Glomerular and tubular function in the diabetic kidney

Advances in Chronic Kidney Disease

Volumn 21, Issue 3, 2014, Pages 297-303

  Blantz, Roland C ^a   Singh, Prabhleen ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Diabetes; Glomerular filtration; Salt sensitivity; Tubular reabsorption

Indexed keywords

ADENOSINE A1 RECEPTOR; GLUCOSE; SODIUM CHLORIDE; SODIUM GLUCOSE COTRANSPORTER 2; SALT INTAKE;

CALORIC INTAKE; DIABETES MELLITUS; DIABETIC PATIENT; GLOMERULAR DYSFUNCTION; GLOMERULAR FUNCTION; GLOMERULAR HYPERFILTRATION; GLOMERULUS CAPILLARY; GLOMERULUS FILTRATION RATE; GLUCOSE BLOOD LEVEL; HUMAN; HYPERGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; KIDNEY BLOOD FLOW; KIDNEY DEVELOPMENT; KIDNEY FUNCTION; KIDNEY HYPERTROPHY; KIDNEY MASS; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE ABSORPTION; KIDNEY TUBULE DISORDER; KIDNEY TUBULE FUNCTION; KIDNEY TUBULE PRESSURE; MORTALITY; NEPHRECTOMY; NONHUMAN; OXYGEN CONSUMPTION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROXIMAL TUBULAR HYPERPLASIA; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVIEW; SODIUM INTAKE; SODIUM RESTRICTION; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; SURVIVAL; DIABETIC NEPHROPATHY; GLOMERULUS; KIDNEY TUBULE; METABOLISM; PATHOPHYSIOLOGY; SALT INTAKE;

DIABETIC NEPHROPATHIES; HUMANS; KIDNEY GLOMERULUS; KIDNEY TUBULES; SODIUM CHLORIDE, DIETARY;

EID: 84899518098     PISSN: 15485595     EISSN: 15485609     Source Type: Journal    
DOI: 10.1053/j.ackd.2014.03.006     Document Type: Review

References (68)

1. Kanwar Y.S., Sun L., Xie P., Liu F.Y., Chen S. A glimpse of various pathogenetic mechanisms of diabetic nephropathy. Annu Rev Pathol 2011, 6:395-423.
2. Zerbini G., Bonfanti R., Meschi F., et al. Persistent renal hypertrophy and faster decline of glomerular filtration rate precede the development of microalbuminuria in type 1 diabetes. Diabetes 2006, 55(9):2620-2625.
3. Rigalleau V., Garcia M., Lasseur C., et al. Large kidneys predict poor renal outcome in subjects with diabetes and chronic kidney disease. BMC Nephrol 2010, 11(3):3.
4. Bognetti E., Zoja A., Meschi F., Paesano P.L., Chiumello G. Relationship between kidney volume, microalbuminuria and duration of diabetes mellitus. Diabetologia 1996, 39(11):1409.
5. Baumgartl H.J., Sigl G., Banholzer P., Haslbeck M., Standl E. On the prognosis of IDDM patients with large kidneys. Nephrol Dial Transplant 1998, 13(3):630-634.
6. Jerums G., Premaratne E., Panagiotopoulos S., Macisaac R.J. The clinical significance of hyperfiltration in diabetes. Diabetologia 2010, 53(3):2093-2104.
7. Magee G.M., Bilous R.W., Cardwell C.R., Hunter S.J., Kee F., Fogarty D.G. Is hyperfiltration associated with the future risk of developing diabetic nephropathy? A meta-analysis. Diabetologia 2009, 52(4):691-697.
8. Tucker B.J., Collins R.C., Ziegler M.G., Blantz R.C. Disassociation between glomerular hyperfiltration and extracellular volume in diabetic rats. Kidney Int 1991, 39(6):1176-1183.
9. Tucker B.J., Rasch R., Blantz R.C. Glomerular filtration and tubular reabsorption of albumin in pre-proteinuric and proteinuric diabetic rats. J Clin Invest 1993, 92(2):686-694.
10. Huang V., Kirschenmann D., Wead L.M., et al. Effect of chronic salt loading on kidney function in early and established diabetes mellitus in rats. J Lab Clin Med 1997, 130(1):76-82.
11. Vallon V., Richter K., Blantz R.C., Thomson S.C., Osswald H. Glomerular hyperfiltration in experimental diabetes mellitus: potential role of tubular reabsorption. J Am Soc Nephrol 1999, 10(12):2569-2576.
12. Huang H.C., Preisig P.A. G1 kinases and transforming growth factor-beta signaling are associated with a growth pattern switch in diabetes-induced renal growth. Kidney Int 2000, 58(1):162-172.
13. Osorio H., Bautista R., Rios A., Franco M., Santamaría J., Escalante B. Effect of treatment with losartan on salt sensitivity and SGLT2 expression in hypertensive diabetic rats. Diabetes Res Clin Pract 2009, 86(3):e46-e49.
14. Feliers D., Kasinath B.S. Mechanism of VEGF expression by high glucose in proximal tubule epithelial cells. Mol Cell Endocrinol 2010, 314(1):136-142.
15. Marrero M.B., Banes-Berceli A.K., Stern D.M., Eaton D.C. Role of the JAK/STAT signaling pathway in diabetic nephropathy. Am J Physiol Ren Physiol 2006, 290(4):F762-F768.
16. Vallon V., Thomson S.C. Renal function in diabetic disease models: the tubular system in the pathophysiology of the diabetic kidney. Annu Rev Physiol 2012, 74:351-375.
17. Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 2001, 414(6865):813-820.
18. Pfaff I.L., Vallon V. Protein kinase C beta isoenzymes in diabetic kidneys and their relation to nephroprotective actions of the ACE inhibitor lisinopril. Kidney Blood Press Res 2002, 25(5):329-340.
19. Goestemeyer A.K., Marks J., Srai S.K., Debnam E.S., Unwin R.J. GLUT2 protein at the rat proximal tubule brush border membrane correlates with protein kinase C (PKC)-betal and plasma glucose concentration. Diabetologia 2007, 50(10):2209-2217.
20. Meier M., Park J.K., Overheu D., et al. Deletion of protein kinase C-beta isoform invivo reduces renal hypertrophy but not albuminuria in the streptozotocin-induced diabetic mouse model. Diabetes 2007, 56(2):346-354.
21. Kumar A.M., Gupta R.K., Spitzer A. Intracellular sodium in proximal tubules of diabetic rats. Role of glucose. Kidney Int 1988, 33(4):792-797.
22. Vallon V. The proximal tubule in the pathophysiology of the diabetic kidney. Am J Physiol Regul Integr Comp Physiol 2011, 300(5):R1009-R1022.
23. Deng A., Munger K.A., Valdivielso J.M., et al. Increased expression of ornithine decarboxylase in distal tubules of early diabetic rat kidneys: are polyamines paracrine hypertrophic factors?. Diabetes 2003, 52(5):1235-1239.
24. Thomson S.C., Deng A., Bao D., Satriano J., Blantz R.C., Vallon V. Ornithine decarboxylase, kidney size, and the tubular hypothesis of glomerular hyperfiltration in experimental diabetes. J Clin Invest 2001, 107(2):217-224.
25. Thomson S.C., Rieg T., Miracle C., et al. Acute and chronic effects of SGLT2 blockade on glomerular and tubular function in the early diabetic rat. Am J Physiol Regul Integr Comp Physiol 2012, 302(1):R75-R83.
26. Pfaff I.L., Wagner H.J., Vallon V. Immunolocalization of protein kinase C isoenzymes alpha, beta1 and betaII in rat kidney. J Am Soc Nephrol 1999, 10(9):1861-1873.
27. Efendiev R., Budu C.E., Cinelli A.R., Bertorello A.M., Pedemonte C.H. Intracellular Na+ regulates dopamine and angiotensin II receptors availability at the plasma membrane and their cellular responses in renal epithelia. J Biol Chem 2003, 278(31):28719-28726.
28. Lee M.J., Feliers D., Mariappan M.M., et al. A role for AMP-activated protein kinase in diabetes-induced renal hypertrophy. Am J Physiol Ren Physiol 2007, 292(2):F617-F627.
29. Lieberthal W., Levine J.S. The role of the mammalian target of rapamycin (mTOR) in renal disease. J Am Soc Nephrol 2009, 20(12):2493-2502.
30. Thomson S.C., Vallon V., Blantz R.C. Kidney function in early diabetes: the tubular hypothesis of glomerular filtration. Am J Physiol Ren Physiol 2004, 286(1):F8-F15.
31. Vallon V., Komers R. Pathophysiology of the diabetic kidney. Compr Physiol 2011, 1(3):1175-1232.
32. Tucker B.J., Mendonca M.M., Blantz R.C. Contrasting effects of acute insulin infusion on renal function in awake non-diabetic and diabetic rats. J Am Soc Nephrol 1993, 3(10):1686-1693.
33. Blank M.E., Bode F., Huland E., Diedrich D.F., Baumann K. Kinetic studies of D-glucose transport in renal brush-border membrane vesicles of streptozotocin-induced diabetic rats. Biochim Biophys Acta 1985, 844(3):314-319.
34. Vallon V., Huang D.Y., Deng A., Richter K., Blantz R.C., Thomson S. Salt-sensitivity of proximal reabsorption alters macula densa salt and explains the paradoxical effect of dietary salt on glomerular filtration rate in diabetes mellitus. J Am Soc Nephrol 2002, 13:1865-1871.
35. Tucker B.J., Anderson C.M., Thies R.S., Collins R.C., Blantz R.C. Glomerular hemodynamic alterations during acute hyperinsulinemia in normal and diabetic rats. Kidney Int 1992, 42(5):1160-1168.
36. Hostetter T.H., Troy J.L., Brenner B.M. Glomerular hemodynamics in experimental diabetes mellitus. Kidney Int 1981, 19(3):410-415.
37. Palm F., Fasching A., Hansell P., Källskog O. Nitric oxide originating from NOS1 controls oxygen utilization and electrolyte transport efficiency in the diabetic kidney. Am J Physiol Ren Physiol 2010, 298(2):F416-F420.
38. Patinha D., Fasching A., Pinho D., Albino-Teixeira A., Morato M., Palm F. Angiotensin II contributes to glomerular hyperfiltration in diabetic rats independently of adenosine type I receptors. Am J Physiol Ren Physiol 2013, 304(5):F614-F622.
39. Steiner R.W., Tucker B.J., Blantz R.C. Glomerular hemodynamics in rats with chronic sodium depletion: effect of saralasin. J Clin Invest 1979, 64(2):503-512.
40. Steiner R.W., Blantz R.C. Acute reversal by saralasin of multiple intrarenal effects of angiotensin II. Am J Physiol 1979, 237(5):F386-F391.
41. Blantz R.C., Peterson O.W., Gushwa L., Tucker B.J. Effect of modest hyperglycemia on tubuloglomerular feedback activity. Kidney Int Suppl 1982, 12:S206-S212.
42. Blantz R.C., Tucker B.J., Gushwa L., Peterson O.W. Mechanism of diuresis following acute modest hyperglycemia in the rat. Am J Physiol 1983, 244(2):F185-F194.
43. Vallon V., Blantz R.C., Thomson S. Homeostatic efficiency of tubuloglomerular feedback is reduced in established diabetes mellitus in rats. Am J Physiol 1995, 269(6 pt 2):F876-F883.
44. Vallon V., Blantz R.C., Thomson S. Glomerular hyperfiltration and the salt paradox in early type 1 diabetes mellitus: a tubulo-centric view. J Am Soc Nephrol 2003, 14(2):530-537.
45. Thomson S.C., Deng A., Komine N., Hammes J.S., Blantz R.C., Gabbai F.B. Early diabetes as a model for testing the regulation of juxtaglomerular NOS I. Am J Physiol Ren Physiol 2004, 287(5):F732-F738.
46. Ditzel J., Lervang H.H., Brøchner-Mortensen J. Renal sodium metabolism in relation to hypertension in diabetes. Diabete Metab 1989, 15(5 pt 2):292-295.
47. Mbanya J.C., Thomas T.H., Taylor R., Alberti K.G., Wilkinson R. Increased proximal tubular sodium reabsorption in hypertensive patients with type 2 diabetes. Diabet Med 1989, 6(7):614-620.
48. Vervoort G., Veldman B., Berden J.H., Smits P., Wetzels J.F. Glomerular hyperfiltration in type 1 diabetes mellitus results from primary changes in proximal tubular sodium handling without changes in volume expansion. Eur J Clin Invest 2005, 35(5):330-336.
49. Hannedouche T.P., Delgado A.G., Gnionsahe D.A., Boitard C., Lacour B., Grünfeld J.P. Renal hemodynamics and segmental tubular reabsorption in early type 1 diabetes. Kidney Int 1990, 37(4):1126-1133.
50. Thomson S.C., Bachmann S., Bostanjoglo M., et al. Temporal adjustment of the juxtaglomerular apparatus during sustained inhibition of proximal reabsorption. J Clin Invest 1999, 104(8):1149-1158.
51. Thomson S.C., Vallon V., Blantz R.C. Reduced proximal reabsorption resets tubuloglomerular feedback in euvolemic rats. Am J Physiol 1997, 273(3,pt2):R1414-R1420.
52. Thomson S.C., Blantz R.C., Vallon V. Increased tubular flow induces resetting of tubuloglomerular feedback in euvolemic rats. Am J Physiol 1996, 270:F461-F468.
53. Woods L.L., Mizelle H.L., Hall J.E. Control of renal hemodynamics in hyperglycemia: possible role of tubuloglomerular feedback. Am J Physiol 1987, 252(1 pt 2):F65-F73.
54. Vallon V., Schroth J., Satriano J., Blantz R.C., Thomson S.C., Rieg T. Adenosine A(1) receptors determine glomerular hyperfiltration and the salt paradox in early streptozotocin diabetes mellitus. Nephron Physiol 2009, 111(3):p30-p38.
55. Sällström J., Carlsson P.O., Fredholm B.B., Larsson E., Persson A.E., Palm F. Diabetes-induced hyperfiltration in adenosine A(1)-receptor deficient mice lacking the tubuloglomerular feedback mechanism. Acta Physiol (Oxf) 2007, 190(3):253-259.
56. Faulhaber-Walter R., Chen L., Oppermann M., et al. Lack of A1 adenosine receptors augments diabetic hyperfiltration and glomerular injury. J Am Soc Nephrol 2008, 19(4):722-730.
57. Vallon V., Platt K.A., Cunard R., et al. SGLT2 mediates glucose reabsorption in the early proximal tubule. J Am Soc Nephrol 2011, 22(1):104-112.
58. Hummel C.S., Lu C., Loo D.D., Hirayama B.A., Voss A.A., Wright E.M. Glucose transport by human renal Na+/D-glucose cotransporters SGLT1 and SGLT2. Am J Physiol Cell Physiol 2011, 300(1):C14-C21.
59. Thomson S.C., Deng A., Wead L., Richter K., Blantz R.C., Vallon V. An unexpected role for angiotensin II in the link between dietary salt and proximal reabsorption. J Clin Invest 2006, 116:1110-1116.
60. Miracle C.M., Rieg T., Mansoury H., Vallon V., Thomson S.C. Ornithine decarboxylase inhibitor eliminates hyperresponsiveness of the early diabetic proximal tubule to dietary salt. Am J Physiol Renal Physiol 2008, 295(4):F995-F1002.
61. Miller J.A. Renal responses to sodium restriction in patients with early diabetes mellitus. J Am Soc Nephrol 1997, 8(5):749-755.
62. Singh P., Thomson S.C. Salt sensitivity of tubuloglomerular feedback in the early remnant kidney Am J. Physiol Renal Physiol 2014, 306(2):F172-F180.
63. Korner A., Ekoff A.C., Caelsi G., Aperia A. Increased renal metabolism in diabetes. Mechanism and functional implications. Diabetes 1994, 43(5):629-633.
64. Satriano J., Mansoury H., Deng A., et al. Transition of kidney tubule cells to a senescent phenotype in early experimental diabetes. Am J Physiol Cell Physiol 2010, 299(2):C374-C380.
65. Birk C., Richter K., Huang D.Y., Piesch C., Luippold G., Vallon V. The salt paradox of the early diabetic kidney is independent of renal innervation. Kidney Blood Press Res 2003, 26(5-6):344-350.
66. Vallon V., Wead L.M., Blantz R.C. Renal hemodynamics and plasma and kidney angiotensin II in established diabetes mellitus in rats: effect of sodium and salt restriction. J Am Soc Nephrol 1995, 5(10):1761-1767.
67. Ekinci E.I., Clarke S., Thomas M.C., et al. Dietary salt intake and mortality in patients with type 2 diabetes. Diabetes Care 2011, 34(3):703-709.
68. Thomas M.C., Moran J., Forsblom C., et al. The association between dietary sodium intake, ESRD, and all-cause mortality in patients with type 1 diabetes. Diabetes Care 2011, 34(4):861-866.