The role of c-Jun in controlling the EPAC1-dependent induction of the SOCS3 gene in HUVECs

FEBS Letters

Volumn 588, Issue 9, 2014, Pages 1556-1561

  Wiejak, Jolanta ^a   Dunlop, Julia ^a   Yarwood, Stephen J ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

AP1; c Jun; Cyclic AMP; EPAC1; SOCS3; Transcription

Indexed keywords

CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; EXCHANGE PROTEIN ACTIVATED BY CYCLIC AMP; PROTEIN C JUN; SUPPRESSOR OF CYTOKINE SIGNALING 3; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; EMBRYO; ENZYME ACTIVATION; GENE; GENE FUNCTION; GENE IDENTIFICATION; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SOCS3 GENE; UMBILICAL VEIN ENDOTHELIAL CELL;

AP1; C-JUN; CYCLIC AMP; EPAC1; SOCS3; TRANSCRIPTION;

ANIMALS; BASE SEQUENCE; BINDING SITES; CELLS, CULTURED; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MICE; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS C-JUN; STAT3 TRANSCRIPTION FACTOR; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTIONAL ACTIVATION;

EID: 84899643688     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2014.02.038     Document Type: Article

References (21)

1. W.A. Sands, H.D. Woolson, G.R. Milne, C. Rutherford, and T.M. Palmer Exchange protein activated by cyclic AMP (Epac)-mediated induction of suppressor of cytokine signaling 3 (SOCS-3) in vascular endothelial cells Mol. Cell. Biol. 26 2006 6333 6346
2. J. Piessevaux, D. Lavens, F. Peelman, and J. Tavernier The many faces of the SOCS box Cytokine Growth Factor Rev. 19 2008 371 381
3. J.L. Bos Epac proteins: multi-purpose cAMP targets Trends Biochem. Sci. 31 2006 680 686
4. M. Schmidt, C. Sand, K.H. Jakobs, M.C. Michel, and P.A. Weernink Epac and the cardiovascular system Curr. Opin. Pharmacol. 7 2007 193 200
5. S.J. Netherton, J.A. Sutton, L.S. Wilson, R.L. Carter, and D.H. Maurice Both protein kinase A and exchange protein activated by cAMP coordinate adhesion of human vascular endothelial cells Circ. Res. 101 2007 768 776
6. S.J. Yarwood, G. Borland, W.A. Sands, and T.M. Palmer Identification of CCAAT/enhancer-binding proteins as exchange protein activated by cAMP-activated transcription factors that mediate the induction of the SOCS-3 gene J. Biol. Chem. 283 2008 6843 6853
7. H.D. Woolson, V.S. Thomson, C. Rutherford, S.J. Yarwood, and T.M. Palmer Selective inhibition of cytokine-activated extracellular signal-regulated kinase by cyclic AMP via Epac1-dependent induction of suppressor of cytokine signalling-3 Cell. Signal. 21 2009 1706 1715
8. J. Wiejak, J. Dunlop, C. Stoyle, G. Lappin, A. McIlroy, J.D. Pediani, S. Gao, and S.J. Yarwood The protein kinase C inhibitor, Ro-31-7459, is a potent activator of ERK and JNK MAP kinases in HUVECs and yet inhibits cyclic AMP-stimulated SOCS-3 gene induction through inactivation of the transcription factor c-Jun Cell. Signal. 24 2012 1690 1699
9. J. Wiejak, J. Dunlop, S. Gao, G. Borland, and S.J. Yarwood Extracellular signal-regulated kinase mitogen-activated protein kinase-dependent SOCS-3 gene induction requires c-Jun, signal transducer and activator of transcription 3, and specificity protein 3 transcription factors Mol. Pharmacol. 81 2012 657 668
10. A.H. Eid, M.A. Chotani, S. Mitra, T.J. Miller, and N.A. Flavahan Cyclic AMP acts through Rap1 and JNK signaling to increase expression of cutaneous smooth muscle alpha2C-adrenoceptors Am. J. Physiol. Heart Circ. Physiol. 295 2008 H266 H272
11. D. Hochbaum, T. Tanos, F. Ribeiro-Neto, D. Altschuler, and O.A. Coso Activation of JNK by Epac is independent of its activity as a Rap guanine nucleotide exchanger J. Biol. Chem. 278 2003 33738 33746
12. C.J. Auernhammer, C. Bousquet, and S. Melmed Autoregulation of pituitary corticotroph SOCS-3 expression: characterization of the murine SOCS-3 promoter Proc. Natl. Acad. Sci. USA 96 1999 6964 6969
13. A. MacLaren, E.J. Black, W. Clark, and D.A. Gillespie c-Jun-deficient cells undergo premature senescence as a result of spontaneous DNA damage accumulation Mol. Cell. Biol. 24 2004 9006 9018
14. V. Ramberg, L.M. Tracy, M. Samuelsson, L.N. Nilsson, and K. Iverfeldt The CCAAT/enhancer binding protein (C/EBP) delta is differently regulated by fibrillar and oligomeric forms of the Alzheimer amyloid-beta peptide J. Neuroinflammation 8 2011 34
15. J.L. Meinkoth, A.S. Alberts, W. Went, D. Fantozzi, S.S. Taylor, M. Hagiwara, M. Montminy, and J.R. Feramisco Signal transduction through the cAMP-dependent protein kinase Mol. Cell. Biochem. 127-128 1993 179 186
16. R.J. Davis Signal transduction by the JNK group of MAP kinases Cell 103 2000 239 252
17. M. Karin The regulation of AP-1 activity by mitogen-activated protein kinases J. Biol. Chem. 270 1995 16483 16486
18. S.N. Rampersad et al. Cyclic AMP phosphodiesterase 4D (PDE4D) Tethers EPAC1 in a vascular endothelial cadherin (VE-Cad)-based signaling complex and controls cAMP-mediated vascular permeability J. Biol. Chem. 285 2010 33614 33622
19. S.J. Yarwood, E. Kilgour, and N.G. Anderson Cyclic AMP potentiates growth hormone-dependent differentiation of 3T3-F442A preadipocytes: possible involvement of the transcription factor CREB Mol. Cell. Endocrinol. 138 1998 41 50
20. D.H. Cai, D. Wang, J. Keefer, C. Yeamans, K. Hensley, and A.D. Friedman C/EBP alpha:AP-1 leucine zipper heterodimers bind novel DNA elements, activate the PU.1 promoter and direct monocyte lineage commitment more potently than C/EBP alpha homodimers or AP-1 Oncogene 27 2008 2772 2779
21. T. Curran, and B.R. Franza Jr. Fos and Jun: the AP-1 connection Cell 55 1988 395 397