-
1
-
-
1542329005
-
The erbB family: Targets for therapeutic development against cancer and therapeutic strategies using monoclonal antibodies and tyrosine kinase inhibitors
-
Rowinski EK. The erbB family: targets for therapeutic development against cancer and therapeutic strategies using monoclonal antibodies and tyrosine kinase inhibitors. Annu Rev Med. 2004;55:433-457.
-
(2004)
Annu Rev Med
, vol.55
, pp. 433-457
-
-
Rowinski, E.K.1
-
2
-
-
43249096031
-
Structure and relevance of the epidermal growth factor receptor in human cancer
-
Kumar A, Petri ET, Halmos B, et al. Structure and relevance of the epidermal growth factor receptor in human cancer. J Clin Oncol. 2008;26:1742-1751.
-
(2008)
J Clin Oncol
, vol.26
, pp. 1742-1751
-
-
Kumar, A.1
Petri, E.T.2
Halmos, B.3
-
3
-
-
69949162760
-
Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
-
Mok TS, Wu YL, Thongprasert S, et al. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med. 2009;361:947-957.
-
(2009)
N Engl J Med
, vol.361
, pp. 947-957
-
-
Mok, T.S.1
Wu, Y.L.2
Thongprasert, S.3
-
4
-
-
72449160988
-
A randomized phase III study of gefitinib (IRESSA) versus standard chemotherapy (gemcitabine plus cisplatin) as a first-line treatment for never-smokers with advanced or metastatic adenocarcinoma of the lung
-
abst PRS 4
-
Lee JS, Park K, Kim S-W, et al. A randomized phase III study of gefitinib (IRESSA) versus standard chemotherapy (gemcitabine plus cisplatin) as a first-line treatment for never-smokers with advanced or metastatic adenocarcinoma of the lung. J Thor Oncol. 2009;4(SUPPL 19): abst PRS 4.
-
(2009)
J Thor Oncol
, vol.4
, Issue.SUPPL. 19
-
-
Lee, J.S.1
Park, K.2
Kim, S.-W.3
-
5
-
-
75249087060
-
Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): An open label, randomised phase 3 trial
-
Mitsudomi T, Morita S, Yatabe Y, et al. Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial. Lancet Oncol. 2010;11:121-128.
-
(2010)
Lancet Oncol
, vol.11
, pp. 121-128
-
-
Mitsudomi, T.1
Morita, S.2
Yatabe, Y.3
-
6
-
-
77953930730
-
Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR
-
Maemondo M, Inoue A, Kobayashi K, et al. Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. N Engl J Med. 2010;362:2380-2388.
-
(2010)
N Engl J Med
, vol.362
, pp. 2380-2388
-
-
Maemondo, M.1
Inoue, A.2
Kobayashi, K.3
-
7
-
-
79960889662
-
Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): A multicentre, open-label, randomised, phase 3 study
-
Zhou CC, Wu YL, Chen G, et al. Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study. Lancet Oncol. 2011;12: 735-742.
-
(2011)
Lancet Oncol
, vol.12
, pp. 735-742
-
-
Zhou, C.C.1
Wu, Y.L.2
Chen, G.3
-
8
-
-
84857502654
-
Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutations-positive non-small cell lung cancer (EURTAC) a multicenter, open-label, randomized phase 3 trial. Results of the European Erlotinib Versus Chemotherapy (EURTAC) phase III randomized trial
-
Rosell R, Carcereny E, Gervais R, et al. Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutations-positive non-small cell lung cancer (EURTAC) a multicenter, open-label, randomized phase 3 trial. Results of the European Erlotinib Versus Chemotherapy (EURTAC) phase III randomized trial. Lancet Oncol. 2012;13(3):239-246.
-
(2012)
Lancet Oncol
, vol.13
, Issue.3
, pp. 239-246
-
-
Rosell, R.1
Carcereny, E.2
Gervais, R.3
-
9
-
-
13844317894
-
EGFR mutation and resistance of non-small-cell lung cancer to gefitinib
-
Kobayashi S, Boggon TJ, Dayaram T, et al. EGFR mutation and resistance of non-small-cell lung cancer to gefitinib. N Engl J Med. 2005;352:786-792.
-
(2005)
N Engl J Med
, vol.352
, pp. 786-792
-
-
Kobayashi, S.1
Boggon, T.J.2
Dayaram, T.3
-
10
-
-
33751292685
-
Novel D761Y and common secondary T790M mutations in epidermal growth factor receptor-mutant lung adenocarcinoma with acquired resistance to kinase inhibitors
-
Balak MN, Gong Y, Riely GJ, et al. Novel D761Y and common secondary T790M mutations in epidermal growth factor receptor-mutant lung adenocarcinoma with acquired resistance to kinase inhibitors. Clin Cancer Res. 2006;12:6494-6501.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 6494-6501
-
-
Balak, M.N.1
Gong, Y.2
Riely, G.J.3
-
11
-
-
34249075147
-
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
-
Engelman JA, Zajnullahu K, Mitsudomi T, et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science. 2007;316:1039-1043.
-
(2007)
Science
, vol.316
, pp. 1039-1043
-
-
Engelman, J.A.1
Zajnullahu, K.2
Mitsudomi, T.3
-
12
-
-
84877100240
-
Analysis of tumor specimens at the time of acquired resistance to EGFR-TKI therapy in 155 patients with EGFR-mutant lung cancers
-
Yu HA, Arcila ME, Rekhtman N, et al. Analysis of tumor specimens at the time of acquired resistance to EGFR-TKI therapy in 155 patients with EGFR-mutant lung cancers. Clin Cancer Res. 2013;19(8): 2240-2247.
-
(2013)
Clin Cancer Res
, vol.19
, Issue.8
, pp. 2240-2247
-
-
Yu, H.A.1
Arcila, M.E.2
Rekhtman, N.3
-
13
-
-
79953118839
-
Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors
-
75ra26
-
Sequist LV, Waltman BA, Dias-Santagata D, et al. Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors. Sci Transl Med. 2011;3:75ra26.
-
(2011)
Sci Transl Med
, vol.3
-
-
Sequist, L.V.1
Waltman, B.A.2
Dias-Santagata, D.3
-
14
-
-
33750302365
-
Analysis of epidermal growth factor receptor gene mutation in patients with non-small cell lung cancer and acquired resistance to gefitinib
-
Kosaka T, Yatabe Y, Endoh H, et al. Analysis of epidermal growth factor receptor gene mutation in patients with non-small cell lung cancer and acquired resistance to gefitinib. Clin Cancer Res. 2006;12:5764-5769.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 5764-5769
-
-
Kosaka, T.1
Yatabe, Y.2
Endoh, H.3
-
15
-
-
18244371651
-
Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
-
Pao W, Miller VA, Politi KA, et al. Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med. 2005;225/2(3):e73.
-
(2005)
PLoS Med
, vol.2
, Issue.3
-
-
Pao, W.1
Miller, V.A.2
Politi, K.A.3
-
16
-
-
34547625913
-
Oncogenic activity of epidermal growth factor receptor kinase mutant alleles is enhanced by the T790M drug resistance mutation
-
Godin-Heymann N, Bryant I, Rivera MN, et al. Oncogenic activity of epidermal growth factor receptor kinase mutant alleles is enhanced by the T790M drug resistance mutation. Cancer Res. 2006;67:7319-7326.
-
(2006)
Cancer Res
, vol.67
, pp. 7319-7326
-
-
Godin-Heymann, N.1
Bryant, I.2
Rivera, M.N.3
-
17
-
-
33748074447
-
Presence of epidermal growth factor receptor gene T790M mutation as a minor clone in non-small cell lung cancer
-
Inukai M, Toyooka S, Ito S, et al. Presence of epidermal growth factor receptor gene T790M mutation as a minor clone in non-small cell lung cancer. Cancer Res. 2008;266:7854-7858.
-
(2008)
Cancer Res
, vol.266
, pp. 7854-7858
-
-
Inukai, M.1
Toyooka, S.2
Ito, S.3
-
18
-
-
49149118719
-
BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models
-
Li D, Ambrogio L, Shimamura T, et al. BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models. Oncogene. 2008;27(34):4702-4711.
-
(2008)
Oncogene
, vol.27
, Issue.34
, pp. 4702-4711
-
-
Li, D.1
Ambrogio, L.2
Shimamura, T.3
-
19
-
-
84867621201
-
Target binding properties and cellular activity of afatinib (BIBW 2992), an irreversible ErbB family blocker
-
Solca F, Dahl G, Zoephel A, et al. Target binding properties and cellular activity of afatinib (BIBW 2992), an irreversible ErbB family blocker. J Pharmacol Exp Ther. 2012;343(2):342-350.
-
(2012)
J Pharmacol Exp Ther
, vol.343
, Issue.2
, pp. 342-350
-
-
Solca, F.1
Dahl, G.2
Zoephel, A.3
-
20
-
-
84859793822
-
Afatinib pharmacokinetics and metabolism after oral administration to healthy male volunteers
-
Stopfer P, MArzin K, Narjes H, et al. Afatinib pharmacokinetics and metabolism after oral administration to healthy male volunteers. Cancer Chemother Pharmacol. 2012;69(4):1051-1061.
-
(2012)
Cancer Chemother Pharmacol
, vol.69
, Issue.4
, pp. 1051-1061
-
-
Stopfer, P.1
Marzin, K.2
Narjes, H.3
-
21
-
-
77957585027
-
Phase I trial of the irreversible EGFR and HER2 kinase inhibitor BIBW 2992 in patients with advanced solid tumors
-
Yap TA, Vidal L, Adam J, et al. Phase I trial of the irreversible EGFR and HER2 kinase inhibitor BIBW 2992 in patients with advanced solid tumors. J Clin Oncol. 2010;28(25):3965-3972.
-
(2010)
J Clin Oncol
, vol.28
, Issue.25
, pp. 3965-3972
-
-
Yap, T.A.1
Vidal, L.2
Adam, J.3
-
22
-
-
84885994849
-
Pharmacokinetics of afatinib, a selective irreversible ErbB family blocker, in patients with advanced solid tumours
-
Wind S, Schmid M, Erhardt J, Goeldner RG, Stopfer P. Pharmacokinetics of afatinib, a selective irreversible ErbB family blocker, in patients with advanced solid tumours. Clin Pharmacokinet. 2013;52(12):1101-1109.
-
(2013)
Clin Pharmacokinet
, vol.52
, Issue.12
, pp. 1101-1109
-
-
Wind, S.1
Schmid, M.2
Erhardt, J.3
Goeldner, R.G.4
Stopfer, P.5
-
23
-
-
84862819699
-
Afatinib for patients with lung adenocarcinoma and epidermal growth factor receptor mutations (LUX-Lung 2): A phase 2 trial
-
Yang JC, Shih JY, Su WC, et al. Afatinib for patients with lung adenocarcinoma and epidermal growth factor receptor mutations (LUX-Lung 2): a phase 2 trial. Lancet Oncol. 2012;13(5):539-548.
-
(2012)
Lancet Oncol
, vol.13
, Issue.5
, pp. 539-548
-
-
Yang, J.C.1
Shih, J.Y.2
Su, W.C.3
-
24
-
-
84884736973
-
Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations
-
Sequist LV, Yang JC, Yamamoto N, et al. Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations. J Clin Oncol. 2013;31(27):3327-3334.
-
(2013)
J Clin Oncol
, vol.31
, Issue.27
, pp. 3327-3334
-
-
Sequist, L.V.1
Yang, J.C.2
Yamamoto, N.3
-
25
-
-
84884659258
-
LUX-Lung 6: A randomized, open-label, phase III study of afatinib (A) versus gemcitabine/cisplatin (GC) as first-line treatment for Asian patients (pts) with EGFR mutation-positive (EGFR M+) advanced adenocarcinoma of the lung
-
abst 8016
-
Wu YL, Zhou C, Hu CP, et al. LUX-Lung 6: a randomized, open-label, phase III study of afatinib (A) versus gemcitabine/cisplatin (GC) as first-line treatment for Asian patients (pts) with EGFR mutation-positive (EGFR M+) advanced adenocarcinoma of the lung. J Clin Oncol. 2013;31(SUPPL): abst 8016.
-
(2013)
J Clin Oncol
, vol.31
, Issue.SUPPL.
-
-
Wu, Y.L.1
Zhou, C.2
Hu, C.P.3
-
28
-
-
79957916527
-
Effectiveness of tyrosine kinase inhibitors on "uncommon" epidermal growth factor receptor mutations of unknown clinical significance in non-small cell lung cancer
-
Wu JY, Yu CJ, Chang YC, et al. Effectiveness of tyrosine kinase inhibitors on "uncommon" epidermal growth factor receptor mutations of unknown clinical significance in non-small cell lung cancer. Clin Cancer Res. 2011;17(11):3812-3821.
-
(2011)
Clin Cancer Res
, vol.17
, Issue.11
, pp. 3812-3821
-
-
Wu, J.Y.1
Yu, C.J.2
Chang, Y.C.3
-
30
-
-
84862785051
-
Afatinib versus placebo for patients with advanced, metastatic non-small-cell lung cancer after failure of erlotinib, gefitinib, or both, and one or two lines of chemotherapy (LUX-Lung 1): A phase 2b/3 randomised trial
-
Miller VA, Hirsh V, Cadranel J, et al. Afatinib versus placebo for patients with advanced, metastatic non-small-cell lung cancer after failure of erlotinib, gefitinib, or both, and one or two lines of chemotherapy (LUX-Lung 1): a phase 2b/3 randomised trial. Lancet Oncol. 2012;13(5):528-538.
-
(2012)
Lancet Oncol
, vol.13
, Issue.5
, pp. 528-538
-
-
Miller, V.A.1
Hirsh, V.2
Cadranel, J.3
-
31
-
-
74949110711
-
Clinical definition of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer
-
Jackman D, Pao W, Riely GJ, et al. Clinical definition of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer. J Clin Oncol. 2010;28(2): 357-360.
-
(2010)
J Clin Oncol
, vol.28
, Issue.2
, pp. 357-360
-
-
Jackman, D.1
Pao, W.2
Riely, G.J.3
-
32
-
-
84891333707
-
Ability of the Met kinase inhibitor crizotinib and new generation EGFR inhibitors to overcome resistance to EGFR inhibitors
-
Nanjo S, Yamada T, Nishihara H, et al. Ability of the Met kinase inhibitor crizotinib and new generation EGFR inhibitors to overcome resistance to EGFR inhibitors. PLoS One. 2013;8(12):e84700.
-
(2013)
PLoS One
, vol.8
, Issue.12
-
-
Nanjo, S.1
Yamada, T.2
Nishihara, H.3
-
33
-
-
84884618137
-
LUX-Lung 4: A phase II trial of afatinib in patients with advanced non-small-cell lung cancer who progressed during prior treatment with erlotinib, gefitinib or both
-
Katakami N, Atagi S, Goto K, et al. LUX-Lung 4: a phase II trial of afatinib in patients with advanced non-small-cell lung cancer who progressed during prior treatment with erlotinib, gefitinib or both. J Clin Oncol. 2013;31(27):3335-3341.
-
(2013)
J Clin Oncol
, vol.31
, Issue.27
, pp. 3335-3341
-
-
Katakami, N.1
Atagi, S.2
Goto, K.3
-
34
-
-
80052441453
-
Activity and tolerability of afatinib (BIBW 2992) and cetuximab in NSCLC patients with acquired resistance to erlotinib or gefitinib
-
abst 7525
-
Janjigian YY, Groen HJ, Horn L, et al. Activity and tolerability of afatinib (BIBW 2992) and cetuximab in NSCLC patients with acquired resistance to erlotinib or gefitinib. J Clin Oncol. 2011;29(SUPPL): abst 7525.
-
(2011)
J Clin Oncol
, vol.29
, Issue.SUPPL.
-
-
Janjigian, Y.Y.1
Groen, H.J.2
Horn, L.3
-
35
-
-
70349684791
-
Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer
-
Regales L, Gong Y, Shen R, et al. Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer. J Clin Invest. 2009;119(10):3000-3010.
-
(2009)
J Clin Invest
, vol.119
, Issue.10
, pp. 3000-3010
-
-
Regales, L.1
Gong, Y.2
Shen, R.3
-
36
-
-
84879347673
-
Dermatologic adverse events associated with afatinib: An oral ErbB family blocker
-
Lacouture ME, Schadendorf D, Chu CY, et al. Dermatologic adverse events associated with afatinib: an oral ErbB family blocker. Expert Rev Anticancer Ther. 2013;13(6):721-728.
-
(2013)
Expert Rev Anticancer Ther
, vol.13
, Issue.6
, pp. 721-728
-
-
Lacouture, M.E.1
Schadendorf, D.2
Chu, C.Y.3
-
37
-
-
84879347777
-
Diarrhea associated with afatinib: An oral ErbB family blocker
-
Yang JC, Reguart N, Barinoff J, et al. Diarrhea associated with afatinib: an oral ErbB family blocker. Expert Rev Anticancer Ther. 2013;13(6): 729-736.
-
(2013)
Expert Rev Anticancer Ther
, vol.13
, Issue.6
, pp. 729-736
-
-
Yang, J.C.1
Reguart, N.2
Barinoff, J.3
-
38
-
-
84873814691
-
Symptom and quality of life benefit of afatinib in advanced non-small-cell lung cancer patients previously treated with erlotinib or gefitinib: Results of a randomized phase IIb/III trial (LUX-Lung 1)
-
Hirsh V, Cadranel J, Cong XJ, et al. Symptom and quality of life benefit of afatinib in advanced non-small-cell lung cancer patients previously treated with erlotinib or gefitinib: results of a randomized phase IIb/III trial (LUX-Lung 1). J Thorac Oncol. 2013;8:229-237.
-
(2013)
J Thorac Oncol
, vol.8
, pp. 229-237
-
-
Hirsh, V.1
Cadranel, J.2
Cong, X.J.3
-
39
-
-
84884605223
-
Symptom control and quality of life in LUX-Lung 3: A phase III study of afatinib or cisplatin/pemetrexed in patients with advanced lung adenocarcinoma with EGFR mutations
-
Yang JC, Hirsh V, Schuler M, et al. Symptom control and quality of life in LUX-Lung 3: a phase III study of afatinib or cisplatin/pemetrexed in patients with advanced lung adenocarcinoma with EGFR mutations. J Clin Oncol. 2013;31(27):3342-3350.
-
(2013)
J Clin Oncol
, vol.31
, Issue.27
, pp. 3342-3350
-
-
Yang, J.C.1
Hirsh, V.2
Schuler, M.3
-
40
-
-
84899660007
-
-
October 27-31, Sydney, Australia; abst 8061
-
Geater SL, Zhou C, Hu C, et al. LUX-Lung 6: Patient-reported outcomes (PROs) from a randomized open-label, phase III study in first-line advanced NSCLC patients (pts) harboring epidermal growth factor receptor (EGFR) mutations. Abstract at: World Congress on Lung Cancer; October 27-31; 2013; Sydney, Australia; abst 8061.
-
(2013)
LUX-Lung 6: Patient-reported Outcomes (PROs) From a Randomized Open-label, Phase III Study In First-line Advanced NSCLC Patients (pts) Harboring Epidermal Growth Factor Receptor (EGFR) Mutations. Abstract At: World Congress On Lung Cancer
-
-
Geater, S.L.1
Zhou, C.2
Hu, C.3
|