Total chemical synthesis of the enzyme sortase AΔN59 with full catalytic activity

Angewandte Chemie - International Edition

Volumn 53, Issue 18, 2014, Pages 4662-4666

  Deng, Fang Kun ^a   Zhang, Liang ^a   Wang, Ya Ting ^a   Schneewind, Olaf ^a   Kent, Stephen B H ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

chemical ligation; chemical protein synthesis; convergent synthesis; enzyme catalysis; sortase A

Indexed keywords

BACTERIA; BIOSYNTHESIS; CATALYSIS; CELL MEMBRANES; CHAINS; MOLECULES; PEPTIDES; SIZE EXCLUSION CHROMATOGRAPHY;

CHEMICAL LIGATION; CHEMICAL PROTEIN SYNTHESIS; CONVERGENT SYNTHESIS; ENZYME CATALYSIS; SORTASE A;

ENZYMES;

AMINOACYLTRANSFERASE; BACTERIAL PROTEIN; CYSTEINE PROTEINASE; PEPTIDE FRAGMENT; SORTASE A;

AMINO ACID SEQUENCE; CATALYSIS; CHEMISTRY; GEL CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; MOLECULAR GENETICS; PROTEIN FOLDING; SYNTHESIS;

AMINO ACID SEQUENCE; AMINOACYLTRANSFERASES; BACTERIAL PROTEINS; CATALYSIS; CHROMATOGRAPHY, GEL; CYSTEINE ENDOPEPTIDASES; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PROTEIN FOLDING; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 84899570509     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201310900     Document Type: Article

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