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Volumn 45, Issue 6, 2014, Pages 1989-1997

Suppression of lung cancer cell invasion by LKB1 is due to the downregulation of tissue factor and vascular endothelial growth factor, partly dependent on SP1

Author keywords

A549 cells; Invasion; LKB1 STK11; Tissue factor; Vascular endothelial growth factor

Indexed keywords

MESSENGER RNA; PROTEIN KINASE LKB1; THROMBOPLASTIN; TRANSCRIPTION FACTOR SP1; VASCULOTROPIN; PROTEIN SERINE THREONINE KINASE; SP1 PROTEIN, HUMAN; STK11 PROTEIN, HUMAN; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN;

EID: 84899552802     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2014.2351     Document Type: Article
Times cited : (16)

References (30)
  • 1
    • 84893409546 scopus 로고    scopus 로고
    • Improving care and quality of life for patients with lung cancer
    • Bennett A and White J: Improving care and quality of life for patients with lung cancer. Nursing Stand 28: 50-58, 2013.
    • (2013) Nursing Stand , vol.28 , pp. 50-58
    • Bennett, A.1    White, J.2
  • 2
    • 42349115927 scopus 로고    scopus 로고
    • Matrix metalloproteinase-8 functions as a metastasis suppressor through modulation of tumor cell adhesion and invasion
    • Gutierrez-Fernandez A, Fueyo A, Folgueras AR, et al: Matrix metalloproteinase-8 functions as a metastasis suppressor through modulation of tumor cell adhesion and invasion. Cancer Res 68: 2755-2763, 2008.
    • (2008) Cancer Res , vol.68 , pp. 2755-2763
    • Gutierrez-Fernandez, A.1    Fueyo, A.2    Folgueras, A.R.3
  • 3
    • 52049106366 scopus 로고    scopus 로고
    • Chondroitin sulfate E fragments enhance CD44 cleavage and CD44-dependent motility in tumor cells
    • Sugahara KN, Hirata T, Tanaka T, et al: Chondroitin sulfate E fragments enhance CD44 cleavage and CD44-dependent motility in tumor cells. Cancer Res 68: 7191-7199, 2008.
    • (2008) Cancer Res , vol.68 , pp. 7191-7199
    • Sugahara, K.N.1    Hirata, T.2    Tanaka, T.3
  • 4
    • 0042525904 scopus 로고    scopus 로고
    • LKB1 protein expression in the evolution of glandular neoplasia of the lung
    • Ghaffar H, Sahin F, Sanchez-Cepedes M, et al: LKB1 protein expression in the evolution of glandular neoplasia of the lung. Clin Cancer Res 9: 2998-3003, 2003.
    • (2003) Clin Cancer Res , vol.9 , pp. 2998-3003
    • Ghaffar, H.1    Sahin, F.2    Sanchez-Cepedes, M.3
  • 5
    • 0037444404 scopus 로고    scopus 로고
    • Growth and molecular profile of lung cancer cells expressing ectopic LKB1: Down-regulation of the phosphatidylinositol 3′-phosphate kinase/PTEN pathway
    • Jimenez AI, Fernandez P, Dominguez O, Dopazo A and Sanchez-Cespedes M: Growth and molecular profile of lung cancer cells expressing ectopic LKB1: down-regulation of the phosphatidylinositol 3′-phosphate kinase/PTEN pathway. Cancer Res 63: 1382-1388, 2003.
    • (2003) Cancer Res , vol.63 , pp. 1382-1388
    • Jimenez, A.I.1    Fernandez, P.2    Dominguez, O.3    Dopazo, A.4    Sanchez-Cespedes, M.5
  • 6
    • 78650465738 scopus 로고    scopus 로고
    • LKB1 regulated pathways in lung cancer invasion and metastasis
    • Marcus AI and Zhou W: LKB1 regulated pathways in lung cancer invasion and metastasis. J Thorac oncol 5: 1883-1886, 2010.
    • (2010) J Thorac Oncol , vol.5 , pp. 1883-1886
    • Marcus, A.I.1    Zhou, W.2
  • 7
    • 77953279387 scopus 로고    scopus 로고
    • Effect of small interfering RNA-induced LKB1 gene silencing on the biological behavior of lung carcinoma cells
    • In Chinese
    • Liang X, Nan KJ and Xu QZ: Effect of small interfering RNA-induced LKB1 gene silencing on the biological behavior of lung carcinoma cells. Nan Fang Yi Ke Da Xue Xue Bao 27: 1303-1306, 2007 (In Chinese).
    • (2007) Nan Fang Yi Ke Da Xue Xue Bao , vol.27 , pp. 1303-1306
    • Liang, X.1    Nan, K.J.2    Xu, Q.Z.3
  • 8
    • 77950500155 scopus 로고    scopus 로고
    • Effect of transfection of LKB1 on biological behavior of human lung adenocarcinoma cells
    • In Chinese
    • Liang X, Nan KJ, Li CL, Yao Y, Tian T and Wang SH: Effect of transfection of LKB1 on biological behavior of human lung adenocarcinoma cells. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 24: 1140-1142, 2008 (In Chinese).
    • (2008) Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi , vol.24 , pp. 1140-1142
    • Liang, X.1    Nan, K.J.2    Li, C.L.3    Yao, Y.4    Tian, T.5    Wang, S.H.6
  • 9
    • 67449094283 scopus 로고    scopus 로고
    • Overexpression of the LKB1 gene inhibits lung carcinoma cell proliferation partly through degradation of c-myc protein
    • Liang X, Nan KJ, Li ZL and Xu QZ: Overexpression of the LKB1 gene inhibits lung carcinoma cell proliferation partly through degradation of c-myc protein. Oncol Rep 21: 925-931, 2009.
    • (2009) Oncol Rep , vol.21 , pp. 925-931
    • Liang, X.1    Nan, K.J.2    Li, Z.L.3    Xu, Q.Z.4
  • 10
    • 0035903028 scopus 로고    scopus 로고
    • Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice
    • Ylikorkala A, Rossi DJ, Korsisaari N, et al: Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice. Science 293: 1323-1326, 2001.
    • (2001) Science , vol.293 , pp. 1323-1326
    • Ylikorkala, A.1    Rossi, D.J.2    Korsisaari, N.3
  • 11
    • 3142587052 scopus 로고    scopus 로고
    • Dysregulation of HIF and VEGF is a unifying feature of the familial hamartoma syndromes
    • Brugarolas J and Kaelin WG Jr: Dysregulation of HIF and VEGF is a unifying feature of the familial hamartoma syndromes. Cancer Cell 6: 7-10, 2004.
    • (2004) Cancer Cell , vol.6 , pp. 7-10
    • Brugarolas, J.1    Kaelin Jr., W.G.2
  • 12
    • 0036202118 scopus 로고    scopus 로고
    • Expression of tissue factor and vascular endothelial growth factor is associated with angiogenesis in colorectal cancer
    • Nakasaki T, Wada H, Shigemori C, et al: Expression of tissue factor and vascular endothelial growth factor is associated with angiogenesis in colorectal cancer. Am J Hematol 69: 247-254, 2002.
    • (2002) Am J Hematol , vol.69 , pp. 247-254
    • Nakasaki, T.1    Wada, H.2    Shigemori, C.3
  • 13
    • 25144521282 scopus 로고    scopus 로고
    • Regulation of vascular endothelial growth factor (VEGF) production and angiogenesis by tissue factor (TF) in SGC-7901 gastric cancer cells
    • Zhang J, Ding J, Zhang X, Shao X and Hao Z: Regulation of vascular endothelial growth factor (VEGF) production and angiogenesis by tissue factor (TF) in SGC-7901 gastric cancer cells. Cancer Biol Ther 4: 769-772, 2005.
    • (2005) Cancer Biol Ther , vol.4 , pp. 769-772
    • Zhang, J.1    Ding, J.2    Zhang, X.3    Shao, X.4    Hao, Z.5
  • 14
    • 2642668464 scopus 로고    scopus 로고
    • Tissue-factor expression in human non-small-cell lung carcinoma measured by immunohistochemistry: Correlation between tissue factor and angiogenesis
    • Koomagi R and Volm M: Tissue-factor expression in human non-small-cell lung carcinoma measured by immunohistochemistry: correlation between tissue factor and angiogenesis. Int J Cancer 79: 19-22, 1998.
    • (1998) Int J Cancer , vol.79 , pp. 19-22
    • Koomagi, R.1    Volm, M.2
  • 15
    • 77953262899 scopus 로고    scopus 로고
    • Recombinant adenovirus-mediated RNA silencing of tissue factor expression in human islet: An in vitro study
    • In Chinese
    • Li ZL, Xu WJ, Tian PX, et al: Recombinant adenovirus-mediated RNA silencing of tissue factor expression in human islet: an in vitro study. Nan Fang Yi Ke Da Xue Xue Bao 27: 1299-1302, 2007 (In Chinese).
    • (2007) Nan Fang Yi Ke Da Xue Xue Bao , vol.27 , pp. 1299-1302
    • Li, Z.L.1    Xu, W.J.2    Tian, P.X.3
  • 16
    • 34547926839 scopus 로고    scopus 로고
    • LKB1 modulates lung cancer differentiation and metastasis
    • Ji H, Ramsey MR, Hayes DN, et al: LKB1 modulates lung cancer differentiation and metastasis. Nature 448: 807-810, 2007.
    • (2007) Nature , vol.448 , pp. 807-810
    • Ji, H.1    Ramsey, M.R.2    Hayes, D.N.3
  • 17
    • 79957457514 scopus 로고    scopus 로고
    • Small interference RNA targeting tissue factor inhibits human lung adenocarcinoma growth in vitro and in vivo
    • Xu C, Gui Q, Chen W, et al: Small interference RNA targeting tissue factor inhibits human lung adenocarcinoma growth in vitro and in vivo. J Exp Clin Cancer Res 30: 63, 2011.
    • (2011) J Exp Clin Cancer Res , vol.30 , pp. 63
    • Xu, C.1    Gui, Q.2    Chen, W.3
  • 18
    • 0347601704 scopus 로고    scopus 로고
    • Expression of tissue factor mRNA and invasion of blood vessels by tumor cells in non-small cell lung cancer
    • Minamiya Y, Matsuzaki I, Sageshima M, et al: Expression of tissue factor mRNA and invasion of blood vessels by tumor cells in non-small cell lung cancer. Surg Today 34: 1-5, 2004.
    • (2004) Surg Today , vol.34 , pp. 1-5
    • Minamiya, Y.1    Matsuzaki, I.2    Sageshima, M.3
  • 20
    • 34347369232 scopus 로고    scopus 로고
    • Angiogenesis inhibition in the treatment of lung cancer
    • Vokes E, Herbst R and Sandler A: Angiogenesis inhibition in the treatment of lung cancer. Clin Adv Hematol Oncol 4: 1-10, 2006.
    • (2006) Clin Adv Hematol Oncol , vol.4 , pp. 1-10
    • Vokes, E.1    Herbst, R.2    Sandler, A.3
  • 21
    • 41649105281 scopus 로고    scopus 로고
    • Inhibiting colorectal carcinoma growth and metastasis by blocking the expression of VEGF using RNA interference
    • Wang S, Liu H, Ren L, Pan Y and Zhang Y: Inhibiting colorectal carcinoma growth and metastasis by blocking the expression of VEGF using RNA interference. Neoplasia 10: 399-407, 2008.
    • (2008) Neoplasia , vol.10 , pp. 399-407
    • Wang, S.1    Liu, H.2    Ren, L.3    Pan, Y.4    Zhang, Y.5
  • 22
    • 0035260140 scopus 로고    scopus 로고
    • The role of the hemostatic system in tumor growth, metastasis, and angiogenesis: Tissue factor is a bifunctional molecule capable of inducing both fibrin deposition and angiogenesis in cancer
    • Rickles FR, Shoji M and Abe K: The role of the hemostatic system in tumor growth, metastasis, and angiogenesis: tissue factor is a bifunctional molecule capable of inducing both fibrin deposition and angiogenesis in cancer. Int J Hematol 73: 145-150, 2001.
    • (2001) Int J Hematol , vol.73 , pp. 145-150
    • Rickles, F.R.1    Shoji, M.2    Abe, K.3
  • 23
    • 50349086063 scopus 로고    scopus 로고
    • Tissue factor expression in non-small cell lung cancer: Relationship with vascular endothelial growth factor expression, microvascular density, and K-ras mutation
    • Regina S, Rollin J, Blechet C, Iochmann S, Reverdiau P and Gruel Y: Tissue factor expression in non-small cell lung cancer: relationship with vascular endothelial growth factor expression, microvascular density, and K-ras mutation. J Thorac Oncol 3: 689-697, 2008.
    • (2008) J Thorac Oncol , vol.3 , pp. 689-697
    • Regina, S.1    Rollin, J.2    Blechet, C.3    Iochmann, S.4    Reverdiau, P.5    Gruel, Y.6
  • 24
    • 0242525613 scopus 로고    scopus 로고
    • Tissue factor expression correlates with tumor angiogenesis and invasiveness in human hepatocellular carcinoma
    • Poon RT, Lau CP, Ho JW, Yu WC, Fan ST and Wong J: Tissue factor expression correlates with tumor angiogenesis and invasiveness in human hepatocellular carcinoma. Clin Cancer Res 9: 5339-5345, 2003.
    • (2003) Clin Cancer Res , vol.9 , pp. 5339-5345
    • Poon, R.T.1    Lau, C.P.2    Ho, J.W.3    Yu, W.C.4    Fan, S.T.5    Wong, J.6
  • 25
    • 70349678707 scopus 로고    scopus 로고
    • Increased tissue factor expression is associated with reduced survival in non-small cell lung cancer and with mutations of TP53 and PTEN
    • Regina S, Valentin JB, Lachot S, Lemarie E, Rollin J and Gruel Y: Increased tissue factor expression is associated with reduced survival in non-small cell lung cancer and with mutations of TP53 and PTEN. Clin Chem 55: 1834-1842, 2009.
    • (2009) Clin Chem , vol.55 , pp. 1834-1842
    • Regina, S.1    Valentin, J.B.2    Lachot, S.3    Lemarie, E.4    Rollin, J.5    Gruel, Y.6
  • 26
    • 23244443585 scopus 로고    scopus 로고
    • COX-2 inhibitors suppress integrin alpha5 expression in human lung carcinoma cells through activation of Erk: Involvement of Sp1 and AP-1 sites
    • Han S and Roman J: COX-2 inhibitors suppress integrin alpha5 expression in human lung carcinoma cells through activation of Erk: involvement of Sp1 and AP-1 sites. Int J Cancer 116: 536-546, 2005.
    • (2005) Int J Cancer , vol.116 , pp. 536-546
    • Han, S.1    Roman, J.2
  • 27
    • 34247162696 scopus 로고    scopus 로고
    • Elevated expression of vascular endothelial growth factor correlates with increased angiogenesis and decreased progression-free survival among patients with low-grade neuroendocrine tumors
    • Zhang J, Jia Z, Li Q, et al: Elevated expression of vascular endothelial growth factor correlates with increased angiogenesis and decreased progression-free survival among patients with low-grade neuroendocrine tumors. Cancer 109: 1478-1486, 2007.
    • (2007) Cancer , vol.109 , pp. 1478-1486
    • Zhang, J.1    Jia, Z.2    Li, Q.3
  • 28
    • 84857873333 scopus 로고    scopus 로고
    • Gene expression of the tumour suppressor LKB1 is mediated by Sp1, NF-Y and FOXO transcription factors
    • Lutzner N, De-Castro AJ and Rosl F: Gene expression of the tumour suppressor LKB1 is mediated by Sp1, NF-Y and FOXO transcription factors. PLoS One 7: e32590, 2012.
    • (2012) PLoS One , vol.7
    • Lutzner, N.1    De-Castro, A.J.2    Rosl, F.3
  • 29
    • 0035872399 scopus 로고    scopus 로고
    • Constitutive Sp1 activity is essential for differential constitutive expression of vascular endothelial growth factor in human pancreatic adenocarcinoma
    • Shi Q, Le X, Abbruzzese JL, et al: Constitutive Sp1 activity is essential for differential constitutive expression of vascular endothelial growth factor in human pancreatic adenocarcinoma. Cancer Res 61: 4143-4154, 2001.
    • (2001) Cancer Res , vol.61 , pp. 4143-4154
    • Shi, Q.1    Le, X.2    Abbruzzese, J.L.3
  • 30
    • 0033709613 scopus 로고    scopus 로고
    • Sp1 decoy transfected to carcinoma cells suppresses the expression of vascular endothelial growth factor, transforming growth factor beta1, and tissue factor and also cell growth and invasion activities
    • Ishibashi H, Nakagawa K, Onimaru M, et al: Sp1 decoy transfected to carcinoma cells suppresses the expression of vascular endothelial growth factor, transforming growth factor beta1, and tissue factor and also cell growth and invasion activities. Cancer Res 60: 6531-6536, 2000.
    • (2000) Cancer Res , vol.60 , pp. 6531-6536
    • Ishibashi, H.1    Nakagawa, K.2    Onimaru, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.