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Volumn 24, Issue 4, 2014, Pages 157-164

DPP-IV inhibitors: Beyond glycaemic control?

Author keywords

[No Author keywords available]

Indexed keywords

CARDIOVASCULAR AGENT; DIPEPTIDYL PEPTIDASE IV INHIBITOR;

EID: 84899490287     PISSN: 10501738     EISSN: 18732615     Source Type: Journal    
DOI: 10.1016/j.tcm.2013.10.002     Document Type: Review
Times cited : (8)

References (44)
  • 1
    • 0032511580 scopus 로고    scopus 로고
    • Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38
    • UK Prospective Diabetes Study Group
    • Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38. British Medical Journal 1998, 317:703-713. UK Prospective Diabetes Study Group.
    • (1998) British Medical Journal , vol.317 , pp. 703-713
  • 2
    • 34248223285 scopus 로고    scopus 로고
    • Biology of incretins: GLP-1 and GIP
    • Baggio L.L., Drucker D.J. Biology of incretins: GLP-1 and GIP. Gastroenterology 2007, 132:2131-2157.
    • (2007) Gastroenterology , vol.132 , pp. 2131-2157
    • Baggio, L.L.1    Drucker, D.J.2
  • 3
    • 67650747353 scopus 로고    scopus 로고
    • Cardiovascular consequences of drugs used for the treatment of diabetes: potential promise of incretin-based therapies
    • Ban K., Hui S., Drucker D.J., Husain M. Cardiovascular consequences of drugs used for the treatment of diabetes: potential promise of incretin-based therapies. Journal of the American Society of Hypertension 2009, 3:245-259.
    • (2009) Journal of the American Society of Hypertension , vol.3 , pp. 245-259
    • Ban, K.1    Hui, S.2    Drucker, D.J.3    Husain, M.4
  • 4
    • 77950267745 scopus 로고    scopus 로고
    • Glucagon-like peptide (GLP)-1(9-36)amide-mediated cytoprotection is blocked by exendin(9-39) yet does not require the known GLP-1 receptor
    • Ban K., Kim K.H., Cho C.K., Sauve M., Diamandis E.P., Backx P.H., et al. Glucagon-like peptide (GLP)-1(9-36)amide-mediated cytoprotection is blocked by exendin(9-39) yet does not require the known GLP-1 receptor. Endocrinology 2010, 151:1520-1531.
    • (2010) Endocrinology , vol.151 , pp. 1520-1531
    • Ban, K.1    Kim, K.H.2    Cho, C.K.3    Sauve, M.4    Diamandis, E.P.5    Backx, P.H.6
  • 5
    • 43249089631 scopus 로고    scopus 로고
    • Cardioprotective and vasodilatory actions of glucagon-like peptide 1 receptor are mediated through both glucagon-like peptide 1 receptor-dependent and -independent pathways
    • Ban K., Noyan-Ashraf M.H., Hoefer J., Bolz S.S., Drucker D.J., Husain M. Cardioprotective and vasodilatory actions of glucagon-like peptide 1 receptor are mediated through both glucagon-like peptide 1 receptor-dependent and -independent pathways. Circulation 2008, 117:2340-2350.
    • (2008) Circulation , vol.117 , pp. 2340-2350
    • Ban, K.1    Noyan-Ashraf, M.H.2    Hoefer, J.3    Bolz, S.S.4    Drucker, D.J.5    Husain, M.6
  • 6
    • 77955480007 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 increases myocardial glucose uptake via p38alpha MAP kinase-mediated, nitric oxide-dependent mechanisms in conscious dogs with dilated cardiomyopathy
    • Bhashyam S., Fields A.V., Patterson B., Testani J.M., Chen L., Shen Y.T., et al. Glucagon-like peptide-1 increases myocardial glucose uptake via p38alpha MAP kinase-mediated, nitric oxide-dependent mechanisms in conscious dogs with dilated cardiomyopathy. Circulation: Heart Failure 2010, 3(4):512-521.
    • (2010) Circulation: Heart Failure , vol.3 , Issue.4 , pp. 512-521
    • Bhashyam, S.1    Fields, A.V.2    Patterson, B.3    Testani, J.M.4    Chen, L.5    Shen, Y.T.6
  • 7
    • 84899488387 scopus 로고    scopus 로고
    • Boehringer Ingelheim Pharmaceuticals and Eli Lilly and Company, CAROLINA: Cardiovascular outcome study of linagliptin versus glimepiride in patients with type 2 diabetes
    • ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). Available from: 2000 [cited 10.10.13]. NLM Identifier: NCT01243424.
    • Boehringer Ingelheim Pharmaceuticals and Eli Lilly and Company, CAROLINA: Cardiovascular outcome study of linagliptin versus glimepiride in patients with type 2 diabetes. In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). Available from: 2000 [cited 10.10.13]. NLM Identifier: NCT01243424. http://clinicaltrials.gov/show/NCT01243424.
  • 8
    • 12144260853 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 can directly protect the heart against ischemia/reperfusion injury
    • Bose A.K., Mocanu M.M., Carr R.D., Brand C.L., Yellon D.M. Glucagon-like peptide 1 can directly protect the heart against ischemia/reperfusion injury. Diabetes 2005, 54:146-151.
    • (2005) Diabetes , vol.54 , pp. 146-151
    • Bose, A.K.1    Mocanu, M.M.2    Carr, R.D.3    Brand, C.L.4    Yellon, D.M.5
  • 11
    • 84855770694 scopus 로고    scopus 로고
    • Saxagliptin for the treatment of type 2 diabetes mellitus: assessing cardiovascular data
    • Cobble M.E., Frederich R. Saxagliptin for the treatment of type 2 diabetes mellitus: assessing cardiovascular data. Cardiovascular Diabetology 2012, 11:6.
    • (2012) Cardiovascular Diabetology , vol.11 , pp. 6
    • Cobble, M.E.1    Frederich, R.2
  • 13
    • 77954384449 scopus 로고    scopus 로고
    • Exendin-4 stimulates proliferation of human coronary artery endothelial cells through eNOS-, PKA- and PI3K/Akt-dependent pathways and requires GLP-1 receptor
    • Erdogdu O., Nathanson D., Sjoholm A., Nystrom T., Zhang Q. Exendin-4 stimulates proliferation of human coronary artery endothelial cells through eNOS-, PKA- and PI3K/Akt-dependent pathways and requires GLP-1 receptor. Molecular and Cellular Endocrinology 2010, 325(1-2):26-35.
    • (2010) Molecular and Cellular Endocrinology , vol.325 , Issue.1-2 , pp. 26-35
    • Erdogdu, O.1    Nathanson, D.2    Sjoholm, A.3    Nystrom, T.4    Zhang, Q.5
  • 14
    • 77958195997 scopus 로고    scopus 로고
    • The oral dipeptidyl peptidase-4 inhibitor sitagliptin increases circulating endothelial progenitor cells in patients with type 2 diabetes: possible role of stromal-derived factor-1alpha
    • Fadini G.P., Boscaro E., Albiero M., Menegazzo L., Frison V., de K.S., et al. The oral dipeptidyl peptidase-4 inhibitor sitagliptin increases circulating endothelial progenitor cells in patients with type 2 diabetes: possible role of stromal-derived factor-1alpha. Diabetes Care 2010, 33:1607-1609.
    • (2010) Diabetes Care , vol.33 , pp. 1607-1609
    • Fadini, G.P.1    Boscaro, E.2    Albiero, M.3    Menegazzo, L.4    Frison, V.5    de, K.S.6
  • 16
    • 77954988618 scopus 로고    scopus 로고
    • Risk of acute myocardial infarction, stroke, heart failure, and death in elderly Medicare patients treated with rosiglitazone or pioglitazone
    • Graham D.J., Ouellet-Hellstrom R., Macurdy T.E., Ali F., Sholley C., Worrall C., et al. Risk of acute myocardial infarction, stroke, heart failure, and death in elderly Medicare patients treated with rosiglitazone or pioglitazone. The Journal of the American Medical Association 2010, 304:411-418.
    • (2010) The Journal of the American Medical Association , vol.304 , pp. 411-418
    • Graham, D.J.1    Ouellet-Hellstrom, R.2    Macurdy, T.E.3    Ali, F.4    Sholley, C.5    Worrall, C.6
  • 18
    • 57849117801 scopus 로고    scopus 로고
    • Atherosclerosis-an immune disease: the Anitschkov Lecture 2007
    • Hansson G.K. Atherosclerosis-an immune disease: the Anitschkov Lecture 2007. Atherosclerosis 2009, 202:2-10.
    • (2009) Atherosclerosis , vol.202 , pp. 2-10
    • Hansson, G.K.1
  • 19
    • 1142309743 scopus 로고    scopus 로고
    • New directions for protecting the heart against ischaemia-reperfusion injury: targeting the Reperfusion Injury Salvage Kinase (RISK)-pathway
    • Hausenloy D.J., Yellon D.M. New directions for protecting the heart against ischaemia-reperfusion injury: targeting the Reperfusion Injury Salvage Kinase (RISK)-pathway. Cardiovascular Research 2004, 61:448-460.
    • (2004) Cardiovascular Research , vol.61 , pp. 448-460
    • Hausenloy, D.J.1    Yellon, D.M.2
  • 21
    • 84855481995 scopus 로고    scopus 로고
    • Cardiovascular safety with linagliptin in patients with type 2 diabetes mellitus: a pre-specified, prospective, and adjudicated meta-analysis of a phase 3 programme
    • Johansen O.E., Neubacher D., von E.M., Patel S., Woerle H.J. Cardiovascular safety with linagliptin in patients with type 2 diabetes mellitus: a pre-specified, prospective, and adjudicated meta-analysis of a phase 3 programme. Cardiovascular Diabetology 2012, 11:3.
    • (2012) Cardiovascular Diabetology , vol.11 , pp. 3
    • Johansen, O.E.1    Neubacher, D.2    von, E.M.3    Patel, S.4    Woerle, H.J.5
  • 22
    • 77957231074 scopus 로고    scopus 로고
    • Interactive hemodynamic effects of dipeptidyl peptidase-IV inhibition and angiotensin-converting enzyme inhibition in humans
    • Marney A., Kunchakarra S., Byrne L., Brown N.J. Interactive hemodynamic effects of dipeptidyl peptidase-IV inhibition and angiotensin-converting enzyme inhibition in humans. Hypertension 2010, 56:728-733.
    • (2010) Hypertension , vol.56 , pp. 728-733
    • Marney, A.1    Kunchakarra, S.2    Byrne, L.3    Brown, N.J.4
  • 23
    • 33746690405 scopus 로고    scopus 로고
    • Vildagliptin therapy reduces postprandial intestinal triglyceride-rich lipoprotein particles in patients with type 2 diabetes
    • Matikainen N., Manttari S., Schweizer A., Ulvestad A., Mills D., Dunning B.E., et al. Vildagliptin therapy reduces postprandial intestinal triglyceride-rich lipoprotein particles in patients with type 2 diabetes. Diabetologia 2006, 49:2049-2057.
    • (2006) Diabetologia , vol.49 , pp. 2049-2057
    • Matikainen, N.1    Manttari, S.2    Schweizer, A.3    Ulvestad, A.4    Mills, D.5    Dunning, B.E.6
  • 24
    • 84899471961 scopus 로고    scopus 로고
    • Merck, Oxford Diabetes Trials Unit, & Duke Clinical Research Institute, Sitagliptin Cardiovascular Outcome Study (0431-082 AM1) (TECOS). In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). Available from: 2008 [cited 10.10.13]. NLM Identifier: NCT00790205.
    • Merck, Oxford Diabetes Trials Unit, & Duke Clinical Research Institute, Sitagliptin Cardiovascular Outcome Study (0431-082 AM1) (TECOS). In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). Available from: 2008 [cited 10.10.13]. NLM Identifier: NCT00790205. http://clinicaltrials.gov/show/NCT00790205.
  • 25
    • 41849099939 scopus 로고    scopus 로고
    • Effect of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on blood pressure in nondiabetic patients with mild to moderate hypertension
    • Mistry G.C., Maes A.L., Lasseter K.C., Davies M.J., Gottesdiener K.M., Wagner J.A., et al. Effect of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on blood pressure in nondiabetic patients with mild to moderate hypertension. Journal of Clinical Pharmacology 2008, 48:592-598.
    • (2008) Journal of Clinical Pharmacology , vol.48 , pp. 592-598
    • Mistry, G.C.1    Maes, A.L.2    Lasseter, K.C.3    Davies, M.J.4    Gottesdiener, K.M.5    Wagner, J.A.6
  • 26
    • 84871936025 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibitors and cardiovascular risk: a meta-analysis of randomized clinical trials
    • Monami M., Ahren B., Dicembrini I., Mannucci E. Dipeptidyl peptidase-4 inhibitors and cardiovascular risk: a meta-analysis of randomized clinical trials. Diabetes, Obesity & Metabolism 2013, 15:112-120.
    • (2013) Diabetes, Obesity & Metabolism , vol.15 , pp. 112-120
    • Monami, M.1    Ahren, B.2    Dicembrini, I.3    Mannucci, E.4
  • 27
    • 0027391607 scopus 로고
    • Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus
    • Nauck M.A., Heimesaat M.M., Orskov C., Holst J.J., Ebert R., Creutzfeldt W. Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus. The Journal of Clinical Investigation 1993, 91:301-307.
    • (1993) The Journal of Clinical Investigation , vol.91 , pp. 301-307
    • Nauck, M.A.1    Heimesaat, M.M.2    Orskov, C.3    Holst, J.J.4    Ebert, R.5    Creutzfeldt, W.6
  • 28
    • 28144441354 scopus 로고    scopus 로고
    • Active metabolite of GLP-1 mediates myocardial glucose uptake and improves left ventricular performance in conscious dogs with dilated cardiomyopathy
    • Nikolaidis L.A., Elahi D., Shen Y.T., Shannon R.P. Active metabolite of GLP-1 mediates myocardial glucose uptake and improves left ventricular performance in conscious dogs with dilated cardiomyopathy. American Journal of Physiology. Heart and Circulatory Physiology 2005, 289:H2401-H2408.
    • (2005) American Journal of Physiology. Heart and Circulatory Physiology , vol.289
    • Nikolaidis, L.A.1    Elahi, D.2    Shen, Y.T.3    Shannon, R.P.4
  • 29
  • 30
    • 34250212715 scopus 로고    scopus 로고
    • "Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes"
    • Nissen S.E., Wolski K. "Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes". The New England Journal of Medicine 2007, 356:2457-2471.
    • (2007) The New England Journal of Medicine , vol.356 , pp. 2457-2471
    • Nissen, S.E.1    Wolski, K.2
  • 31
    • 84872020915 scopus 로고    scopus 로고
    • Alogliptin ameliorates postprandial lipemia and postprandial endothelial dysfunction in non-diabetic subjects: a preliminary report
    • Noda Y., Miyoshi T., Oe H., Ohno Y., Nakamura K., Toh N., et al. Alogliptin ameliorates postprandial lipemia and postprandial endothelial dysfunction in non-diabetic subjects: a preliminary report. Cardiovascular Diabetology 2013, 12:8.
    • (2013) Cardiovascular Diabetology , vol.12 , pp. 8
    • Noda, Y.1    Miyoshi, T.2    Oe, H.3    Ohno, Y.4    Nakamura, K.5    Toh, N.6
  • 32
    • 38749113743 scopus 로고    scopus 로고
    • Non-fasting triglycerides and risk of for myocardial infarction and death among women and men
    • Nordestgaard B.G., Benn M., Schnohr P., Tybjaerg-Hansen A. Non-fasting triglycerides and risk of for myocardial infarction and death among women and men. Ugeskrift for Laeger 2007, 169:3865-3868.
    • (2007) Ugeskrift for Laeger , vol.169 , pp. 3865-3868
    • Nordestgaard, B.G.1    Benn, M.2    Schnohr, P.3    Tybjaerg-Hansen, A.4
  • 33
    • 79955952000 scopus 로고    scopus 로고
    • Sitagliptin, a dipeptidyl peptidase-4 inhibitor, decreases systolic blood pressure in Japanese hypertensive patients with type 2 diabetes
    • Ogawa S., Ishiki M., Nako K., Okamura M., Senda M., Mori T., et al. Sitagliptin, a dipeptidyl peptidase-4 inhibitor, decreases systolic blood pressure in Japanese hypertensive patients with type 2 diabetes. The Tohoku Journal of Experimental Medicine 2011, 223:133-135.
    • (2011) The Tohoku Journal of Experimental Medicine , vol.223 , pp. 133-135
    • Ogawa, S.1    Ishiki, M.2    Nako, K.3    Okamura, M.4    Senda, M.5    Mori, T.6
  • 34
  • 35
    • 77951934948 scopus 로고    scopus 로고
    • DPP-4 inhibition by sitagliptin improves the myocardial response to dobutamine stress and mitigates stunning in a pilot study of patients with coronary artery disease
    • Read P.A., Khan F.Z., Heck P.M., Hoole S.P., Dutka D.P. DPP-4 inhibition by sitagliptin improves the myocardial response to dobutamine stress and mitigates stunning in a pilot study of patients with coronary artery disease. Circulation. Cardiovascular Imaging 2010, 3:195-201.
    • (2010) Circulation. Cardiovascular Imaging , vol.3 , pp. 195-201
    • Read, P.A.1    Khan, F.Z.2    Heck, P.M.3    Hoole, S.P.4    Dutka, D.P.5
  • 38
    • 75249100556 scopus 로고    scopus 로고
    • Insulin-like actions of glucagon-like peptide-1: a dual receptor hypothesis
    • Tomas E., Habener J.F. Insulin-like actions of glucagon-like peptide-1: a dual receptor hypothesis. Trends in Endocrinology and Metabolism 2010, 21:59-67.
    • (2010) Trends in Endocrinology and Metabolism , vol.21 , pp. 59-67
    • Tomas, E.1    Habener, J.F.2
  • 40
    • 0001095690 scopus 로고    scopus 로고
    • Reduced postprandial concentrations of intact biologically active glucagon-like peptide 1 in type 2 diabetic patients
    • Vilsboll T., Krarup T., Deacon C.F., Madsbad S., Holst J.J. Reduced postprandial concentrations of intact biologically active glucagon-like peptide 1 in type 2 diabetic patients. Diabetes 2001, 50:609-613.
    • (2001) Diabetes , vol.50 , pp. 609-613
    • Vilsboll, T.1    Krarup, T.2    Deacon, C.F.3    Madsbad, S.4    Holst, J.J.5
  • 42
    • 9344227376 scopus 로고    scopus 로고
    • Cardioprotective functions of atrial natriuretic peptide and B-type natriuretic peptide: a brief review
    • Woods R.L. Cardioprotective functions of atrial natriuretic peptide and B-type natriuretic peptide: a brief review. Clinical and Experimental Pharmacology and Physiology 2004, 31:791-794.
    • (2004) Clinical and Experimental Pharmacology and Physiology , vol.31 , pp. 791-794
    • Woods, R.L.1
  • 44
    • 79551706382 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 improves proliferation and differentiation of endothelial progenitor cells via upregulating VEGF generation
    • Xiao-Yun X., Zhao-Hui M., Ke C., Hong-Hui H., Yan-Hong X. Glucagon-like peptide-1 improves proliferation and differentiation of endothelial progenitor cells via upregulating VEGF generation. Medical Science Monitor 2011, 17(2):BR35-BR41.
    • (2011) Medical Science Monitor , vol.17 , Issue.2
    • Xiao-Yun, X.1    Zhao-Hui, M.2    Ke, C.3    Hong-Hui, H.4    Yan-Hong, X.5


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