Growth, metabolism, and growth inhibitors of mesenchymal stem cells

Tissue Engineering - Part A

Volumn 15, Issue 8, 2009, Pages 1877-1886

  Schop, Deborah ^a   Janssen, Frank W ^a,b   Van Rijn, Linda D S ^a,c   Fernandes, Hugo ^b   Bloem, Rolf M ^d   De Bruijn, Joost D ^a,c,e   Van Dijkhuizen Radersma, Riemke ^a,c  

^a XPand Biotechnology BV   (Netherlands)

^b UNIVERSITY OF TWENTE   (Netherlands)

^c Progentix Orthobiology BV   (Netherlands)

^d Department of Orthopaedic Surgery Reinier de Graaf Gasthuis ^*  (Netherlands)

^e QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOCHEMISTRY; CELL MEMBRANES; FLOWCHARTING; GLUCOSE; MAMMALS; METABOLISM; METABOLITES; TISSUE;

BONE MARROW STROMAL CELLS; ENERGY SOURCE; EXPANSION FACTORS; GROWTH INHIBITION; GROWTH INHIBITOR; INHIBITORY CONCENTRATION; MAMMALIAN SPECIES; MESENCHYMAL STEM CELL; METABOLITE PRODUCTION; NUTRIENT CONSUMPTION; THERAPEUTIC APPLICATION;

CELL CULTURE;

AMMONIA; GLUCOSE; GLUTAMINE; LACTIC ACID;

ANIMAL CELL; ARTICLE; CELL GROWTH; GOAT; GROWTH INHIBITION; HUMAN; HUMAN CELL; MAMMAL; MESENCHYMAL STEM CELL; METABOLITE; MULTIPOTENT STEM CELL; NONHUMAN; NUTRIENT; PRIORITY JOURNAL; RAT; SPECIES DIFFERENCE;

CAPRA HIRCUS; MAMMALIA; RATTUS;

ADULT; AMMONIA; ANIMALS; CELL PROLIFERATION; CELL SHAPE; GLUCOSE; GLUTAMINE; GOATS; GROWTH INHIBITORS; HUMANS; LACTIC ACID; MESENCHYMAL STEM CELLS; MULTIPOTENT STEM CELLS; ORGAN SPECIFICITY; RATS; TIME FACTORS; TISSUE DONORS;

EID: 68749109438     PISSN: 19373341     EISSN: 1937335X     Source Type: Journal    
DOI: 10.1089/ten.tea.2008.0345     Document Type: Article

References (34)

1. Prockop, D.J. Marrow stromal cells as stem cells for non-hematopoietic tissues. Science 276, 71, 1997.
2. Pittenger, M.F., Mackay, A.M., Beck, S.C., Jaiswal, R.K., Douglas, R., Mosca, J.D., Moorman, M.A., Simonetti, D.W., Craig, S., and Marshak, D.R. Multilineage potential of adult human mesenchymal stem cells. Science 284, 143, 1999.
3. Caplan, A.I., and Bruder, S.P. Mesenchymal stem cells: building blocks for molecular medicine in the 21st century. Trends Mol Med 7, 259, 2001.
4. Caplan, A.I. Mesenchymal stem cells. J Orthop Res 9, 641, 1991.
5. Aubin, J.E. Bone stem cells. J Cell Biochem Suppl 30-31, 73, 1998.
6. de Bruijn, J.D., and van Blitterswijk, CA. New developments in implant coatings: biomimetics and tissue engineering. In: Walenkamp, G., ed. Biomaterials in Surgery. Stuttgart: Georg Thieme Verlag, 1998, pp. 77-82.
7. Martin, I., Wendt, D., and Heberer, M. The role of bior-eactors in tissue engineering. Trends Biotechnol 22, 80, 2004.
8. Portner, R., Nagel-Heyer, S., Goepfert, C., Adamietz, P., and Meenen, N.M. Bioreactor design for tissue engineering. J Biosci Bioeng 100, 235, 2005.
9. Frauenschuh, S., Reichmann, E., Ibold, Y., Goetz, P.M., Sit-tinger, M., and Ringe, J. A microcarrier-based cultivation system for expansion of primary mesenchymal stem cells. Biotechnol Prog 23, 187, 2007.
10. Schop, D., Janssen, F.W., Borgart, E., de Bruijn, J.D., and van Dijkhuizen-Radersma, R. Expansion of mesenchymal stem cells using a microcarrier-based cultivation system: growth and metabolism. J Tissue Eng Regen Med 2, 126, 2008.
11. Glacken, M.W. Catabolic control of mammalian cell culture. Biotechnology 6, 1041, 1988.
12. Newsholme, P., and Newsholme, E.A. Rates of utilization of glucose, glutamine and oleate and formation of end-products by mouse peritoneal macrophages in culture. Biochem J 261, 211, 1989.
13. Ozturk, S.S., and Palsson, B.O. Growth, metabolic, and antibody kinetics of hybridoma cell culture: 2. Effect of serum concentration, dissolved oxygen concentration, and medium pH in a batch reactor. Biotechnol Prog 7, 481, 1991.
14. Ljuggren, J., and Haggstrom, L. Catabolic control of hybridoma cells by glucose and glutamine limited fed batch cultures. Biotechnol Bioeng 44, 808, 1994.
15. Schneider, M., Marison, I.W., and von Stockar, U. The importance of ammonia in mammalian cell culture. J Biotechnol 49, 161, 1996.
16. Hassell, T., Gleave, S., and Butler, M. Growth inhibition in animal cell culture. The effect of lactate and ammonia. Appl Biochem Biotechnol 30, 29, 1991.
17. Dean, R.T., Jessup, W., and Roberts, C.R. Effect of exogenous amines on mammalian cells, with particular reference to membrane flow. Biochem J 217, 27, 1984.
18. de Bruijn, J.D., van den Brink, I., Bovell, Y.P., and van Blitterswijk, CA. Tissue engineering of goat bone: osteogenic potential of goat bone marrow cells. Bioceramics 11, 497, 1998.
19. Both, S.K., van der Muijsenberg, A.J.C., van Blitterswijk, CA., de Boer, J., and de Bruijn, J.D. A rapid and efficient method for expansion of human mesenchymal stem cells. Tissue Eng 13, 3, 2007.
20. Xiao, Y., Peperzak, V., van Rijn, L.D.S., Borst, J., and de Bruijn, J.D. Dexamethasone treatment during the expansion phase maintains sternness of mesenchymal stem cells (In preparation).
21. D'Ippolito, G., Diabira, S., Howard, G., and Schiller, P. Low oxygen tensions inhibits osteogenic differentiation and enhances sternness of human MIAMI cells. Bone 39, 513, 2006.
22. Phinney, D.G., Kopen, G., Righter, W., Webster, S., Tremain, N., and Prockop, D.J. Donor variation in the growth properties and osteogenic potential of human marrow stromal cells. J Cell Biochem 75, 424, 1999.
23. Mendes, S.C., Tibbe, J.M., Veenhof, M., Bakker, K., Both, S., Platenburg, P.P., Oner, F.C., de Bruijn, J.D., and van Blitterswijk, CA. Bone tissue engineered implants using human bone marrow stromal cells: effect of culture conditions and donor age. Tissue Eng 8, 911, 2002.
24. Siddappa, R., Licht, R., van Blitterswijk, C.A., and de Boer, J. Donor variation and loss of multipotency during in vitro expansion of human mesenchymal stem cells for bone tissue engineering. J Orthop Res 25, 1029, 2007.
25. Tritsch, G.L., and Moore, G.E. Spontaneous decomposition of glutamine in cell culture media. Exp Cell Res 25, 360, 1962.
26. Capiaumont, J., Legrand, C., Carbonell, D., Dousset, B., Belleville, F., and Nabet, P. Methods for reducing the ammonia in hybridoma cell cultures. J Biotechnol 39, 49, 1995.
27. Lao, M.S., and Toth, D. Effects of ammonium and lactate on growth and metabolism of a recombinant Chinese hamster ovary cell culture. Biotechnol Prog 13, 688, 1997.
28. Neermann, J., and Wagner, R. Comparative analysis of glucose and glutamine metabolism in transformed mammalian cell line, insect and primary liver cells. J Cell Physiol 166, 152, 1996.
29. Grant, J.L., and Smith, B. Bone marrow gas tensions, bone marrow blood flow, and erythropoiesis in man. Ann Intern Med 58, 801, 1963.
30. Wang, D.W., Fermor, B., Gimble, J.M., Awad, H.A., and Guilak, F. Influence of oxygen on the proliferation and metabolism of adipose derived adult stem cells. J Cell Physiol 204, 184, 2005.
31. Ozturk, S.S., Riley, M.R., and Palsson, B.O. Effects of ammonia and lactate on hybridoma growth, metabolism, and antibody production. Biotechnol Bioeng 39, 418, 1992.
32. McQueen, A., and Bailey, J.E. Effect of ammonium ion and extracellular pH on hybridoma cell metabolism and antibody production. Biotechnol Bioeng 35, 1067, 1990.
33. Reuveny, S., Velez, D., Macmillan, J.D., and Miller, L. Factors affecting cell growth and monoclonal antibody production in stirred reactors. J Immunol Methods 86, 53, 1986.
34. Patel, S.D., Papoutsakis, E.T., Winter, J.N., and Miller, W.M. The lactate issue revisited: novel feeding protocols to examine inhibition of cell proliferation and glucose metabolism in hematopoietic cell culture. Biotechnol Prog 16, 885, 2000.