Erythropoietin prevents cognitive impairment and oxidative parameters in Wistar rats subjected to pneumococcal meningitis

Translational Research

Volumn 163, Issue 5, 2014, Pages 503-513

  Barichello, Tatiana ^a,d   Simões, Lutiana R ^a   Generoso, Jaqueline S ^a   Sangiogo, Gustavo ^a   Danielski, Lucineia Gainski ^c   Florentino, Drielly ^c   Dominguini, Diogo ^b   Comim, Clarissa M ^c   Petronilho, Fabricia ^c   Quevedo, João ^b,d  

^a UNIVERSIDADE DO EXTREMO SUL CATARINENSE   (Brazil)

^b Laboratory of Experimental Physiopathology   (Brazil)

^c UNIVERSITY OF SOUTHERN SANTA CATARINA   (Brazil)

^d UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

5 5 dithiobis (2 nitrobenzoic acid); 5 thio 2 nitrobenzoic acid; Abbreviations; BBB; blood brain barrier; CAT; catalase; central nervous system; cerebrospinal fluid; CNS; CSF; DTNB; EPO; erythropoietin; MPO; myeloperoxidase; NF B; nuclear transcription factor kappa B; reactive oxygen species; ROS; SOD; superoxide dismutase; TBARS; thiobarbituric acid reactive species; TLR; TNB; toll like receptor

Indexed keywords

CATALASE; ERYTHROPOIETIN; MYELOPEROXIDASE; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; FRONTAL CORTEX; HABITUATION; HIPPOCAMPUS; LIPID PEROXIDATION; MALE; MEMORY DISORDER; NONHUMAN; NOVEL OBJECT RECOGNITION TEST; OXIDATIVE STRESS; PNEUMOCOCCAL MENINGITIS; PRIORITY JOURNAL; PROTEIN CARBONYLATION; PROTEIN DEGRADATION; RAT; TASK PERFORMANCE;

ANIMALS; BEHAVIOR, ANIMAL; CATALASE; COGNITION DISORDERS; ERYTHROPOIETIN; LIPID PEROXIDATION; MENINGITIS, PNEUMOCOCCAL; OXIDATIVE STRESS; PEROXIDASE; PROTEIN CARBONYLATION; RATS; RATS, WISTAR; SUPEROXIDE DISMUTASE;

EID: 84899526350     PISSN: 19315244     EISSN: 18781810     Source Type: Journal    
DOI: 10.1016/j.trsl.2013.12.008     Document Type: Article

References (47)

1. K. Grimwood, T.M. Nolan, L. Bond, V.A. Anderson, C. Catroppa, and E.H. Keir Risk factors for adverse outcomes of bacterial meningitis J Paediatr Child Health 32 1996 457 462
2. B.B. Mook-Kanamori, M. Geldhoff, T. van der Poll, and D. van de Beek Pathogenesis and pathophysiology of pneumococcal meningitis Clin Microbiol Rev 24 2011 557 591
3. T. Barichello, J.S. Generoso, A. Collodel, A.P. Moreira, and S.M. Almeida Pathophysiology of acute meningitis caused by Streptococcus pneumoniae and adjunctive therapy approaches Arq Neuropsiquiatr 70 2012 366 372
4. U. Koppe, N. Suttorp, and B. Opitz Recognition of Streptococcus pneumoniae by the innate immune system Cell Microbiol 14 2012 460 466
5. M.L. Hanke, and T. Kielian Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential Clin Sci (Lond) 121 2011 367 387
6. Z. Kronfol, and D.G. Remick Cytokines and the brain: implications for clinical psychiatry Am J Psychiatry 157 2000 683 694
7. R. Malley, P. Henneke, and S.C. Morse et al. Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection Proc Natl Acad Sci U S A 100 2003 1966 1971
8. N.S. Kenneth, S. Mudie, S. Naron, and S. Rocha TFR1 interacts with the IKK complex and is involved in IKK-NF-kappaB signalling Biochem J 449 2013 275 284
9. C.M. Tato, and C.A. Hunter Host-pathogen interactions: subversion and utilization of the NF-kappa B pathway during infection Infect Immunol 70 2002 3311 3317
10. M. Klein, U. Koedel, and H.W. Pfister Oxidative stress in pneumococcal meningitis: a future target for adjunctive therapy? Prog Neurobiol 80 2006 269 280
11. C. Szabo Multiple pathways of peroxynitrite cytotoxicity Toxicol Lett 140-141 2003 105 112
12. T. Barichello, J.S. Generoso, G. Milioli, S.G. Elias, and A.L. Teixeira Pathophysiology of bacterial infection of the central nervous system and its putative role in the pathogenesis of behavioral changes Rev Bras Psiquiatr 35 2013 81 87
13. T. Barichello, J.S. Generoso, and C. Silvestre et al. Circulating concentrations, cerebral output of the CINC-1 and blood-brain barrier disruption in Wistar rats after pneumococcal meningitis induction Eur J Clin Microbiol Infect Dis 31 2012 2005 2009
14. T. Barichello, G.D. Fagundes, and J.S. Generoso et al. Brain-blood barrier breakdown and pro-inflammatory mediators in neonate rats submitted meningitis by Streptococcus pneumoniae Brain Res 1471 2012 162 168
15. M.J. Koury, and M.C. Bondurant The molecular mechanism of erythropoietin action Eur J Biochem 210 1992 649 663
16. S. Genc, T.F. Koroglu, and K. Genc Erythropoietin and the nervous system Brain Res 12 2004 1 2
17. A. Kumral, S. Genc, and E. Ozer et al. Erythropoietin downregulates bax and DP5 proapoptotic gene expression in neonatal hypoxic-ischemic brain injury Biol Neonate 89 2006 205 210
18. A. Kumral, F. Tuzun, M.G. Oner, S. Genc, N. Duman, and H. Ozkan Erythropoietin in neonatal brain protection: the past, the present and the future Brain Dev 33 2011 632 643
19. T. Barichello, J.S. Pereira, and G.D. Savi et al. A kinetic study of the cytokine/chemokines levels and disruption of blood-brain barrier in infant rats after pneumococcal meningitis J Neuroimmunol 233 2011 12 17
20. National Institutes of Health Guide for the care and use of laboratory animals NIH publications no. 80-23 2011 National Institutes of Health Bethesda, MD
21. J.E. Irazuzta, R.K. Pretzlaff, B. Zingarelli, V. Xue, and F. Zemlan Modulation of nuclear factor-kappaB activation and decreased markers of neurological injury associated with hypothermic therapy in experimental bacterial meningitis Crit Care Med 30 2002 2553 2559
22. T. Barichello, G.D. Savi, and G.Z. Silva et al. Antibiotic therapy prevents, in part, the oxidative stress in the rat brain after meningitis induced by Streptococcus pneumoniae Neurosci Lett 478 2010 93 96
23. S.L. Leib, J.M. Clements, and R.L. Lindberg et al. Inhibition of matrix metalloproteinases and tumour necrosis factor alpha converting enzyme as adjuvant therapy in pneumococcal meningitis matrix metalloproteinases: multifunctional effectors of inflammation in multiple sclerosis and bacterial meningitis Brain 124 2001 1734 1742
24. T. Barichello, J.C. Goncalves, and J.S. Generoso et al. Attenuation of cognitive impairment by the nonbacteriolytic antibiotic daptomycin in Wistar rats submitted to pneumococcal meningitis BMC Neurosci 14 2013 42
25. H.H. Draper, and M. Hadley Malondialdehyde determination as index of lipid peroxidation Methods Enzymol 186 1990 421 431
26. R.L. Levine, D. Garland, and C.N. Oliver et al. Determination of carbonyl content in oxidatively modified proteins Methods Enzymol 186 1990 464 478
27. J.V. Bannister, and L. Calabrese Assays for superoxide dismutase Methods Biochem Anal 32 1987 279 312
28. U.K. Laemmli Cleavage of structural proteins during the assembly of the head of bacteriophage T4 Nature 227 1970 680 685
29. L.C. Green, D.A. Wagner, J. Glogowski, P.L. Skipper, J.S. Wishnok, and S.R. Tannenbaum Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids Anal Biochem 126 1982 131 138
30. L.M. De Young, J.B. Kheifets, S.J. Ballaron, and J.M. Young Edema and cell infiltration in the phorbol ester-treated mouse ear are temporally separate and can be differentially modulated by pharmacologic agents Agents Actions 26 1989 335 341
31. M.R. Vianna, M. Alonso, and H. Viola et al. Role of hippocampal signaling pathways in long-term memory formation of a nonassociative learning task in the rat Learn Mem 7 2000 333 340
32. M.N. de Lima, D.C. Laranja, E. Bromberg, R. Roesler, and N. Schroder Pre- or post-training administration of the NMDA receptor blocker MK-801 impairs object recognition memory in rats Behav Brain Res 156 2005 139 143
33. J.H. Medina, N. Schroder, and I. Izquierdo Two different properties of short- and long-term memory Behav Brain Res 103 1999 119 121
34. C.M. Comim, O.J. Cassol Jr., and I. Abreu et al. Erythropoietin reverts cognitive impairment and alters the oxidative parameters and energetic metabolism in sepsis animal model J Neural Transm 119 2012 1267 1274
35. Y. Li, M.E. Ogle, G.C. Wallace, Z.Y. Lu, S.P. Yu, and L. Wei Erythropoietin attenuates intracerebral hemorrhage by diminishing matrix metalloproteinases and maintaining blood-brain barrier integrity in mice Acta Neurochir Suppl 105 2008 105 112
36. M. Chau, D. Chen, and L. Wei Erythropoietin attenuates inflammatory factors and cell death in neonatal rats with intracerebral hemorrhage Acta Neurochir Suppl 111 2011 299 305
37. D. Agnello, P. Bigini, and P. Villa et al. Erythropoietin exerts an anti-inflammatory effect on the CNS in a model of experimental autoimmune encephalomyelitis Brain Res 952 2002 128 134
38. W. Jelkmann Erythropoietin: structure, control of production, and function Physiol Rev 72 1992 449 489
39. N.S. Chandel, E. Maltepe, E. Goldwasser, C.E. Mathieu, M.C. Simon, and P.T. Schumacker Mitochondrial reactive oxygen species trigger hypoxia-induced transcription Proc Natl Acad Sci U S A 95 1998 11715 11720
40. K. Chin, X. Yu, and B. Beleslin-Cokic et al. Production and processing of erythropoietin receptor transcripts in brain Brain Res Mol Brain Res 81 2000 29 42
41. A. Chattopadhyay, T.D. Choudhury, D. Bandyopadhyay, and A.G. Datta Protective effect of erythropoietin on the oxidative damage of erythrocyte membrane by hydroxyl radical Biochem Pharmacol 59 2000 419 425
42. M. Nairz, T. Sonnweber, A. Schroll, I. Theurl, and G. Weiss The pleiotropic effects of erythropoietin in infection and inflammation Microbes Infect 14 2012 238 246
43. G. Calapai, M.C. Marciano, and F. Corica et al. Erythropoietin protects against brain ischemic injury by inhibition of nitric oxide formation Eur J Pharmacol 401 2000 349 356
44. T. Barichello, G.Z. Silva, and J.S. Generoso et al. Time-dependent behavioral recovery after pneumococcal meningitis in rats J Neural Transm 117 2010 819 826
45. T. Barichello, A.L. Santos, and G.D. Savi et al. Antioxidant treatment prevents cognitive impairment and oxidative damage in pneumococcal meningitis survivor rats Metab Brain Dis 27 2012 587 593
46. R.A. Harris, and S. Amor Sweet and sour: oxidative and carbonyl stress in neurological disorders CNS Neurol Disord Drug Targets 10 2011 82 107
47. D. van de Beek, B. Schmand, and J. de Gans et al. Cognitive impairment in adults with good recovery after bacterial meningitis J Infect Dis 186 2002 1047 1052