Identification of absorbed constituents in the rabbit plasma and cerebrospinal fluid after intranasal administration of asari radix et rhizoma by HS-SPME-GC-MS and HPLC-APCI-IT-TOF-MSN

Molecules

Volumn 19, Issue 4, 2014, Pages 4857-4879

  Li, Chen ^a   Xu, Feng ^a   Xie, De Mei ^a   Jing, Yu ^a   Shang, Ming Ying ^a   Liu, Guang Xue ^a   Wang, Xuan ^a   Cai, Shao Qing ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Absorption; Additive effect; Asarum heterotropoides var. mandshuricum; Cerebrospinal fluid; Effective substance; GC MS; Intranasal administration; LC MS; Nasal therapy; SPME

Indexed keywords

ALKANE; AMIDE; BENZENE DERIVATIVE; HERBACEOUS AGENT; LIGNAN; PLANT EXTRACT; PROPIONIC ACID DERIVATIVE; TERPENE;

ANIMAL; BLOOD; CEREBROSPINAL FLUID; CHEMISTRY; INTRANASAL DRUG ADMINISTRATION; ISOLATION AND PURIFICATION; MAGNOLIACEAE; MALE; RABBIT; RHIZOME;

ADMINISTRATION, INTRANASAL; ALKANES; ANIMALS; BENZENE DERIVATIVES; DRUGS, CHINESE HERBAL; LIGNANS; MAGNOLIACEAE; MALE; MONOTERPENES; PLANT EXTRACTS; POLYUNSATURATED ALKAMIDES; PROPIONATES; RABBITS; RHIZOME;

EID: 84899541608     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules19044857     Document Type: Article

References (24)

1. Gao, S.Z. Zhongyi Biliaofa Quanshu A Comprehensive Treatise on Nasal Therapy of Traditional Chinese Medicine, 1st ed.; Huaxia Publishing House: Beijing, China, 1994; pp. 33-401.
2. Pires, A.; Fortuna, A.; Alves, G.; Falcao, A. Intranasal drug delivery: How, why and what for J. Pharm. Pharm. Sci. 2009, 12, 288-311.
3. Yu, L.; Chen, Q.L.; Guo, S.S.; Liu, Y.D. Overview on intranasal delivery of Chinese medicine in curing systemic diseases. Asia Pac. Trad. Med. 2008, 4, 88-91.
4. Feng, J.; Li, F.; Zhao, Y.; Feng, Y.; Abe, Y. Brain pharmacokinetics of tetramethylpyrazine after intranasal and intravenous administration in awake rats. Int. J. Pharm. 2009, 375, 55-60.
5. Yao, Z.; Lu, Y.; Du, S.; Chen, X.; Wang, Y. Study on pharmacokinetics of jasminoidin in rabbits administered Xingnaojing Naristillae by nasal medication. Chin. J. Chin. Mater. Med. 2010, 35, 1871-1873.
6. Gong, Z.N.; Xu, L.Y.; Song, J.Z.; Tao, J.S.; Ma, S.R. Study on rat nasal administration with emulsion of Chinese herb Angelica Dahurica. Chin. J. Clin. Pharm. 2001, 10, 370-373.
7. Guo, X.J.; Li, J.Y.; Lin, C.Y.; Yang, F. Exploration on nasal administration of traditional Chinese medicine for treating brain diseases. J. Guangdong Pharm. Coll. 2011, 27, 211-214.
8. Zhao, B.C.; Wu, H.Y. Study on the prescribing rules of traditional Chinese medicines for the treatment of migraine by intranasal administration. Asia Pac. Trad. Med. 2010, 6, 132-133.
9. Han, A.R.; Kim, H.J.; Shin, M.; Hong, M.; Kim, Y.S.; Bae, H. Constituents of Asarum sieboldii with inhibitory activity on lipopolysaccharide (LPS)-induced NO production in BV-2 microglial cells. Chem. Biodivers. 2008, 5, 346-351.
10. Wagner, H.; Bauer, R.; Melchart, D.; Xiao, P.G.; Staudinger, A. Chromatographic Fingerprint Analysis of Herbal Medicines, 2nd ed.; Springer: Vienna, Austria, 2011; Volume 1, pp. 45-58.
11. Yuan, X.Q.; Sun L.F.; Zheng, J. Analgesic components of Asarum and its mechanisms. Shanghai J. Trad. Chin. Med. 2009, 43, 72-75.
12. Li, C.; Xu, F.; Cao, C.; Shang, M.Y.; Zhang, C.Y.; Yu, J.; Liu, G.X.; Wang, X.; Cai, S.Q. Comparative analysis of two species of Asari Radix et Rhizoma by electronic nose, headspace GC-MS and chemometrics. J. Pharm. Biomed. Anal. 2013, 85, 231-238.
13. Yan, G.; Li, Q.; Tan, H.; Ge, T. Electrospray ionization ion-trap time-of-flight tandem mass spectrometry of two furofurans: sesamin and gmelinol. Rapid Commun. Mass Spectrom. 2007, 21, 3613-3620.
14. Struijs, K.; Vincken, J.P.; Gruppen, H. Comparison of atmospheric pressure chemical ionization and electrospray ionization mass spectrometry for the detection of lignans from sesame seeds. Rapid Commun. Mass Spectrom. 2008, 22, 3615-3623.
15. Eklund, P.C.; Backman, M.J.; Kronberg, L.A.; Smeds, A.I.; Sjöholm, R.E. Identification of lignans by liquid chromatography-electrospray ionization ion-trap mass spectrometry. J. Mass Spectrom. 2008, 43, 97-107.
16. Xing, J.; Zhang, S.Q.; Zhong, D.F.; Jia, J.M. Rapid identification of Acanthopanax senticosus mixture by liquid chromatography-electrospray ion trap mass spectrometry. J. Chin. Mass Spectrom. Soc. 2004, 25, 198-203.
17. Quang, T.H.; Ngan, N.T.; Minh, C.V.; Kiem, P.V.; Tai, B.H.; Thao, N.P.; Song, S.B.; Kim, Y.H. Anti-inflammatory and PPAR transactivational effects of secondary metabolites from the roots of Asarum sieboldii. Bioorg. Med. Chem. Lett. 2012, 22, 2527-2533.
18. Boonen, J.; Baert, B.; Burvenich, C.; Blondeel, P.; de Saeger, S.; de Spiegeleer, B. LC-MS profiling of N-alkylamides in Spilanthes acmella extract and the transmucosal behaviour of its main bio-active spilanthol. J. Pharm. Biomed. Anal. 2010, 53, 243-249.
19. Thomsen, M.O.; Fretté, X.C.; Christensen, K.B.; Christensen, L.P.; Grevsen, K. Seasonal variations in the concentrations of lipophilic compounds and phenolic acids in the roots of Echinacea purpurea and Echinacea pallida. J. Agric. Food Chem. 2012, 60, 12131-12141.
20. Mudge, E.; Lopes-Lutz, D.; Brown, P.; Schieber, A. Analysis of alkylamides in Echinacea plant materials and dietary supplements by ultrafast liquid chromatography with diode array and mass spectrometric detection. J. Agric. Food Chem. 2011, 59, 8086-8094.
21. Cech, N.B.; Eleazer, M.S.; Shoffner, L.T.; Crosswhite, M.R.; Davis, A.C.; Mortenson, A.M. High performance liquid chromatography/electrospray ionization mass spectrometry for simultaneous analysis of alkamides and caffeic acid derivatives from Echinacea purpurea extracts. J. Chromatogr. A 2006, 1103, 219-228.
22. Yasuda, I.; Takeya, K.; Itokawa, H. Structures of Amides from Asiasarum heterotropoides MAEK. var. mand shuricum MAEK. Chem. Pharm. Bull. 1981, 29, 564-566.
23. Zhang, S.X.; Tani, T.; Yamaji, S.; Gao, X.L.; Wang, X.; Cai, S.Q.; Zhao, Y.Y. Studies on chemical constituents from radix and rhizome of Asarum longerhizomatosum. Chin. Trad. Herba. Drugs 2002, 33, 297-299.
24. Illum, L. Nasal drug delivery-Possibilities, problems and solutions. J. Control. Release 2003, 87, 187-198.