Chart review of patients on valsartan-based single-pill combinations vs. ARB-based free combinations for BP goal achievement

Current Medical Research and Opinion

Volumn 26, Issue 9, 2010, Pages 2203-2212

  Chang, Joanne ^a   Yang, Weiyi ^a   Fellers, Thomas ^a   Kahler, Kristijan H ^a   Orloff, John ^a   Xie, Jipan ^b   Tsaneva, Magda ^b   Yu, Andrew P ^b   Wu, Eric Q ^b  

^a NOVARTIS PHARMA AG   (Switzerland)

^b ANALYSIS GROUP   (United States)

Author keywords

Angiotensin II receptor blocker based free combination; Blood pressure goal achievement; Chart review; Valsartan based single pill combination

Indexed keywords

AMLODIPINE; AMLODIPINE PLUS VALSARTAN; ANGIOTENSIN RECEPTOR ANTAGONIST; ANTIHYPERTENSIVE AGENT; CALCIUM CHANNEL BLOCKING AGENT; CANDESARTAN; DILTIAZEM; FELODIPINE; HYDROCHLOROTHIAZIDE; HYDROCHLOROTHIAZIDE PLUS VALSARTAN; IRBESARTAN; ISRADIPINE; LOSARTAN; NICARDIPINE; NIFEDIPINE; OLMESARTAN; TELMISARTAN; VALSARTAN;

ADULT; AGED; ARTICLE; BLOOD PRESSURE MEASUREMENT; BLOOD PRESSURE REGULATION; CHRONIC KIDNEY DISEASE; COMORBIDITY; CONTROLLED STUDY; DEMOGRAPHY; DIABETES MELLITUS; DRUG EFFICACY; FEMALE; HAZARD RATIO; HUMAN; HYPERTENSION; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; PHYSICIAN; PILL; TREATMENT DURATION; TREATMENT OUTCOME;

ADULT; AGED; ANGIOTENSIN RECEPTOR ANTAGONISTS; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; COMORBIDITY; DOWN-REGULATION; DRUG COMBINATIONS; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; TABLETS; TETRAZOLES; TREATMENT OUTCOME; VALINE;

EID: 77955626786     PISSN: 03007995     EISSN: 14734877     Source Type: Journal    
DOI: 10.1185/03007995.2010.500883     Document Type: Article

References (27)

1. Chobanian AV, Bakris GL, Black HR, et al. and the National High Blood Pressure Education Program Coordinating Committee. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. U.S. Department of Health and Human Services, National Institute of Health. Available at: http://www.nhlbi.nih.gov/ guidelines/hypertension/jnc7full.pdf [Last accessed 3 March 2009]
2. Rosendorff C, Black HR, Cannon CP, et al. Treatment of hypertension in the prevention and management of ischemic heart disease: a scientific statement from the American Heart Association council for high blood pressure research and the councils on clinical cardiology and epidemiology and prevention. Circulation 2007;115:2761-2788
3. European Society of Hypertension-European Society of Cardiology Guidelines Committee. 2003 European Society of Hypertension-European Society of Cardiology guidelines for the management of arterial hypertension. J Hypertens 2003;21:1011-1053
4. Gu Q, Paulose-Ram R, Dillon C, et al. Antihypertensive medication use among US adults with hypertension. Circulation 2006;113:213-221
5. Hajjar I, Kotchen TA. Trends in the prevalence, awareness, treatment, and control of hypertension in the United States, 1988-2000. JAMA 2003;290: 199-206
6. Ong KL, Cheung BM, Man YB, et al. Prevalence, awareness, treatment, and control of hypertension among United States adults, 1999-20 Hypertension 2007;49:69-75
7. Law MR, Wald NJ, Morris JK, et al. Value of low dose combination treatment with blood pressure lowering drugs: analysis of 354 randomised trials. BMJ 2003;326:1427-1431
8. Neutel JM. Prescribing patterns in hypertension: the emerging role of fixeddose combinations for attaining BP goals in hypertensive patients. Curr Med Res Opin 2008;24:2389-2401
9. Dezii CM. A retrospective study of persistence with single-pill combination therapy vs. concurrent two-pill therapy in patients with hypertension. Manag Care 2000;9(Suppl.):2-6
10. Jackson KC 2nd, Sheng X, Nelson RE, et al. Adherence with multiple-combination antihypertensive pharmacotherapies in a US managed care database. Clin Ther 2008;30:1558-1563
11. Bangalore S, Kamalakkannan G, Parkar S, et al. Fixed-dose combinations improve medication compliance: a meta-analysis. Am J Med 2007; 120:713-719
12. Gupta AK, Arshad S, Poulter NR. Compliance, safety, and effectiveness of fixed-dose combinations of antihypertensive agents: a meta-analysis. Hypertension 2010;55:399-407
13. Yang W, Chang J, Kahler KH, et al.Compliance and healthcare utilization among patients with hypertension treated with single pill vs. free combination antihypertensive therapy: U.S. national and state level results from a claims database analysis. Accepted as poster presentation at the ISPOR 15th Annual International Meeting, Atlanta GA, May 15-19, 2010
14. Sapienza S, Sacco P, Floyd K, et al. Results of a pilot pharmacotherapy quality improvement program using fixed-dose, combination amlodipine/benazepril antihypertensive therapy in a long-term care setting. Clin Ther 2003;25: 1872-1887
15. Shaya FT, Du D, Gbarayor CM, et al. Predictors of compliance with antihypertensive therapy in a high-risk medicaid population. J Natl Med Assoc 2009;101:34-39
16. Taylor AA, Shoheiber O. Adherence to antihypertensive therapy with fixeddose amlodipine besylate/benazepril HCl versus comparable componentbased therapy. Congest Heart Fail 2003;9:324-332
17. Brixner DI, Jackson 2nd KC, Sheng X, et al. Assessment of adherence, persistence, and costs among valsartan and hydrochlorothiazide retrospective cohorts in free-and fixed-dose combinations. Curr Med Res Opin 2008;24: 2597-2607
18. Bramley TJ, Gerbino PP, Nightengale BS, et al. Relationship of blood pressure control to adherence with antihypertensive monotherapy in 13 managed care organizations. J Manag Care Pharm 2006;12:239-245
19. Ebbutt AF, Elsdon-Dew RW. A multicentre study examining the substitution of Trasidrex for the free combination of Slow-Trasicor and Navidrex-K. J Int Med Res 1979;7:524-527
20. Forrest WA. An open comparison between free and a fixed combination of diuretic and beta-blocker in the management of essential hypertension. J Int Med Res 1980;8:127-131
21. Nissinen A, Tuomilehto J. Evaluation of the antihypertensive effect of atenolol in fixed or free combination with chlorthalidone. Pharmatherapeutica 1980;2: 462-468
22. Asplund J, Danielson M, Ohman P. Patients compliance in hypertension-the importance of number of tablets. Br J Clin Pharmacol 1984;17:547-552
23. Graham RD. Treating mild-to-moderate hypertension: a comparison of lisinopril-hydrochlorothiazide fixed combination with captopril and hydrochlorothiazide free combination. J Hum Hypertens 1991;5(Suppl. 2):59-60
24. Mancia G, Omboni S; CARDIO (CAndesaRtan combined with DIuretic in hypertensiOn) Study Group. Candesartan plus hydrochlorothiazide fixed combination vs previous monotherapy plus diuretic in poorly controlled essential hypertensive patients. Blood Press Suppl 2004;2:11-17
25. Schweizer J, Hilsmann U, Neumann G, et al. Efficacy and safety of valsartan 160/HCTZ 25 mg in fixed combination in hypertensive patients not controlled by candesartan 32 mg plus HCTZ 25 mg in free combination. Curr Med Res Opin 2007;23:2877-2885
26. Centers for Disease Control and Prevention. National Center for Health Statistics. Compressed Mortality File 1999-2020
27. CDC WONDER Online database. Available at: http://wonder.cdc.gov/cmf- icd10.html [Last accessed 4 August 2008]