Noonan and LEOPARD syndrome Shp2 variants induce heart displacement defects in zebrafish

Development (Cambridge)

Volumn 141, Issue 9, 2014, Pages 1961-1970

  Bonetti, Monica ^a   Overman, Jeroen Paardekooper ^a   Tessadori, Federico ^a   Noël, Emily ^a   Bakkers, Jeroen ^a   den Hertog, Jeroen ^a,b  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b LEIDEN UNIVERSITY   (Netherlands)

Author keywords

LEOPARD syndrome; MAPK; Noonan syndrome; Shp2; Zebrafish

Indexed keywords

2 (2 CHLORO 4 IODOANILINO) N CYCLOPROPYLMETHOXY 3,4 DIFLUOROBENZAMIDE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN TYROSINE PHOSPHATASE SHP 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATRIOVENTRICULAR BLOCK; CELL MIGRATION; CELL MOTION; CONTROLLED STUDY; ENDOCARDIAL CUSHION; GASTRULATION; HEART CYCLE; HEART DEVELOPMENT; HEART DISEASE; HEART DISPLACEMENT DEFECT; HEART FUNCTION; HEART MUSCLE CELL; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; IN VIVO STUDY; LEOPARD SYNDROME; NONHUMAN; NOONAN SYNDROME; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; ZEBRA FISH;

LEOPARD SYNDROME; MAPK; NOONAN SYNDROME; SHP2; ZEBRAFISH;

ANIMALS; BENZAMIDES; BODY PATTERNING; CELL MOVEMENT; CILIA; EMBRYO, NONMAMMALIAN; HEART DEFECTS, CONGENITAL; HEART FUNCTION TESTS; HUMANS; LEOPARD SYNDROME; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MUTATION; MYOCYTES, CARDIAC; NOONAN SYNDROME; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 11; ZEBRAFISH; ZEBRAFISH PROTEINS;

EID: 84899624551     PISSN: 09501991     EISSN: 14779129     Source Type: Journal    
DOI: 10.1242/dev.106310     Document Type: Article

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