메뉴 건너뛰기




Volumn 8, Issue , 2014, Pages 183-192

Clinical and comparative utility of afatinib in non-small cell lung cancer

Author keywords

Afatinib; EGFR; NSCLC; Tyrosine kinase inhibitor

Indexed keywords

AFATINIB; ANTIBIOTIC AGENT; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; GEFITINIB; LOPERAMIDE; PLACEBO; SUNSCREEN;

EID: 84899647744     PISSN: 11775475     EISSN: 11775491     Source Type: Journal    
DOI: 10.2147/BTT.S40567     Document Type: Review
Times cited : (37)

References (40)
  • 1
    • 1542329005 scopus 로고    scopus 로고
    • The erbB family: Targets for therapeutic development against cancer and therapeutic strategies using monoclonal antibodies and tyrosine kinase inhibitors
    • Rowinski EK. The erbB family: targets for therapeutic development against cancer and therapeutic strategies using monoclonal antibodies and tyrosine kinase inhibitors. Annu Rev Med. 2004;55:433-457.
    • (2004) Annu Rev Med , vol.55 , pp. 433-457
    • Rowinski, E.K.1
  • 2
    • 43249096031 scopus 로고    scopus 로고
    • Structure and relevance of the epidermal growth factor receptor in human cancer
    • Kumar A, Petri ET, Halmos B, et al. Structure and relevance of the epidermal growth factor receptor in human cancer. J Clin Oncol. 2008;26:1742-1751.
    • (2008) J Clin Oncol , vol.26 , pp. 1742-1751
    • Kumar, A.1    Petri, E.T.2    Halmos, B.3
  • 3
    • 69949162760 scopus 로고    scopus 로고
    • Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
    • Mok TS, Wu YL, Thongprasert S, et al. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med. 2009;361:947-957.
    • (2009) N Engl J Med , vol.361 , pp. 947-957
    • Mok, T.S.1    Wu, Y.L.2    Thongprasert, S.3
  • 4
    • 72449160988 scopus 로고    scopus 로고
    • A randomized phase III study of gefitinib (IRESSA) versus standard chemotherapy (gemcitabine plus cisplatin) as a first-line treatment for never-smokers with advanced or metastatic adenocarcinoma of the lung
    • abst PRS 4
    • Lee JS, Park K, Kim S-W, et al. A randomized phase III study of gefitinib (IRESSA) versus standard chemotherapy (gemcitabine plus cisplatin) as a first-line treatment for never-smokers with advanced or metastatic adenocarcinoma of the lung. J Thor Oncol. 2009;4(SUPPL 19): abst PRS 4.
    • (2009) J Thor Oncol , vol.4 , Issue.SUPPL. 19
    • Lee, J.S.1    Park, K.2    Kim, S.-W.3
  • 5
    • 75249087060 scopus 로고    scopus 로고
    • Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): An open label, randomised phase 3 trial
    • Mitsudomi T, Morita S, Yatabe Y, et al. Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial. Lancet Oncol. 2010;11:121-128.
    • (2010) Lancet Oncol , vol.11 , pp. 121-128
    • Mitsudomi, T.1    Morita, S.2    Yatabe, Y.3
  • 6
    • 77953930730 scopus 로고    scopus 로고
    • Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR
    • Maemondo M, Inoue A, Kobayashi K, et al. Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. N Engl J Med. 2010;362:2380-2388.
    • (2010) N Engl J Med , vol.362 , pp. 2380-2388
    • Maemondo, M.1    Inoue, A.2    Kobayashi, K.3
  • 7
    • 79960889662 scopus 로고    scopus 로고
    • Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): A multicentre, open-label, randomised, phase 3 study
    • Zhou CC, Wu YL, Chen G, et al. Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study. Lancet Oncol. 2011;12: 735-742.
    • (2011) Lancet Oncol , vol.12 , pp. 735-742
    • Zhou, C.C.1    Wu, Y.L.2    Chen, G.3
  • 8
    • 84857502654 scopus 로고    scopus 로고
    • Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutations-positive non-small cell lung cancer (EURTAC) a multicenter, open-label, randomized phase 3 trial. Results of the European Erlotinib Versus Chemotherapy (EURTAC) phase III randomized trial
    • Rosell R, Carcereny E, Gervais R, et al. Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutations-positive non-small cell lung cancer (EURTAC) a multicenter, open-label, randomized phase 3 trial. Results of the European Erlotinib Versus Chemotherapy (EURTAC) phase III randomized trial. Lancet Oncol. 2012;13(3):239-246.
    • (2012) Lancet Oncol , vol.13 , Issue.3 , pp. 239-246
    • Rosell, R.1    Carcereny, E.2    Gervais, R.3
  • 9
    • 13844317894 scopus 로고    scopus 로고
    • EGFR mutation and resistance of non-small-cell lung cancer to gefitinib
    • Kobayashi S, Boggon TJ, Dayaram T, et al. EGFR mutation and resistance of non-small-cell lung cancer to gefitinib. N Engl J Med. 2005;352:786-792.
    • (2005) N Engl J Med , vol.352 , pp. 786-792
    • Kobayashi, S.1    Boggon, T.J.2    Dayaram, T.3
  • 10
    • 33751292685 scopus 로고    scopus 로고
    • Novel D761Y and common secondary T790M mutations in epidermal growth factor receptor-mutant lung adenocarcinoma with acquired resistance to kinase inhibitors
    • Balak MN, Gong Y, Riely GJ, et al. Novel D761Y and common secondary T790M mutations in epidermal growth factor receptor-mutant lung adenocarcinoma with acquired resistance to kinase inhibitors. Clin Cancer Res. 2006;12:6494-6501.
    • (2006) Clin Cancer Res , vol.12 , pp. 6494-6501
    • Balak, M.N.1    Gong, Y.2    Riely, G.J.3
  • 11
    • 34249075147 scopus 로고    scopus 로고
    • MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
    • Engelman JA, Zajnullahu K, Mitsudomi T, et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science. 2007;316:1039-1043.
    • (2007) Science , vol.316 , pp. 1039-1043
    • Engelman, J.A.1    Zajnullahu, K.2    Mitsudomi, T.3
  • 12
    • 84877100240 scopus 로고    scopus 로고
    • Analysis of tumor specimens at the time of acquired resistance to EGFR-TKI therapy in 155 patients with EGFR-mutant lung cancers
    • Yu HA, Arcila ME, Rekhtman N, et al. Analysis of tumor specimens at the time of acquired resistance to EGFR-TKI therapy in 155 patients with EGFR-mutant lung cancers. Clin Cancer Res. 2013;19(8): 2240-2247.
    • (2013) Clin Cancer Res , vol.19 , Issue.8 , pp. 2240-2247
    • Yu, H.A.1    Arcila, M.E.2    Rekhtman, N.3
  • 13
    • 79953118839 scopus 로고    scopus 로고
    • Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors
    • 75ra26
    • Sequist LV, Waltman BA, Dias-Santagata D, et al. Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors. Sci Transl Med. 2011;3:75ra26.
    • (2011) Sci Transl Med , vol.3
    • Sequist, L.V.1    Waltman, B.A.2    Dias-Santagata, D.3
  • 14
    • 33750302365 scopus 로고    scopus 로고
    • Analysis of epidermal growth factor receptor gene mutation in patients with non-small cell lung cancer and acquired resistance to gefitinib
    • Kosaka T, Yatabe Y, Endoh H, et al. Analysis of epidermal growth factor receptor gene mutation in patients with non-small cell lung cancer and acquired resistance to gefitinib. Clin Cancer Res. 2006;12:5764-5769.
    • (2006) Clin Cancer Res , vol.12 , pp. 5764-5769
    • Kosaka, T.1    Yatabe, Y.2    Endoh, H.3
  • 15
    • 18244371651 scopus 로고    scopus 로고
    • Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
    • Pao W, Miller VA, Politi KA, et al. Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med. 2005;225/2(3):e73.
    • (2005) PLoS Med , vol.2 , Issue.3
    • Pao, W.1    Miller, V.A.2    Politi, K.A.3
  • 16
    • 34547625913 scopus 로고    scopus 로고
    • Oncogenic activity of epidermal growth factor receptor kinase mutant alleles is enhanced by the T790M drug resistance mutation
    • Godin-Heymann N, Bryant I, Rivera MN, et al. Oncogenic activity of epidermal growth factor receptor kinase mutant alleles is enhanced by the T790M drug resistance mutation. Cancer Res. 2006;67:7319-7326.
    • (2006) Cancer Res , vol.67 , pp. 7319-7326
    • Godin-Heymann, N.1    Bryant, I.2    Rivera, M.N.3
  • 17
    • 33748074447 scopus 로고    scopus 로고
    • Presence of epidermal growth factor receptor gene T790M mutation as a minor clone in non-small cell lung cancer
    • Inukai M, Toyooka S, Ito S, et al. Presence of epidermal growth factor receptor gene T790M mutation as a minor clone in non-small cell lung cancer. Cancer Res. 2008;266:7854-7858.
    • (2008) Cancer Res , vol.266 , pp. 7854-7858
    • Inukai, M.1    Toyooka, S.2    Ito, S.3
  • 18
    • 49149118719 scopus 로고    scopus 로고
    • BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models
    • Li D, Ambrogio L, Shimamura T, et al. BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models. Oncogene. 2008;27(34):4702-4711.
    • (2008) Oncogene , vol.27 , Issue.34 , pp. 4702-4711
    • Li, D.1    Ambrogio, L.2    Shimamura, T.3
  • 19
    • 84867621201 scopus 로고    scopus 로고
    • Target binding properties and cellular activity of afatinib (BIBW 2992), an irreversible ErbB family blocker
    • Solca F, Dahl G, Zoephel A, et al. Target binding properties and cellular activity of afatinib (BIBW 2992), an irreversible ErbB family blocker. J Pharmacol Exp Ther. 2012;343(2):342-350.
    • (2012) J Pharmacol Exp Ther , vol.343 , Issue.2 , pp. 342-350
    • Solca, F.1    Dahl, G.2    Zoephel, A.3
  • 20
    • 84859793822 scopus 로고    scopus 로고
    • Afatinib pharmacokinetics and metabolism after oral administration to healthy male volunteers
    • Stopfer P, MArzin K, Narjes H, et al. Afatinib pharmacokinetics and metabolism after oral administration to healthy male volunteers. Cancer Chemother Pharmacol. 2012;69(4):1051-1061.
    • (2012) Cancer Chemother Pharmacol , vol.69 , Issue.4 , pp. 1051-1061
    • Stopfer, P.1    Marzin, K.2    Narjes, H.3
  • 21
    • 77957585027 scopus 로고    scopus 로고
    • Phase I trial of the irreversible EGFR and HER2 kinase inhibitor BIBW 2992 in patients with advanced solid tumors
    • Yap TA, Vidal L, Adam J, et al. Phase I trial of the irreversible EGFR and HER2 kinase inhibitor BIBW 2992 in patients with advanced solid tumors. J Clin Oncol. 2010;28(25):3965-3972.
    • (2010) J Clin Oncol , vol.28 , Issue.25 , pp. 3965-3972
    • Yap, T.A.1    Vidal, L.2    Adam, J.3
  • 22
    • 84885994849 scopus 로고    scopus 로고
    • Pharmacokinetics of afatinib, a selective irreversible ErbB family blocker, in patients with advanced solid tumours
    • Wind S, Schmid M, Erhardt J, Goeldner RG, Stopfer P. Pharmacokinetics of afatinib, a selective irreversible ErbB family blocker, in patients with advanced solid tumours. Clin Pharmacokinet. 2013;52(12):1101-1109.
    • (2013) Clin Pharmacokinet , vol.52 , Issue.12 , pp. 1101-1109
    • Wind, S.1    Schmid, M.2    Erhardt, J.3    Goeldner, R.G.4    Stopfer, P.5
  • 23
    • 84862819699 scopus 로고    scopus 로고
    • Afatinib for patients with lung adenocarcinoma and epidermal growth factor receptor mutations (LUX-Lung 2): A phase 2 trial
    • Yang JC, Shih JY, Su WC, et al. Afatinib for patients with lung adenocarcinoma and epidermal growth factor receptor mutations (LUX-Lung 2): a phase 2 trial. Lancet Oncol. 2012;13(5):539-548.
    • (2012) Lancet Oncol , vol.13 , Issue.5 , pp. 539-548
    • Yang, J.C.1    Shih, J.Y.2    Su, W.C.3
  • 24
    • 84884736973 scopus 로고    scopus 로고
    • Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations
    • Sequist LV, Yang JC, Yamamoto N, et al. Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations. J Clin Oncol. 2013;31(27):3327-3334.
    • (2013) J Clin Oncol , vol.31 , Issue.27 , pp. 3327-3334
    • Sequist, L.V.1    Yang, J.C.2    Yamamoto, N.3
  • 25
    • 84884659258 scopus 로고    scopus 로고
    • LUX-Lung 6: A randomized, open-label, phase III study of afatinib (A) versus gemcitabine/cisplatin (GC) as first-line treatment for Asian patients (pts) with EGFR mutation-positive (EGFR M+) advanced adenocarcinoma of the lung
    • abst 8016
    • Wu YL, Zhou C, Hu CP, et al. LUX-Lung 6: a randomized, open-label, phase III study of afatinib (A) versus gemcitabine/cisplatin (GC) as first-line treatment for Asian patients (pts) with EGFR mutation-positive (EGFR M+) advanced adenocarcinoma of the lung. J Clin Oncol. 2013;31(SUPPL): abst 8016.
    • (2013) J Clin Oncol , vol.31 , Issue.SUPPL.
    • Wu, Y.L.1    Zhou, C.2    Hu, C.P.3
  • 26
  • 28
    • 79957916527 scopus 로고    scopus 로고
    • Effectiveness of tyrosine kinase inhibitors on "uncommon" epidermal growth factor receptor mutations of unknown clinical significance in non-small cell lung cancer
    • Wu JY, Yu CJ, Chang YC, et al. Effectiveness of tyrosine kinase inhibitors on "uncommon" epidermal growth factor receptor mutations of unknown clinical significance in non-small cell lung cancer. Clin Cancer Res. 2011;17(11):3812-3821.
    • (2011) Clin Cancer Res , vol.17 , Issue.11 , pp. 3812-3821
    • Wu, J.Y.1    Yu, C.J.2    Chang, Y.C.3
  • 30
    • 84862785051 scopus 로고    scopus 로고
    • Afatinib versus placebo for patients with advanced, metastatic non-small-cell lung cancer after failure of erlotinib, gefitinib, or both, and one or two lines of chemotherapy (LUX-Lung 1): A phase 2b/3 randomised trial
    • Miller VA, Hirsh V, Cadranel J, et al. Afatinib versus placebo for patients with advanced, metastatic non-small-cell lung cancer after failure of erlotinib, gefitinib, or both, and one or two lines of chemotherapy (LUX-Lung 1): a phase 2b/3 randomised trial. Lancet Oncol. 2012;13(5):528-538.
    • (2012) Lancet Oncol , vol.13 , Issue.5 , pp. 528-538
    • Miller, V.A.1    Hirsh, V.2    Cadranel, J.3
  • 31
    • 74949110711 scopus 로고    scopus 로고
    • Clinical definition of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer
    • Jackman D, Pao W, Riely GJ, et al. Clinical definition of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer. J Clin Oncol. 2010;28(2): 357-360.
    • (2010) J Clin Oncol , vol.28 , Issue.2 , pp. 357-360
    • Jackman, D.1    Pao, W.2    Riely, G.J.3
  • 32
    • 84891333707 scopus 로고    scopus 로고
    • Ability of the Met kinase inhibitor crizotinib and new generation EGFR inhibitors to overcome resistance to EGFR inhibitors
    • Nanjo S, Yamada T, Nishihara H, et al. Ability of the Met kinase inhibitor crizotinib and new generation EGFR inhibitors to overcome resistance to EGFR inhibitors. PLoS One. 2013;8(12):e84700.
    • (2013) PLoS One , vol.8 , Issue.12
    • Nanjo, S.1    Yamada, T.2    Nishihara, H.3
  • 33
    • 84884618137 scopus 로고    scopus 로고
    • LUX-Lung 4: A phase II trial of afatinib in patients with advanced non-small-cell lung cancer who progressed during prior treatment with erlotinib, gefitinib or both
    • Katakami N, Atagi S, Goto K, et al. LUX-Lung 4: a phase II trial of afatinib in patients with advanced non-small-cell lung cancer who progressed during prior treatment with erlotinib, gefitinib or both. J Clin Oncol. 2013;31(27):3335-3341.
    • (2013) J Clin Oncol , vol.31 , Issue.27 , pp. 3335-3341
    • Katakami, N.1    Atagi, S.2    Goto, K.3
  • 34
    • 80052441453 scopus 로고    scopus 로고
    • Activity and tolerability of afatinib (BIBW 2992) and cetuximab in NSCLC patients with acquired resistance to erlotinib or gefitinib
    • abst 7525
    • Janjigian YY, Groen HJ, Horn L, et al. Activity and tolerability of afatinib (BIBW 2992) and cetuximab in NSCLC patients with acquired resistance to erlotinib or gefitinib. J Clin Oncol. 2011;29(SUPPL): abst 7525.
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Janjigian, Y.Y.1    Groen, H.J.2    Horn, L.3
  • 35
    • 70349684791 scopus 로고    scopus 로고
    • Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer
    • Regales L, Gong Y, Shen R, et al. Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer. J Clin Invest. 2009;119(10):3000-3010.
    • (2009) J Clin Invest , vol.119 , Issue.10 , pp. 3000-3010
    • Regales, L.1    Gong, Y.2    Shen, R.3
  • 36
    • 84879347673 scopus 로고    scopus 로고
    • Dermatologic adverse events associated with afatinib: An oral ErbB family blocker
    • Lacouture ME, Schadendorf D, Chu CY, et al. Dermatologic adverse events associated with afatinib: an oral ErbB family blocker. Expert Rev Anticancer Ther. 2013;13(6):721-728.
    • (2013) Expert Rev Anticancer Ther , vol.13 , Issue.6 , pp. 721-728
    • Lacouture, M.E.1    Schadendorf, D.2    Chu, C.Y.3
  • 37
    • 84879347777 scopus 로고    scopus 로고
    • Diarrhea associated with afatinib: An oral ErbB family blocker
    • Yang JC, Reguart N, Barinoff J, et al. Diarrhea associated with afatinib: an oral ErbB family blocker. Expert Rev Anticancer Ther. 2013;13(6): 729-736.
    • (2013) Expert Rev Anticancer Ther , vol.13 , Issue.6 , pp. 729-736
    • Yang, J.C.1    Reguart, N.2    Barinoff, J.3
  • 38
    • 84873814691 scopus 로고    scopus 로고
    • Symptom and quality of life benefit of afatinib in advanced non-small-cell lung cancer patients previously treated with erlotinib or gefitinib: Results of a randomized phase IIb/III trial (LUX-Lung 1)
    • Hirsh V, Cadranel J, Cong XJ, et al. Symptom and quality of life benefit of afatinib in advanced non-small-cell lung cancer patients previously treated with erlotinib or gefitinib: results of a randomized phase IIb/III trial (LUX-Lung 1). J Thorac Oncol. 2013;8:229-237.
    • (2013) J Thorac Oncol , vol.8 , pp. 229-237
    • Hirsh, V.1    Cadranel, J.2    Cong, X.J.3
  • 39
    • 84884605223 scopus 로고    scopus 로고
    • Symptom control and quality of life in LUX-Lung 3: A phase III study of afatinib or cisplatin/pemetrexed in patients with advanced lung adenocarcinoma with EGFR mutations
    • Yang JC, Hirsh V, Schuler M, et al. Symptom control and quality of life in LUX-Lung 3: a phase III study of afatinib or cisplatin/pemetrexed in patients with advanced lung adenocarcinoma with EGFR mutations. J Clin Oncol. 2013;31(27):3342-3350.
    • (2013) J Clin Oncol , vol.31 , Issue.27 , pp. 3342-3350
    • Yang, J.C.1    Hirsh, V.2    Schuler, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.