The PI3K/Akt signaling pathway exerts effects on the implantation of mouse embryos by regulating the expression of RhoA

International Journal of Molecular Medicine

Volumn 33, Issue 5, 2014, Pages 1089-1096

  Liu, Liyuan ^a   Wang, Yingxiong ^a   Yu, Qiubo ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Embryo implantation; Implantation site; Inter implantation site; Phosphoinositide 3 kinase Akt; RhoA

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; PHOSPHATE BUFFERED SALINE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; CHROMONE DERIVATIVE; MORPHOLINE DERIVATIVE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; EMBRYO; FEMALE; GENE EXPRESSION; GENE FUNCTION; GESTATION PERIOD; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; MOUSE EMBRYO; NIDATION; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; QUANTITATIVE STUDY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY;

ANIMALS; CHROMONES; EMBRYO IMPLANTATION; FEMALE; MICE; MORPHOLINES; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PREGNANCY; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; RHOA GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION;

EID: 84899501007     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2014.1701     Document Type: Article

References (31)

1. Banerjee P, Sapru K, Strakova Z and Fazleabas AT: Chorionic gonadotropin regulates prostaglandin E synthase via a phosphatidylinositol 3-kinase-extracellular regulatory kinase pathway in a human endometrial epithelial cell line: implications for endometrial responses for embryo implantation. Endocrinology 150: 4326-4337, 2009.
2. Sales KJ, Grant V, Catalano RD and Jabbour HN: Chorionic gonadotrophin regulates CXCR4 expression in human endometrium via E-series prostanoid receptor 2 signalling to PI3K-ERK1/2: implications for fetal-maternal crosstalk for embryo implantation. Mol Hum Reprod 17: 22-32, 2011.
3. Singh M, Chaudhry P and Asselin E: Bridging endometrial receptivity and implantation: network of hormones, cytokines, and growth factors. J Endocrinol 210: 5-14, 2011.
4. Timpson P, McGhee EJ, Morton JP, et al: Spatial regulation of RhoA activity during pancreatic cancer cell invasion driven by mutant p53. Cancer Res 71: 747-757, 2011.
5. Lazarini M, Traina F, Machado-Neto JA, et al: ARHGAP21 is a RhoGAP for RhoA and RhoC with a role in proliferation and migration of prostate adenocarcinoma cells. Biochim Biophys Acta 1832: 365-374, 2012.
6. Nalbant P, Chang YC, Birkenfeld J, Chang ZF and Bokoch GM: Guanine nucleotide exchange factor-H1 regulates cell migration via localized activation of RhoA at the leading edge. Mol Biol Cell 20: 4070-4082, 2009.
7. Bischof P and Campana A: A model for implantation of the human blastocyst and early placentation. Hum Reprod Update 2: 262-270, 1996. (Pubitemid 26355415)
8. Shiokawa S, Sakai K, Akimoto Y, et al: Function of the small guanosine triphosphate-binding protein RhoA in the process of implantation. J Clin Endocrinol Metab 85: 4742-4749, 2000. (Pubitemid 32157661)
9. Melendez J, Stengel K, Zhou X, et al: RhoA GTPase is dispensable for actomyosin regulation but is essential for mitosis in primary mouse embryonic fibroblasts. J Biol Chem 286: 15132-15137, 2011.
10. Yuan TL, Wulf G, Burga L and Cantley LC: Cell-to-cell variability in PI3K protein level regulates PI3K-AKT pathway activity in cell populations. Curr Biol 21: 173-183, 2011.
11. Fang J, Ding M, Yang L, Liu LZ and Jiang BH: PI3K/PTEN/AKT signaling regulates prostate tumor angiogenesis. Cell Signal 19: 2487-2497, 2007. (Pubitemid 47531929)
12. Osaki M, Oshimura M and Ito H: PI3K-Akt pathway: its functions and alterations in human cancer. Apoptosis 9: 667-676, 2004. (Pubitemid 40941196)
13. Zhu LJ, Bagchi MK and Bagchi IC: Attenuation of calcitonin gene expression in pregnant rat uterus leads to a block in embryonic implantation. Endocrinology 139: 330-339, 1998. (Pubitemid 28166326)
14. Song H, Han K and Lim H: Progesterone supplementation extends uterine receptivity for blastocyst implantation in mice. Reproduction 133: 487-493, 2007. (Pubitemid 46359536)
15. Li S, Chen X, Ding Y, Liu X, Wang Y and He J: Expression of translationally controlled tumor protein (TCTP) in the uterus of mice of early pregnancy and its possible significance during embryo implantation. Hum Reprod 26: 2972-2980, 2011.
16. Nallasamy S, Li Q, Bagchi MK and Bagchi IC: Msx homeobox genes critically regulate embryo implantation by controlling paracrine signaling between uterine stroma and epithelium. PLoS Genet 8: e1002500, 2012.
17. Carson DD, Bagchi I, Dey SK, et al: Embryo implantation. Dev Biol 223: 217-237, 2000. (Pubitemid 30485589)
18. Dey SK, Lim H, Das SK, et al: Molecular cues to implantation. Endocr Rev 25: 341-373, 2004. (Pubitemid 38780665)
19. Ramathal CY, Bagchi IC, Taylor RN and Bagchi MK: Endometrial decidualization: of mice and men. Semin Reprod Med 28: 17-26, 2010.
20. Gentilini D, Busacca M, Di Francesco S, Vignali M, Viganò P and Di Blasio AM: PI3K/Akt and ERK1/2 signalling pathways are involved in endometrial cell migration induced by 17beta-estradiol and growth factors. Mol Hum Reprod 13: 317-322, 2007. (Pubitemid 47061642)
21. Riley JK, Carayannopoulos MO, Wyman AH, Chi M and Moley KH: Phosphatidylinositol 3-kinase activity is critical for glucose metabolism and embryo survival in murine blastocysts. J Biol Chem 281: 6010-6019, 2006. (Pubitemid 43847702)
22. Riley JK, Carayannopoulos MO, Wyman AH, Chi M, Ratajczak CK and Moley KH: The PI3K/Akt pathway is present and functional in the preimplantation mouse embryo. Dev Biol 284: 377-386, 2005. (Pubitemid 41199813)
23. Chen Q, Zhang Y, Lu J, et al: Embryo-uterine cross-talk during implantation: the role of Wnt signaling. Mol Hum Reprod 15: 215-221, 2009.
24. Kawamura K, Kawamura N, Sato W, Fukuda J Kumagai J and Tanaka T: Brain-derived neurotrophic factor promotes implantation and subsequent placental development by stimulating trophoblast cell growth and survival. Endocrinology 150: 3774-3782, 2009.
25. Vanhaesebroeck B, Ali K, Bilancio A, Geering B and Foukas LC: Signalling by PI3K isoforms: insights from gene-targeted mice. Trends Biochem Sci 30: 194-204, 2005. (Pubitemid 40463309)
26. Larue L and Bellacosa A: Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3′ kinase/AKT pathways. Oncogene 24: 7443-7454, 2005. (Pubitemid 41637984)
27. Zuo T, Liu TM, Lan X, et al: Epigenetic silencing mediated through activated PI3K/AKT signaling in breast cancer. Cancer Res 71: 1752-1762, 2011.
28. Wu R, Hu TC, Rehemtulla A, Fearon ER and Cho KR: Preclinical testing of PI3K/AKT/mTOR signaling inhibitors in a mouse model of ovarian endometrioid adenocarcinoma. Clin Cancer Res 17: 7359-7372, 2011.
29. Fournier NM, Lee B, Banasr M, Elsayed M and Duman RS: Vascular endothelial growth factor regulates adult hippocampal cell proliferation through MEK/ERK- and PI3K/Akt-dependent signaling. Neuropharmacology 63: 642-652, 2012.
30. Hou TC, Lin JJ, Wen HC, Chen LC, Hsu SP and Lee WS: Folic acid inhibits endothelial cell migration through inhibiting the RhoA activity mediated by activating the folic acid receptor/cSrc/p190RhoGAP-signaling pathway. Biochem Pharmacol 85: 376-384, 2013.
31. Kato K, Yazawa T, Taki K, et al: The inositol 5-phosphatase SHIP2 is an effector of RhoA and is involved in cell polarity and migration. Mol Biol Cell 23: 2593-2604, 2012.