Reprogramming the mechanism of action of chlorambucil by coupling to a G-quadruplex ligand

Journal of the American Chemical Society

Volumn 136, Issue 16, 2014, Pages 5860-5863

  Di Antonio, Marco ^a,b   McLuckie, Keith I E ^b   Balasubramanian, Shankar ^a,b,c  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b CANCER RESEARCH UK CAMBRIDGE RESEARCH INSTITUTE   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROLIFERATION; CROSSLINKING; DNA; LIGANDS;

ALKYLATING AGENTS; CROSS LINKING AGENTS; DNA DOUBLE STRAND BREAKS; INTERSTRAND CROSS-LINKS; MECHANISM OF ACTION; NITROGEN MUSTARDS; NUCLEOTIDE EXCISION REPAIR; SINGLE-STRANDED DNA;

REPAIR;

CHLORAMBUCIL; DOUBLE STRANDED DNA; GUANINE QUADRUPLEX; SINGLE STRANDED DNA; AMINOQUINOLINE DERIVATIVE; CROSS LINKING REAGENT; DNA ADDUCT; LIGAND; PICOLINIC ACID DERIVATIVE; PYRIDOSTATIN;

ARTICLE; DOUBLE STRANDED DNA BREAK; DRUG MECHANISM; DRUG STRUCTURE; TUMOR SUPPRESSOR GENE; CELL LINE; CHEMISTRY; DNA ADDUCT; DRUG EFFECTS; HUMAN; METABOLISM;

AMINOQUINOLINES; CELL LINE; CHLORAMBUCIL; CROSS-LINKING REAGENTS; DNA ADDUCTS; G-QUADRUPLEXES; HUMANS; LIGANDS; PICOLINIC ACIDS;

EID: 84899499515     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja5014344     Document Type: Article

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