The eosinophil surface receptor epidermal growth factor-like module containing mucin-like hormone receptor 1 (EMR1): A novel therapeutic target for eosinophilic disorders

Journal of Allergy and Clinical Immunology

Volumn 133, Issue 5, 2014, Pages

  Legrand, Fanny ^a   Tomasevic, Nenad ^b   Simakova, Olga ^a   Lee, Chyi Chia Richard ^c   Wang, Zengfang ^c   Raffeld, Mark ^c   Makiya, Michelle A ^a   Palath, Varghese ^b   Leung, John ^b   Baer, Mark ^b   Yarranton, Geoffrey ^b   Maric, Irina ^a   Bebbington, Christopher ^b   Klion, Amy D ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b KaloBios Pharmaceuticals   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

afucosylated antibody; eosinophil; eosinophilia; Epidermal growth factor like module containing mucin like hormone receptor 1; hypereosinophilic syndrome; mAb therapy

Indexed keywords

CD34 ANTIGEN; EPIDERMAL GROWTH FACTOR RECEPTOR; MESSENGER RNA; RECOMBINANT EPIDERMAL GROWTH FACTOR LIKE MODULE CONTAINING MUCIN-LIKE HORMONE RECEPTOR 1; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; CHIMERIC ANTIBODY; EPIDERMAL GROWTH FACTOR LIKE MODULE CONTAINING MUCIN LIKE HORMONE RECEPTOR 1; IMMUNOGLOBULIN G1 ANTIBODY; LYMPHOCYTE MEMBRANE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD CELL; BLOOD LEVEL; BONE MARROW; BONE MARROW CELL; CELL DIFFERENTIATION; CELL LINE; CLINICAL ARTICLE; CONTROLLED STUDY; EOSINOPHIL; EOSINOPHIL COUNT; EOSINOPHILIA; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MACACA FASCICULARIS; MALE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANIMAL CELL; ANTIBODY DEPENDENT LYMPHOCYTOTOXICITY; CELL KILLING; CORRELATION ANALYSIS; DRUG EFFICACY; DRUG TARGETING; EOSINOPHILIC DISORDER; GENE EXPRESSION REGULATION; GRANULOCYTE; HUMAN TISSUE; HYPEREOSINOPHILIC SYNDROME; NATURAL KILLER CELL; NOSE POLYP; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN BLOOD LEVEL; REAL TIME POLYMERASE CHAIN REACTION; SINGLE DRUG DOSE; SKIN BIOPSY;

AFUCOSYLATED ANTIBODY; EOSINOPHIL; EOSINOPHILIA; EPIDERMAL GROWTH FACTOR-LIKE MODULE CONTAINING MUCIN-LIKE HORMONE RECEPTOR 1; HYPEREOSINOPHILIC SYNDROME; MAB THERAPY;

ANTIBODIES, MONOCLONAL, MURINE-DERIVED; BONE MARROW CELLS; CD4-POSITIVE T-LYMPHOCYTES; EOSINOPHILIA; EOSINOPHILS; FEMALE; GENE EXPRESSION REGULATION; HUMANS; IMMUNOGLOBULIN G; K562 CELLS; MALE; MEMBRANE GLYCOPROTEINS; MUCINS; RECEPTORS, G-PROTEIN-COUPLED; U937 CELLS;

EID: 84899646792     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2013.11.041     Document Type: Article

References (33)

1. P. Valent, A.D. Klion, H.P. Horny, F. Roufosse, J. Gotlib, and P.F. Weller et al. Contemporary consensus proposal on criteria and classification of eosinophilic disorders and related syndromes J Allergy Clin Immunol 130 2012 607 612.e9
2. M.E. Wechsler, P.C. Fulkerson, B.S. Bochner, G.M. Gauvreau, G.J. Gleich, and T. Henkel et al. Novel targeted therapies for eosinophilic disorders J Allergy Clin Immunol 130 2012 563 571
3. B.S. Bochner, and G.J. Gleich What targeting eosinophils has taught us about their role in diseases J Allergy Clin Immunol 126 2010 16 27
4. M.J. Kwakkenbos, E.N. Kop, M. Stacey, M. Matmati, S. Gordon, and H.H. Lin et al. The EGF-TM7 family: a postgenomic view Immunogenetics 55 2004 655 666
5. E. Wandel, A. Saalbach, D. Sittig, C. Gebhardt, and G. Aust Thy-1 (CD90) is an interacting partner for CD97 on activated endothelial cells J Immunol 188 2012 1442 1450
6. S. Yona, H.H. Lin, P. Dri, J.Q. Davies, R.P. Hayhoe, and S.M. Lewis et al. Ligation of the adhesion-GPCR EMR2 regulates human neutrophil function FASEB J 22 2008 741 751
7. A.J. McKnight, and S. Gordon The EGF-TM7 family: unusual structures at the leukocyte surface J Leukoc Biol 63 1998 271 280
8. S. Gordon, J. Hamann, H.H. Lin, and M. Stacey F4/80 and the related adhesion-GPCRs Eur J Immunol 41 2011 2472 2476
9. J. Hamann, N. Koning, W. Pouwels, L.H. Ulfman, M. van Eijk, and M. Stacey et al. EMR1, the human homolog of F4/80, is an eosinophil-specific receptor Eur J Immunol 37 2007 2797 2802
10. D.A. Plager, J.C. Kahl, Y.W. Asmann, A.E. Nilson, J.F. Pallanch, and O. Friedman et al. Gene transcription changes in asthmatic chronic rhinosinusitis with nasal polyps and comparison to those in atopic dermatitis PLoS One 5 2010 e11450
11. N. Yamane-Ohnuki, S. Kinoshita, M. Inoue-Urakubo, M. Kusunoki, S. Iida, and R. Nakano et al. Establishment of FUT8 knockout Chinese hamster ovary cells: an ideal host cell line for producing completely defucosylated antibodies with enhanced antibody-dependent cellular cytotoxicity Biotechnol Bioeng 87 2004 614 622
12. I. Maric, J. Robyn, D.D. Metcalfe, M.P. Fay, M. Carter, and T. Wilson et al. KIT D816V-associated systemic mastocytosis with eosinophilia and FIP1L1/PDGFRA-associated chronic eosinophilic leukemia are distinct entities J Allergy Clin Immunol 120 2007 680 687
13. A.S. Kirshenbaum, J.P. Goff, T. Semere, B. Foster, L.M. Scott, and D.D. Metcalfe Demonstration that human mast cells arise from a progenitor cell population that is CD34(+), c-kit(+), and expresses aminopeptidase N (CD13) Blood 94 1999 2333 2342
14. M.W. Al-Rabia, M.G. Blaylock, D.W. Sexton, L. Thomson, and G.M. Walsh Granule protein changes and membrane receptor phenotype in maturing human eosinophils cultured from CD34+ progenitors Clin Exp Allergy 33 2003 640 648
15. M. Shalit, S. Sekhsaria, S. Mauhorter, S. Mahanti, and H.L. Malech Early commitment to the eosinophil lineage by cultured human peripheral blood CD34+ cells: messenger RNA analysis J Allergy Clin Immunol 98 1996 344 354
16. T.K. Hart, R.M. Cook, P. Zia-Amirhosseini, E. Minthorn, T.S. Sellers, and B.E. Maleeff et al. Preclinical efficacy and safety of mepolizumab (SB-240563), a humanized monoclonal antibody to IL-5, in cynomolgus monkeys J Allergy Clin Immunol 108 2001 250 257
17. R. Kolbeck, A. Kozhich, M. Koike, L. Peng, C.K. Andersson, and M.M. Damschroder et al. MEDI-563, a humanized anti-IL-5 receptor alpha mAb with enhanced antibody-dependent cell-mediated cytotoxicity function J Allergy Clin Immunol 125 2010 1344 1353.e2
18. B.S. Bochner, W. Book, W.W. Busse, J. Butterfield, G.T. Furuta, and G.J. Gleich et al. Workshop report from the National Institutes of Health Taskforce on the Research Needs of Eosinophil-Associated Diseases (TREAD) J Allergy Clin Immunol 130 2012 587 596
19. W.W. Busse, R. Katial, D. Gossage, S. Sari, B. Wang, and R. Kolbeck et al. Safety profile, pharmacokinetics, and biologic activity of MEDI-563, an anti-IL-5 receptor alpha antibody, in a phase I study of subjects with mild asthma J Allergy Clin Immunol 125 2010 1237 1244.e2
20. S.A. Hudson, H. Herrmann, J. Du, P. Cox, B. Haddad el, and B. Butler et al. Developmental, malignancy-related, and cross-species analysis of eosinophil, mast cell, and basophil siglec-8 expression J Clin Immunol 31 2011 1045 1053
21. A. Cerutti, I. Puga, and M. Cols New helping friends for B cells Eur J Immunol 42 2012 1956 1968
22. V.T. Chu, A. Frohlich, G. Steinhauser, T. Scheel, T. Roch, and S. Fillatreau et al. Eosinophils are required for the maintenance of plasma cells in the bone marrow Nat Immunol 12 2011 151 159
23. E. Schaller, A.J. Macfarlane, R.A. Rupec, S. Gordon, A.J. McKnight, and K. Pfeffer Inactivation of the F4/80 glycoprotein in the mouse germ line Mol Cell Biol 22 2002 8035 8043
24. J.X. Gray, M. Haino, M.J. Roth, J.E. Maguire, P.N. Jensen, and A. Yarme et al. CD97 is a processed, seven-transmembrane, heterodimeric receptor associated with inflammation J Immunol 157 1996 5438 5447
25. J. Hamann, J.O. Wishaupt, R.A. van Lier, T.J. Smeets, F.C. Breedveld, and P.P. Tak Expression of the activation antigen CD97 and its ligand CD55 in rheumatoid synovial tissue Arthritis Rheum 42 1999 650 658
26. Y.S. Huang, N.Y. Chiang, C.H. Hu, C.C. Hsiao, K.F. Cheng, and W.P. Tsai et al. Activation of myeloid cell-specific adhesion class G protein-coupled receptor EMR2 via ligation-induced translocation and interaction of receptor subunits in lipid raft microdomains Mol Cell Biol 32 2012 1408 1420
27. M.J. Kwakkenbos, M. Matmati, O. Madsen, W. Pouwels, Y. Wang, and R.E. Bontrop et al. An unusual mode of concerted evolution of the EGF-TM7 receptor chimera EMR2 FASEB J 20 2006 2582 2584
28. I. Maric, J. Robyn, D.D. Metcalfe, M.P. Fay, M. Carter, and T. Wilson et al. KIT D816V-associated systemic mastocytosis with eosinophilia and FIP1L1/PDGFRA-associated chronic eosinophilic leukemia are distinct entities J Allergy Clin Immunol 120 2007 680 687
29. J. Hamann, N. Koning, W. Pouwels, L.H. Ulfman, M. van Eijk, and M. Stacey et al. EMR1, the human homolog of F4/80, is an eosinophil-specific receptor Eur J Immunol 37 2007 2797 2802
30. S.A. Hudson, H. Herrmann, J. Du, P. Cox, B. Haddad el, and B. Butler et al. Developmental, malignancy-related, and cross-species analysis of eosinophil, mast cell, and basophil siglec-8 expression J Clin Immunol 31 2011 1045 1053
31. A.D. Klion, R. Mejia, E.W. Cowen, K.C. Dowdell, K. Dunleavy, and G.A. Fahle et al. Chronic active Epstein-Barr virus infection: a novel cause of lymphocytic variant hypereosinophilic syndrome Blood 121 2013 2364 2366
32. G.T. Furuta, A.F. Kagalwalla, J.J. Lee, P. Alumkai, B.T. Maybruck, and S. Fillon et al. The oesophageal string test: a novel, minimally invasive method measures mucosal inflammation in eosinophilic oesophagitis Gut 62 2013 1395 1405
33. R. Gopinath, L.E. Hanna, V. Kumaraswami, V. Perumal, V. Kavitha, and V. Vijayasekaran et al. Perturbations in eosinophil homeostasis following treatment for lymphatic filariasis Infect Immun 68 2000 93 99