Drug adherence to olmesartan/amlodipine fixed combination in an Italian clinical practice setting

ClinicoEconomics and Outcomes Research

Volumn 6, Issue 1, 2014, Pages 209-215

  Esposti, Luca Degli ^a   Saragoni, Stefania ^a   Buda, Stefano ^a   Esposti, Ezio Degli ^a  

^a Economics and Outcomes Research   (Italy)

Author keywords

Antihypertensive therapy; Blood pressure; Hypertension; Multi drug pill; Pharmaceutical database; Proportion of days covered

Indexed keywords

AMLODIPINE; AMLODIPINE PLUS OLMESARTAN; OLMESARTAN;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL PRACTICE; COHORT ANALYSIS; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; FEMALE; HUMAN; HYPERTENSION; ITALY; MALE; MEDICATION COMPLIANCE; MONOTHERAPY; PATIENT ASSESSMENT; PATIENT COMPLIANCE; PRESCRIPTION; RETROSPECTIVE STUDY; TOTAL QUALITY MANAGEMENT; TREATMENT DURATION;

EID: 84899640329     PISSN: None     EISSN: 11786981     Source Type: Journal    
DOI: 10.2147/CEOR.S55245     Document Type: Article

References (34)

1. Egan BM, Zhao Y, Axon RN. US trends in prevalence, awareness, treatment, and control of hypertension, 1988-2008. JAMA. 2010;303(20): 2043-2050.
2. Ezzati M, Oza S, Danaei G, Murray CJ. Trends and cardiovascular mortality effects of state-level blood pressure and uncontrolled hypertension in the United States. Circulation. 2008;117(7):905-914.
3. [No authors listed]. Prevalence of chronic diseases in older Italians: comparing self-reported and clinical diagnoses. The Italian Longitudinal Study on Aging Working Group. Int J Epidemiol. 1997;26(5):995-1002.
4. De Giusti M, Dito E, Pagliaro B, et al. A survey on blood pressure levels and hypertension control in a sample of the Italian general population. High Blood Press Cardiovasc Prev. 2012;19(3):129-135.
5. Krause T, Lovibond K, Caulfield M, McCormack T, Williams B; Guideline Development Group. Management of hypertension: summary of NICE guidance. BMJ. 2011;343:d4891.
6. Chobanian AV, Bakris GL, Black HR, et al; Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. National Heart, Lung, and Blood Institute; National High Blood Pressure Education Program Coordinating Committee. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension. 2003;42(6):1206-1252.
7. Mancia G, De Backer G, Dominiczak A, et al; Management of Arterial Hypertension of the European Society of Hypertension; European Society of Cardiology. 2007 Guidelines for the management of arterial hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens. 2007;25(6): 1105-1187.
8. Cheung BM, Lau CP, Kumana CR. Combination therapy for hypertension. Hong Kong Med J. 2003;9(3):224-226.
9. Frank J. Managing hypertension using combination therapy. Am Fam Physician. 2008;77(9):1279-1286.
10. Di Bari M, Balzi D, Roberts AT, et al. Prognostic stratification of older persons based on simple administrative data: development and validation of the "Silver Code," to be used in emergency department triage. J Gerontol A Biol Sci Med Sci. 2010;65(2):159-164.
11. Brocco S, Visentin C, Fedeli U, et al. Monitoring the occurrence of diabetes mellitus and its major complications: the combined use of different administrative databases. Cardiovasc Diabetol. 2007;6:5.
12. Ministero del lavoro, della Salute e delle Politiche Sociali. Rapporto annuale sulle attività di ricovero ospedaliero [Annual report on the activities of hospitalization]. 2009. Available from: http://www. salute.gov.it/imgs/C_17_pubblicazioni_1491_allegato.pdf. Accessed December 22, 2013. Italian.
13. Degli Esposti L, Degli Esposti E, Valpiani G, et al. A retrospective, population-based analysis of persistence with antihypertensive drug therapy in primary care practice in Italy. Clin Ther. 2002;24(8):1347-1357.
14. Catalan VS, LeLorier J. Predictors of long-term persistence on statins in a subsidized clinical population. Value Health. 2000;3(6): 417-426.
15. Ho PM, Rumsfeld JS, Masoudi FA, et al. Effect of medication nonadherence on hospitalization and mortality among patients with diabetes mellitus. Arch Intern Med. 2006;166:1836-1841.
16. Degli Esposti L, Valpiani G. Pharmacoeconomic burden of undertreating hypertension. Pharmacoeconomics. 2004;22(14):907-928.
17. Paramore LC, Halpern MT, Lapuerta P, et al. Impact of poorly controlled hypertension on healthcare resource utilization and cost. Am J Manag Care. 2001;7(4):389-398.
18. McCombs JS, Nichol MB, Newman CM, Sclar DA. The costs of interrupting antihypertensive drug therapy in a Medicaid population. Med Care. 1994;32(3):214-226.
19. Bloom BS. Continuation of initial antihypertensive medication after 1 year of therapy. Clin Ther. 1998;20(4):671-681.
20. Caro JJ, Salas M, Speckman JL, Raggio G, Jackson JD. Persistence with treatment for hypertension in actual practice. CMAJ. 1999;160(1): 31-37.
21. Degli Esposti L, Saragoni S, Benemei S, et al. Adherence to antihypertensive medications and health outcomes among newly treated hypertensive patients. Clinicoecon Outcomes Res. 2011;3:47-54.
22. Degli Esposti L, Saragoni S, Batacchi P, et al. Adherence to statin treatment and health outcomes in an Italian cohort of newly treated patients: results from an administrative database analysis. Clin Ther. 2012;34(1):190-199.
23. Virnig BA, McBean M. Administrative data for public health surveillance and planning. Ann Rev Public Health. 2001;22:213-230.
24. Black N. Why we need observational studies to evaluate the effectiveness of health care. BMJ. 1996;312(7040):1215-1218.
25. Ho PM, Bryson CL, Rumsfeld JS. Medication adherence: its importance in cardiovascular outcomes. Circulation. 2009;119(23):3028-3035.
26. Bangalore S, Kamalakkannan G, Parkar S, Messerli FH. Fixed-dose combinations improve medication compliance: a meta-analysis. Am J Med. 2007;120(8):713-719.
27. Gupta AK, Arshad S, Poulter NR. Compliance, safety, and effectiveness of fixed-dose combinations of antihypertensive agents: a meta-analysis. Hypertension. 2010;55(2):399-407.
28. Zeng F, Patel BV, Andrews L, Frech-Tamas F, Rudolph AE. Adherence and persistence of single-pill ARB/CCB combination therapy compared to multiple-pill ARB/CCB regimens. Curr Med Res Opin. 2010;26(12): 2877-2887.
29. Chang J, Yang W, Fellers T, et al. Chart review of patients on valsartanbased single-pill combinations vs ARB-based free combinations for BP goal achievement. Curr Med Res Opin. 2010;26(9):2203-2212.
30. Volpe M, Brommer P, Haag U, Miele C. Efficacy and tolerability of olmesartan medoxomil combined with amlodipine in patients with moderate to severe hypertension after amlodipine monotherapy: a randomized, double-blind, parallel-group, multicentre study. Clin Drug Investig. 2009;29(1):11-25.
31. Barrios V, Brommer P, Haag U, Calderón A, Escobar C. Olmesartan medoxomil plus amlodipine increases efficacy in patients with moderate-to-severe hypertension after monotherapy: a randomized, double-blind, parallel-group, multicentre study. Clin Drug Investig. 2009;29(7):427-439.
32. Law MR, Morris JK, Wald NJ. Use of blood pressure lowering drugs in the prevention of cardiovascular disease: meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies. BMJ. 2009;338:b1665.
33. Riley GF. Administrative and claims records as sources of health care cost data. Med Care. 2009;47:S51-S55.
34. Dick RS, Steen EB, editors. The Computer-Based Patient Record: An Essential Technology for Health Care. Washington, DC: National Academy Press; 1991.