
20. Solomon P.R., Hirschoff A., Kelly B., et al. A 7 minute neurocognitive screening battery highly sensitive to Alzheimer's disease. Arch Neurol 1998, 55:349-355.
21. Schuit A.J., Schouten E.G., Westerterp K.R., Saris W.H. Validity of the Physical Activity Scale for the Elderly (PASE): According to energy expenditure assessed by the doubly labeled water method. J Clin Epidemiol 1997, 50:541-546.
22. Guralnik J.M., Simonsick E.M., Ferrucci L., et al. A short physical performance battery assessing lower extremity function: Association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol 1994, 49:M85-M94.
23. Fowkes F.G., Low L.P., Tuta S., Kozak J. AGATHA Investigators. Ankle-brachial index and extent of atherothrombosis in 8891 patients with or at risk of vascular disease: Results of the international AGATHA study. Eur Heart J 2006, 27:1861-1867.
24. Fowkes F.G., Murray G.D., Butcher I., et al. Ankle brachial index combined with Framingham Risk Score to predict cardiovascular events and mortality: A meta-analysis. JAMA 2008, 300:197-208. Ankle Brachial Index Collaboration.
25. Searle S.D., Mitnitski A., Gahbauer E.A., et al. A standard procedure for creating a frailty index. BMC Geriatr 2008, 8:24.
26. McNeil B.J., Hanley J.A., Funkenstein H.H., Wallman J. Paired receiver operating characteristic curves and the effect of history on radiographic interpretation. CT of the head as a case study. Radiology 1983, 149:75-77.
27. Rockwood K., Song X., MacKnight C., et al. A global clinical measure of fitness and frailty in elderly people. CMAJ 2005, 173:489-495.
28. Hubbard R.E., Woodhouse K.W. Frailty, inflammation and the elderly. Biogerontology 2010, 11:635-641.
29. Rafnsson S.B., Deary I.J., Smith F.B., et al. Cognitive decline and markers of inflammation and hemostasis: The Edinburgh Artery Study. J Am Geriatr Soc 2007, 55:700-707.
30. Dowlati Y., Herrmann N., Swardfager W., et al. A meta-analysis of cytokines in major depression. Biol Psychiatry 2010, 67:446-457.
31. Handschin C., Spiegelman B.M. The role of exercise and PGC1alpha in inflammation and chronic disease. Nature 2008, 454:463-469.
32. Pedersen B.K. The diseasome of physical inactivity-and the role of myokines in muscle-fat cross talk. J Physiol 2009, 587:5559-5568.
33. Carcaillon L., Blanco C., Alonso-Bouzon C., et al. Sex differences in the association between serum levels of testosterone and frailty in an elderly population: The Toledo Study for Healthy Aging. PLoS One 2012, 7:e32401.
34. Hyde Z., Flicker L., Almeida O.P., et al. Low free testosterone predicts frailty in older men:the health in men study. J Clin Endocrinol Metab 2010, 95:3165-3172.
35. Payette H., Roubenoff R., Jacques P.F., et al. Insulin-like growth factor-1 and interleukin 6 predict sarcopenia in very old community-living men and women: The Framingham Heart Study. J Am Geriatr Soc 2003, 51:1237-1243.
36. Sakuma K., Yamaguchi A. Sarcopenia and age-related endocrine function. Int J Endocrinol 2012, 2012:127362.
37. Voznesensky M., Walsh S., Dauser D., et al. The association between dehydroepiandosterone and frailty in older men and women. Age Ageing 2009, 38:401-406.