-
1
-
-
0024509701
-
Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome
-
Choo Q. L., Kuo G., Weiner A. J., Overby L. R., Bradley D. W., Houghton M. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science: 1989; 244 4902 359 362 (Pubitemid 19117877)
-
(1989)
Science
, vol.244
, Issue.4902
, pp. 359-362
-
-
Choo, Q.-L.1
Kuo, G.2
Weiner, A.J.3
Overby, L.R.4
Bradley, D.W.5
Houghton, M.6
-
2
-
-
0022868893
-
Treatment of chronic non-A,non-B hepatitis with recombinant human alpha interferon. A preliminary report
-
Hoofnagle J. H., Mullen K. D., Jones D. B., et al. Treatment of chronic non-A, non-B hepatitis with recombinant human alpha interferon. A preliminary report. N Engl J Med: 1986; 315 25 1575 1578 (Pubitemid 17055392)
-
(1986)
New England Journal of Medicine
, vol.315
, Issue.25
, pp. 1575-1578
-
-
Hoofnagle, J.H.1
Mullen, K.D.2
Jones, D.B.3
-
3
-
-
0025847155
-
Ribavirin treatment for chronic hepatitis C
-
Reichard O., Andersson J., Schvarcz R., Weiland O. Ribavirin treatment for chronic hepatitis C. Lancet: 1991; 337 8749 1058 1061
-
(1991)
Lancet
, vol.337
, Issue.8749
, pp. 1058-1061
-
-
Reichard, O.1
Andersson, J.2
Schvarcz, R.3
Weiland, O.4
-
4
-
-
1542377471
-
Antiviral Action of Ribavirin in Chronic Hepatitis C
-
DOI 10.1053/j.gastro.2003.12.002
-
Pawlotsky J. M., Dahari H., Neumann A. U., et al. Antiviral action of ribavirin in chronic hepatitis C. Gastroenterology: 2004; 126 3 703 714 (Pubitemid 38298318)
-
(2004)
Gastroenterology
, vol.126
, Issue.3
, pp. 703-714
-
-
Pawlotsky, J.-M.1
Dahari, H.2
Neumann, A.U.3
Hezode, C.4
Germanidis, G.5
Lonjon, I.6
Castera, L.7
Dhumeaux, D.8
-
5
-
-
0037179698
-
Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection
-
Fried M. W., Shiffman M. L., Reddy K. R., et al. Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N Engl J Med: 2002; 347 13 975 982
-
(2002)
N Engl J Med
, vol.347
, Issue.13
, pp. 975-982
-
-
Fried, M.W.1
Shiffman, M.L.2
Reddy, K.R.3
-
6
-
-
0035934568
-
Peginterferon alfa-2b plus ribavirin compared with interferonalfa-2b plus ribavirin for initial treatment of chronic hepatitis C: A randomised trial
-
DOI 10.1016/S0140-6736(01)06102-5
-
Manns M. P., McHutchison J. G., Gordon S. C., et al. Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet: 2001; 358 9286 958 965 (Pubitemid 32913521)
-
(2001)
Lancet
, vol.358
, Issue.9286
, pp. 958-965
-
-
Manns, M.P.1
McHutchison, J.G.2
Gordon, S.C.3
Rustgi, V.K.4
Shiffman, M.5
Reindollar, R.6
Goodman, Z.D.7
Koury, K.8
Ling, M.-H.9
Albrecht, J.K.10
-
7
-
-
84876582239
-
Treatment of chronic hepatitis C: Current and future
-
Pawlotsky J. M. Treatment of chronic hepatitis C: current and future. Curr Top Microbiol Immunol: 2013; 369 321 342
-
(2013)
Curr Top Microbiol Immunol
, vol.369
, pp. 321-342
-
-
Pawlotsky, J.M.1
-
8
-
-
0037228023
-
Antiviral effect and virus-host interactions in response to alpha interferon, gamma interferon, poly(I)-poly(C), tumor necrosis factor alpha, and ribavirin in hepatitis C virus subgenomic replicons
-
DOI 10.1128/JVI.77.2.1092-1104.2003
-
Lanford R. E., Guerra B., Lee H., et al. Antiviral effect and virus-host interactions in response to alpha interferon, gamma interferon, poly(i)-poly(c), tumor necrosis factor alpha, and ribavirin in hepatitis C virus subgenomic replicons. J Virol: 2003; 77 2 1092 1104 (Pubitemid 36055531)
-
(2003)
Journal of Virology
, vol.77
, Issue.2
, pp. 1092-1104
-
-
Lanford, R.E.1
Guerra, B.2
Lee, H.3
Averett, D.R.4
Pfeiffer, B.5
Chavez, D.6
Notvall, L.7
Bigger, C.8
-
9
-
-
70349292099
-
Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance
-
Ge D., Fellay J., Thompson A. J., et al. Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature: 2009; 461 7262 399 401
-
(2009)
Nature
, vol.461
, Issue.7262
, pp. 399-401
-
-
Ge, D.1
Fellay, J.2
Thompson, A.J.3
-
10
-
-
0032475822
-
Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon- therapy
-
DOI 10.1126/science.282.5386.103
-
Neumann A. U., Lam N. P., Dahari H., et al. Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy. Science: 1998; 282 5386 103 107 (Pubitemid 28471138)
-
(1998)
Science
, vol.282
, Issue.5386
, pp. 103-107
-
-
Neumann, A.U.1
Lam, N.P.2
Dahari, H.3
Gretch, D.R.4
Wiley, T.E.5
Layden, T.J.6
Perelson, A.S.7
-
11
-
-
80055046594
-
Hepatitis C viral kinetics in the era of direct acting antiviral agents and IL28B
-
Dahari H., Guedj J., Perelson A. S., Layden T. J. Hepatitis C viral kinetics in the era of direct acting antiviral agents and IL28B. Curr Hepat Rep: 2011; 10 3 214 227
-
(2011)
Curr Hepat Rep
, vol.10
, Issue.3
, pp. 214-227
-
-
Dahari, H.1
Guedj, J.2
Perelson, A.S.3
Layden, T.J.4
-
12
-
-
84899651167
-
Targets for antiviral therapy of hepatitis C
-
Rupp D., Bartenshlager R. Targets for antiviral therapy of hepatitis C. Semin Liver Dis: 2014; 34 9 21
-
(2014)
Semin Liver Dis
, vol.34
, pp. 9-21
-
-
Rupp, D.1
Bartenshlager, R.2
-
13
-
-
40949117600
-
The cyclophilin inhibitor Debio-025 shows potent anti-hepatitis C effect in patients coinfected with hepatitis C and human immunodeficiency virus
-
DOI 10.1002/hep.22131
-
Flisiak R., Horban A., Gallay P., et al. The cyclophilin inhibitor Debio-025 shows potent anti-hepatitis C effect in patients coinfected with hepatitis C and human immunodeficiency virus. Hepatology: 2008; 47 3 817 826 (Pubitemid 351449673)
-
(2008)
Hepatology
, vol.47
, Issue.3
, pp. 817-826
-
-
Flisiak, R.1
Horban, A.2
Gallay, P.3
Bobardt, M.4
Selvarajah, S.5
Wiercinska-Drapalo, A.6
Siwak, E.7
Cielniak, I.8
Higersberger, J.9
Kierkus, J.10
Aeschlimann, C.11
Grosgurin, P.12
Nicolas-Metral, V.13
Dumont, J.-M.14
Porchet, H.15
Crabbe, R.16
Scalfaro, P.17
-
14
-
-
84877258007
-
Treatment of HCV infection by targeting microRNA
-
Janssen H. L., Reesink H. W., Lawitz E. J., et al. Treatment of HCV infection by targeting microRNA. N Engl J Med: 2013; 368 18 1685 1694
-
(2013)
N Engl J Med
, vol.368
, Issue.18
, pp. 1685-1694
-
-
Janssen, H.L.1
Reesink, H.W.2
Lawitz, E.J.3
-
15
-
-
83555174694
-
In vitro selection and characterization of HCV replicons resistant to multiple non-nucleoside polymerase inhibitors
-
Delang L., Vliegen I., Leyssen P., Neyts J. In vitro selection and characterization of HCV replicons resistant to multiple non-nucleoside polymerase inhibitors. J Hepatol: 2012; 56 1 41 48
-
(2012)
J Hepatol
, vol.56
, Issue.1
, pp. 41-48
-
-
Delang, L.1
Vliegen, I.2
Leyssen, P.3
Neyts, J.4
-
16
-
-
79955103901
-
Treatment failure and resistance with direct-acting antiviral drugs against hepatitis C virus
-
Pawlotsky J. M. Treatment failure and resistance with direct-acting antiviral drugs against hepatitis C virus. Hepatology: 2011; 53 5 1742 1751
-
(2011)
Hepatology
, vol.53
, Issue.5
, pp. 1742-1751
-
-
Pawlotsky, J.M.1
-
17
-
-
84859412455
-
Effect of IL28B genotype on early viral kinetics during interferon-free treatment of patients with chronic hepatitis C
-
Chu T. W., Kulkarni R., Gane E. J., et al. Effect of IL28B genotype on early viral kinetics during interferon-free treatment of patients with chronic hepatitis C. Gastroenterology: 2012; 142 4 790 795
-
(2012)
Gastroenterology
, vol.142
, Issue.4
, pp. 790-795
-
-
Chu, T.W.1
Kulkarni, R.2
Gane, E.J.3
-
18
-
-
84881405876
-
Faldaprevir and deleobuvir for HCV genotype 1 infection
-
Zeuzem S., Soriano V., Asselah T., et al. Faldaprevir and deleobuvir for HCV genotype 1 infection. N Engl J Med: 2013; 369 7 630 639
-
(2013)
N Engl J Med
, vol.369
, Issue.7
, pp. 630-639
-
-
Zeuzem, S.1
Soriano, V.2
Asselah, T.3
-
19
-
-
84877739274
-
Sofosbuvir for hepatitis C genotype 2 or 3 in patients without treatment options
-
POSITRON Study; FUSION Study
-
Jacobson I. M., Gordon S. C., Kowdley K. V., et al. POSITRON Study; FUSION Study. Sofosbuvir for hepatitis C genotype 2 or 3 in patients without treatment options. N Engl J Med: 2013; 368 20 1867 1877
-
(2013)
N Engl J Med
, vol.368
, Issue.20
, pp. 1867-1877
-
-
Jacobson, I.M.1
Gordon, S.C.2
Kowdley, K.V.3
-
20
-
-
84877730954
-
Sofosbuvir for previously untreated chronic hepatitis C infection
-
Lawitz E., Mangia A., Wyles D., et al. Sofosbuvir for previously untreated chronic hepatitis C infection. N Engl J Med: 2013; 368 20 1878 1887
-
(2013)
N Engl J Med
, vol.368
, Issue.20
, pp. 1878-1887
-
-
Lawitz, E.1
Mangia, A.2
Wyles, D.3
-
21
-
-
84892751187
-
Sofosbuvir + ribavirin for 12 or 24 weeks for patients with HCV genotype 2 or 3: The VALENCE trial
-
Zeuzem S., Dusheiko G. M., Salupere R., et al. Sofosbuvir + ribavirin for 12 or 24 weeks for patients with HCV genotype 2 or 3: the VALENCE trial. Hepatology: 2013; 58 01 733A
-
(2013)
Hepatology
, vol.58
, Issue.1
-
-
Zeuzem, S.1
Dusheiko, G.M.2
Salupere, R.3
-
22
-
-
79957448889
-
Second-phase hepatitis C virus RNA decline during telaprevir-based therapy increases with drug effectiveness: Implications for treatment duration
-
Guedj J., Perelson A. S. Second-phase hepatitis C virus RNA decline during telaprevir-based therapy increases with drug effectiveness: implications for treatment duration. Hepatology: 2011; 53 6 1801 1808
-
(2011)
Hepatology
, vol.53
, Issue.6
, pp. 1801-1808
-
-
Guedj, J.1
Perelson, A.S.2
-
23
-
-
84867253160
-
The application and mechanism of action of ribavirin in therapy of hepatitis C
-
Thomas E., Ghany M. G., Liang T. J. The application and mechanism of action of ribavirin in therapy of hepatitis C. Antivir Chem Chemother: 2012; 23 1 1 12
-
(2012)
Antivir Chem Chemother
, vol.23
, Issue.1
, pp. 1-12
-
-
Thomas, E.1
Ghany, M.G.2
Liang, T.J.3
-
24
-
-
84884718503
-
The importance of drug-drug interactions in the DAA era
-
05
-
Back D., Else L. The importance of drug-drug interactions in the DAA era. Dig Liver Dis: 2013; 45 05 S343 S348
-
(2013)
Dig Liver Dis
, vol.45
-
-
Back, D.1
Else, L.2
-
25
-
-
79953176289
-
Boceprevir for previously treated chronic HCV genotype 1 infection
-
HCV RESPOND-2 Investigators
-
Bacon B. R., Gordon S. C., Lawitz E., et al. HCV RESPOND-2 Investigators. Boceprevir for previously treated chronic HCV genotype 1 infection. N Engl J Med: 2011; 364 13 1207 1217
-
(2011)
N Engl J Med
, vol.364
, Issue.13
, pp. 1207-1217
-
-
Bacon, B.R.1
Gordon, S.C.2
Lawitz, E.3
-
26
-
-
84882908504
-
Triple therapy in treatment-experienced patients with HCV-cirrhosis in a multicentre cohort of the French Early Access Programme (ANRS CO20-CUPIC) - NCT01514890
-
CUPIC Study Group
-
Hézode C., Fontaine H., Dorival C., et al. CUPIC Study Group. Triple therapy in treatment-experienced patients with HCV-cirrhosis in a multicentre cohort of the French Early Access Programme (ANRS CO20-CUPIC) - NCT01514890. J Hepatol: 2013; 59 3 434 441
-
(2013)
J Hepatol
, vol.59
, Issue.3
, pp. 434-441
-
-
Hézode, C.1
Fontaine, H.2
Dorival, C.3
-
27
-
-
79959438789
-
Telaprevir for previously untreated chronic hepatitis C virus infection
-
ADVANCE Study Team
-
Jacobson I. M., McHutchison J. G., Dusheiko G., et al. ADVANCE Study Team. Telaprevir for previously untreated chronic hepatitis C virus infection. N Engl J Med: 2011; 364 25 2405 2416
-
(2011)
N Engl J Med
, vol.364
, Issue.25
, pp. 2405-2416
-
-
Jacobson, I.M.1
McHutchison, J.G.2
Dusheiko, G.3
-
28
-
-
77950817619
-
Telaprevir for previously treated chronic HCV infection
-
PROVE3 Study Team
-
McHutchison J. G., Manns M. P., Muir A. J., et al. PROVE3 Study Team. Telaprevir for previously treated chronic HCV infection. N Engl J Med: 2010; 362 14 1292 1303
-
(2010)
N Engl J Med
, vol.362
, Issue.14
, pp. 1292-1303
-
-
McHutchison, J.G.1
Manns, M.P.2
Muir, A.J.3
-
29
-
-
79953173221
-
Boceprevir for untreated chronic HCV genotype 1 infection
-
SPRINT-2 Investigators
-
Poordad F., McCone J. Jr, Bacon B. R., et al. SPRINT-2 Investigators. Boceprevir for untreated chronic HCV genotype 1 infection. N Engl J Med: 2011; 364 13 1195 1206
-
(2011)
N Engl J Med
, vol.364
, Issue.13
, pp. 1195-1206
-
-
Poordad, F.1
McCone, Jr.M.J.2
Bacon, B.R.3
-
30
-
-
84879198467
-
Simeprevir (TMC435) with peginterferon/ribavirin for chronic HCV genotype-1 infection in treatment-naive patients: Results from QUEST-1, a Phase III trial
-
Jacobson I., Dore G. J., Foster G. R., et al. Simeprevir (TMC435) with peginterferon/ribavirin for chronic HCV genotype-1 infection in treatment-naive patients: results from QUEST-1, a Phase III trial. J Hepatol: 2013; 58 01 S574
-
(2013)
J Hepatol
, vol.58
, Issue.1
-
-
Jacobson, I.1
Dore, G.J.2
Foster, G.R.3
-
31
-
-
84879198467
-
Simeprevir (TMC435) with peginterferon/ribavirin for treatment of chronic HCV genotype-1 infection in treatment-naive patients: Results from QUEST-2, a Phase III trial
-
Manns M., Marcellin P., Poordad F. PF., et al. Simeprevir (TMC435) with peginterferon/ribavirin for treatment of chronic HCV genotype-1 infection in treatment-naive patients: results from QUEST-2, a Phase III trial. J Hepatol: 2013; 58 01 S568
-
(2013)
J Hepatol
, vol.58
, Issue.1
-
-
Manns, M.1
Marcellin, P.2
Poordad, F.P.3
-
32
-
-
84892614710
-
Simeprevir (TMC435) with peginterferon/ribavirin for treatment of chronic HCV genotype-1 infection in treatment-naive patients: Results from QUEST-2, a Phase III trial
-
Poordad F., Manns M. P., Marcellin P., et al. Simeprevir (TMC435) with peginterferon/ribavirin for treatment of chronic HCV genotype-1 infection in treatment-naive patients: results from QUEST-2, a Phase III trial. Gastroenterology: 2013; 144 S151 S151
-
(2013)
Gastroenterology
, vol.144
-
-
Poordad, F.1
Manns, M.P.2
Marcellin, P.3
-
33
-
-
84861109960
-
Genotype and subtype profiling of PSI-7977 as a nucleotide inhibitor of hepatitis C virus
-
Lam A. M., Espiritu C., Bansal S., et al. Genotype and subtype profiling of PSI-7977 as a nucleotide inhibitor of hepatitis C virus. Antimicrob Agents Chemother: 2012; 56 6 3359 3368
-
(2012)
Antimicrob Agents Chemother
, vol.56
, Issue.6
, pp. 3359-3368
-
-
Lam, A.M.1
Espiritu, C.2
Bansal, S.3
-
34
-
-
84881241885
-
Structure-activity relationships in the development of allosteric hepatitis C virus RNA-dependent RNA polymerase inhibitors: Ten years of research
-
Haudecoeur R., Peuchmaur M., Ahmed-Belkacem A., Pawlotsky J. M., Boumendjel A. Structure-activity relationships in the development of allosteric hepatitis C virus RNA-dependent RNA polymerase inhibitors: ten years of research. Med Res Rev: 2013; 33 5 934 984
-
(2013)
Med Res Rev
, vol.33
, Issue.5
, pp. 934-984
-
-
Haudecoeur, R.1
Peuchmaur, M.2
Ahmed-Belkacem, A.3
Pawlotsky, J.M.4
Boumendjel, A.5
-
35
-
-
84874644131
-
Modeling shows that the NS5A inhibitor daclatasvir has two modes of action and yields a shorter estimate of the hepatitis C virus half-life
-
Guedj J., Dahari H., Rong L., et al. Modeling shows that the NS5A inhibitor daclatasvir has two modes of action and yields a shorter estimate of the hepatitis C virus half-life. Proc Natl Acad Sci U S A: 2013; 110 10 3991 3996
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, Issue.10
, pp. 3991-3996
-
-
Guedj, J.1
Dahari, H.2
Rong, L.3
-
36
-
-
84898981873
-
Kinetic analyses of antiviral suppression by NS5A inhibitors reveal early and potent inhibition of viral assembly and release of infectious virus
-
McGivern D. R., Masaki T., Ping L. F., et al. Kinetic analyses of antiviral suppression by NS5A inhibitors reveal early and potent inhibition of viral assembly and release of infectious virus. Hepatology: 2013; 58 01 246A
-
(2013)
Hepatology
, vol.58
, Issue.1
-
-
McGivern, D.R.1
Masaki, T.2
Ping, L.F.3
-
37
-
-
84880299420
-
NS5A inhibitors in the treatment of hepatitis C
-
Pawlotsky J. M. NS5A inhibitors in the treatment of hepatitis C. J Hepatol: 2013; 59 2 375 382
-
(2013)
J Hepatol
, vol.59
, Issue.2
, pp. 375-382
-
-
Pawlotsky, J.M.1
-
38
-
-
84880304436
-
Alisporivir plus ribavirin achieves high rates of sustained HCV clearance (SVR24) as interferon (IFN)-free or IFN-add-on regimen in treatment-naive patients with HCV GT2 or GT3: Final results from VITAL-1 study
-
Pawlotsky J. M., Sarin S. K., Foster G. R., et al. Alisporivir plus ribavirin achieves high rates of sustained HCV clearance (SVR24) as interferon (IFN)-free or IFN-add-on regimen in treatment-naive patients with HCV GT2 or GT3: final results from VITAL-1 study. Hepatology: 2012; 56 309A 310A
-
(2012)
Hepatology
, vol.56
-
-
Pawlotsky, J.M.1
Sarin, S.K.2
Foster, G.R.3
-
39
-
-
84895736477
-
SVR results of a once-daily regimen of simeprevir (TMC435) plus sofosbuvir (GS-7977) with or without ribavirin in cirrhotic and non-cirrhotic HCV genotype 1 treatment-naïve and prior null responder patients: The COSMOS study
-
Jacobson I. M., Ghalib R. H., Rodriguez-Torres M., et al. SVR results of a once-daily regimen of simeprevir (TMC435) plus sofosbuvir (GS-7977) with or without ribavirin in cirrhotic and non-cirrhotic HCV genotype 1 treatment-naïve and prior null responder patients: the COSMOS study. Hepatology: 2013; 58 01 1379A
-
(2013)
Hepatology
, vol.58
, Issue.1
-
-
Jacobson, I.M.1
Ghalib, R.H.2
Rodriguez-Torres, M.3
|