Activated scavenger receptor a promotes glial internalization of Aβ

PLoS ONE

Volumn 9, Issue 4, 2014, Pages

  Zhang, He ^a,b   Su, Ya Jing ^c   Zhou, Wei Wei ^a   Wang, Shao Wei ^a   Xu, Peng Xin ^a   Yu, Xiao Lin ^a   Liu, Rui Tian ^a  

^a INSTITUTE OF PROCESS ENGINEERING   (China)

^b Tsinghua University   (China)

^c NINGXIA UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; HEXAPEPTIDE; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN XD4; SCAVENGER RECEPTOR A; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); MEMBRANE PROTEIN; MSR1 PROTEIN, HUMAN; MSR1 PROTEIN, MOUSE; PEPTIDE; PEPTIDE FRAGMENT; SCAVENGER RECEPTOR; XD4 PEPTIDE;

ARTICLE; ASTROCYTE; CONTROLLED STUDY; CYTOTOXICITY; GLIA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR TRANSPORT; MICROGLIA; PHAGOCYTOSIS; PINOCYTOSIS; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; ANIMAL; ASTROCYTOMA; BRAIN CORTEX; CELL CULTURE; CELL LINE; CYTOLOGY; DRUG EFFECTS; DRUG SCREENING; METABOLISM; MOUSE; PATHOLOGY; PHYSIOLOGY; RAT; SECRETION (PROCESS); TUMOR CELL LINE;

AMYLOID BETA-PEPTIDES; ANIMALS; ASTROCYTES; ASTROCYTOMA; CELL LINE; CELL LINE, TUMOR; CELLS, CULTURED; CEREBRAL CORTEX; DRUG EVALUATION, PRECLINICAL; HUMANS; INTERLEUKIN-1BETA; MEMBRANE PROTEINS; MICE; MICROGLIA; PEPTIDE FRAGMENTS; PEPTIDES; PHAGOCYTOSIS; RATS; RECEPTORS, SCAVENGER; SCAVENGER RECEPTORS, CLASS A; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84899500870     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0094197     Document Type: Article

References (33)

1. Lee CY, Landreth GE (2010) The role of microglia in amyloid clearance from the AD brain. J Neural Transm 117: 949-960.
2. Hardy J, Selkoe DJ (2002) The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297: 353-356. (Pubitemid 34790756)
3. Broersen K, Rousseau F, Schymkowitz J (2010) The culprit behind amyloid beta peptide related neurotoxicity in Alzheimer's disease: oligomer size or conformation? Alzheimers Res Ther 2: 12.
4. Verdier Y, Zarandi M, Penke B (2004) Amyloid beta-peptide interactions with neuronal and glial cell plasma membrane: binding sites and implications for Alzheimer's disease. J Pept Sci 10: 229-248. (Pubitemid 38594184)
5. Lue LF, Walker DG, Rogers J (2001) Modeling microglial activation in Alzheimer's disease with human postmortem microglial cultures. Neurobiol Aging 22: 945-956. (Pubitemid 34066563)
6. Prokop S, Miller KR, Heppner FL (2013) Microglia actions in Alzheimer's disease. Acta Neuropathol 126: 461-477.
7. Mandrekar S, Jiang Q, Lee CY, Koenigsknecht-Talboo J, Holtzman DM, et al. (2009) Microglia mediate the clearance of soluble Abeta through fluid phase macropinocytosis. J Neurosci 29: 4252-4262.
8. D'Andrea MR, Cole GM, Ard MD (2004) The microglial phagocytic role with specific plaque types in the Alzheimer disease brain. Neurobiol Aging 25: 675-683. (Pubitemid 38686491)
9. Mohamed A, Posse de Chaves E (2011) Abeta internalization by neurons and glia. Int J Alzheimers Dis 2011: 127984.
10. Husemann J, Loike JD, Anankov R, Febbraio M, Silverstein SC (2002) Scavenger receptors in neurobiology and neuropathology: their role on microglia and other cells of the nervous system. Glia 40: 195-205. (Pubitemid 35337377)
11. Paresce DM, Ghosh RN, Maxfield FR (1996) Microglial cells internalize aggregates of the Alzheimer's disease amyloid beta-protein via a scavenger receptor. Neuron 17: 553-565. (Pubitemid 26322226)
12. Bamberger ME, Harris ME, McDonald DR, Husemann J, Landreth GE (2003) A cell surface receptor complex for fibrillar beta-amyloid mediates microglial activation. J Neurosci 23: 2665-2674. (Pubitemid 36418601)
13. Reed-Geaghan EG, Savage JC, Hise AG, Landreth GE (2009) CD14 and toll-like receptors 2 and 4 are required for fibrillar A{beta}-stimulated microglial activation. J Neurosci 29: 11982-11992.
14. Yu X, Yi H, Guo C, Zuo D, Wang Y, et al. (2011) Pattern recognition scavenger receptor CD204 attenuates Toll-like receptor 4-induced NF-kappaB activation by directly inhibiting ubiquitination of tumor necrosis factor (TNF) receptor-associated factor 6. J Biol Chem 286: 18795-18806.
15. Stuart LM, Bell SA, Stewart CR, Silver JM, Richard J, et al. (2007) CD36 signals to the actin cytoskeleton and regulates microglial migration via a p130Cas complex. J Biol Chem 282: 27392-27401. (Pubitemid 47501980)
16. Wilkinson K, El Khoury J (2012) Microglial scavenger receptors and their roles in the pathogenesis of Alzheimer's disease. Int J Alzheimers Dis 2012: 489456.
17. Hsu HY, Chiu SL, Wen MH, Chen KY, Hua KF (2001) Ligands of macrophage scavenger receptor induce cytokine expression via differential modulation of protein kinase signaling pathways. J Biol Chem 276: 28719-28730.
18. Cornejo F, von Bernhardi R (2013) Role of scavenger receptors in glia-mediated neuroinflammatory response associated with Alzheimer's disease. Mediators Inflamm 2013: 895651.
19. Alarcon R, Fuenzalida C, Santibanez M, von Bernhardi R (2005) Expression of scavenger receptors in glial cells. Comparing the adhesion of astrocytes and microglia from neonatal rats to surface-bound beta-amyloid. J Biol Chem 280: 30406-30415. (Pubitemid 41216224)
20. Jones RS, Minogue AM, Connor TJ, Lynch MA (2013) Amyloid-beta-induced astrocytic phagocytosis is mediated by CD36, CD47 and RAGE. J Neuroimmune Pharmacol 8: 301-311.
21. Frenkel D, Wilkinson K, Zhao L, Hickman SE, Means TK, et al. (2013) Scara1 deficiency impairs clearance of soluble amyloid-beta by mononuclear phagocytes and accelerates Alzheimer's-like disease progression. Nat Commun 4: 2030.
22. Dahlgren KN, Manelli AM, Stine WB Jr, Baker LK, Krafft GA, et al. (2002) Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability. J Biol Chem 277: 32046-32053. (Pubitemid 34969015)
23. Yang CN, Shiao YJ, Shie FS, Guo BS, Chen PH, et al. (2011) Mechanism mediating oligomeric Abeta clearance by naive primary microglia. Neurobiol Dis 42: 221-230.
24. Lacor PN, Buniel MC, Furlow PW, Clemente AS, Velasco PT, et al. (2007) Abeta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease. J Neurosci 27: 796-807. (Pubitemid 46174498)
25. Ransohoff RM, Perry VH (2009) Microglial physiology: unique stimuli, specialized responses. Annu Rev Immunol 27: 119-145.
26. Frautschy SA, Yang F, Irrizarry M, Hyman B, Saido TC, et al. (1998) Microglial response to amyloid plaques in APPsw transgenic mice. Am J Pathol 152: 307-317. (Pubitemid 28028071)
27. Allaman I, Gavillet M, Belanger M, Laroche T, Viertl D, et al. (2010) Amyloid-beta aggregates cause alterations of astrocytic metabolic phenotype: impact on neuronal viability. J Neurosci 30: 3326-3338.
28. El Khoury J, Hickman SE, Thomas CA, Cao L, Silverstein SC, et al. (1996) Scavenger receptor-mediated adhesion of microglia to beta-amyloid fibrils. Nature 382: 716-719. (Pubitemid 26282177)
29. Xue D, Zhao M, Wang YJ, Wang L, Yang Y, et al. (2012) A multifunctional peptide rescues memory deficits in Alzheimer's disease transgenic mice by inhibiting Abeta42-induced cytotoxicity and increasing microglial phagocytosis. Neurobiol Dis 46: 701-709.
30. Coller SP, Paulnock DM (2001) Signaling pathways initiated in macrophages after engagement of type A scavenger receptors. J Leukoc Biol 70: 142-148. (Pubitemid 32613674)
31. Rogers J, Lue LF (2001) Microglial chemotaxis, activation, and phagocytosis of amyloid beta-peptide as linked phenomena in Alzheimer's disease. Neurochem Int 39: 333-340. (Pubitemid 32907397)
32. Tuppo EE, Arias HR (2005) The role of inflammation in Alzheimer's disease. Int J Biochem Cell Biol 37: 289-305. (Pubitemid 39330191)
33. Mukhopadhyay S, Varin A, Chen Y, Liu B, Tryggvason K, et al. (2011) SR-A/MARCO-mediated ligand delivery enhances intracellular TLR and NLR function, but ligand scavenging from cell surface limits TLR4 response to pathogens. Blood 117: 1319-1328.