Pax8 has a critical role in epithelial cell survival and proliferation

Cell Death and Disease

Volumn 4, Issue 7, 2013, Pages

  Di Palma, T ^a   Filippone, M G ^a   Pierantoni, G M ^b   Fusco, A ^a,b   Soddu, S ^c   Zannini, M ^a  

^a CNR   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

Cell survival; Pax8; Thyroid epithelial cells; Tp53inp1

Indexed keywords

CASPASE 3; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN; PROTEIN TP53INP1; TRANSCRIPTION FACTOR PAX8; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVATION; EPITHELIUM CELL; GENE SILENCING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

EID: 84881072034     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2013.262     Document Type: Article

References (47)

1. Dahl E, Koseki H, Balling R. Pax genes and organogenesis. Bioessays 1997; 19: 755-765.
2. Walther C, Guenet JL, Simon D, Deutsch U, Jostes B, Goulding MD et al. Pax: a murine multigene family of paired box-containing genes. Genomics 1991; 11: 424-434.
3. Lang D, Powell SK, Plummer RS, Young KP, Ruggeri BA. PAX genes: roles in development, pathophysiology, and cancer. Biochem Pharmacol 2007; 73: 1-14.
4. Muratovska A, Zhou C, He S, Goodyer P, Eccles MR. Paired-Box genes are frequently expressed in cancer and often required for cancer cell survival. Oncogene 2003; 22: 7989-7997.
5. Plachov D, Chowdhury K, Walther C, Simon D, Guenet JL, Gruss P. Pax8, a murine paired box gene expressed in the developing excretory system and thyroid gland. Development 1990; 110: 643-651.
6. Mansouri A, Chowdhury K, Gruss P. Follicular cells of the thyroid gland require Pax8 gene function. Nat Genet 1998; 19: 87-90.
7. Pasca di Magliano M, Di Lauro R, Zannini M. Pax8 has a key role in thyroid cell differentiation. Proc Natl Acad Sci USA 2000; 97: 13144-13149.
8. Ohno M, Zannini M, Levy O, Carrasco N, di Lauro R. The paired-domain transcription factor Pax8 binds to the upstream enhancer of the rat sodium/iodide symporter gene and participates in both thyroid-specific and cyclic-AMP-dependent transcription. Mol Cell Biol 1999; 19: 2051-2060.
9. Zannini M, Francis-Lang H, Plachov D, Di Lauro R. Pax-8, a paired domain-containing protein, binds to a sequence overlapping the recognition site of a homeodomain and activates transcription from two thyroid-specific promoters. Mol Cell Biol 1992; 12: 4230-4241.
10. Tong GX, Memeo L, Colarossi C, Hamele-Bena D, Magi-Galluzzi C, Zhou M et al. PAX8 and PAX2 immunostaining facilitates the diagnosis of primary epithelial neoplasms of the male genital tract. Am J Surg Pathol 2011; 35: 1473-1483.
11. De Felice M, Di Lauro R. Thyroid development and its disorders: genetics and molecular mechanisms. Endocr Rev 2004; 25: 722-746.
12. Al Taji E, Biebermann H, Limanova Z, Hnikova O, Zikmund J, Dame C et al. Screening for mutations in transcription factors in a Czech cohort of 170 patients with congenital and early-onset hypothyroidism: identification of a novel PAX8 mutation in dominantly inherited early-onset non-autoimmune hypothyroidism. Eur J Endocrinol 2007; 156: 521-529.
13. Di Palma T, Zampella E, Filippone MG, Macchia PE, Ris-Stalpers C, de Vroede M et al. Characterization of a novel loss-of-function mutation of PAX8 associated with congenital hypothyroidism. Clin Endocrinol (Oxf) 2010; 73: 808-814.
14. Macchia PE, Lapi P, Krude H, Pirro MT, Missero C, Chiovato L et al. PAX8 mutations associated with congenital hypothyroidism caused by thyroid dysgenesis. Nat Genet 1998; 19: 83-86.
15. Tong GX, Yu WM, Beaubier NT, Weeden EM, Hamele-Bena D, Mansukhani MM et al. Expression of PAX8 in normal and neoplastic renal tissues: an immunohistochemical study. Mod Pathol 2009; 22: 1218-1227.
16. Tong GX, Weeden EM, Hamele-Bena D, Huan Y, Unger P, Memeo L et al. Expression of PAX8 in nephrogenic adenoma and clear cell adenocarcinoma of the lower urinary tract: evidence of related histogenesis? Am J Surg Pathol 2008; 32: 1380-1387.
17. Bowen NJ, Logani S, Dickerson EB, Kapa LB, Akhtar M, Benigno BB et al. Emerging roles for PAX8 in ovarian cancer and endosalpingeal development. Gynecol Oncol 2007; 104: 331-337.
18. Nonaka D, Tang Y, Chiriboga L, Rivera M, Ghossein R. Diagnostic utility of thyroid transcription factors Pax8 and TTF-2 (FoxE1) in thyroid epithelial neoplasms. Mod Pathol 2008; 21: 192-200.
19. Ros P, Rossi DL, Acebron A, Santisteban P. Thyroid-specific gene expression in the multi-step process of thyroid carcinogenesis. Biochimie 1999; 81: 389-396.
20. Sangoi AR, Ohgami RS, Pai RK, Beck AH, McKenney JK. PAX8 expression reliably distinguishes pancreatic well-differentiated neuroendocrine tumors from ileal and pulmonary well-differentiated neuroendocrine tumors and pancreatic acinar cell carcinoma. Mod Pathol 2011; 24: 412-424.
21. Eberhardt NL, Grebe SK, McIver B, Reddi HV. The role of the PAX8/PPARgamma fusion oncogene in the pathogenesis of follicular thyroid cancer. Mol Cell Endocrinol 2010; 321: 50-56.
22. Espadinha C, Cavaco BM, Leite V. PAX8PPARgamma stimulates cell viability and modulates expression of thyroid-specific genes in a human thyroid cell line. Thyroid 2007; 17: 497-509.
23. Cheung L, Messina M, Gill A, Clarkson A, Learoyd D, Delbridge L et al. Detection of the PAX8-PPAR gamma fusion oncogene in both follicular thyroid carcinomas and adenomas. J Clin Endocrinol Metab 2003; 88: 354-357.
24. Schaner ME, Ross DT, Ciaravino G, Sorlie T, Troyanskaya O, Diehn M et al. Gene expression patterns in ovarian carcinomas. Mol Biol Cell 2003; 14: 4376-4386.
25. Poleev A, Fickenscher H, Mundlos S, Winterpacht A, Zabel B, Fidler A et al. PAX8, a human paired box gene: isolation and expression in developing thyroid, kidney and Wilms' tumors. Development 1992; 116: 611-623.
26. Chen YJ, Campbell HG, Wiles AK, Eccles MR, Reddel RR, Braithwaite AW et al. PAX8 regulates telomerase reverse transcriptase and telomerase RNA component in glioma. Cancer Res 2008; 68: 5724-5732.
27. Okamura S, Arakawa H, Tanaka T, Nakanishi H, Ng CC, Taya Y et al. p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis. Mol Cell 2001; 8: 85-94.
28. Tomasini R, Samir AA, Carrier A, Isnardon D, Cecchinelli B, Soddu S et al. TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity. J Biol Chem 2003; 278: 37722-37729.
29. Fusco A, Berlingieri MT, Di Fiore PP, Portella G, Grieco M, Vecchio G. One-and two-step transformations of rat thyroid epithelial cells by retroviral oncogenes. Mol Cell Biol 1987; 7: 3365-3370.
30. Di Palma T, Conti A, de Cristofaro T, Scala S, Nitsch L, Zannini M. Identification of novel Pax8 targets in FRTL-5 thyroid cells by gene silencing and expression microarray analysis. PLoS One 2011; 6: e25162.
31. Bouchard M, Souabni A, Mandler M, Neubuser A, Busslinger M. Nephric lineage specification by Pax2 and Pax8. Genes Dev 2002; 16: 2958-2970.
32. Narlis M, Grote D, Gaitan Y, Boualia SK, Bouchard M. Pax2 and pax8 regulate branching morphogenesis and nephron differentiation in the developing kidney. J Am Soc Nephrol 2007; 18: 1121-1129.
33. Torban E, Eccles MR, Favor J, Goodyer PR. PAX2 suppresses apoptosis in renal collecting duct cells. Am J Pathol 2000; 157: 833-842.
34. Rossi DL, Acebron A, Santisteban P. Function of the homeo and paired domain proteins TTF-1 and Pax-8 in thyroid cell proliferation. J Biol Chem 1995; 270: 23139-23142.
35. Fagman H, Amendola E, Parrillo L, Zoppoli P, Marotta P, Scarfo M et al. Gene expression profiling at early organogenesis reveals both common and diverse mechanisms in foregut patterning. Dev Biol 2011; 359: 163-175.
36. Eccles MR, Yun K, Reeve AE, Fidler AE. Comparative in situ hybridization analysis of PAX2, PAX8, and WT1 gene transcription in human fetal kidney and Wilms' tumors. Am J Pathol 1995; 146: 40-45.
37. Long KB, Srivastava A, Hirsch MS, Hornick JL. PAX8 Expression in well-differentiated pancreatic endocrine tumors: correlation with clinicopathologic features and comparison with gastrointestinal and pulmonary carcinoid tumors. Am J Surg Pathol 2010; 34: 723-729.
38. Cheung HW, Cowley GS, Weir BA, Boehm JS, Rusin S, Scott JA et al. Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer. Proc Natl Acad Sci USA 2011; 108: 12372-12377.
39. Li CG, Nyman JE, Braithwaite AW, Eccles MR. PAX8 promotes tumor cell growth by transcriptionally regulating E2F1 and stabilizing RB protein. Oncogene 2011; 30: 4824-4834.
40. DeGregori J, Johnson DG. Distinct and overlapping roles for E2F family members in transcription, proliferation and apoptosis. Curr Mol Med 2006; 6: 739-748.
41. Tomasini R, Samir AA, Pebusque MJ, Calvo EL, Totaro S, Dagorn JC et al. P53-dependent expression of the stress-induced protein (SIP). Eur J Cell Biol 2002; 81: 294-301.
42. Bishop JA, Sharma R, Westra WH. PAX8 immunostaining of anaplastic thyroid carcinoma: a reliable means of discerning thyroid origin for undifferentiated tumors of the head and neck. Hum Pathol 2011; 42: 1873-1877.
43. Zhang P, Zuo H, Nakamura Y, Nakamura M, Wakasa T, Kakudo K. Immunohistochemical analysis of thyroid-specific transcription factors in thyroid tumors. Pathol Int 2006; 56: 240-245.
44. Lavra L, Rinaldo C, Ulivieri A, Luciani E, Fidanza P, Giacomelli L et al. The loss of the p53 activator HIPK2 is responsible for galectin-3 overexpression in well differentiated thyroid carcinomas. PLoS One 2011; 6: e20665.
45. Pierantoni GM, Rinaldo C, Mottolese M, Di Benedetto A, Esposito F, Soddu S et al. High-mobility group A1 inhibits p53 by cytoplasmic relocalization of its proapoptotic activator HIPK2. J Clin Invest 2007; 117: 693-702.
46. Di Palma T, Nitsch R, Mascia A, Nitsch L, Di Lauro R, Zannini M. The paired domain-containing factor Pax8 and the homeodomain-containing factor TTF-1 directly interact and synergistically activate transcription. J Biol Chem 2003; 278: 3395-3402.
47. de Cristofaro T, Di Palma T, Ferraro A, Corrado A, Lucci V, Franco R et al. TAZ/WWTR1 is overexpressed in papillary thyroid carcinoma. Eur J Cancer 2011; 47: 926-933.