Crystal structures of human CtBP in complex with substrate MTOB reveal active site features useful for inhibitor design

FEBS Letters

Volumn 588, Issue 9, 2014, Pages 1743-1748

  Hilbert, Brendan J ^a   Grossman, Steven R ^b   Schiffer, Celia A ^a   Royer, William E ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

Cancer target; Dehydrogenase; NADH; Transcriptional coregulator

Indexed keywords

4 METHYLTHIO 2 OXOBUTYRIC ACID; C TERMINAL BINDING PROTEIN 1; C TERMINAL BINDING PROTEIN 2; COREPRESSOR PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; DEXTRO ISOMER SPECIFIC 2 HYDROXYACID DEHYDROGENASE; DISSOCIATION; DRUG DESIGN; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; HYDROGEN BOND; HYDROPHILICITY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

MUS;

CANCER TARGET; DEHYDROGENASE; NADH; TRANSCRIPTIONAL COREGULATOR;

ALCOHOL OXIDOREDUCTASES; AMINO ACID MOTIFS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DNA-BINDING PROTEINS; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; HYDROGEN BONDING; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; METHIONINE; MODELS, MOLECULAR; NERVE TISSUE PROTEINS; PROTEIN BINDING;

EID: 84899639429     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2014.03.026     Document Type: Article

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